ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

engulfment and cell motility domain 2, putative

Species:

Leishmania mexicana

UniProt:

E9ASS4_LEIMU

TriTrypDb:

LmxM.36.1540

Length:

934

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005096	GTPase activator activity	4	7
GO:0008047	enzyme activator activity	3	7
GO:0030234	enzyme regulator activity	2	7
GO:0030695	GTPase regulator activity	4	7
GO:0060589	nucleoside-triphosphatase regulator activity	3	7
GO:0098772	molecular function regulator activity	1	7
GO:0140677	molecular function activator activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	356	360	PF00656	0.605
CLV_NRD_NRD_1	14	16	PF00675	0.500
CLV_NRD_NRD_1	197	199	PF00675	0.759
CLV_NRD_NRD_1	450	452	PF00675	0.699
CLV_NRD_NRD_1	594	596	PF00675	0.521
CLV_NRD_NRD_1	674	676	PF00675	0.353
CLV_NRD_NRD_1	911	913	PF00675	0.523
CLV_PCSK_KEX2_1	14	16	PF00082	0.497
CLV_PCSK_KEX2_1	196	198	PF00082	0.756
CLV_PCSK_KEX2_1	450	452	PF00082	0.699
CLV_PCSK_KEX2_1	674	676	PF00082	0.353
CLV_PCSK_KEX2_1	826	828	PF00082	0.353
CLV_PCSK_PC1ET2_1	826	828	PF00082	0.353
CLV_PCSK_SKI1_1	110	114	PF00082	0.524
CLV_PCSK_SKI1_1	659	663	PF00082	0.454
CLV_PCSK_SKI1_1	674	678	PF00082	0.270
CLV_PCSK_SKI1_1	917	921	PF00082	0.291
DEG_APCC_DBOX_1	673	681	PF00400	0.334
DEG_SPOP_SBC_1	200	204	PF00917	0.510
DEG_SPOP_SBC_1	23	27	PF00917	0.559
DEG_SPOP_SBC_1	337	341	PF00917	0.615
DEG_SPOP_SBC_1	574	578	PF00917	0.705
DEG_SPOP_SBC_1	64	68	PF00917	0.730
DEG_SPOP_SBC_1	695	699	PF00917	0.335
DEG_SPOP_SBC_1	707	711	PF00917	0.301
DEG_SPOP_SBC_1	884	888	PF00917	0.450
DOC_CKS1_1	171	176	PF01111	0.505
DOC_CKS1_1	299	304	PF01111	0.706
DOC_CYCLIN_RxL_1	672	679	PF00134	0.449
DOC_CYCLIN_yClb1_LxF_4	790	796	PF00134	0.317
DOC_MAPK_DCC_7	172	180	PF00069	0.511
DOC_MAPK_DCC_7	534	544	PF00069	0.398
DOC_MAPK_DCC_7	788	798	PF00069	0.317
DOC_MAPK_gen_1	659	668	PF00069	0.446
DOC_MAPK_gen_1	674	680	PF00069	0.270
DOC_MAPK_gen_1	786	795	PF00069	0.390
DOC_MAPK_gen_1	912	920	PF00069	0.332
DOC_MAPK_MEF2A_6	662	670	PF00069	0.449
DOC_PP2B_LxvP_1	178	181	PF13499	0.750
DOC_PP2B_LxvP_1	410	413	PF13499	0.617
DOC_PP4_FxxP_1	171	174	PF00568	0.626
DOC_USP7_MATH_1	104	108	PF00917	0.713
DOC_USP7_MATH_1	181	185	PF00917	0.521
DOC_USP7_MATH_1	191	195	PF00917	0.552
DOC_USP7_MATH_1	209	213	PF00917	0.538
DOC_USP7_MATH_1	22	26	PF00917	0.671
