Zn-finger in Ran binding protein and others domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zn-finger in Ran binding protein and others, putative

Species:

Leishmania mexicana

UniProt:

E9ASR2_LEIMU

TriTrypDb:

LmxM.36.1420

Length:

561

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASR2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0003729	mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	119	121	PF00675	0.574
CLV_NRD_NRD_1	175	177	PF00675	0.576
CLV_NRD_NRD_1	257	259	PF00675	0.582
CLV_NRD_NRD_1	26	28	PF00675	0.673
CLV_NRD_NRD_1	407	409	PF00675	0.447
CLV_NRD_NRD_1	542	544	PF00675	0.392
CLV_NRD_NRD_1	555	557	PF00675	0.551
CLV_NRD_NRD_1	89	91	PF00675	0.600
CLV_PCSK_KEX2_1	175	177	PF00082	0.605
CLV_PCSK_KEX2_1	257	259	PF00082	0.638
CLV_PCSK_KEX2_1	26	28	PF00082	0.526
CLV_PCSK_KEX2_1	407	409	PF00082	0.447
CLV_PCSK_SKI1_1	11	15	PF00082	0.589
CLV_PCSK_SKI1_1	175	179	PF00082	0.549
CLV_PCSK_SKI1_1	180	184	PF00082	0.472
CLV_PCSK_SKI1_1	231	235	PF00082	0.666
CLV_PCSK_SKI1_1	265	269	PF00082	0.502
CLV_PCSK_SKI1_1	544	548	PF00082	0.565
CLV_PCSK_SKI1_1	557	561	PF00082	0.593
CLV_Separin_Metazoa	172	176	PF03568	0.605
DEG_Nend_UBRbox_1	1	4	PF02207	0.548
DOC_CKS1_1	21	26	PF01111	0.669
DOC_CYCLIN_yCln2_LP_2	233	239	PF00134	0.518
DOC_MAPK_gen_1	257	266	PF00069	0.542
DOC_MAPK_HePTP_8	254	266	PF00069	0.423
DOC_MAPK_MEF2A_6	257	266	PF00069	0.423
DOC_MAPK_MEF2A_6	54	63	PF00069	0.540
DOC_PP2B_LxvP_1	233	236	PF13499	0.671
DOC_PP2B_LxvP_1	59	62	PF13499	0.415
DOC_PP4_FxxP_1	18	21	PF00568	0.423
DOC_PP4_FxxP_1	203	206	PF00568	0.676
DOC_PP4_FxxP_1	426	429	PF00568	0.485
DOC_USP7_MATH_1	126	130	PF00917	0.375
DOC_USP7_MATH_1	419	423	PF00917	0.501
DOC_USP7_MATH_1	438	442	PF00917	0.475
DOC_USP7_MATH_1	78	82	PF00917	0.570
DOC_USP7_UBL2_3	525	529	PF12436	0.363
DOC_WW_Pin1_4	20	25	PF00397	0.677
DOC_WW_Pin1_4	249	254	PF00397	0.648
DOC_WW_Pin1_4	305	310	PF00397	0.528
DOC_WW_Pin1_4	413	418	PF00397	0.475
DOC_WW_Pin1_4	487	492	PF00397	0.687
LIG_14-3-3_CanoR_1	175	184	PF00244	0.542
LIG_14-3-3_CanoR_1	26	31	PF00244	0.672
LIG_14-3-3_CanoR_1	285	294	PF00244	0.564
LIG_14-3-3_CanoR_1	418	426	PF00244	0.449
LIG_14-3-3_CanoR_1	476	484	PF00244	0.644
LIG_14-3-3_CanoR_1	54	60	PF00244	0.671
LIG_14-3-3_CanoR_1	551	556	PF00244	0.666
