Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASR6_LEIMU

TriTrypDb:

LmxM.36.1460

Length:

653

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASR6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	344	348	PF00656	0.731
CLV_NRD_NRD_1	101	103	PF00675	0.732
CLV_NRD_NRD_1	248	250	PF00675	0.664
CLV_NRD_NRD_1	326	328	PF00675	0.840
CLV_NRD_NRD_1	424	426	PF00675	0.728
CLV_NRD_NRD_1	433	435	PF00675	0.634
CLV_NRD_NRD_1	511	513	PF00675	0.744
CLV_NRD_NRD_1	52	54	PF00675	0.798
CLV_NRD_NRD_1	627	629	PF00675	0.612
CLV_NRD_NRD_1	645	647	PF00675	0.519
CLV_PCSK_FUR_1	99	103	PF00082	0.729
CLV_PCSK_KEX2_1	101	103	PF00082	0.732
CLV_PCSK_KEX2_1	247	249	PF00082	0.665
CLV_PCSK_KEX2_1	326	328	PF00082	0.840
CLV_PCSK_KEX2_1	424	426	PF00082	0.833
CLV_PCSK_KEX2_1	433	435	PF00082	0.692
CLV_PCSK_KEX2_1	51	53	PF00082	0.786
CLV_PCSK_KEX2_1	511	513	PF00082	0.744
CLV_PCSK_KEX2_1	627	629	PF00082	0.617
CLV_PCSK_KEX2_1	645	647	PF00082	0.515
CLV_PCSK_PC7_1	243	249	PF00082	0.565
CLV_PCSK_PC7_1	420	426	PF00082	0.731
CLV_PCSK_SKI1_1	231	235	PF00082	0.547
CLV_PCSK_SKI1_1	326	330	PF00082	0.838
CLV_PCSK_SKI1_1	456	460	PF00082	0.723
CLV_PCSK_SKI1_1	511	515	PF00082	0.737
DEG_SCF_FBW7_1	558	563	PF00400	0.520
DEG_SCF_FBW7_2	457	463	PF00400	0.697
DEG_SPOP_SBC_1	206	210	PF00917	0.661
DEG_SPOP_SBC_1	251	255	PF00917	0.839
DEG_SPOP_SBC_1	408	412	PF00917	0.801
DEG_SPOP_SBC_1	516	520	PF00917	0.718
DEG_SPOP_SBC_1	78	82	PF00917	0.734
DOC_CKS1_1	457	462	PF01111	0.714
DOC_CYCLIN_RxL_1	323	333	PF00134	0.837
DOC_MAPK_DCC_7	481	490	PF00069	0.601
DOC_MAPK_gen_1	101	112	PF00069	0.476
DOC_MAPK_MEF2A_6	481	490	PF00069	0.606
DOC_PP1_RVXF_1	58	65	PF00149	0.797
DOC_PP2B_LxvP_1	483	486	PF13499	0.514
DOC_PP4_FxxP_1	29	32	PF00568	0.830
DOC_PP4_FxxP_1	64	67	PF00568	0.791
DOC_USP7_MATH_1	133	137	PF00917	0.535
DOC_USP7_MATH_1	173	177	PF00917	0.776
DOC_USP7_MATH_1	223	227	PF00917	0.677
DOC_USP7_MATH_1	33	37	PF00917	0.750
DOC_USP7_MATH_1	371	375	PF00917	0.742
DOC_USP7_MATH_1	408	412	PF00917	0.764
DOC_USP7_MATH_1	416	420	PF00917	0.734
DOC_USP7_MATH_1	461	465	PF00917	0.658
DOC_USP7_MATH_1	570	574	PF00917	0.772
DOC_USP7_MATH_1	577	581	PF00917	0.609
DOC_USP7_MATH_1	97	101	PF00917	0.652
DOC_USP7_MATH_2	461	467	PF00917	0.548
DOC_WW_Pin1_4	150	155	PF00397	0.621
DOC_WW_Pin1_4	162	167	PF00397	0.825
DOC_WW_Pin1_4	18	23	PF00397	0.640
DOC_WW_Pin1_4	216	221	PF00397	0.718
DOC_WW_Pin1_4	262	267	PF00397	0.762
DOC_WW_Pin1_4	277	282	PF00397	0.681
DOC_WW_Pin1_4	337	342	PF00397	0.834
DOC_WW_Pin1_4	350	355	PF00397	0.646
DOC_WW_Pin1_4	360	365	PF00397	0.646
DOC_WW_Pin1_4	386	391	PF00397	0.852
DOC_WW_Pin1_4	456	461	PF00397	0.680
DOC_WW_Pin1_4	464	469	PF00397	0.668
DOC_WW_Pin1_4	474	479	PF00397	0.595
