LeishMANIAdb
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Serine/threonine protein kinase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Serine/threonine protein kinase
Gene product:
protein kinase, putative,serine/threonine protein kinase, putative
Species:
Leishmania mexicana
UniProt:
E9ASS3_LEIMU
TriTrypDb:
LmxM.36.1530
Length:
501

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 6
Forrest at al. (procyclic) no yes: 6
Silverman et al. no yes: 0
Pissara et al. no yes: 33
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 10
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 10
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 67
NetGPI no yes: 0, no: 67
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASS3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS3

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 68
GO:0006793 phosphorus metabolic process 3 68
GO:0006796 phosphate-containing compound metabolic process 4 68
GO:0006807 nitrogen compound metabolic process 2 68
GO:0008152 metabolic process 1 68
GO:0009987 cellular process 1 68
GO:0016310 phosphorylation 5 68
GO:0019538 protein metabolic process 3 68
GO:0036211 protein modification process 4 68
GO:0043170 macromolecule metabolic process 3 68
GO:0043412 macromolecule modification 4 68
GO:0044237 cellular metabolic process 2 68
GO:0044238 primary metabolic process 2 68
GO:0071704 organic substance metabolic process 2 68
GO:1901564 organonitrogen compound metabolic process 3 68
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 68
GO:0003824 catalytic activity 1 68
GO:0004672 protein kinase activity 3 68
GO:0005488 binding 1 68
GO:0005524 ATP binding 5 68
GO:0016301 kinase activity 4 68
GO:0016740 transferase activity 2 68
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 68
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 68
GO:0017076 purine nucleotide binding 4 68
GO:0030554 adenyl nucleotide binding 5 68
GO:0032553 ribonucleotide binding 3 68
GO:0032555 purine ribonucleotide binding 4 68
GO:0032559 adenyl ribonucleotide binding 5 68
GO:0035639 purine ribonucleoside triphosphate binding 4 68
GO:0036094 small molecule binding 2 68
GO:0043167 ion binding 2 68
GO:0043168 anion binding 3 68
GO:0097159 organic cyclic compound binding 2 68
GO:0097367 carbohydrate derivative binding 2 68
GO:0140096 catalytic activity, acting on a protein 2 68
GO:1901265 nucleoside phosphate binding 3 68
GO:1901363 heterocyclic compound binding 2 68
GO:0004674 protein serine/threonine kinase activity 4 48

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 455 459 PF00656 0.385
CLV_NRD_NRD_1 226 228 PF00675 0.252
