LisH domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASR8_LEIMU

TriTrypDb:

LmxM.36.1480

Length:

411

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	26	30	PF00656	0.341
CLV_C14_Caspase3-7	354	358	PF00656	0.540
CLV_NRD_NRD_1	232	234	PF00675	0.676
CLV_PCSK_SKI1_1	19	23	PF00082	0.457
CLV_PCSK_SKI1_1	196	200	PF00082	0.399
CLV_PCSK_SKI1_1	92	96	PF00082	0.508
DEG_Nend_UBRbox_2	1	3	PF02207	0.614
DEG_SPOP_SBC_1	405	409	PF00917	0.669
DOC_CKS1_1	283	288	PF01111	0.512
DOC_CYCLIN_RxL_1	200	211	PF00134	0.525
DOC_CYCLIN_RxL_1	308	318	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	280	286	PF00134	0.579
DOC_MAPK_gen_1	16	25	PF00069	0.470
DOC_MAPK_gen_1	300	309	PF00069	0.404
DOC_MAPK_gen_1	328	337	PF00069	0.615
DOC_MAPK_MEF2A_6	10	17	PF00069	0.501
DOC_MAPK_MEF2A_6	131	140	PF00069	0.427
DOC_USP7_MATH_1	114	118	PF00917	0.470
DOC_USP7_MATH_1	201	205	PF00917	0.256
DOC_USP7_MATH_1	406	410	PF00917	0.735
DOC_USP7_MATH_1	53	57	PF00917	0.667
DOC_WW_Pin1_4	156	161	PF00397	0.644
DOC_WW_Pin1_4	205	210	PF00397	0.439
DOC_WW_Pin1_4	282	287	PF00397	0.495
DOC_WW_Pin1_4	317	322	PF00397	0.299
DOC_WW_Pin1_4	380	385	PF00397	0.470
DOC_WW_Pin1_4	58	63	PF00397	0.620
LIG_14-3-3_CanoR_1	135	141	PF00244	0.394
LIG_14-3-3_CanoR_1	276	281	PF00244	0.509
LIG_14-3-3_CanoR_1	324	328	PF00244	0.558
LIG_Actin_WH2_2	309	326	PF00022	0.524
LIG_APCC_ABBA_1	15	20	PF00400	0.469
LIG_APCC_ABBA_1	307	312	PF00400	0.433
LIG_BRCT_BRCA1_1	125	129	PF00533	0.525
LIG_BRCT_BRCA1_1	250	254	PF00533	0.400
LIG_BRCT_BRCA1_1	394	398	PF00533	0.487
LIG_BRCT_BRCA1_1	4	8	PF00533	0.434
LIG_FHA_1	145	151	PF00498	0.620
LIG_FHA_1	20	26	PF00498	0.462
LIG_FHA_1	200	206	PF00498	0.485
LIG_FHA_1	330	336	PF00498	0.623
LIG_FHA_1	387	393	PF00498	0.380
LIG_FHA_1	98	104	PF00498	0.694
LIG_FHA_2	137	143	PF00498	0.397
LIG_FHA_2	206	212	PF00498	0.446
LIG_FHA_2	283	289	PF00498	0.533
LIG_FHA_2	337	343	PF00498	0.441
LIG_FHA_2	58	64	PF00498	0.705
LIG_PTAP_UEV_1	249	254	PF05743	0.539
LIG_SH2_STAP1	294	298	PF00017	0.515
LIG_SH2_STAP1	359	363	PF00017	0.547
LIG_SH2_STAT3	294	297	PF00017	0.520
LIG_SH2_STAT5	179	182	PF00017	0.411
LIG_SH2_STAT5	305	308	PF00017	0.390
LIG_SH3_3	247	253	PF00018	0.493
LIG_SH3_3	280	286	PF00018	0.531
LIG_SH3_3	378	384	PF00018	0.398
LIG_SH3_3	399	405	PF00018	0.658
LIG_SH3_3	59	65	PF00018	0.627
LIG_SUMO_SIM_par_1	20	27	PF11976	0.591
LIG_TRAF2_1	272	275	PF00917	0.488
