NYN domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASS0_LEIMU

TriTrypDb:

LmxM.36.1500

Length:

913

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASS0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASS0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	215	219	PF00656	0.544
CLV_C14_Caspase3-7	311	315	PF00656	0.642
CLV_C14_Caspase3-7	405	409	PF00656	0.594
CLV_C14_Caspase3-7	425	429	PF00656	0.343
CLV_C14_Caspase3-7	459	463	PF00656	0.442
CLV_C14_Caspase3-7	511	515	PF00656	0.587
CLV_C14_Caspase3-7	630	634	PF00656	0.677
CLV_NRD_NRD_1	296	298	PF00675	0.615
CLV_NRD_NRD_1	695	697	PF00675	0.484
CLV_NRD_NRD_1	752	754	PF00675	0.572
CLV_NRD_NRD_1	838	840	PF00675	0.599
CLV_NRD_NRD_1	842	844	PF00675	0.572
CLV_PCSK_KEX2_1	246	248	PF00082	0.568
CLV_PCSK_KEX2_1	295	297	PF00082	0.620
CLV_PCSK_KEX2_1	695	697	PF00082	0.482
CLV_PCSK_KEX2_1	752	754	PF00082	0.572
CLV_PCSK_KEX2_1	860	862	PF00082	0.692
CLV_PCSK_KEX2_1	893	895	PF00082	0.541
CLV_PCSK_KEX2_1	897	899	PF00082	0.567
CLV_PCSK_KEX2_1	909	911	PF00082	0.619
CLV_PCSK_PC1ET2_1	246	248	PF00082	0.568
CLV_PCSK_PC1ET2_1	860	862	PF00082	0.652
CLV_PCSK_PC1ET2_1	893	895	PF00082	0.582
CLV_PCSK_PC1ET2_1	897	899	PF00082	0.596
CLV_PCSK_PC1ET2_1	909	911	PF00082	0.619
CLV_PCSK_PC7_1	242	248	PF00082	0.374
CLV_PCSK_SKI1_1	237	241	PF00082	0.536
CLV_PCSK_SKI1_1	402	406	PF00082	0.504
CLV_PCSK_SKI1_1	433	437	PF00082	0.416
CLV_PCSK_SKI1_1	53	57	PF00082	0.449
CLV_PCSK_SKI1_1	553	557	PF00082	0.631
CLV_PCSK_SKI1_1	662	666	PF00082	0.642
CLV_PCSK_SKI1_1	696	700	PF00082	0.597
CLV_PCSK_SKI1_1	85	89	PF00082	0.624
DEG_APCC_DBOX_1	84	92	PF00400	0.617
DEG_COP1_1	325	334	PF00400	0.501
DEG_SPOP_SBC_1	587	591	PF00917	0.574
DOC_CYCLIN_RxL_1	430	439	PF00134	0.444
DOC_CYCLIN_RxL_1	548	560	PF00134	0.627
DOC_CYCLIN_yClb5_NLxxxL_5	673	682	PF00134	0.457
DOC_MAPK_FxFP_2	543	546	PF00069	0.461
DOC_MAPK_gen_1	612	621	PF00069	0.647
DOC_MAPK_gen_1	82	91	PF00069	0.619
DOC_MAPK_gen_1	843	853	PF00069	0.655
DOC_MAPK_MEF2A_6	675	682	PF00069	0.445
DOC_MAPK_RevD_3	680	696	PF00069	0.454
DOC_PP1_RVXF_1	206	213	PF00149	0.476
DOC_PP1_SILK_1	201	206	PF00149	0.455
DOC_PP2B_LxvP_1	600	603	PF13499	0.652
DOC_PP4_FxxP_1	543	546	PF00568	0.426
DOC_PP4_FxxP_1	55	58	PF00568	0.474
