RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted RanGDP binding protein

Species:

Leishmania mexicana

UniProt:

E9ASR1_LEIMU

TriTrypDb:

LmxM.36.1410

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.631
CLV_C14_Caspase3-7	638	642	PF00656	0.321
CLV_C14_Caspase3-7	662	666	PF00656	0.735
CLV_C14_Caspase3-7	855	859	PF00656	0.633
CLV_NRD_NRD_1	226	228	PF00675	0.504
CLV_NRD_NRD_1	29	31	PF00675	0.667
CLV_NRD_NRD_1	354	356	PF00675	0.563
CLV_NRD_NRD_1	455	457	PF00675	0.631
CLV_NRD_NRD_1	504	506	PF00675	0.458
CLV_NRD_NRD_1	576	578	PF00675	0.586
CLV_NRD_NRD_1	591	593	PF00675	0.385
CLV_NRD_NRD_1	795	797	PF00675	0.403
CLV_PCSK_KEX2_1	29	31	PF00082	0.657
CLV_PCSK_KEX2_1	354	356	PF00082	0.615
CLV_PCSK_KEX2_1	455	457	PF00082	0.631
CLV_PCSK_KEX2_1	504	506	PF00082	0.458
CLV_PCSK_KEX2_1	591	593	PF00082	0.490
CLV_PCSK_KEX2_1	794	796	PF00082	0.368
CLV_PCSK_SKI1_1	238	242	PF00082	0.620
CLV_PCSK_SKI1_1	577	581	PF00082	0.582
CLV_PCSK_SKI1_1	713	717	PF00082	0.489
DEG_APCC_DBOX_1	29	37	PF00400	0.758
DEG_APCC_DBOX_1	692	700	PF00400	0.485
DEG_APCC_DBOX_1	793	801	PF00400	0.498
DEG_Nend_UBRbox_1	1	4	PF02207	0.473
DEG_SCF_FBW7_1	404	410	PF00400	0.670
DEG_SCF_FBW7_1	649	656	PF00400	0.490
DEG_SCF_FBW7_1	738	745	PF00400	0.442
DEG_SPOP_SBC_1	76	80	PF00917	0.701
DOC_CKS1_1	404	409	PF01111	0.672
DOC_CKS1_1	650	655	PF01111	0.496
DOC_CYCLIN_RxL_1	574	583	PF00134	0.555
DOC_MAPK_gen_1	196	205	PF00069	0.407
DOC_MAPK_gen_1	281	290	PF00069	0.392
DOC_MAPK_gen_1	29	38	PF00069	0.732
DOC_MAPK_gen_1	808	817	PF00069	0.498
DOC_MAPK_HePTP_8	158	170	PF00069	0.475
DOC_MAPK_MEF2A_6	161	170	PF00069	0.472
DOC_PP1_RVXF_1	323	330	PF00149	0.529
DOC_PP1_RVXF_1	503	510	PF00149	0.530
DOC_PP1_RVXF_1	695	702	PF00149	0.475
DOC_USP7_MATH_1	132	136	PF00917	0.776
DOC_USP7_MATH_1	173	177	PF00917	0.599
DOC_USP7_MATH_1	233	237	PF00917	0.599
DOC_USP7_MATH_1	37	41	PF00917	0.505
DOC_USP7_MATH_1	385	389	PF00917	0.565
DOC_USP7_MATH_1	445	449	PF00917	0.731
DOC_USP7_MATH_1	669	673	PF00917	0.585
DOC_USP7_MATH_1	77	81	PF00917	0.642
DOC_WW_Pin1_4	112	117	PF00397	0.744
DOC_WW_Pin1_4	291	296	PF00397	0.379
DOC_WW_Pin1_4	393	398	PF00397	0.649
DOC_WW_Pin1_4	403	408	PF00397	0.635
DOC_WW_Pin1_4	465	470	PF00397	0.727
DOC_WW_Pin1_4	471	476	PF00397	0.678
DOC_WW_Pin1_4	534	539	PF00397	0.658
DOC_WW_Pin1_4	541	546	PF00397	0.617
DOC_WW_Pin1_4	55	60	PF00397	0.739
DOC_WW_Pin1_4	649	654	PF00397	0.589
DOC_WW_Pin1_4	738	743	PF00397	0.560
DOC_WW_Pin1_4	810	815	PF00397	0.447
DOC_WW_Pin1_4	842	847	PF00397	0.602
LIG_14-3-3_CanoR_1	137	142	PF00244	0.473
LIG_14-3-3_CanoR_1	15	19	PF00244	0.687
LIG_14-3-3_CanoR_1	2	8	PF00244	0.513
LIG_14-3-3_CanoR_1	313	322	PF00244	0.574
LIG_14-3-3_CanoR_1	32	37	PF00244	0.647
LIG_14-3-3_CanoR_1	364	371	PF00244	0.631
LIG_14-3-3_CanoR_1	431	436	PF00244	0.437
LIG_14-3-3_CanoR_1	532	538	PF00244	0.563
LIG_14-3-3_CanoR_1	659	664	PF00244	0.658
LIG_14-3-3_CanoR_1	820	828	PF00244	0.377
LIG_APCC_ABBAyCdc20_2	505	511	PF00400	0.317
LIG_BIR_III_4	556	560	PF00653	0.425
LIG_BIR_III_4	704	708	PF00653	0.392
LIG_BRCT_BRCA1_1	543	547	PF00533	0.468