DOC_USP7_MATH_1	247	251	PF00917	0.741
DOC_USP7_MATH_1	257	261	PF00917	0.611
DOC_USP7_MATH_1	276	280	PF00917	0.615
DOC_USP7_MATH_1	344	348	PF00917	0.646
DOC_USP7_MATH_1	459	463	PF00917	0.674
DOC_USP7_MATH_1	574	578	PF00917	0.557
DOC_USP7_MATH_1	62	66	PF00917	0.562
DOC_USP7_MATH_1	645	649	PF00917	0.532
DOC_USP7_MATH_1	689	693	PF00917	0.375
DOC_USP7_MATH_1	702	706	PF00917	0.350
DOC_USP7_MATH_1	708	712	PF00917	0.317
DOC_USP7_MATH_2	333	339	PF00917	0.573
DOC_USP7_UBL2_3	909	913	PF12436	0.535
DOC_WW_Pin1_4	125	130	PF00397	0.712
DOC_WW_Pin1_4	170	175	PF00397	0.527
DOC_WW_Pin1_4	201	206	PF00397	0.617
DOC_WW_Pin1_4	226	231	PF00397	0.676
DOC_WW_Pin1_4	234	239	PF00397	0.657
DOC_WW_Pin1_4	298	303	PF00397	0.621
DOC_WW_Pin1_4	309	314	PF00397	0.626
DOC_WW_Pin1_4	340	345	PF00397	0.668
DOC_WW_Pin1_4	465	470	PF00397	0.697
DOC_WW_Pin1_4	578	583	PF00397	0.559
DOC_WW_Pin1_4	60	65	PF00397	0.645
DOC_WW_Pin1_4	641	646	PF00397	0.566
DOC_WW_Pin1_4	698	703	PF00397	0.381
DOC_WW_Pin1_4	767	772	PF00397	0.421
LIG_14-3-3_CanoR_1	151	156	PF00244	0.720
LIG_14-3-3_CanoR_1	265	272	PF00244	0.689
LIG_14-3-3_CanoR_1	381	389	PF00244	0.557
LIG_14-3-3_CanoR_1	478	485	PF00244	0.705
LIG_14-3-3_CanoR_1	573	582	PF00244	0.676
LIG_14-3-3_CanoR_1	612	621	PF00244	0.745
LIG_14-3-3_CanoR_1	664	669	PF00244	0.382
LIG_14-3-3_CanoR_1	675	681	PF00244	0.235
LIG_14-3-3_CanoR_1	69	79	PF00244	0.539
LIG_14-3-3_CanoR_1	827	833	PF00244	0.263
LIG_Actin_WH2_2	899	914	PF00022	0.535
LIG_APCC_ABBA_1	863	868	PF00400	0.334
LIG_BIR_II_1	1	5	PF00653	0.618
LIG_BIR_III_4	808	812	PF00653	0.334
LIG_BRCT_BRCA1_1	344	348	PF00533	0.680
LIG_BRCT_BRCA1_1	717	721	PF00533	0.449
LIG_BRCT_BRCA1_1	94	98	PF00533	0.674
LIG_CaM_IQ_9	422	438	PF13499	0.597
LIG_FHA_1	238	244	PF00498	0.707
LIG_FHA_1	267	273	PF00498	0.685
LIG_FHA_1	412	418	PF00498	0.640
LIG_FHA_1	420	426	PF00498	0.650
LIG_FHA_1	509	515	PF00498	0.488
LIG_FHA_1	550	556	PF00498	0.506
LIG_FHA_1	683	689	PF00498	0.334
LIG_FHA_1	731	737	PF00498	0.334
LIG_FHA_1	801	807	PF00498	0.334
LIG_FHA_1	884	890	PF00498	0.487
LIG_FHA_2	541	547	PF00498	0.394
LIG_FHA_2	629	635	PF00498	0.572
LIG_LIR_Apic_2	169	174	PF02991	0.626
LIG_LIR_Apic_2	586	592	PF02991	0.482
LIG_LIR_Gen_1	102	112	PF02991	0.616
LIG_LIR_Gen_1	246	255	PF02991	0.732
LIG_LIR_Gen_1	345	352	PF02991	0.501
LIG_LIR_Gen_1	48	57	PF02991	0.656
LIG_LIR_Gen_1	546	555	PF02991	0.429