DOC_USP7_MATH_1	155	159	PF00917	0.514
DOC_USP7_MATH_1	22	26	PF00917	0.563
DOC_USP7_MATH_1	313	317	PF00917	0.678
DOC_USP7_MATH_1	563	567	PF00917	0.586
DOC_USP7_MATH_1	570	574	PF00917	0.595
DOC_USP7_MATH_1	587	591	PF00917	0.748
DOC_USP7_MATH_1	603	607	PF00917	0.526
DOC_USP7_MATH_1	614	618	PF00917	0.602
DOC_USP7_MATH_1	638	642	PF00917	0.708
DOC_USP7_MATH_1	70	74	PF00917	0.488
DOC_USP7_MATH_1	703	707	PF00917	0.664
DOC_USP7_MATH_1	716	720	PF00917	0.526
DOC_USP7_MATH_1	729	733	PF00917	0.628
DOC_USP7_MATH_1	760	764	PF00917	0.780
DOC_USP7_MATH_1	813	817	PF00917	0.517
DOC_USP7_MATH_2	262	268	PF00917	0.494
DOC_USP7_UBL2_3	418	422	PF12436	0.501
DOC_USP7_UBL2_3	840	844	PF12436	0.624
DOC_USP7_UBL2_3	893	897	PF12436	0.592
DOC_USP7_UBL2_3	905	909	PF12436	0.544
DOC_WW_Pin1_4	11	16	PF00397	0.469
DOC_WW_Pin1_4	253	258	PF00397	0.650
DOC_WW_Pin1_4	502	507	PF00397	0.564
DOC_WW_Pin1_4	518	523	PF00397	0.556
DOC_WW_Pin1_4	666	671	PF00397	0.601
DOC_WW_Pin1_4	736	741	PF00397	0.586
DOC_WW_Pin1_4	809	814	PF00397	0.630
LIG_14-3-3_CanoR_1	249	254	PF00244	0.504
LIG_14-3-3_CanoR_1	479	486	PF00244	0.503
LIG_14-3-3_CanoR_1	516	525	PF00244	0.540
LIG_14-3-3_CanoR_1	541	546	PF00244	0.449
LIG_14-3-3_CanoR_1	612	621	PF00244	0.682
LIG_14-3-3_CanoR_1	695	701	PF00244	0.605
LIG_14-3-3_CanoR_1	846	853	PF00244	0.539
LIG_BIR_III_2	468	472	PF00653	0.545
LIG_BIR_III_2	854	858	PF00653	0.585
LIG_BRCT_BRCA1_1	164	168	PF00533	0.427
LIG_CaM_IQ_9	832	848	PF13499	0.580
LIG_FHA_1	151	157	PF00498	0.480
LIG_FHA_1	234	240	PF00498	0.355
LIG_FHA_1	253	259	PF00498	0.564
LIG_FHA_1	376	382	PF00498	0.466
LIG_FHA_1	44	50	PF00498	0.414
LIG_FHA_1	503	509	PF00498	0.653
LIG_FHA_1	589	595	PF00498	0.696
LIG_FHA_1	614	620	PF00498	0.611
LIG_FHA_1	627	633	PF00498	0.492
LIG_FHA_1	656	662	PF00498	0.512
LIG_FHA_1	685	691	PF00498	0.463
LIG_FHA_2	213	219	PF00498	0.516
LIG_FHA_2	285	291	PF00498	0.561
LIG_FHA_2	403	409	PF00498	0.466
LIG_FHA_2	509	515	PF00498	0.522
LIG_FHA_2	52	58	PF00498	0.329
LIG_FHA_2	810	816	PF00498	0.663
LIG_GBD_Chelix_1	190	198	PF00786	0.433
LIG_IBAR_NPY_1	126	128	PF08397	0.435
LIG_IRF3_LxIS_1	163	170	PF10401	0.406
LIG_LIR_Apic_2	54	58	PF02991	0.248
LIG_LIR_Apic_2	540	546	PF02991	0.417
LIG_LIR_Gen_1	165	172	PF02991	0.329
