B box-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASS5_LEIMU

TriTrypDb:

LmxM.36.1550

Length:

848

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASS5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS5

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0008270	zinc ion binding	6	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0046914	transition metal ion binding	5	6
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	20	24	PF00656	0.611
CLV_C14_Caspase3-7	679	683	PF00656	0.652
CLV_C14_Caspase3-7	783	787	PF00656	0.744
CLV_C14_Caspase3-7	821	825	PF00656	0.655
CLV_NRD_NRD_1	273	275	PF00675	0.701
CLV_NRD_NRD_1	397	399	PF00675	0.655
CLV_NRD_NRD_1	421	423	PF00675	0.617
CLV_NRD_NRD_1	641	643	PF00675	0.530
CLV_NRD_NRD_1	749	751	PF00675	0.627
CLV_NRD_NRD_1	812	814	PF00675	0.826
CLV_NRD_NRD_1	839	841	PF00675	0.837
CLV_PCSK_FUR_1	419	423	PF00082	0.612
CLV_PCSK_KEX2_1	272	274	PF00082	0.705
CLV_PCSK_KEX2_1	3	5	PF00082	0.805
CLV_PCSK_KEX2_1	397	399	PF00082	0.655
CLV_PCSK_KEX2_1	421	423	PF00082	0.617
CLV_PCSK_KEX2_1	498	500	PF00082	0.603
CLV_PCSK_KEX2_1	641	643	PF00082	0.530
CLV_PCSK_KEX2_1	749	751	PF00082	0.627
CLV_PCSK_KEX2_1	839	841	PF00082	0.806
CLV_PCSK_PC1ET2_1	3	5	PF00082	0.805
CLV_PCSK_PC1ET2_1	498	500	PF00082	0.649
CLV_PCSK_SKI1_1	333	337	PF00082	0.352
CLV_PCSK_SKI1_1	374	378	PF00082	0.655
CLV_PCSK_SKI1_1	40	44	PF00082	0.748
CLV_PCSK_SKI1_1	498	502	PF00082	0.723
CLV_PCSK_SKI1_1	719	723	PF00082	0.547
CLV_PCSK_SKI1_1	774	778	PF00082	0.818
DEG_APCC_DBOX_1	641	649	PF00400	0.540
DEG_SPOP_SBC_1	26	30	PF00917	0.525
DOC_CKS1_1	597	602	PF01111	0.761
DOC_CYCLIN_RxL_1	771	782	PF00134	0.812
DOC_CYCLIN_yCln2_LP_2	80	86	PF00134	0.675
DOC_MAPK_gen_1	3	11	PF00069	0.733
DOC_MAPK_gen_1	734	742	PF00069	0.821
DOC_MAPK_gen_1	839	846	PF00069	0.838
DOC_MAPK_MEF2A_6	4	13	PF00069	0.520
DOC_MAPK_MEF2A_6	839	848	PF00069	0.836
DOC_MAPK_RevD_3	383	398	PF00069	0.581
DOC_PP4_FxxP_1	70	73	PF00568	0.691
DOC_USP7_MATH_1	219	223	PF00917	0.664
DOC_USP7_MATH_1	22	26	PF00917	0.728
DOC_USP7_MATH_1	225	229	PF00917	0.457
DOC_USP7_MATH_1	408	412	PF00917	0.633
DOC_USP7_MATH_1	608	612	PF00917	0.651
DOC_USP7_MATH_1	73	77	PF00917	0.671
DOC_USP7_MATH_1	822	826	PF00917	0.754
DOC_WW_Pin1_4	145	150	PF00397	0.748
DOC_WW_Pin1_4	173	178	PF00397	0.469
DOC_WW_Pin1_4	221	226	PF00397	0.547
DOC_WW_Pin1_4	425	430	PF00397	0.539