DOC_WW_Pin1_4	491	496	PF00397	0.751
DOC_WW_Pin1_4	556	561	PF00397	0.665
DOC_WW_Pin1_4	566	571	PF00397	0.654
DOC_WW_Pin1_4	84	89	PF00397	0.505
LIG_14-3-3_CanoR_1	168	172	PF00244	0.684
LIG_14-3-3_CanoR_1	207	212	PF00244	0.811
LIG_14-3-3_CanoR_1	231	241	PF00244	0.673
LIG_14-3-3_CanoR_1	249	258	PF00244	0.752
LIG_14-3-3_CanoR_1	273	278	PF00244	0.564
LIG_14-3-3_CanoR_1	303	311	PF00244	0.652
LIG_14-3-3_CanoR_1	350	354	PF00244	0.563
LIG_14-3-3_CanoR_1	372	377	PF00244	0.733
LIG_14-3-3_CanoR_1	433	440	PF00244	0.735
LIG_14-3-3_CanoR_1	51	61	PF00244	0.563
LIG_14-3-3_CanoR_1	565	570	PF00244	0.792
LIG_14-3-3_CanoR_1	578	582	PF00244	0.622
LIG_BIR_II_1	1	5	PF00653	0.524
LIG_BRCT_BRCA1_1	271	275	PF00533	0.673
LIG_BRCT_BRCA1_1	540	544	PF00533	0.713
LIG_BRCT_BRCA1_1	582	586	PF00533	0.456
LIG_FHA_1	252	258	PF00498	0.737
LIG_FHA_1	434	440	PF00498	0.706
LIG_FHA_1	520	526	PF00498	0.566
LIG_FHA_1	557	563	PF00498	0.686
LIG_FHA_1	586	592	PF00498	0.687
LIG_FHA_2	185	191	PF00498	0.576
LIG_FHA_2	199	205	PF00498	0.692
LIG_FHA_2	26	32	PF00498	0.571
LIG_FHA_2	342	348	PF00498	0.768
LIG_FHA_2	350	356	PF00498	0.730
LIG_FHA_2	433	439	PF00498	0.692
LIG_FHA_2	501	507	PF00498	0.782
LIG_FHA_2	512	518	PF00498	0.707
LIG_FHA_2	616	622	PF00498	0.658
LIG_LIR_Apic_2	28	32	PF02991	0.669
LIG_LIR_Apic_2	335	341	PF02991	0.828
LIG_LIR_Gen_1	584	595	PF02991	0.584
LIG_LIR_Nem_3	477	483	PF02991	0.524
LIG_LIR_Nem_3	584	590	PF02991	0.692
LIG_LIR_Nem_3	597	602	PF02991	0.615
LIG_PDZ_Class_1	648	653	PF00595	0.799
LIG_Pex14_2	586	590	PF04695	0.454
LIG_RPA_C_Fungi	96	108	PF08784	0.657
LIG_SH2_CRK	338	342	PF00017	0.538
LIG_SH2_STAP1	211	215	PF00017	0.544
LIG_SH2_STAP1	587	591	PF00017	0.553
LIG_SH2_STAT5	587	590	PF00017	0.518
LIG_SH3_3	120	126	PF00018	0.678
LIG_SH3_3	135	141	PF00018	0.680
LIG_SH3_3	145	151	PF00018	0.647
LIG_SH3_3	153	159	PF00018	0.513
LIG_SH3_3	348	354	PF00018	0.598
LIG_SH3_3	365	371	PF00018	0.628
LIG_SH3_3	444	450	PF00018	0.714
LIG_SUMO_SIM_par_1	126	132	PF11976	0.755
LIG_SUMO_SIM_par_1	87	92	PF11976	0.755
LIG_TRFH_1	181	185	PF08558	0.625
LIG_WRC_WIRS_1	551	556	PF05994	0.688
LIG_WW_3	459	463	PF00397	0.716
MOD_CDC14_SPxK_1	363	366	PF00782	0.572
MOD_CDK_SPK_2	216	221	PF00069	0.525
MOD_CDK_SPxK_1	162	168	PF00069	0.553
MOD_CDK_SPxK_1	18	24	PF00069	0.643
MOD_CDK_SPxK_1	360	366	PF00069	0.570
MOD_CDK_SPxK_1	386	392	PF00069	0.767
MOD_CDK_SPxK_1	456	462	PF00069	0.716
MOD_CDK_SPxxK_3	474	481	PF00069	0.548
MOD_CDK_SPxxK_3	491	498	PF00069	0.561
MOD_CK1_1	115	121	PF00069	0.763
MOD_CK1_1	210	216	PF00069	0.670
MOD_CK1_1	224	230	PF00069	0.769
MOD_CK1_1	232	238	PF00069	0.672
MOD_CK1_1	252	258	PF00069	0.842
MOD_CK1_1	265	271	PF00069	0.625
MOD_CK1_1	276	282	PF00069	0.712
MOD_CK1_1	3	9	PF00069	0.520
