Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASS7_LEIMU

TriTrypDb:

LmxM.36.1570

Length:

476

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASS7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS7

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	116	118	PF00675	0.543
CLV_NRD_NRD_1	196	198	PF00675	0.689
CLV_NRD_NRD_1	205	207	PF00675	0.600
CLV_NRD_NRD_1	229	231	PF00675	0.661
CLV_NRD_NRD_1	256	258	PF00675	0.769
CLV_NRD_NRD_1	339	341	PF00675	0.811
CLV_NRD_NRD_1	80	82	PF00675	0.566
CLV_NRD_NRD_1	91	93	PF00675	0.540
CLV_PCSK_KEX2_1	116	118	PF00082	0.591
CLV_PCSK_KEX2_1	195	197	PF00082	0.682
CLV_PCSK_KEX2_1	205	207	PF00082	0.606
CLV_PCSK_KEX2_1	229	231	PF00082	0.694
CLV_PCSK_KEX2_1	339	341	PF00082	0.811
CLV_PCSK_KEX2_1	82	84	PF00082	0.561
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.561
CLV_PCSK_SKI1_1	155	159	PF00082	0.482
CLV_PCSK_SKI1_1	389	393	PF00082	0.620
CLV_PCSK_SKI1_1	411	415	PF00082	0.551
CLV_PCSK_SKI1_1	458	462	PF00082	0.480
CLV_PCSK_SKI1_1	466	470	PF00082	0.417
CLV_Separin_Metazoa	386	390	PF03568	0.532
CLV_Separin_Metazoa	89	93	PF03568	0.544
DEG_APCC_DBOX_1	115	123	PF00400	0.433
DEG_APCC_DBOX_1	364	372	PF00400	0.554
DOC_CYCLIN_RxL_1	454	464	PF00134	0.583
DOC_MAPK_gen_1	133	141	PF00069	0.551
DOC_MAPK_gen_1	406	412	PF00069	0.433
DOC_MAPK_gen_1	81	90	PF00069	0.557
DOC_MAPK_MEF2A_6	155	162	PF00069	0.562
DOC_MAPK_MEF2A_6	17	24	PF00069	0.633
DOC_MAPK_MEF2A_6	174	183	PF00069	0.299
DOC_USP7_MATH_1	228	232	PF00917	0.710
DOC_USP7_MATH_1	290	294	PF00917	0.718
DOC_USP7_MATH_1	3	7	PF00917	0.767
DOC_USP7_MATH_1	329	333	PF00917	0.796
DOC_USP7_MATH_1	347	351	PF00917	0.684
DOC_USP7_MATH_1	36	40	PF00917	0.528
DOC_USP7_MATH_1	428	432	PF00917	0.665
DOC_USP7_UBL2_3	407	411	PF12436	0.555
DOC_WW_Pin1_4	235	240	PF00397	0.634
DOC_WW_Pin1_4	257	262	PF00397	0.672
DOC_WW_Pin1_4	333	338	PF00397	0.705
DOC_WW_Pin1_4	442	447	PF00397	0.712
LIG_14-3-3_CanoR_1	229	239	PF00244	0.750
LIG_14-3-3_CanoR_1	353	360	PF00244	0.544
LIG_14-3-3_CanoR_1	381	388	PF00244	0.617
LIG_BIR_II_1	1	5	PF00653	0.633
LIG_CaM_IQ_9	34	50	PF13499	0.418
LIG_Clathr_ClatBox_1	159	163	PF01394	0.559
LIG_EH1_1	396	404	PF00400	0.528
LIG_FHA_1	207	213	PF00498	0.582
LIG_FHA_1	25	31	PF00498	0.526
LIG_FHA_1	352	358	PF00498	0.548
LIG_FHA_2	21	27	PF00498	0.628
LIG_FHA_2	353	359	PF00498	0.547
LIG_GBD_Chelix_1	461	469	PF00786	0.493
LIG_LIR_Apic_2	238	244	PF02991	0.667
LIG_LIR_Gen_1	188	198	PF02991	0.627
LIG_LIR_Nem_3	188	193	PF02991	0.585
LIG_MAD2	280	288	PF02301	0.702
LIG_NRBOX	464	470	PF00104	0.498
LIG_NRBOX	86	92	PF00104	0.503
LIG_SH2_CRK	241	245	PF00017	0.635
LIG_SH2_NCK_1	267	271	PF00017	0.646
LIG_SH2_SRC	241	244	PF00017	0.661
LIG_SH2_SRC	267	270	PF00017	0.717
LIG_SH2_STAP1	375	379	PF00017	0.580
LIG_SH2_STAP1	55	59	PF00017	0.447
LIG_SH3_2	250	255	PF14604	0.580
LIG_SH3_3	247	253	PF00018	0.581
LIG_SH3_3	343	349	PF00018	0.722
LIG_SH3_CIN85_PxpxPR_1	200	205	PF14604	0.575
LIG_SUMO_SIM_anti_2	86	92	PF11976	0.551
LIG_SUMO_SIM_par_1	158	163	PF11976	0.559
LIG_TRAF2_1	301	304	PF00917	0.687
LIG_TRAF2_1	383	386	PF00917	0.574
LIG_TRAF2_1	94	97	PF00917	0.483
LIG_UBA3_1	87	93	PF00899	0.521
LIG_WW_3	242	246	PF00397	0.661
MOD_CDC14_SPxK_1	336	339	PF00782	0.801
MOD_CDK_SPxK_1	333	339	PF00069	0.786
MOD_CDK_SPxxK_3	257	264	PF00069	0.496
MOD_CDK_SPxxK_3	333	340	PF00069	0.778
MOD_CK1_1	10	16	PF00069	0.608
MOD_CK1_1	135	141	PF00069	0.389
MOD_CK1_1	18	24	PF00069	0.560
MOD_CK1_1	210	216	PF00069	0.697
MOD_CK1_1	231	237	PF00069	0.687
MOD_CK1_1	293	299	PF00069	0.753
MOD_CK1_1	429	435	PF00069	0.660
MOD_CK1_1	445	451	PF00069	0.602
MOD_CK2_1	122	128	PF00069	0.516
MOD_CK2_1	185	191	PF00069	0.569
MOD_CK2_1	298	304	PF00069	0.684
MOD_CK2_1	380	386	PF00069	0.678
MOD_Cter_Amidation	106	109	PF01082	0.322
MOD_GlcNHglycan	1	4	PF01048	0.749
MOD_GlcNHglycan	105	108	PF01048	0.511
MOD_GlcNHglycan	17	20	PF01048	0.417
MOD_GlcNHglycan	209	212	PF01048	0.695
MOD_GlcNHglycan	292	295	PF01048	0.813
MOD_GlcNHglycan	316	319	PF01048	0.747
MOD_GlcNHglycan	331	334	PF01048	0.787
MOD_GlcNHglycan	349	352	PF01048	0.671
MOD_GlcNHglycan	399	402	PF01048	0.548
MOD_GlcNHglycan	426	429	PF01048	0.743
MOD_GlcNHglycan	9	12	PF01048	0.549
MOD_GSK3_1	11	18	PF00069	0.577
MOD_GSK3_1	128	135	PF00069	0.554
MOD_GSK3_1	20	27	PF00069	0.448
MOD_GSK3_1	206	213	PF00069	0.673
MOD_GSK3_1	231	238	PF00069	0.661
MOD_GSK3_1	290	297	PF00069	0.705
MOD_GSK3_1	3	10	PF00069	0.622
MOD_GSK3_1	306	313	PF00069	0.714
MOD_GSK3_1	320	327	PF00069	0.677
MOD_GSK3_1	329	336	PF00069	0.654
MOD_GSK3_1	347	354	PF00069	0.606
MOD_GSK3_1	36	43	PF00069	0.440
MOD_GSK3_1	424	431	PF00069	0.591
MOD_N-GLC_1	294	299	PF02516	0.742
MOD_N-GLC_1	434	439	PF02516	0.788
MOD_NEK2_1	1	6	PF00069	0.692
MOD_NEK2_1	15	20	PF00069	0.408
MOD_NEK2_1	298	303	PF00069	0.751
MOD_NEK2_1	426	431	PF00069	0.753
MOD_NEK2_2	294	299	PF00069	0.681
MOD_PIKK_1	128	134	PF00454	0.571
MOD_PIKK_1	298	304	PF00454	0.805
MOD_PIKK_1	320	326	PF00454	0.651
MOD_PKA_2	132	138	PF00069	0.575
MOD_PKA_2	228	234	PF00069	0.728
MOD_PKA_2	352	358	PF00069	0.558
MOD_PKA_2	380	386	PF00069	0.610
MOD_PKA_2	397	403	PF00069	0.437
MOD_PKA_2	429	435	PF00069	0.668
MOD_Plk_1	294	300	PF00069	0.698
MOD_Plk_1	375	381	PF00069	0.589
MOD_Plk_1	434	440	PF00069	0.782
MOD_Plk_4	26	32	PF00069	0.450
MOD_Plk_4	271	277	PF00069	0.694
MOD_ProDKin_1	235	241	PF00069	0.639
MOD_ProDKin_1	257	263	PF00069	0.673
MOD_ProDKin_1	333	339	PF00069	0.743
MOD_ProDKin_1	442	448	PF00069	0.708
MOD_SUMO_for_1	148	151	PF00179	0.563
MOD_SUMO_for_1	165	168	PF00179	0.342
MOD_SUMO_rev_2	128	138	PF00179	0.563
MOD_SUMO_rev_2	21	30	PF00179	0.495
TRG_DiLeu_BaEn_1	408	413	PF01217	0.431
TRG_DiLeu_BaEn_1	464	469	PF01217	0.499
TRG_DiLeu_BaEn_4	421	427	PF01217	0.502
TRG_DiLeu_BaEn_4	96	102	PF01217	0.557
TRG_ENDOCYTIC_2	190	193	PF00928	0.595
TRG_ER_diArg_1	115	117	PF00400	0.479
TRG_ER_diArg_1	195	197	PF00400	0.697
TRG_ER_diArg_1	204	206	PF00400	0.557
TRG_ER_diArg_1	228	230	PF00400	0.704
TRG_ER_diArg_1	339	341	PF00400	0.757
TRG_Pf-PMV_PEXEL_1	117	121	PF00026	0.560
TRG_Pf-PMV_PEXEL_1	411	415	PF00026	0.489
TRG_Pf-PMV_PEXEL_1	42	46	PF00026	0.421
TRG_Pf-PMV_PEXEL_1	466	471	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7F5	Leptomonas seymouri	55%	98%
A0A0S4ISW4	Bodo saltans	32%	100%
A0A1X0P856	Trypanosomatidae	38%	100%
A0A3Q8INJ9	Leishmania donovani	94%	100%
A0A3R7RIJ2	Trypanosoma rangeli	38%	100%
A4HP16	Leishmania braziliensis	77%	100%
A4IDC6	Leishmania infantum	93%	100%
Q4Q1R9	Leishmania major	93%	100%
V5BU44	Trypanosoma cruzi	39%	100%