LIG_LIR_Gen_1	34	43	PF02991	0.321
LIG_LIR_Gen_1	382	391	PF02991	0.339
LIG_LIR_Gen_1	5	11	PF02991	0.437
LIG_LIR_Gen_1	590	601	PF02991	0.398
LIG_LIR_LC3C_4	849	853	PF02991	0.549
LIG_LIR_Nem_3	139	145	PF02991	0.369
LIG_LIR_Nem_3	165	169	PF02991	0.317
LIG_LIR_Nem_3	34	38	PF02991	0.321
LIG_LIR_Nem_3	411	416	PF02991	0.369
LIG_LIR_Nem_3	5	9	PF02991	0.413
LIG_LIR_Nem_3	590	596	PF02991	0.678
LIG_MYND_1	756	760	PF01753	0.463
LIG_PAM2_1	524	536	PF00658	0.415
LIG_PCNA_yPIPBox_3	612	625	PF02747	0.591
LIG_PTB_Apo_2	485	492	PF02174	0.463
LIG_PTB_Phospho_1	485	491	PF10480	0.462
LIG_RPA_C_Fungi	107	119	PF08784	0.370
LIG_RPA_C_Fungi	144	156	PF08784	0.264
LIG_SH2_CRK	421	425	PF00017	0.558
LIG_SH2_CRK	491	495	PF00017	0.367
LIG_SH2_NCK_1	466	470	PF00017	0.581
LIG_SH2_SRC	466	469	PF00017	0.543
LIG_SH2_SRC	593	596	PF00017	0.378
LIG_SH2_SRC	745	748	PF00017	0.687
LIG_SH2_SRC	807	810	PF00017	0.484
LIG_SH2_STAP1	747	751	PF00017	0.546
LIG_SH2_STAT5	128	131	PF00017	0.424
LIG_SH2_STAT5	416	419	PF00017	0.368
LIG_SH2_STAT5	485	488	PF00017	0.377
LIG_SH2_STAT5	496	499	PF00017	0.391
LIG_SH2_STAT5	593	596	PF00017	0.378
LIG_SH2_STAT5	681	684	PF00017	0.513
LIG_SH2_STAT5	745	748	PF00017	0.687
LIG_SH3_3	392	398	PF00018	0.521
LIG_SH3_3	468	474	PF00018	0.570
LIG_SH3_3	717	723	PF00018	0.753
LIG_SH3_3	754	760	PF00018	0.637
LIG_SH3_3	817	823	PF00018	0.550
LIG_SUMO_SIM_par_1	519	527	PF11976	0.511
LIG_TRAF2_1	267	270	PF00917	0.718
LIG_TRAF2_1	474	477	PF00917	0.463
LIG_TYR_ITSM	589	596	PF00017	0.402
LIG_WRC_WIRS_1	163	168	PF05994	0.374
LIG_WRC_WIRS_1	52	57	PF05994	0.255
LIG_WRC_WIRS_1	746	751	PF05994	0.627
MOD_CDK_SPK_2	809	814	PF00069	0.615
MOD_CDK_SPxxK_3	253	260	PF00069	0.474
MOD_CDK_SPxxK_3	502	509	PF00069	0.519
MOD_CK1_1	13	19	PF00069	0.524
MOD_CK1_1	150	156	PF00069	0.477
MOD_CK1_1	158	164	PF00069	0.453
MOD_CK1_1	170	176	PF00069	0.347
MOD_CK1_1	189	195	PF00069	0.428
MOD_CK1_1	252	258	PF00069	0.679
MOD_CK1_1	373	379	PF00069	0.458
MOD_CK1_1	439	445	PF00069	0.575
MOD_CK1_1	588	594	PF00069	0.716
MOD_CK1_1	617	623	PF00069	0.638
MOD_CK1_1	669	675	PF00069	0.606
MOD_CK1_1	715	721	PF00069	0.702
MOD_CK1_1	736	742	PF00069	0.505
MOD_CK1_1	767	773	PF00069	0.720
MOD_CK1_1	784	790	PF00069	0.725