MOD_CK1_1	384	390	PF00069	0.847
MOD_CK1_1	464	470	PF00069	0.702
MOD_CK1_1	494	500	PF00069	0.574
MOD_CK1_1	515	521	PF00069	0.823
MOD_CK1_1	539	545	PF00069	0.800
MOD_CK1_1	55	61	PF00069	0.727
MOD_CK1_1	568	574	PF00069	0.726
MOD_CK1_1	580	586	PF00069	0.552
MOD_CK1_1	634	640	PF00069	0.588
MOD_CK2_1	133	139	PF00069	0.587
MOD_CK2_1	184	190	PF00069	0.528
MOD_CK2_1	198	204	PF00069	0.604
MOD_CK2_1	25	31	PF00069	0.571
MOD_CK2_1	304	310	PF00069	0.830
MOD_CK2_1	349	355	PF00069	0.861
MOD_CK2_1	371	377	PF00069	0.766
MOD_CK2_1	385	391	PF00069	0.699
MOD_CK2_1	394	400	PF00069	0.702
MOD_CK2_1	500	506	PF00069	0.779
MOD_CK2_1	511	517	PF00069	0.711
MOD_CK2_1	529	535	PF00069	0.527
MOD_CK2_1	615	621	PF00069	0.670
MOD_CK2_1	68	74	PF00069	0.629
MOD_DYRK1A_RPxSP_1	216	220	PF00069	0.628
MOD_DYRK1A_RPxSP_1	350	354	PF00069	0.563
MOD_GlcNHglycan	114	117	PF01048	0.748
MOD_GlcNHglycan	135	138	PF01048	0.560
MOD_GlcNHglycan	15	18	PF01048	0.651
MOD_GlcNHglycan	169	172	PF01048	0.724
MOD_GlcNHglycan	175	178	PF01048	0.747
MOD_GlcNHglycan	221	224	PF01048	0.737
MOD_GlcNHglycan	226	229	PF01048	0.824
MOD_GlcNHglycan	231	234	PF01048	0.773
MOD_GlcNHglycan	35	38	PF01048	0.715
MOD_GlcNHglycan	411	414	PF01048	0.540
MOD_GlcNHglycan	441	444	PF01048	0.621
MOD_GlcNHglycan	514	517	PF01048	0.801
MOD_GlcNHglycan	525	528	PF01048	0.639
MOD_GlcNHglycan	532	535	PF01048	0.531
MOD_GlcNHglycan	54	57	PF01048	0.507
MOD_GlcNHglycan	541	544	PF01048	0.575
MOD_GlcNHglycan	575	578	PF01048	0.756
MOD_GlcNHglycan	583	586	PF01048	0.660
MOD_GlcNHglycan	82	85	PF01048	0.763
MOD_GSK3_1	146	153	PF00069	0.618
MOD_GSK3_1	157	164	PF00069	0.806
MOD_GSK3_1	179	186	PF00069	0.612
MOD_GSK3_1	206	213	PF00069	0.832
MOD_GSK3_1	219	226	PF00069	0.616
MOD_GSK3_1	249	256	PF00069	0.826
MOD_GSK3_1	265	272	PF00069	0.592
MOD_GSK3_1	273	280	PF00069	0.710
MOD_GSK3_1	3	10	PF00069	0.521
MOD_GSK3_1	305	312	PF00069	0.642
MOD_GSK3_1	333	340	PF00069	0.804
MOD_GSK3_1	381	388	PF00069	0.838
MOD_GSK3_1	39	46	PF00069	0.813
MOD_GSK3_1	390	397	PF00069	0.676
MOD_GSK3_1	428	435	PF00069	0.570
MOD_GSK3_1	497	504	PF00069	0.702
MOD_GSK3_1	51	58	PF00069	0.617
MOD_GSK3_1	511	518	PF00069	0.613
MOD_GSK3_1	519	526	PF00069	0.665
MOD_GSK3_1	535	542	PF00069	0.642
MOD_GSK3_1	556	563	PF00069	0.727
MOD_GSK3_1	566	573	PF00069	0.767
MOD_GSK3_1	577	584	PF00069	0.534
MOD_GSK3_1	590	597	PF00069	0.535
MOD_GSK3_1	602	609	PF00069	0.564
MOD_GSK3_1	627	634	PF00069	0.556
MOD_GSK3_1	80	87	PF00069	0.555
MOD_N-GLC_1	13	18	PF02516	0.639
MOD_N-GLC_1	319	324	PF02516	0.727
MOD_N-GLC_1	330	335	PF02516	0.603
MOD_NEK2_1	1	6	PF00069	0.611
MOD_NEK2_1	161	166	PF00069	0.668
MOD_NEK2_1	383	388	PF00069	0.650
MOD_NEK2_1	432	437	PF00069	0.737
MOD_NEK2_1	529	534	PF00069	0.736
MOD_NEK2_1	581	586	PF00069	0.751
MOD_NEK2_1	590	595	PF00069	0.633
MOD_NEK2_1	602	607	PF00069	0.558
MOD_NEK2_2	211	216	PF00069	0.545
MOD_PIKK_1	319	325	PF00454	0.780
MOD_PIKK_1	497	503	PF00454	0.727
MOD_PKA_1	433	439	PF00069	0.635
MOD_PKA_1	51	57	PF00069	0.783
MOD_PKA_1	511	517	PF00069	0.732
MOD_PKA_1	627	633	PF00069	0.603
MOD_PKA_2	167	173	PF00069	0.684
MOD_PKA_2	206	212	PF00069	0.677
MOD_PKA_2	305	311	PF00069	0.563
MOD_PKA_2	33	39	PF00069	0.666
MOD_PKA_2	349	355	PF00069	0.819
MOD_PKA_2	371	377	PF00069	0.734
MOD_PKA_2	414	420	PF00069	0.558
MOD_PKA_2	432	438	PF00069	0.706
MOD_PKA_2	461	467	PF00069	0.722
MOD_PKA_2	497	503	PF00069	0.608
MOD_PKA_2	51	57	PF00069	0.670
MOD_PKA_2	511	517	PF00069	0.724
MOD_PKA_2	529	535	PF00069	0.570
MOD_PKA_2	577	583	PF00069	0.643
MOD_PKA_2	615	621	PF00069	0.672
MOD_PKA_2	627	633	PF00069	0.554
MOD_PKB_1	247	255	PF00069	0.551
MOD_Plk_1	198	204	PF00069	0.727
MOD_Plk_1	309	315	PF00069	0.722
MOD_Plk_1	333	339	PF00069	0.638
MOD_Plk_1	505	511	PF00069	0.735
MOD_Plk_1	536	542	PF00069	0.825
MOD_Plk_1	7	13	PF00069	0.730
MOD_Plk_2-3	199	205	PF00069	0.639
MOD_Plk_2-3	615	621	PF00069	0.724
MOD_Plk_2-3	68	74	PF00069	0.524
MOD_Plk_4	253	259	PF00069	0.634
MOD_Plk_4	333	339	PF00069	0.825
MOD_Plk_4	577	583	PF00069	0.771
MOD_ProDKin_1	150	156	PF00069	0.621
MOD_ProDKin_1	162	168	PF00069	0.827
MOD_ProDKin_1	18	24	PF00069	0.643
MOD_ProDKin_1	216	222	PF00069	0.719
MOD_ProDKin_1	262	268	PF00069	0.758
MOD_ProDKin_1	277	283	PF00069	0.681
MOD_ProDKin_1	337	343	PF00069	0.834
MOD_ProDKin_1	350	356	PF00069	0.647
MOD_ProDKin_1	360	366	PF00069	0.649
MOD_ProDKin_1	386	392	PF00069	0.851
MOD_ProDKin_1	456	462	PF00069	0.682
MOD_ProDKin_1	464	470	PF00069	0.667
MOD_ProDKin_1	474	480	PF00069	0.595
MOD_ProDKin_1	491	497	PF00069	0.751
MOD_ProDKin_1	556	562	PF00069	0.666
MOD_ProDKin_1	566	572	PF00069	0.651
MOD_ProDKin_1	84	90	PF00069	0.499
MOD_SUMO_for_1	632	635	PF00179	0.684
TRG_DiLeu_BaLyEn_6	453	458	PF01217	0.715
TRG_ENDOCYTIC_2	587	590	PF00928	0.698
TRG_ENDOCYTIC_2	599	602	PF00928	0.632
TRG_ER_diArg_1	247	249	PF00400	0.665
TRG_ER_diArg_1	300	303	PF00400	0.658
TRG_ER_diArg_1	326	328	PF00400	0.840
TRG_ER_diArg_1	423	425	PF00400	0.720
TRG_ER_diArg_1	432	434	PF00400	0.638
TRG_ER_diArg_1	51	53	PF00400	0.729
TRG_ER_diArg_1	510	512	PF00400	0.734
TRG_ER_diArg_1	554	557	PF00400	0.709
TRG_ER_diArg_1	627	629	PF00400	0.643
TRG_ER_diArg_1	638	641	PF00400	0.570
TRG_ER_diArg_1	98	101	PF00400	0.724
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.728

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IK06	Leishmania donovani	78%	100%
A4HP06	Leishmania braziliensis	50%	100%
A4HP26	Leishmania braziliensis	49%	100%
A4IDB5	Leishmania infantum	77%	100%
Q4Q1T0	Leishmania major	78%	100%