Putative translation elongation factor 1-beta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation elongation factor 1-beta, putative

Species:

Leishmania mexicana

UniProt:

E9ASR3_LEIMU

TriTrypDb:

LmxM.36.1430

Length:

208

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 1
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 2
Pissara et al.	yes	yes: 22

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Cellular components
Term	Name	Level	Count
GO:0005853	eukaryotic translation elongation factor 1 complex	2	22
GO:0032991	protein-containing complex	1	22
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ASR3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR3

Function

Biological processes
Term	Name	Level	Count
GO:0006414	translational elongation	5	2
GO:0008152	metabolic process	1	2
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009987	cellular process	1	2
GO:0034645	obsolete cellular macromolecule biosynthetic process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	22
GO:0003746	translation elongation factor activity	4	22
GO:0005488	binding	1	22
GO:0008135	translation factor activity, RNA binding	3	22
GO:0045182	translation regulator activity	1	22
GO:0090079	translation regulator activity, nucleic acid binding	2	22
GO:0097159	organic cyclic compound binding	2	22
GO:1901363	heterocyclic compound binding	2	22
GO:0005085	guanyl-nucleotide exchange factor activity	3	2
GO:0030234	enzyme regulator activity	2	2
GO:0030695	GTPase regulator activity	4	2
GO:0060589	nucleoside-triphosphatase regulator activity	3	2
GO:0098772	molecular function regulator activity	1	2
GO:0140677	molecular function activator activity	2	2
GO:0140678	molecular function inhibitor activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	105	109	PF00082	0.616
CLV_PCSK_SKI1_1	113	117	PF00082	0.551
CLV_PCSK_SKI1_1	65	69	PF00082	0.714
CLV_PCSK_SKI1_1	99	103	PF00082	0.631
DOC_MAPK_gen_1	168	176	PF00069	0.348
DOC_USP7_MATH_1	121	125	PF00917	0.424
DOC_USP7_UBL2_3	108	112	PF12436	0.604
DOC_USP7_UBL2_3	113	117	PF12436	0.566
DOC_WW_Pin1_4	18	23	PF00397	0.505
LIG_14-3-3_CanoR_1	46	51	PF00244	0.517
LIG_APCC_ABBA_1	88	93	PF00400	0.613
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BRCT_BRCA1_1	123	127	PF00533	0.374
LIG_BRCT_BRCA1_1	30	34	PF00533	0.421
LIG_Clathr_ClatBox_1	173	177	PF01394	0.352
LIG_FHA_1	133	139	PF00498	0.345
LIG_FHA_2	1	7	PF00498	0.523
LIG_FHA_2	92	98	PF00498	0.609
LIG_Integrin_isoDGR_2	8	10	PF01839	0.464
LIG_Pex14_2	16	20	PF04695	0.526
LIG_Pex14_2	30	34	PF04695	0.374
LIG_SUMO_SIM_par_1	172	179	PF11976	0.352
LIG_TRAF2_1	94	97	PF00917	0.567
LIG_UBA3_1	173	180	PF00899	0.346
MOD_CK1_1	21	27	PF00069	0.499
MOD_CK2_1	91	97	PF00069	0.628
MOD_GlcNHglycan	181	184	PF01048	0.374
MOD_PKA_1	65	71	PF00069	0.574
MOD_Plk_1	132	138	PF00069	0.367
MOD_Plk_2-3	196	202	PF00069	0.363
MOD_Plk_4	121	127	PF00069	0.352
MOD_Plk_4	46	52	PF00069	0.520
MOD_ProDKin_1	18	24	PF00069	0.507
MOD_SUMO_for_1	115	118	PF00179	0.554
MOD_SUMO_rev_2	109	115	PF00179	0.516
MOD_SUMO_rev_2	123	131	PF00179	0.332
MOD_SUMO_rev_2	151	161	PF00179	0.371
MOD_SUMO_rev_2	177	182	PF00179	0.352
MOD_SUMO_rev_2	63	68	PF00179	0.738
MOD_SUMO_rev_2	93	101	PF00179	0.648
TRG_DiLeu_BaEn_4	97	103	PF01217	0.615
TRG_NLS_MonoExtC_3	112	117	PF00514	0.623
TRG_NLS_MonoExtN_4	112	117	PF00514	0.698

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W7	Leptomonas seymouri	85%	100%
A0A0N1HZF7	Leptomonas seymouri	61%	87%
A0A0S4JC29	Bodo saltans	70%	100%
A0A0S4JK70	Bodo saltans	54%	85%
A0A1X0P9D3	Trypanosomatidae	75%	100%
A0A1X0PA37	Trypanosomatidae	59%	91%
A0A3Q8IVV7	Leishmania donovani	89%	99%
A0A3R7MFZ8	Trypanosoma rangeli	72%	100%
A0A3S5H7W1	Leishmania donovani	62%	87%
A0A422N8N9	Trypanosoma rangeli	62%	91%
A4HAJ1	Leishmania braziliensis	60%	100%
A4HAJ3	Leishmania braziliensis	61%	100%
A4HAJ7	Leishmania braziliensis	58%	100%
A4HP03	Leishmania braziliensis	85%	100%
A4I9P1	Leishmania infantum	62%	87%
A4IDB2	Leishmania infantum	88%	99%
D0A2X9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	68%	100%
E9B4Q3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	61%	85%
O70251	Mus musculus	43%	92%
O74173	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	97%
O81918	Beta vulgaris	37%	90%
O96827	Drosophila melanogaster	43%	94%
P12262	Artemia salina	38%	100%
P24534	Homo sapiens	41%	92%
P29412	Sus scrofa	33%	93%
P29522	Bombyx mori	46%	94%
P29545	Oryza sativa subsp. japonica	39%	93%
P29692	Homo sapiens	52%	74%
P30151	Xenopus laevis	42%	92%
P32471	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	33%	100%
P34460	Caenorhabditis elegans	43%	98%
P34826	Oryctolagus cuniculus	42%	92%
P34827	Trypanosoma cruzi	61%	94%
P48006	Arabidopsis thaliana	38%	90%
P57776	Mus musculus	49%	74%
P78590	Candida albicans (strain WO-1)	33%	98%
P93447	Spuriopimpinella brachycarpa	38%	92%
Q40680	Oryza sativa subsp. japonica	36%	91%
Q40682	Oryza sativa subsp. japonica	38%	92%
Q4Q3C1	Leishmania major	68%	100%
Q4R3D4	Macaca fascicularis	52%	74%
Q5E983	Bos taurus	42%	92%
Q66NE2	Leishmania major	87%	100%
Q68FR9	Rattus norvegicus	50%	74%
Q69BZ7	Penicillium citrinum	33%	91%
Q6DET9	Xenopus tropicalis	40%	91%
Q84WM9	Arabidopsis thaliana	37%	91%
Q9GRF8	Dictyostelium discoideum	42%	96%
Q9SI20	Arabidopsis thaliana	40%	90%
Q9YGQ1	Gallus gallus	42%	92%