MOD_CK2_1	23	29	PF00069	0.561
MOD_CK2_1	264	270	PF00069	0.702
MOD_CK2_1	342	348	PF00069	0.721
MOD_CK2_1	653	659	PF00069	0.591
MOD_CK2_1	785	791	PF00069	0.658
MOD_Cter_Amidation	857	860	PF01082	0.687
MOD_Cter_Amidation	895	898	PF01082	0.567
MOD_GlcNHglycan	122	125	PF01048	0.549
MOD_GlcNHglycan	131	134	PF01048	0.404
MOD_GlcNHglycan	15	18	PF01048	0.544
MOD_GlcNHglycan	157	160	PF01048	0.546
MOD_GlcNHglycan	408	411	PF01048	0.501
MOD_GlcNHglycan	424	427	PF01048	0.630
MOD_GlcNHglycan	480	483	PF01048	0.461
MOD_GlcNHglycan	528	531	PF01048	0.482
MOD_GlcNHglycan	559	562	PF01048	0.552
MOD_GlcNHglycan	563	566	PF01048	0.554
MOD_GlcNHglycan	629	632	PF01048	0.650
MOD_GlcNHglycan	636	639	PF01048	0.711
MOD_GlcNHglycan	64	67	PF01048	0.450
MOD_GlcNHglycan	640	643	PF01048	0.718
MOD_GlcNHglycan	714	717	PF01048	0.670
MOD_GlcNHglycan	724	727	PF01048	0.594
MOD_GlcNHglycan	735	738	PF01048	0.654
MOD_GlcNHglycan	76	80	PF01048	0.606
MOD_GlcNHglycan	772	775	PF01048	0.754
MOD_GlcNHglycan	778	781	PF01048	0.755
MOD_GlcNHglycan	791	795	PF01048	0.553
MOD_GlcNHglycan	815	818	PF01048	0.511
MOD_GlcNHglycan	848	851	PF01048	0.660
MOD_GlcNHglycan	861	864	PF01048	0.670
MOD_GSK3_1	158	165	PF00069	0.474
MOD_GSK3_1	233	240	PF00069	0.518
MOD_GSK3_1	249	256	PF00069	0.630
MOD_GSK3_1	271	278	PF00069	0.708
MOD_GSK3_1	279	286	PF00069	0.635
MOD_GSK3_1	326	333	PF00069	0.770
MOD_GSK3_1	371	378	PF00069	0.437
MOD_GSK3_1	402	409	PF00069	0.677
MOD_GSK3_1	435	442	PF00069	0.594
MOD_GSK3_1	508	515	PF00069	0.538
MOD_GSK3_1	537	544	PF00069	0.332
MOD_GSK3_1	557	564	PF00069	0.556
MOD_GSK3_1	585	592	PF00069	0.634
MOD_GSK3_1	613	620	PF00069	0.612
MOD_GSK3_1	634	641	PF00069	0.661
MOD_GSK3_1	680	687	PF00069	0.294
MOD_GSK3_1	703	710	PF00069	0.570
MOD_GSK3_1	712	719	PF00069	0.638
MOD_GSK3_1	729	736	PF00069	0.662
MOD_GSK3_1	760	767	PF00069	0.646
MOD_GSK3_1	781	788	PF00069	0.760
MOD_GSK3_1	803	810	PF00069	0.510
MOD_N-GLC_1	422	427	PF02516	0.494
MOD_N-GLC_1	570	575	PF02516	0.704
MOD_N-GLC_1	617	622	PF02516	0.593
MOD_N-GLC_1	626	631	PF02516	0.489
MOD_NEK2_1	147	152	PF00069	0.349
MOD_NEK2_1	212	217	PF00069	0.494
MOD_NEK2_1	303	308	PF00069	0.580
MOD_NEK2_1	370	375	PF00069	0.476
MOD_NEK2_1	435	440	PF00069	0.358
MOD_NEK2_1	456	461	PF00069	0.377