CLV_NRD_NRD_1 350 352 PF00675 0.507
CLV_NRD_NRD_1 395 397 PF00675 0.274
CLV_NRD_NRD_1 471 473 PF00675 0.302
CLV_NRD_NRD_1 59 61 PF00675 0.392
CLV_PCSK_KEX2_1 169 171 PF00082 0.319
CLV_PCSK_KEX2_1 226 228 PF00082 0.269
CLV_PCSK_KEX2_1 249 251 PF00082 0.272
CLV_PCSK_KEX2_1 294 296 PF00082 0.384
CLV_PCSK_KEX2_1 349 351 PF00082 0.440
CLV_PCSK_KEX2_1 394 396 PF00082 0.292
CLV_PCSK_KEX2_1 471 473 PF00082 0.285
CLV_PCSK_KEX2_1 59 61 PF00082 0.323
CLV_PCSK_PC1ET2_1 169 171 PF00082 0.365
CLV_PCSK_PC1ET2_1 249 251 PF00082 0.242
CLV_PCSK_PC1ET2_1 294 296 PF00082 0.360
CLV_PCSK_PC1ET2_1 394 396 PF00082 0.297
CLV_PCSK_SKI1_1 174 178 PF00082 0.307
CLV_PCSK_SKI1_1 299 303 PF00082 0.338
CLV_PCSK_SKI1_1 336 340 PF00082 0.405
CLV_PCSK_SKI1_1 383 387 PF00082 0.365
CLV_PCSK_SKI1_1 471 475 PF00082 0.234
CLV_Separin_Metazoa 81 85 PF03568 0.167
DEG_APCC_DBOX_1 39 47 PF00400 0.447
DOC_CKS1_1 302 307 PF01111 0.324
DOC_CKS1_1 437 442 PF01111 0.288
DOC_CYCLIN_yCln2_LP_2 35 41 PF00134 0.292
DOC_MAPK_gen_1 174 183 PF00069 0.310
DOC_MAPK_gen_1 339 347 PF00069 0.488
DOC_MAPK_gen_1 394 400 PF00069 0.267
DOC_MAPK_MEF2A_6 349 356 PF00069 0.544
DOC_MAPK_MEF2A_6 361 368 PF00069 0.545
DOC_MAPK_RevD_3 155 170 PF00069 0.339
DOC_MAPK_RevD_3 236 250 PF00069 0.271
DOC_PP1_RVXF_1 372 378 PF00149 0.510
DOC_PP1_RVXF_1 469 476 PF00149 0.252
DOC_USP7_MATH_1 2 6 PF00917 0.568
DOC_USP7_MATH_1 202 206 PF00917 0.244
DOC_USP7_UBL2_3 138 142 PF12436 0.264
DOC_WW_Pin1_4 212 217 PF00397 0.313
DOC_WW_Pin1_4 26 31 PF00397 0.682
DOC_WW_Pin1_4 301 306 PF00397 0.318
DOC_WW_Pin1_4 436 441 PF00397 0.307
DOC_WW_Pin1_4 75 80 PF00397 0.319
LIG_14-3-3_CanoR_1 351 357 PF00244 0.512
LIG_14-3-3_CanoR_1 361 365 PF00244 0.574
LIG_14-3-3_CanoR_1 488 494 PF00244 0.404
LIG_APCC_ABBA_1 398 403 PF00400 0.169
LIG_APCC_ABBAyCdc20_2 169 175 PF00400 0.304
LIG_BIR_II_1 1 5 PF00653 0.570
LIG_BIR_III_1 1 5 PF00653 0.348
LIG_BIR_III_3 1 5 PF00653 0.348
LIG_BRCT_BRCA1_1 35 39 PF00533 0.507
LIG_BRCT_BRCA1_1 437 441 PF00533 0.414
LIG_CaM_IQ_9 421 437 PF13499 0.381
LIG_Clathr_ClatBox_1 418 422 PF01394 0.169
LIG_deltaCOP1_diTrp_1 484 493 PF00928 0.379
LIG_FHA_1 17 23 PF00498 0.451
LIG_FHA_1 304 310 PF00498 0.440
LIG_FHA_1 333 339 PF00498 0.292
LIG_FHA_1 361 367 PF00498 0.497
LIG_FHA_1 370 376 PF00498 0.411
LIG_FHA_1 409 415 PF00498 0.314
LIG_FHA_2 201 207 PF00498 0.312
LIG_FHA_2 22 28 PF00498 0.515
LIG_FHA_2 339 345 PF00498 0.435
LIG_FHA_2 453 459 PF00498 0.374
LIG_FHA_2 76 82 PF00498 0.174
LIG_Integrin_isoDGR_2 469 471 PF01839 0.169
LIG_IRF3_LxIS_1 305 312 PF10401 0.221
LIG_LIR_Apic_2 215 221 PF02991 0.306
LIG_LIR_Gen_1 438 449 PF02991 0.279
LIG_LIR_Gen_1 96 105 PF02991 0.286
