Leucine_Rich_repeat

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Leucine_Rich_repeat

Gene product:

Leucine Rich Repeat, putative

Species:

Leishmania mexicana

UniProt:

E9ASS6_LEIMU

TriTrypDb:

LmxM.36.1560

Length:

503

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	7
GO:0120025	plasma membrane bounded cell projection	3	6
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1

Expansion

Sequence features

E9ASS6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.451
CLV_C14_Caspase3-7	90	94	PF00656	0.468
CLV_NRD_NRD_1	174	176	PF00675	0.327
CLV_PCSK_FUR_1	172	176	PF00082	0.327
CLV_PCSK_KEX2_1	174	176	PF00082	0.327
CLV_PCSK_SKI1_1	165	169	PF00082	0.291
CLV_PCSK_SKI1_1	263	267	PF00082	0.476
CLV_PCSK_SKI1_1	390	394	PF00082	0.641
CLV_PCSK_SKI1_1	445	449	PF00082	0.636
CLV_PCSK_SKI1_1	482	486	PF00082	0.606
DEG_SPOP_SBC_1	334	338	PF00917	0.499
DEG_SPOP_SBC_1	358	362	PF00917	0.646
DOC_ANK_TNKS_1	348	355	PF00023	0.529
DOC_CDC14_PxL_1	143	151	PF14671	0.328
DOC_CDC14_PxL_1	237	245	PF14671	0.415
DOC_CDC14_PxL_1	461	469	PF14671	0.547
DOC_CDC14_PxL_1	67	75	PF14671	0.383
DOC_CKS1_1	22	27	PF01111	0.555
DOC_CYCLIN_RxL_1	195	203	PF00134	0.388
DOC_MAPK_gen_1	107	117	PF00069	0.405
DOC_MAPK_gen_1	263	273	PF00069	0.446
DOC_MAPK_MEF2A_6	110	119	PF00069	0.398
DOC_MAPK_MEF2A_6	238	245	PF00069	0.419
DOC_MAPK_MEF2A_6	432	441	PF00069	0.542
DOC_PP1_RVXF_1	267	274	PF00149	0.402
DOC_PP2B_LxvP_1	448	451	PF13499	0.563
DOC_USP7_MATH_1	23	27	PF00917	0.637
DOC_USP7_MATH_1	321	325	PF00917	0.506
DOC_USP7_MATH_1	358	362	PF00917	0.783
DOC_USP7_MATH_1	366	370	PF00917	0.615
DOC_USP7_MATH_1	382	386	PF00917	0.546
DOC_USP7_MATH_1	427	431	PF00917	0.521
DOC_USP7_MATH_2	496	502	PF00917	0.532
DOC_USP7_UBL2_3	493	497	PF12436	0.507
DOC_WW_Pin1_4	21	26	PF00397	0.596
LIG_14-3-3_CanoR_1	110	119	PF00244	0.447
LIG_14-3-3_CanoR_1	165	173	PF00244	0.252
LIG_14-3-3_CanoR_1	174	179	PF00244	0.385
LIG_14-3-3_CanoR_1	231	240	PF00244	0.477
LIG_Actin_WH2_2	28	43	PF00022	0.488
LIG_BIR_III_4	380	384	PF00653	0.578
LIG_BRCT_BRCA1_1	112	116	PF00533	0.369
LIG_FHA_1	110	116	PF00498	0.370
LIG_FHA_1	183	189	PF00498	0.392
LIG_FHA_1	192	198	PF00498	0.276
LIG_FHA_1	208	214	PF00498	0.406
LIG_FHA_1	387	393	PF00498	0.618
LIG_FHA_1	458	464	PF00498	0.615
LIG_FHA_2	136	142	PF00498	0.538
LIG_FHA_2	166	172	PF00498	0.258
LIG_FHA_2	242	248	PF00498	0.376
LIG_FHA_2	302	308	PF00498	0.632
LIG_FHA_2	34	40	PF00498	0.427
LIG_FHA_2	473	479	PF00498	0.600
LIG_FHA_2	88	94	PF00498	0.453
LIG_IBAR_NPY_1	50	52	PF08397	0.500
LIG_Integrin_isoDGR_2	471	473	PF01839	0.595
LIG_Integrin_RGD_1	16	18	PF01839	0.604
LIG_LIR_Gen_1	113	124	PF02991	0.375
LIG_LIR_Gen_1	410	418	PF02991	0.585
LIG_LIR_Gen_1	419	428	PF02991	0.457
LIG_LIR_Nem_3	113	119	PF02991	0.368
LIG_LIR_Nem_3	410	416	PF02991	0.596
LIG_LIR_Nem_3	419	425	PF02991	0.552
LIG_LIR_Nem_3	46	52	PF02991	0.475
LIG_Pex14_2	148	152	PF04695	0.457
LIG_PTB_Apo_2	206	213	PF02174	0.252
LIG_SH2_CRK	422	426	PF00017	0.503
LIG_SH2_PTP2	76	79	PF00017	0.397
LIG_SH2_STAP1	214	218	PF00017	0.282
LIG_SH2_STAP1	306	310	PF00017	0.633
LIG_SH2_STAT3	97	100	PF00017	0.474
LIG_SH2_STAT5	422	425	PF00017	0.444
LIG_SH2_STAT5	457	460	PF00017	0.528
LIG_SH2_STAT5	57	60	PF00017	0.452
LIG_SH2_STAT5	76	79	PF00017	0.397
LIG_SH3_3	17	23	PF00018	0.556
LIG_SH3_3	190	196	PF00018	0.207
LIG_SUMO_SIM_anti_2	460	465	PF11976	0.535
LIG_SUMO_SIM_par_1	198	203	PF11976	0.340
LIG_TRAF2_1	36	39	PF00917	0.441
LIG_TRAF2_1	451	454	PF00917	0.559
MOD_CK1_1	369	375	PF00069	0.622
MOD_CK2_1	165	171	PF00069	0.258
MOD_CK2_1	310	316	PF00069	0.606
MOD_CK2_1	33	39	PF00069	0.437
MOD_CK2_1	472	478	PF00069	0.694
MOD_GlcNHglycan	233	236	PF01048	0.500
MOD_GlcNHglycan	252	256	PF01048	0.403
MOD_GlcNHglycan	323	326	PF01048	0.671
MOD_GlcNHglycan	345	348	PF01048	0.659
MOD_GlcNHglycan	366	369	PF01048	0.643
MOD_GlcNHglycan	429	432	PF01048	0.501
MOD_GSK3_1	297	304	PF00069	0.571
MOD_GSK3_1	334	341	PF00069	0.675
MOD_GSK3_1	360	367	PF00069	0.612
MOD_GSK3_1	369	376	PF00069	0.683
MOD_GSK3_1	382	389	PF00069	0.644
MOD_GSK3_1	416	423	PF00069	0.542
MOD_GSK3_1	57	64	PF00069	0.461
MOD_LATS_1	108	114	PF00433	0.380
MOD_N-GLC_2	6	8	PF02516	0.587
MOD_NEK2_1	150	155	PF00069	0.408
MOD_NEK2_1	176	181	PF00069	0.294
MOD_NEK2_1	191	196	PF00069	0.321
MOD_NEK2_1	200	205	PF00069	0.333
MOD_NEK2_1	212	217	PF00069	0.318
MOD_NEK2_1	297	302	PF00069	0.556
MOD_NEK2_1	397	402	PF00069	0.571
MOD_NEK2_1	40	45	PF00069	0.496
MOD_NEK2_1	55	60	PF00069	0.304
MOD_PIKK_1	24	30	PF00454	0.475
MOD_PKA_1	174	180	PF00069	0.207
MOD_PKA_2	109	115	PF00069	0.447
MOD_PKA_2	174	180	PF00069	0.248
MOD_PKA_2	472	478	PF00069	0.610
MOD_PKB_1	172	180	PF00069	0.340
MOD_PKB_1	229	237	PF00069	0.278
MOD_Plk_1	33	39	PF00069	0.621
MOD_Plk_4	241	247	PF00069	0.412
MOD_Plk_4	360	366	PF00069	0.679
MOD_Plk_4	420	426	PF00069	0.497
MOD_Plk_4	459	465	PF00069	0.536
MOD_ProDKin_1	21	27	PF00069	0.597
MOD_SUMO_rev_2	34	43	PF00179	0.452
TRG_DiLeu_BaEn_2	143	149	PF01217	0.359
TRG_DiLeu_BaEn_2	419	425	PF01217	0.554
TRG_ENDOCYTIC_2	413	416	PF00928	0.589
TRG_ENDOCYTIC_2	422	425	PF00928	0.504
TRG_ENDOCYTIC_2	52	55	PF00928	0.480
TRG_ENDOCYTIC_2	76	79	PF00928	0.369
TRG_ER_diArg_1	172	175	PF00400	0.293
TRG_NES_CRM1_1	239	252	PF08389	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P712	Leptomonas seymouri	47%	100%
A0A3Q8IIX2	Leishmania donovani	85%	100%
A4IDC5	Leishmania infantum	86%	100%
E9AIX7	Leishmania braziliensis	69%	100%
Q4Q1S0	Leishmania major	87%	100%