MOD_NEK2_1	508	513	PF00069	0.568
MOD_NEK2_2	48	53	PF00069	0.385
MOD_PIKK_1	70	76	PF00454	0.485
MOD_PIKK_1	760	766	PF00454	0.614
MOD_PKA_1	859	865	PF00069	0.747
MOD_PKA_2	446	452	PF00069	0.468
MOD_PKA_2	478	484	PF00069	0.376
MOD_PKA_2	614	620	PF00069	0.689
MOD_PKA_2	813	819	PF00069	0.471
MOD_PKA_2	875	881	PF00069	0.654
MOD_PKB_1	110	118	PF00069	0.377
MOD_PKB_1	247	255	PF00069	0.425
MOD_PKB_1	75	83	PF00069	0.493
MOD_Plk_1	271	277	PF00069	0.701
MOD_Plk_1	617	623	PF00069	0.593
MOD_Plk_1	844	850	PF00069	0.463
MOD_Plk_2-3	264	270	PF00069	0.561
MOD_Plk_4	158	164	PF00069	0.500
MOD_Plk_4	199	205	PF00069	0.399
MOD_Plk_4	396	402	PF00069	0.541
MOD_Plk_4	456	462	PF00069	0.344
MOD_Plk_4	508	514	PF00069	0.531
MOD_Plk_4	589	595	PF00069	0.596
MOD_Plk_4	620	626	PF00069	0.558
MOD_ProDKin_1	11	17	PF00069	0.461
MOD_ProDKin_1	253	259	PF00069	0.656
MOD_ProDKin_1	502	508	PF00069	0.563
MOD_ProDKin_1	518	524	PF00069	0.554
MOD_ProDKin_1	666	672	PF00069	0.597
MOD_ProDKin_1	736	742	PF00069	0.584
MOD_ProDKin_1	809	815	PF00069	0.635
MOD_SUMO_for_1	551	554	PF00179	0.607
MOD_SUMO_for_1	708	711	PF00179	0.503
MOD_SUMO_rev_2	139	145	PF00179	0.372
MOD_SUMO_rev_2	319	329	PF00179	0.820
MOD_SUMO_rev_2	348	358	PF00179	0.743
TRG_DiLeu_BaEn_1	367	372	PF01217	0.508
TRG_DiLeu_BaLyEn_6	27	32	PF01217	0.567
TRG_ENDOCYTIC_2	142	145	PF00928	0.349
TRG_ENDOCYTIC_2	421	424	PF00928	0.455
TRG_ENDOCYTIC_2	491	494	PF00928	0.361
TRG_ENDOCYTIC_2	593	596	PF00928	0.378
TRG_ER_diArg_1	109	112	PF00400	0.324
TRG_ER_diArg_1	294	297	PF00400	0.693
TRG_ER_diArg_1	694	696	PF00400	0.485
TRG_ER_diArg_1	751	753	PF00400	0.562
TRG_NLS_Bipartite_1	843	863	PF00514	0.649
TRG_NLS_Bipartite_1	879	896	PF00514	0.699
TRG_NLS_MonoExtN_4	857	863	PF00514	0.606
TRG_NLS_MonoExtN_4	890	896	PF00514	0.665
TRG_Pf-PMV_PEXEL_1	516	520	PF00026	0.512

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W5	Leptomonas seymouri	60%	94%
A0A0S4JFW1	Bodo saltans	33%	100%
A0A1X0P867	Trypanosomatidae	38%	100%
A0A3S5H820	Leishmania donovani	86%	96%
A0A422NID2	Trypanosoma rangeli	38%	100%
A4HP10	Leishmania braziliensis	71%	100%
A4IDB9	Leishmania infantum	87%	96%
D0A2Z0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
Q4Q1S6	Leishmania major	86%	100%