LIG_LIR_Nem_3 36 42 PF02991 0.477
LIG_LIR_Nem_3 438 444 PF02991 0.279
LIG_LIR_Nem_3 445 451 PF02991 0.262
LIG_LIR_Nem_3 492 496 PF02991 0.264
LIG_LIR_Nem_3 94 100 PF02991 0.268
LIG_NRBOX 237 243 PF00104 0.257
LIG_PCNA_PIPBox_1 487 496 PF02747 0.169
LIG_PCNA_yPIPBox_3 278 288 PF02747 0.168
LIG_Pex14_1 393 397 PF04695 0.267
LIG_Pex14_2 16 20 PF04695 0.349
LIG_Pex14_2 463 467 PF04695 0.284
LIG_SH2_GRB2like 127 130 PF00017 0.309
LIG_SH2_NCK_1 127 131 PF00017 0.308
LIG_SH2_PTP2 218 221 PF00017 0.302
LIG_SH2_PTP2 310 313 PF00017 0.224
LIG_SH2_PTP2 397 400 PF00017 0.169
LIG_SH2_SRC 127 130 PF00017 0.310
LIG_SH2_STAP1 200 204 PF00017 0.284
LIG_SH2_STAP1 229 233 PF00017 0.310
LIG_SH2_STAP1 57 61 PF00017 0.197
LIG_SH2_STAT3 77 80 PF00017 0.167
LIG_SH2_STAT5 218 221 PF00017 0.306
LIG_SH2_STAT5 310 313 PF00017 0.372
LIG_SH2_STAT5 397 400 PF00017 0.272
LIG_SH2_STAT5 42 45 PF00017 0.369
LIG_SH2_STAT5 454 457 PF00017 0.246
LIG_SH2_STAT5 77 80 PF00017 0.368
LIG_SH2_STAT5 97 100 PF00017 0.285
LIG_SUMO_SIM_anti_2 420 425 PF11976 0.324
LIG_SUMO_SIM_par_1 416 422 PF11976 0.304
LIG_TRAF2_1 24 27 PF00917 0.583
LIG_TRAF2_1 328 331 PF00917 0.521
LIG_TRAF2_1 341 344 PF00917 0.519
LIG_TRAF2_1 78 81 PF00917 0.167
LIG_TYR_ITIM 241 246 PF00017 0.329
LIG_UBA3_1 241 249 PF00899 0.273
LIG_WRC_WIRS_1 490 495 PF05994 0.169
MOD_CDK_SPxxK_3 301 308 PF00069 0.170
MOD_CK1_1 297 303 PF00069 0.175
MOD_CK1_1 320 326 PF00069 0.520
MOD_CK1_1 369 375 PF00069 0.422
MOD_CK1_1 389 395 PF00069 0.334
MOD_CK1_1 428 434 PF00069 0.296
MOD_CK1_1 452 458 PF00069 0.269
MOD_CK1_1 489 495 PF00069 0.448
MOD_CK1_1 49 55 PF00069 0.288
MOD_CK2_1 200 206 PF00069 0.339
MOD_CK2_1 21 27 PF00069 0.479
MOD_CK2_1 338 344 PF00069 0.382
MOD_CK2_1 364 370 PF00069 0.401
MOD_CK2_1 439 445 PF00069 0.292
MOD_CK2_1 75 81 PF00069 0.198
MOD_Cter_Amidation 469 472 PF01082 0.284
MOD_GlcNHglycan 177 180 PF01048 0.302
MOD_GlcNHglycan 284 287 PF01048 0.302
MOD_GlcNHglycan 319 322 PF01048 0.437
MOD_GlcNHglycan 326 329 PF01048 0.454
MOD_GlcNHglycan 48 51 PF01048 0.279
MOD_GlcNHglycan 85 88 PF01048 0.380
MOD_GSK3_1 136 143 PF00069 0.360
MOD_GSK3_1 208 215 PF00069 0.322
MOD_GSK3_1 297 304 PF00069 0.391
MOD_GSK3_1 320 327 PF00069 0.549
MOD_GSK3_1 360 367 PF00069 0.422
MOD_GSK3_1 385 392 PF00069 0.317
MOD_GSK3_1 413 420 PF00069 0.324
MOD_GSK3_1 42 49 PF00069 0.308
MOD_GSK3_1 435 442 PF00069 0.360
MOD_NEK2_1 182 187 PF00069 0.280
MOD_NEK2_1 194 199 PF00069 0.272
MOD_NEK2_1 261 266 PF00069 0.288
MOD_NEK2_1 309 314 PF00069 0.327
MOD_NEK2_1 360 365 PF00069 0.421
MOD_OFUCOSY 90 95 PF10250 0.167
MOD_PKA_1 294 300 PF00069 0.321
MOD_PKA_2 294 300 PF00069 0.301