LIG_14-3-3_CanoR_1	64	68	PF00244	0.571
LIG_BRCT_BRCA1_1	131	135	PF00533	0.431
LIG_BRCT_BRCA1_1	325	329	PF00533	0.466
LIG_BRCT_BRCA1_1	35	39	PF00533	0.671
LIG_BRCT_BRCA1_1	527	531	PF00533	0.348
LIG_CSL_BTD_1	21	24	PF09270	0.615
LIG_FHA_1	345	351	PF00498	0.558
LIG_FHA_1	56	62	PF00498	0.615
LIG_FHA_2	195	201	PF00498	0.637
LIG_FHA_2	306	312	PF00498	0.493
LIG_FHA_2	367	373	PF00498	0.675
LIG_FHA_2	389	395	PF00498	0.543
LIG_FHA_2	465	471	PF00498	0.575
LIG_HOMEOBOX	280	283	PF00046	0.470
LIG_LIR_Apic_2	200	206	PF02991	0.666
LIG_LIR_Apic_2	311	315	PF02991	0.557
LIG_LIR_Apic_2	423	429	PF02991	0.475
LIG_LIR_Gen_1	189	199	PF02991	0.512
LIG_LIR_Nem_3	113	119	PF02991	0.457
LIG_LIR_Nem_3	189	194	PF02991	0.497
LIG_PDZ_Class_2	556	561	PF00595	0.620
LIG_Pex14_1	455	459	PF04695	0.592
LIG_Pex14_2	18	22	PF04695	0.572
LIG_SH2_CRK	116	120	PF00017	0.484
LIG_SH2_CRK	56	60	PF00017	0.726
LIG_SH2_NCK_1	161	165	PF00017	0.380
LIG_SH2_NCK_1	196	200	PF00017	0.646
LIG_SH2_STAP1	527	531	PF00017	0.449
LIG_SH2_STAT3	384	387	PF00017	0.754
LIG_SH2_STAT5	196	199	PF00017	0.587
LIG_SH2_STAT5	330	333	PF00017	0.532
LIG_SH2_STAT5	384	387	PF00017	0.754
LIG_SH2_STAT5	396	399	PF00017	0.449
LIG_SH2_STAT5	459	462	PF00017	0.594
LIG_SH2_STAT5	56	59	PF00017	0.704
LIG_SH3_2	21	26	PF14604	0.482
LIG_SH3_3	18	24	PF00018	0.671
LIG_SH3_3	271	277	PF00018	0.601
LIG_SH3_3	361	367	PF00018	0.337
LIG_SH3_3	443	449	PF00018	0.731
LIG_SH3_3	552	558	PF00018	0.610
LIG_TRAF2_1	169	172	PF00917	0.549
LIG_TYR_ITIM	114	119	PF00017	0.461
MOD_CDK_SPK_2	413	418	PF00069	0.475
MOD_CDK_SPxK_1	20	26	PF00069	0.486
MOD_CDK_SPxxK_3	20	27	PF00069	0.623
MOD_CK1_1	129	135	PF00069	0.494
MOD_CK1_1	33	39	PF00069	0.623
MOD_CK1_1	406	412	PF00069	0.362
MOD_CK1_1	514	520	PF00069	0.671
MOD_CK1_1	550	556	PF00069	0.572
MOD_CK1_1	66	72	PF00069	0.651
MOD_CK1_1	95	101	PF00069	0.474
MOD_CK2_1	164	170	PF00069	0.460
MOD_CK2_1	192	198	PF00069	0.505
MOD_CK2_1	305	311	PF00069	0.515
MOD_CK2_1	366	372	PF00069	0.678
MOD_CK2_1	388	394	PF00069	0.502
MOD_CK2_1	514	520	PF00069	0.489
MOD_GlcNHglycan	2	5	PF01048	0.650
MOD_GlcNHglycan	430	433	PF01048	0.779
MOD_GlcNHglycan	439	443	PF01048	0.612
MOD_GlcNHglycan	46	49	PF01048	0.692
MOD_GlcNHglycan	51	54	PF01048	0.692
MOD_GlcNHglycan	547	550	PF01048	0.655
MOD_GSK3_1	190	197	PF00069	0.543