DOC_WW_Pin1_4	485	490	PF00397	0.634
DOC_WW_Pin1_4	596	601	PF00397	0.760
DOC_WW_Pin1_4	92	97	PF00397	0.756
LIG_14-3-3_CanoR_1	194	198	PF00244	0.654
LIG_14-3-3_CanoR_1	252	260	PF00244	0.642
LIG_14-3-3_CanoR_1	40	47	PF00244	0.743
LIG_14-3-3_CanoR_1	401	409	PF00244	0.472
LIG_14-3-3_CanoR_1	448	454	PF00244	0.583
LIG_14-3-3_CanoR_1	477	482	PF00244	0.769
LIG_14-3-3_CanoR_1	627	633	PF00244	0.763
LIG_14-3-3_CanoR_1	743	747	PF00244	0.720
LIG_14-3-3_CanoR_1	789	796	PF00244	0.713
LIG_14-3-3_CanoR_1	797	807	PF00244	0.638
LIG_14-3-3_CanoR_1	839	846	PF00244	0.837
LIG_Actin_WH2_2	359	376	PF00022	0.646
LIG_Actin_WH2_2	388	405	PF00022	0.654
LIG_APCC_ABBA_1	287	292	PF00400	0.530
LIG_BIR_II_1	1	5	PF00653	0.808
LIG_BIR_III_4	342	346	PF00653	0.537
LIG_BRCT_BRCA1_1	66	70	PF00533	0.747
LIG_BRCT_BRCA1_1	824	828	PF00533	0.541
LIG_deltaCOP1_diTrp_1	118	127	PF00928	0.604
LIG_DLG_GKlike_1	477	484	PF00625	0.765
LIG_EH1_1	406	414	PF00400	0.560
LIG_FHA_1	554	560	PF00498	0.526
LIG_FHA_1	585	591	PF00498	0.808
LIG_FHA_1	597	603	PF00498	0.674
LIG_FHA_1	687	693	PF00498	0.681
LIG_FHA_1	799	805	PF00498	0.816
LIG_FHA_1	839	845	PF00498	0.839
LIG_FHA_2	100	106	PF00498	0.691
LIG_FHA_2	166	172	PF00498	0.490
LIG_FHA_2	18	24	PF00498	0.642
LIG_FHA_2	28	34	PF00498	0.631
LIG_FHA_2	436	442	PF00498	0.580
LIG_FHA_2	806	812	PF00498	0.703
LIG_LIR_Apic_2	550	555	PF02991	0.605
LIG_LIR_Apic_2	67	73	PF02991	0.715
LIG_LIR_Gen_1	105	115	PF02991	0.388
LIG_LIR_Gen_1	224	233	PF02991	0.555
LIG_LIR_Gen_1	480	489	PF02991	0.680
LIG_LIR_Gen_1	67	74	PF02991	0.415
LIG_LIR_Nem_3	105	111	PF02991	0.418
LIG_LIR_Nem_3	146	150	PF02991	0.704
LIG_LIR_Nem_3	224	229	PF02991	0.556
LIG_LIR_Nem_3	349	355	PF02991	0.564
LIG_LIR_Nem_3	480	484	PF02991	0.682
LIG_LIR_Nem_3	67	71	PF02991	0.737
LIG_LIR_Nem_3	697	702	PF02991	0.643
LIG_PDZ_Class_2	843	848	PF00595	0.834
LIG_PTAP_UEV_1	215	220	PF05743	0.770
LIG_SH2_CRK	497	501	PF00017	0.722
LIG_SH2_NCK_1	552	556	PF00017	0.604
LIG_SH2_STAP1	355	359	PF00017	0.633
LIG_SH2_STAP1	662	666	PF00017	0.822
LIG_SH2_STAT5	197	200	PF00017	0.694
LIG_SH2_STAT5	552	555	PF00017	0.606
LIG_SH2_STAT5	806	809	PF00017	0.825
LIG_SH3_3	174	180	PF00018	0.441
LIG_SH3_3	210	216	PF00018	0.777
LIG_SH3_3	59	65	PF00018	0.524
LIG_SH3_3	594	600	PF00018	0.833
LIG_SH3_3	637	643	PF00018	0.657
LIG_SH3_3	741	747	PF00018	0.835
LIG_SUMO_SIM_anti_2	76	82	PF11976	0.582
LIG_SUMO_SIM_par_1	82	88	PF11976	0.688