MOD_PKA_2 33 39 PF00069 0.609
MOD_PKA_2 360 366 PF00069 0.482
MOD_PKA_2 428 434 PF00069 0.169
MOD_PKA_2 83 89 PF00069 0.388
MOD_Plk_1 330 336 PF00069 0.490
MOD_Plk_1 389 395 PF00069 0.326
MOD_Plk_4 116 122 PF00069 0.391
MOD_Plk_4 279 285 PF00069 0.246
MOD_Plk_4 297 303 PF00069 0.215
MOD_Plk_4 42 48 PF00069 0.314
MOD_Plk_4 489 495 PF00069 0.410
MOD_Plk_4 51 57 PF00069 0.287
MOD_ProDKin_1 212 218 PF00069 0.313
MOD_ProDKin_1 26 32 PF00069 0.684
MOD_ProDKin_1 301 307 PF00069 0.318
MOD_ProDKin_1 436 442 PF00069 0.307
MOD_ProDKin_1 75 81 PF00069 0.319
MOD_SUMO_rev_2 105 115 PF00179 0.370
MOD_SUMO_rev_2 132 139 PF00179 0.262
TRG_DiLeu_BaEn_1 88 93 PF01217 0.290
TRG_ENDOCYTIC_2 243 246 PF00928 0.309
TRG_ENDOCYTIC_2 310 313 PF00928 0.381
TRG_ENDOCYTIC_2 397 400 PF00928 0.302
TRG_ENDOCYTIC_2 401 404 PF00928 0.269
TRG_ENDOCYTIC_2 97 100 PF00928 0.327
TRG_ER_diArg_1 226 228 PF00400 0.284
TRG_ER_diArg_1 349 351 PF00400 0.563
TRG_ER_diArg_1 395 397 PF00400 0.279
TRG_ER_diArg_1 471 473 PF00400 0.309
TRG_ER_diArg_1 59 62 PF00400 0.428
TRG_NLS_MonoExtN_4 292 297 PF00514 0.389
TRG_Pf-PMV_PEXEL_1 315 319 PF00026 0.452
TRG_Pf-PMV_PEXEL_1 336 340 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 472 476 PF00026 0.251

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3N5 Leptomonas seymouri 34% 100%
A0A0N0P953 Leptomonas seymouri 35% 100%
A0A0N1I9A0 Leptomonas seymouri 30% 77%
A0A0N1PD05 Leptomonas seymouri 33% 100%
A0A0S4IMB7 Bodo saltans 37% 100%
A0A0S4IRZ7 Bodo saltans 32% 100%
A0A0S4IVW1 Bodo saltans 24% 80%
A0A0S4IX86 Bodo saltans 34% 100%
A0A0S4J7K4 Bodo saltans 26% 100%
A0A0S4J804 Bodo saltans 37% 96%
A0A0S4JIJ6 Bodo saltans 28% 89%
A0A0S4JQN5 Bodo saltans 28% 71%
A0A1X0NIA0 Trypanosomatidae 33% 100%
A0A1X0NIX2 Trypanosomatidae 31% 100%
A0A1X0NJV4 Trypanosomatidae 28% 98%
A0A1X0NUB2 Trypanosomatidae 31% 86%
A0A1X0P1A2 Trypanosomatidae 28% 100%
A0A1X0P527 Trypanosomatidae 33% 100%
A0A1X0P549 Trypanosomatidae 35% 100%
A0A1X0P863 Trypanosomatidae 56% 100%
A0A1X0P8W3 Trypanosomatidae 35% 68%
A0A1X0P994 Trypanosomatidae 56% 100%
A0A3Q8IAQ1 Leishmania donovani 40% 100%
A0A3Q8IFK8 Leishmania donovani 36% 100%
A0A3Q8IFW0 Leishmania donovani 32% 100%
A0A3Q8IJM9 Leishmania donovani 36% 100%
A0A3Q8INQ4 Leishmania donovani 30% 100%
A0A3R7KCZ4 Trypanosoma rangeli 33% 100%
A0A3S7X5M4 Leishmania donovani 31% 76%
A0A3S7X6T8 Leishmania donovani 36% 100%
A0A3S7X7Y2 Leishmania donovani 29% 100%
A0A3S7X9R4 Leishmania donovani 29% 100%
A0A3S7X9S2 Leishmania donovani 29% 100%
A0A3S7XAL3 Leishmania donovani 82% 100%
A0A3S7XAT9 Leishmania donovani 95% 100%
A0A422NCP0 Trypanosoma rangeli 57% 100%
A0A422NH41 Trypanosoma rangeli 29% 87%