MOD_GSK3_1	26	33	PF00069	0.668
MOD_GSK3_1	460	467	PF00069	0.455
MOD_GSK3_1	483	490	PF00069	0.700
MOD_GSK3_1	507	514	PF00069	0.567
MOD_GSK3_1	547	554	PF00069	0.668
MOD_N-GLC_1	285	290	PF02516	0.603
MOD_N-GLC_1	388	393	PF02516	0.515
MOD_N-GLC_1	403	408	PF02516	0.449
MOD_N-GLC_2	153	155	PF02516	0.385
MOD_NEK2_1	30	35	PF00069	0.679
MOD_NEK2_1	316	321	PF00069	0.460
MOD_NEK2_1	323	328	PF00069	0.441
MOD_NEK2_1	403	408	PF00069	0.449
MOD_NEK2_1	412	417	PF00069	0.449
MOD_NEK2_1	49	54	PF00069	0.639
MOD_NEK2_1	547	552	PF00069	0.488
MOD_NEK2_1	63	68	PF00069	0.538
MOD_NEK2_2	346	351	PF00069	0.427
MOD_NEK2_2	78	83	PF00069	0.550
MOD_OFUCOSY	284	289	PF10250	0.487
MOD_OFUCOSY	77	82	PF10250	0.559
MOD_PIKK_1	483	489	PF00454	0.644
MOD_PK_1	551	557	PF00069	0.669
MOD_PKA_1	175	181	PF00069	0.549
MOD_PKA_1	26	32	PF00069	0.422
MOD_PKA_2	175	181	PF00069	0.566
MOD_PKA_2	26	32	PF00069	0.713
MOD_PKA_2	284	290	PF00069	0.542
MOD_PKA_2	406	412	PF00069	0.388
MOD_PKA_2	475	481	PF00069	0.516
MOD_PKA_2	550	556	PF00069	0.702
MOD_PKA_2	63	69	PF00069	0.648
MOD_Plk_1	296	302	PF00069	0.553
MOD_Plk_2-3	192	198	PF00069	0.625
MOD_Plk_2-3	366	372	PF00069	0.645
MOD_Plk_4	26	32	PF00069	0.677
MOD_Plk_4	346	352	PF00069	0.468
MOD_ProDKin_1	20	26	PF00069	0.678
MOD_ProDKin_1	249	255	PF00069	0.641
MOD_ProDKin_1	305	311	PF00069	0.528
MOD_ProDKin_1	413	419	PF00069	0.475
MOD_ProDKin_1	487	493	PF00069	0.690
MOD_SUMO_rev_2	361	370	PF00179	0.360
TRG_DiLeu_BaEn_1	179	184	PF01217	0.321
TRG_DiLeu_BaEn_1	99	104	PF01217	0.583
TRG_ENDOCYTIC_2	116	119	PF00928	0.481
TRG_ENDOCYTIC_2	56	59	PF00928	0.706
TRG_ER_diArg_1	174	176	PF00400	0.602
TRG_ER_diArg_1	25	27	PF00400	0.669
TRG_ER_diArg_1	465	468	PF00400	0.480
TRG_ER_diArg_1	531	534	PF00400	0.482
TRG_NLS_MonoExtC_3	119	124	PF00514	0.566
TRG_Pf-PMV_PEXEL_1	368	372	PF00026	0.537

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3U7	Leptomonas seymouri	54%	98%
A0A0S4JG42	Bodo saltans	39%	100%
A0A1X0P892	Trypanosomatidae	46%	100%
A0A3R7KC50	Trypanosoma rangeli	47%	100%
A0A3S7XAK2	Leishmania donovani	89%	100%
A4HP02	Leishmania braziliensis	75%	100%
A4ICJ4	Leishmania infantum	89%	100%
D0A2X8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
Q4Q1T4	Leishmania major	90%	100%
V5BJY2	Trypanosoma cruzi	46%	100%