LIG_LIR_Gen_1	679	689	PF02991	0.334
LIG_LIR_Gen_1	792	802	PF02991	0.334
LIG_LIR_Nem_3	162	168	PF02991	0.747
LIG_LIR_Nem_3	246	251	PF02991	0.737
LIG_LIR_Nem_3	345	351	PF02991	0.502
LIG_LIR_Nem_3	41	47	PF02991	0.628
LIG_LIR_Nem_3	464	470	PF02991	0.652
LIG_LIR_Nem_3	48	53	PF02991	0.621
LIG_LIR_Nem_3	543	548	PF02991	0.401
LIG_LIR_Nem_3	679	684	PF02991	0.334
LIG_LIR_Nem_3	792	798	PF02991	0.334
LIG_LIR_Nem_3	898	902	PF02991	0.530
LIG_LYPXL_S_1	43	47	PF13949	0.693
LIG_LYPXL_yS_3	44	47	PF13949	0.741
LIG_Pex14_2	866	870	PF04695	0.334
LIG_SH2_CRK	91	95	PF00017	0.489
LIG_SH2_NCK_1	379	383	PF00017	0.502
LIG_SH2_STAP1	545	549	PF00017	0.576
LIG_SH2_STAT3	17	20	PF00017	0.522
LIG_SH2_STAT5	262	265	PF00017	0.514
LIG_SH2_STAT5	548	551	PF00017	0.579
LIG_SH2_STAT5	743	746	PF00017	0.334
LIG_SH2_STAT5	853	856	PF00017	0.458
LIG_SH2_STAT5	859	862	PF00017	0.468
LIG_SH3_3	141	147	PF00018	0.641
LIG_SH3_3	171	177	PF00018	0.624
LIG_SH3_3	228	234	PF00018	0.647
LIG_SH3_3	241	247	PF00018	0.581
LIG_SH3_3	296	302	PF00018	0.619
LIG_SH3_3	316	322	PF00018	0.462
LIG_SH3_3	414	420	PF00018	0.559
LIG_SH3_3	579	585	PF00018	0.591
LIG_SUMO_SIM_anti_2	324	330	PF11976	0.511
LIG_SUMO_SIM_anti_2	468	475	PF11976	0.564
LIG_SUMO_SIM_par_1	119	125	PF11976	0.525
LIG_SUMO_SIM_par_1	321	327	PF11976	0.682
LIG_SUMO_SIM_par_1	421	427	PF11976	0.606
LIG_SUMO_SIM_par_1	468	475	PF11976	0.564
LIG_TRAF2_1	215	218	PF00917	0.765
LIG_TRAF2_1	333	336	PF00917	0.678
LIG_TRAF2_1	461	464	PF00917	0.574
LIG_WRC_WIRS_1	168	173	PF05994	0.505
LIG_WRC_WIRS_1	289	294	PF05994	0.587
LIG_WRC_WIRS_1	504	509	PF05994	0.599
MOD_CDK_SPK_2	201	206	PF00069	0.512
MOD_CK1_1	170	176	PF00069	0.524
MOD_CK1_1	212	218	PF00069	0.636
MOD_CK1_1	229	235	PF00069	0.583
MOD_CK1_1	237	243	PF00069	0.585
MOD_CK1_1	338	344	PF00069	0.623
MOD_CK1_1	346	352	PF00069	0.620
MOD_CK1_1	415	421	PF00069	0.541
MOD_CK1_1	431	437	PF00069	0.648
MOD_CK1_1	468	474	PF00069	0.634
MOD_CK1_1	487	493	PF00069	0.458
MOD_CK1_1	508	514	PF00069	0.486
MOD_CK1_1	578	584	PF00069	0.528
MOD_CK1_1	611	617	PF00069	0.704
MOD_CK1_1	623	629	PF00069	0.635
MOD_CK1_1	63	69	PF00069	0.640
MOD_CK1_1	697	703	PF00069	0.469
MOD_CK1_1	706	712	PF00069	0.301
MOD_CK1_1	883	889	PF00069	0.445
MOD_CK1_1	92	98	PF00069	0.706
MOD_CK2_1	212	218	PF00069	0.759
MOD_CK2_1	23	29	PF00069	0.655
MOD_CK2_1	272	278	PF00069	0.689
MOD_CK2_1	540	546	PF00069	0.413
MOD_CK2_1	628	634	PF00069	0.570
MOD_Cter_Amidation	448	451	PF01082	0.513
MOD_Cter_Amidation	824	827	PF01082	0.399
MOD_DYRK1A_RPxSP_1	298	302	PF00069	0.516
MOD_GlcNHglycan	183	186	PF01048	0.642
MOD_GlcNHglycan	213	217	PF01048	0.778
MOD_GlcNHglycan	269	272	PF01048	0.739
MOD_GlcNHglycan	274	277	PF01048	0.620
MOD_GlcNHglycan	429	433	PF01048	0.789
MOD_GlcNHglycan	437	440	PF01048	0.641
MOD_GlcNHglycan	507	510	PF01048	0.716
MOD_GlcNHglycan	54	57	PF01048	0.513
MOD_GlcNHglycan	557	560	PF01048	0.485
MOD_GlcNHglycan	633	638	PF01048	0.718
MOD_GlcNHglycan	645	648	PF01048	0.513
MOD_GlcNHglycan	91	94	PF01048	0.667
MOD_GlcNHglycan	95	98	PF01048	0.618
MOD_GSK3_1	110	117	PF00069	0.681
MOD_GSK3_1	121	128	PF00069	0.616
MOD_GSK3_1	145	152	PF00069	0.668
MOD_GSK3_1	218	225	PF00069	0.707
MOD_GSK3_1	232	239	PF00069	0.676
MOD_GSK3_1	257	264	PF00069	0.733
MOD_GSK3_1	272	279	PF00069	0.674
MOD_GSK3_1	331	338	PF00069	0.643
MOD_GSK3_1	339	346	PF00069	0.609
MOD_GSK3_1	411	418	PF00069	0.635
MOD_GSK3_1	424	431	PF00069	0.672
MOD_GSK3_1	503	510	PF00069	0.713
MOD_GSK3_1	574	581	PF00069	0.543
MOD_GSK3_1	60	67	PF00069	0.662
MOD_GSK3_1	608	615	PF00069	0.589
MOD_GSK3_1	623	630	PF00069	0.631
MOD_GSK3_1	641	648	PF00069	0.515
MOD_GSK3_1	660	667	PF00069	0.320
MOD_GSK3_1	676	683	PF00069	0.383
MOD_GSK3_1	694	701	PF00069	0.396
MOD_GSK3_1	702	709	PF00069	0.307
MOD_GSK3_1	721	728	PF00069	0.317
MOD_GSK3_1	765	772	PF00069	0.380
MOD_GSK3_1	880	887	PF00069	0.561
MOD_GSK3_1	89	96	PF00069	0.688
MOD_N-GLC_1	110	115	PF02516	0.623
MOD_N-GLC_1	309	314	PF02516	0.525
MOD_N-GLC_1	443	448	PF02516	0.688
MOD_N-GLC_1	695	700	PF02516	0.357
MOD_N-GLC_1	800	805	PF02516	0.317
MOD_NEK2_1	121	126	PF00069	0.533
MOD_NEK2_1	272	277	PF00069	0.538
MOD_NEK2_1	282	287	PF00069	0.629
MOD_NEK2_1	484	489	PF00069	0.508
MOD_NEK2_1	505	510	PF00069	0.611
MOD_NEK2_1	555	560	PF00069	0.497
MOD_NEK2_1	668	673	PF00069	0.373
MOD_NEK2_1	676	681	PF00069	0.445
MOD_NEK2_1	721	726	PF00069	0.399
MOD_NEK2_1	800	805	PF00069	0.350
MOD_NEK2_1	98	103	PF00069	0.734
MOD_NEK2_2	104	109	PF00069	0.699
MOD_NEK2_2	191	196	PF00069	0.537
MOD_NEK2_2	828	833	PF00069	0.216
MOD_NEK2_2	83	88	PF00069	0.498
MOD_PIKK_1	224	230	PF00454	0.642
MOD_PIKK_1	383	389	PF00454	0.508
MOD_PIKK_1	484	490	PF00454	0.701
MOD_PK_1	662	668	PF00069	0.316
MOD_PK_1	715	721	PF00069	0.449
MOD_PKA_1	826	832	PF00069	0.366
MOD_PKA_2	145	151	PF00069	0.735
MOD_PKA_2	23	29	PF00069	0.660
MOD_PKA_2	264	270	PF00069	0.738
MOD_PKA_2	380	386	PF00069	0.556
MOD_PKA_2	435	441	PF00069	0.593
MOD_PKA_2	477	483	PF00069	0.703
MOD_PKA_2	555	561	PF00069	0.367
MOD_PKA_2	611	617	PF00069	0.617
MOD_PKA_2	730	736	PF00069	0.334
MOD_PKA_2	787	793	PF00069	0.317
MOD_PKA_2	826	832	PF00069	0.366
MOD_PKA_2	892	898	PF00069	0.459
MOD_PKB_1	298	306	PF00069	0.530
MOD_Plk_1	218	224	PF00069	0.591
MOD_Plk_1	38	44	PF00069	0.662
MOD_Plk_1	428	434	PF00069	0.810
MOD_Plk_1	800	806	PF00069	0.317
MOD_Plk_2-3	218	224	PF00069	0.540
MOD_Plk_4	324	330	PF00069	0.513
MOD_Plk_4	362	368	PF00069	0.515
MOD_Plk_4	405	411	PF00069	0.757
MOD_Plk_4	412	418	PF00069	0.648
MOD_Plk_4	468	474	PF00069	0.516
MOD_Plk_4	487	493	PF00069	0.458
MOD_Plk_4	5	11	PF00069	0.407
MOD_Plk_4	575	581	PF00069	0.663
MOD_Plk_4	676	682	PF00069	0.414
MOD_ProDKin_1	125	131	PF00069	0.709
MOD_ProDKin_1	170	176	PF00069	0.525
MOD_ProDKin_1	201	207	PF00069	0.618
MOD_ProDKin_1	226	232	PF00069	0.677
MOD_ProDKin_1	234	240	PF00069	0.659
MOD_ProDKin_1	298	304	PF00069	0.624
MOD_ProDKin_1	309	315	PF00069	0.624
MOD_ProDKin_1	340	346	PF00069	0.670
MOD_ProDKin_1	465	471	PF00069	0.697
MOD_ProDKin_1	578	584	PF00069	0.557
MOD_ProDKin_1	60	66	PF00069	0.649
MOD_ProDKin_1	641	647	PF00069	0.562
MOD_ProDKin_1	698	704	PF00069	0.381
MOD_ProDKin_1	767	773	PF00069	0.421
MOD_SUMO_for_1	714	717	PF00179	0.449
MOD_SUMO_rev_2	356	365	PF00179	0.707
MOD_SUMO_rev_2	895	904	PF00179	0.431
TRG_DiLeu_BaEn_1	324	329	PF01217	0.510
TRG_ENDOCYTIC_2	165	168	PF00928	0.694
TRG_ENDOCYTIC_2	398	401	PF00928	0.503
TRG_ENDOCYTIC_2	44	47	PF00928	0.741
TRG_ENDOCYTIC_2	548	551	PF00928	0.411
TRG_ENDOCYTIC_2	748	751	PF00928	0.339
TRG_ENDOCYTIC_2	849	852	PF00928	0.506
TRG_ENDOCYTIC_2	91	94	PF00928	0.490
TRG_ER_diArg_1	13	15	PF00400	0.508
TRG_ER_diArg_1	195	198	PF00400	0.534
TRG_ER_diArg_1	450	452	PF00400	0.754
TRG_ER_diArg_1	674	676	PF00400	0.353
TRG_ER_diArg_1	786	789	PF00400	0.395
TRG_ER_diArg_1	870	873	PF00400	0.348
TRG_NLS_MonoExtC_3	10	15	PF00514	0.622
TRG_Pf-PMV_PEXEL_1	220	224	PF00026	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB6	Leptomonas seymouri	33%	98%
A0A3S7XAP8	Leishmania donovani	81%	100%
A4HP14	Leishmania braziliensis	55%	100%
A4IDC3	Leishmania infantum	81%	100%
Q4Q1S2	Leishmania major	79%	100%