LIG_TRAF2_1	438	441	PF00917	0.481
LIG_WRC_WIRS_1	478	483	PF05994	0.766
LIG_WW_3	746	750	PF00397	0.742
MOD_CK1_1	148	154	PF00069	0.679
MOD_CK1_1	16	22	PF00069	0.753
MOD_CK1_1	204	210	PF00069	0.756
MOD_CK1_1	25	31	PF00069	0.720
MOD_CK1_1	428	434	PF00069	0.678
MOD_CK1_1	447	453	PF00069	0.414
MOD_CK1_1	522	528	PF00069	0.848
MOD_CK1_1	626	632	PF00069	0.639
MOD_CK1_1	651	657	PF00069	0.516
MOD_CK1_1	790	796	PF00069	0.833
MOD_CK1_1	95	101	PF00069	0.795
MOD_CK2_1	225	231	PF00069	0.624
MOD_CK2_1	412	418	PF00069	0.571
MOD_CK2_1	435	441	PF00069	0.579
MOD_CK2_1	712	718	PF00069	0.504
MOD_CK2_1	760	766	PF00069	0.648
MOD_Cter_Amidation	395	398	PF01082	0.556
MOD_GlcNHglycan	121	124	PF01048	0.500
MOD_GlcNHglycan	14	18	PF01048	0.672
MOD_GlcNHglycan	150	153	PF01048	0.649
MOD_GlcNHglycan	189	193	PF01048	0.576
MOD_GlcNHglycan	216	219	PF01048	0.604
MOD_GlcNHglycan	221	224	PF01048	0.613
MOD_GlcNHglycan	390	394	PF01048	0.510
MOD_GlcNHglycan	403	406	PF01048	0.523
MOD_GlcNHglycan	449	452	PF01048	0.373
MOD_GlcNHglycan	508	512	PF01048	0.714
MOD_GlcNHglycan	521	524	PF01048	0.614
MOD_GlcNHglycan	536	541	PF01048	0.643
MOD_GlcNHglycan	561	564	PF01048	0.563
MOD_GlcNHglycan	574	577	PF01048	0.631
MOD_GlcNHglycan	678	681	PF01048	0.773
MOD_GlcNHglycan	714	717	PF01048	0.520
MOD_GlcNHglycan	75	78	PF01048	0.623
MOD_GSK3_1	125	132	PF00069	0.664
MOD_GSK3_1	13	20	PF00069	0.654
MOD_GSK3_1	135	142	PF00069	0.700
MOD_GSK3_1	193	200	PF00069	0.749
MOD_GSK3_1	204	211	PF00069	0.615
MOD_GSK3_1	22	29	PF00069	0.553
MOD_GSK3_1	221	228	PF00069	0.544
MOD_GSK3_1	397	404	PF00069	0.645
MOD_GSK3_1	408	415	PF00069	0.455
MOD_GSK3_1	423	430	PF00069	0.460
MOD_GSK3_1	553	560	PF00069	0.626
MOD_GSK3_1	568	575	PF00069	0.675
MOD_GSK3_1	608	615	PF00069	0.718
MOD_GSK3_1	623	630	PF00069	0.708
MOD_GSK3_1	644	651	PF00069	0.613
MOD_GSK3_1	682	689	PF00069	0.719
MOD_GSK3_1	787	794	PF00069	0.841
MOD_GSK3_1	834	841	PF00069	0.789
MOD_GSK3_1	90	97	PF00069	0.802
MOD_N-GLC_1	129	134	PF02516	0.491
MOD_N-GLC_2	474	476	PF02516	0.736
MOD_NEK2_1	150	155	PF00069	0.512
MOD_NEK2_1	165	170	PF00069	0.418
MOD_NEK2_1	188	193	PF00069	0.592
MOD_NEK2_1	203	208	PF00069	0.469
MOD_NEK2_1	290	295	PF00069	0.379
MOD_NEK2_1	412	417	PF00069	0.645
MOD_NEK2_1	51	56	PF00069	0.530
MOD_NEK2_1	559	564	PF00069	0.593
MOD_NEK2_1	742	747	PF00069	0.664
MOD_NEK2_1	778	783	PF00069	0.519
MOD_NEK2_1	827	832	PF00069	0.717
MOD_NEK2_1	99	104	PF00069	0.500
MOD_NEK2_2	369	374	PF00069	0.654
MOD_OFUCOSY	205	212	PF10250	0.484
MOD_OFUCOSY	291	297	PF10250	0.530
MOD_PIKK_1	197	203	PF00454	0.767
MOD_PIKK_1	34	40	PF00454	0.786
MOD_PIKK_1	649	655	PF00454	0.592
MOD_PIKK_1	834	840	PF00454	0.836
MOD_PKA_1	397	403	PF00069	0.651
MOD_PKA_1	813	819	PF00069	0.825
MOD_PKA_1	839	845	PF00069	0.839
MOD_PKA_2	193	199	PF00069	0.762
MOD_PKA_2	251	257	PF00069	0.625
MOD_PKA_2	396	402	PF00069	0.592
MOD_PKA_2	447	453	PF00069	0.583
MOD_PKA_2	590	596	PF00069	0.843
MOD_PKA_2	626	632	PF00069	0.580
MOD_PKA_2	736	742	PF00069	0.673
MOD_PKA_2	788	794	PF00069	0.657
MOD_PKA_2	838	844	PF00069	0.839
MOD_Plk_1	104	110	PF00069	0.454
MOD_Plk_1	170	176	PF00069	0.597
MOD_Plk_1	188	194	PF00069	0.787
MOD_Plk_1	22	28	PF00069	0.624
MOD_Plk_1	328	334	PF00069	0.382
MOD_Plk_1	389	395	PF00069	0.579
MOD_Plk_1	455	461	PF00069	0.565
MOD_Plk_1	584	590	PF00069	0.761
MOD_Plk_1	612	618	PF00069	0.752
MOD_Plk_1	666	672	PF00069	0.681
MOD_Plk_1	760	766	PF00069	0.757
MOD_Plk_2-3	760	766	PF00069	0.750
MOD_Plk_4	170	176	PF00069	0.471
MOD_Plk_4	347	353	PF00069	0.607
MOD_Plk_4	408	414	PF00069	0.538
MOD_Plk_4	428	434	PF00069	0.464
MOD_Plk_4	477	483	PF00069	0.724
MOD_Plk_4	584	590	PF00069	0.800
MOD_Plk_4	694	700	PF00069	0.515
MOD_Plk_4	99	105	PF00069	0.503
MOD_ProDKin_1	145	151	PF00069	0.744
MOD_ProDKin_1	173	179	PF00069	0.480
MOD_ProDKin_1	221	227	PF00069	0.526
MOD_ProDKin_1	425	431	PF00069	0.532
MOD_ProDKin_1	485	491	PF00069	0.630
MOD_ProDKin_1	596	602	PF00069	0.762
MOD_ProDKin_1	92	98	PF00069	0.754
MOD_SUMO_rev_2	228	236	PF00179	0.547
MOD_SUMO_rev_2	350	359	PF00179	0.561
TRG_DiLeu_BaEn_1	585	590	PF01217	0.762
TRG_DiLeu_BaLyEn_6	156	161	PF01217	0.413
TRG_DiLeu_BaLyEn_6	597	602	PF01217	0.547
TRG_DiLeu_BaLyEn_6	655	660	PF01217	0.724
TRG_ENDOCYTIC_2	497	500	PF00928	0.580
TRG_ER_diArg_1	272	274	PF00400	0.705
TRG_ER_diArg_1	419	422	PF00400	0.614
TRG_ER_diArg_1	618	621	PF00400	0.686
TRG_ER_diArg_1	640	642	PF00400	0.546
TRG_ER_diArg_1	748	750	PF00400	0.628
TRG_NES_CRM1_1	69	82	PF08389	0.400
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.660
TRG_Pf-PMV_PEXEL_1	499	503	PF00026	0.723

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7XAN9	Leishmania donovani	84%	100%
A4HP15	Leishmania braziliensis	63%	100%
A4IDC4	Leishmania infantum	84%	100%
Q4Q1S1	Leishmania major	83%	100%