LIG_TRAF2_1	49	52	PF00917	0.617
MOD_CDK_SPxxK_3	317	324	PF00069	0.287
MOD_CK1_1	154	160	PF00069	0.664
MOD_CK1_1	333	339	PF00069	0.502
MOD_CK2_1	136	142	PF00069	0.405
MOD_CK2_1	282	288	PF00069	0.486
MOD_CK2_1	323	329	PF00069	0.541
MOD_CK2_1	336	342	PF00069	0.579
MOD_CK2_1	57	63	PF00069	0.703
MOD_GlcNHglycan	104	107	PF01048	0.651
MOD_GlcNHglycan	117	120	PF01048	0.627
MOD_GlcNHglycan	218	221	PF01048	0.631
MOD_GlcNHglycan	250	253	PF01048	0.623
MOD_GlcNHglycan	29	32	PF01048	0.558
MOD_GlcNHglycan	359	362	PF01048	0.520
MOD_GSK3_1	136	143	PF00069	0.434
MOD_GSK3_1	19	26	PF00069	0.412
MOD_GSK3_1	201	208	PF00069	0.467
MOD_GSK3_1	248	255	PF00069	0.595
MOD_GSK3_1	329	336	PF00069	0.599
MOD_GSK3_1	35	42	PF00069	0.564
MOD_GSK3_1	357	364	PF00069	0.569
MOD_GSK3_1	392	399	PF00069	0.517
MOD_GSK3_1	53	60	PF00069	0.580
MOD_GSK3_1	65	72	PF00069	0.767
MOD_GSK3_1	97	104	PF00069	0.575
MOD_N-GLC_1	361	366	PF02516	0.567
MOD_NEK2_1	136	141	PF00069	0.397
MOD_NEK2_1	199	204	PF00069	0.546
MOD_NEK2_1	238	243	PF00069	0.579
MOD_NEK2_1	296	301	PF00069	0.427
MOD_NEK2_1	323	328	PF00069	0.546
MOD_NEK2_1	370	375	PF00069	0.584
MOD_NEK2_1	392	397	PF00069	0.536
MOD_NEK2_1	40	45	PF00069	0.511
MOD_PIKK_1	151	157	PF00454	0.662
MOD_PIKK_1	365	371	PF00454	0.628
MOD_PIKK_1	69	75	PF00454	0.689
MOD_PKA_2	101	107	PF00069	0.621
MOD_PKA_2	108	114	PF00069	0.608
MOD_PKA_2	238	244	PF00069	0.536
MOD_PKA_2	275	281	PF00069	0.521
MOD_PKA_2	323	329	PF00069	0.481
MOD_Plk_1	123	129	PF00069	0.680
MOD_Plk_1	141	147	PF00069	0.376
MOD_Plk_1	19	25	PF00069	0.463
MOD_Plk_1	333	339	PF00069	0.672
MOD_Plk_4	35	41	PF00069	0.480
MOD_Plk_4	392	398	PF00069	0.515
MOD_ProDKin_1	156	162	PF00069	0.635
MOD_ProDKin_1	205	211	PF00069	0.441
MOD_ProDKin_1	282	288	PF00069	0.494
MOD_ProDKin_1	317	323	PF00069	0.295
MOD_ProDKin_1	380	386	PF00069	0.467
MOD_ProDKin_1	58	64	PF00069	0.622
TRG_Pf-PMV_PEXEL_1	271	275	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK24	Leptomonas seymouri	53%	93%
A0A0S4JIK9	Bodo saltans	32%	96%
A0A1X0P835	Trypanosomatidae	36%	83%
A0A3R7KEY6	Trypanosoma rangeli	40%	88%
A0A3S7XAM2	Leishmania donovani	93%	100%
A4HP08	Leishmania braziliensis	77%	100%
A4HP27	Leishmania braziliensis	76%	100%
A4IDB7	Leishmania infantum	93%	100%
D0A2Y8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
Q4Q1S8	Leishmania major	89%	100%
V5B4F6	Trypanosoma cruzi	39%	91%