A0A422NT89 Trypanosoma rangeli 25% 76%
A0A509AHB6 Plasmodium berghei (strain Anka) 29% 96%
A4H9L8 Leishmania braziliensis 30% 100%
A4HCE6 Leishmania braziliensis 39% 100%
A4HED7 Leishmania braziliensis 30% 100%
A4HJT5 Leishmania braziliensis 36% 100%
A4HJW2 Leishmania braziliensis 33% 93%
A4HKG9 Leishmania braziliensis 31% 100%
A4HLR0 Leishmania braziliensis 31% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HNI1 Leishmania braziliensis 36% 96%
A4HP12 Leishmania braziliensis 58% 100%
A4HP13 Leishmania braziliensis 88% 100%
A4HZW8 Leishmania infantum 40% 100%
A4I1T4 Leishmania infantum 30% 100%
A4I7A1 Leishmania infantum 36% 100%
A4I7C4 Leishmania infantum 32% 100%
A4I7Z6 Leishmania infantum 31% 76%
A4I960 Leishmania infantum 36% 100%
A4I9Y5 Leishmania infantum 29% 100%
A4IBT4 Leishmania infantum 29% 100%
A4IBT9 Leishmania infantum 29% 100%
A4IC37 Leishmania infantum 36% 100%
A4IDC1 Leishmania infantum 57% 98%
A4IDC2 Leishmania infantum 96% 100%
C9ZWI1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
C9ZWK2 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
D0A2Z1 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0A2Z6 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 55% 100%
D0AA64 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 29% 87%
E9AFM1 Leishmania major 29% 100%
E9AFZ2 Leishmania major 36% 96%
E9ASS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 58% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 39% 100%
E9B296 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9B2B7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B2V8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 76%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B745 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
O35942 Mus musculus 29% 100%
P11837 Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139) 25% 72%
P15735 Homo sapiens 29% 100%
Q08942 Trypanosoma brucei brucei 33% 100%
Q0VD22 Bos taurus 27% 100%
Q16816 Homo sapiens 29% 100%
Q2QMI0 Oryza sativa subsp. japonica 30% 100%
Q4Q1S3 Leishmania major 96% 100%
Q4Q1S4 Leishmania major 58% 100%
Q4Q2Z2 Leishmania major 29% 100%
Q4Q3Y9 Leishmania major 36% 100%
Q4Q598 Leishmania major 31% 100%
Q4Q5T9 Leishmania major 33% 94%
Q4Q5W2 Leishmania major 36% 100%
Q4QBQ2 Leishmania major 40% 100%
Q5KQF5 Oryza sativa subsp. japonica 29% 100%
Q9CAU7 Arabidopsis thaliana 25% 83%
Q9GNR4 Leishmania major 29% 100%
V5BHW8 Trypanosoma cruzi 24% 79%
V5BPJ0 Trypanosoma cruzi 57% 100%
V5D579 Trypanosoma cruzi 33% 100%
V5DFW9 Trypanosoma cruzi 29% 86%
V5DKY9 Trypanosoma cruzi 34% 81%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS