EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASR5_LEIMU

TriTrypDb:

LmxM.36.1450

Length:

154

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.423
CLV_NRD_NRD_1	56	58	PF00675	0.538
CLV_PCSK_SKI1_1	140	144	PF00082	0.356
CLV_PCSK_SKI1_1	49	53	PF00082	0.411
CLV_PCSK_SKI1_1	86	90	PF00082	0.379
DEG_SPOP_SBC_1	101	105	PF00917	0.512
DOC_USP7_MATH_1	101	105	PF00917	0.573
DOC_USP7_MATH_1	3	7	PF00917	0.713
LIG_14-3-3_CanoR_1	133	137	PF00244	0.504
LIG_14-3-3_CanoR_1	86	91	PF00244	0.392
LIG_14-3-3_CanoR_1	94	100	PF00244	0.429
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_4	129	133	PF00653	0.496
LIG_BRCT_BRCA1_1	64	68	PF00533	0.610
LIG_FHA_1	8	14	PF00498	0.481
LIG_FHA_2	67	73	PF00498	0.433
LIG_LIR_Gen_1	74	84	PF02991	0.406
LIG_LIR_Nem_3	137	142	PF02991	0.357
LIG_LIR_Nem_3	31	36	PF02991	0.422
LIG_LIR_Nem_3	74	80	PF02991	0.382
LIG_NRBOX	142	148	PF00104	0.518
LIG_PCNA_yPIPBox_3	22	33	PF02747	0.336
LIG_SH2_STAT5	23	26	PF00017	0.426
LIG_SH3_1	42	48	PF00018	0.383
LIG_SH3_3	10	16	PF00018	0.651
LIG_SH3_3	42	48	PF00018	0.403
LIG_SUMO_SIM_par_1	78	83	PF11976	0.343
LIG_TRAF2_1	118	121	PF00917	0.490
LIG_WRC_WIRS_1	136	141	PF05994	0.252
MOD_CK1_1	135	141	PF00069	0.277
MOD_CK1_1	6	12	PF00069	0.668
MOD_CK1_1	66	72	PF00069	0.553
MOD_CK2_1	135	141	PF00069	0.254
MOD_CK2_1	72	78	PF00069	0.503
MOD_GlcNHglycan	1	4	PF01048	0.718
MOD_GlcNHglycan	104	107	PF01048	0.550
MOD_GlcNHglycan	111	114	PF01048	0.640
MOD_GSK3_1	142	149	PF00069	0.550
MOD_GSK3_1	3	10	PF00069	0.502
MOD_GSK3_1	62	69	PF00069	0.397
MOD_N-GLC_1	107	112	PF02516	0.496
MOD_N-GLC_2	95	97	PF02516	0.363
MOD_NEK2_1	100	105	PF00069	0.484
MOD_NEK2_1	146	151	PF00069	0.571
MOD_NEK2_1	93	98	PF00069	0.378
MOD_PKA_2	132	138	PF00069	0.505
MOD_PKA_2	93	99	PF00069	0.421
MOD_Plk_2-3	72	78	PF00069	0.375
MOD_Plk_4	142	148	PF00069	0.477
MOD_Plk_4	63	69	PF00069	0.517
MOD_Plk_4	72	78	PF00069	0.384
MOD_SUMO_rev_2	55	65	PF00179	0.519
TRG_ER_diLys_1	150	154	PF00400	0.508
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.492

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX85	Leptomonas seymouri	65%	92%
A0A0S4JG18	Bodo saltans	54%	100%
A0A1X0P8S8	Trypanosomatidae	53%	97%
A0A3Q8IKE9	Leishmania donovani	88%	99%
A0A422NI72	Trypanosoma rangeli	54%	100%
A4HP05	Leishmania braziliensis	82%	100%
A4IDB4	Leishmania infantum	89%	99%
D0A2Y1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	100%
Q4Q1T1	Leishmania major	91%	100%
V5BJX8	Trypanosoma cruzi	52%	100%