LIG_deltaCOP1_diTrp_1	491	497	PF00928	0.439
LIG_FHA_1	138	144	PF00498	0.778
LIG_FHA_1	250	256	PF00498	0.607
LIG_FHA_1	33	39	PF00498	0.655
LIG_FHA_1	404	410	PF00498	0.718
LIG_FHA_1	415	421	PF00498	0.649
LIG_FHA_1	437	443	PF00498	0.651
LIG_FHA_1	496	502	PF00498	0.510
LIG_FHA_1	738	744	PF00498	0.571
LIG_FHA_1	77	83	PF00498	0.652
LIG_FHA_1	843	849	PF00498	0.596
LIG_FHA_2	581	587	PF00498	0.336
LIG_FHA_2	653	659	PF00498	0.580
LIG_FHA_2	669	675	PF00498	0.418
LIG_FHA_2	811	817	PF00498	0.393
LIG_Integrin_RGD_1	198	200	PF01839	0.501
LIG_LIR_Apic_2	301	305	PF02991	0.472
LIG_LIR_Apic_2	568	574	PF02991	0.440
LIG_LIR_Gen_1	188	197	PF02991	0.545
LIG_LIR_Gen_1	285	295	PF02991	0.407
LIG_LIR_Nem_3	188	193	PF02991	0.587
LIG_LIR_Nem_3	215	219	PF02991	0.444
LIG_LIR_Nem_3	239	244	PF02991	0.592
LIG_LIR_Nem_3	285	290	PF02991	0.475
LIG_LIR_Nem_3	294	299	PF02991	0.414
LIG_LIR_Nem_3	491	497	PF02991	0.609
LIG_PDZ_Class_2	866	871	PF00595	0.660
LIG_Pex14_1	42	46	PF04695	0.623
LIG_Pex14_1	571	575	PF04695	0.441
LIG_PTB_Apo_2	337	344	PF02174	0.550
LIG_Rb_LxCxE_1	611	634	PF01857	0.491
LIG_Rb_LxCxE_1	712	732	PF01857	0.258
LIG_SH2_CRK	216	220	PF00017	0.473
LIG_SH2_GRB2like	358	361	PF00017	0.604
LIG_SH2_STAP1	358	362	PF00017	0.601
LIG_SH2_STAT5	46	49	PF00017	0.512
LIG_SH2_STAT5	575	578	PF00017	0.501
LIG_SH3_1	19	25	PF00018	0.601
LIG_SH3_3	140	146	PF00018	0.720
LIG_SH3_3	19	25	PF00018	0.707
LIG_SH3_3	402	408	PF00018	0.632
LIG_SH3_3	539	545	PF00018	0.578
LIG_SH3_3	647	653	PF00018	0.452
LIG_SUMO_SIM_anti_2	836	845	PF11976	0.533
LIG_SUMO_SIM_par_1	812	819	PF11976	0.430
LIG_TRAF2_1	59	62	PF00917	0.637
LIG_UBA3_1	219	228	PF00899	0.347
MOD_CDC14_SPxK_1	474	477	PF00782	0.589
MOD_CDK_SPxK_1	471	477	PF00069	0.546
MOD_CK1_1	148	154	PF00069	0.767
MOD_CK1_1	222	228	PF00069	0.549
MOD_CK1_1	232	238	PF00069	0.443
MOD_CK1_1	470	476	PF00069	0.703
MOD_CK1_1	48	54	PF00069	0.682
MOD_CK1_1	534	540	PF00069	0.649
MOD_CK1_1	664	670	PF00069	0.592
MOD_CK1_1	78	84	PF00069	0.681
MOD_CK1_1	783	789	PF00069	0.459
MOD_CK1_1	799	805	PF00069	0.340
MOD_CK1_1	837	843	PF00069	0.582
MOD_CK2_1	108	114	PF00069	0.572
MOD_CK2_1	521	527	PF00069	0.493
MOD_CK2_1	580	586	PF00069	0.368
MOD_CK2_1	668	674	PF00069	0.432
MOD_CK2_1	742	748	PF00069	0.429
MOD_CK2_1	830	836	PF00069	0.526
MOD_GlcNHglycan	162	166	PF01048	0.636
MOD_GlcNHglycan	210	213	PF01048	0.518
MOD_GlcNHglycan	230	234	PF01048	0.579
MOD_GlcNHglycan	238	241	PF01048	0.702
MOD_GlcNHglycan	268	271	PF01048	0.688
MOD_GlcNHglycan	411	414	PF01048	0.732
MOD_GlcNHglycan	425	428	PF01048	0.725
MOD_GlcNHglycan	447	450	PF01048	0.722
MOD_GlcNHglycan	533	536	PF01048	0.646
MOD_GlcNHglycan	547	550	PF01048	0.541
MOD_GlcNHglycan	678	681	PF01048	0.597
MOD_GlcNHglycan	744	747	PF01048	0.371
MOD_GlcNHglycan	824	827	PF01048	0.528
MOD_GSK3_1	104	111	PF00069	0.762
MOD_GSK3_1	145	152	PF00069	0.758
MOD_GSK3_1	173	180	PF00069	0.607
MOD_GSK3_1	208	215	PF00069	0.502
MOD_GSK3_1	218	225	PF00069	0.468
MOD_GSK3_1	229	236	PF00069	0.464
MOD_GSK3_1	259	266	PF00069	0.555
MOD_GSK3_1	313	320	PF00069	0.542
MOD_GSK3_1	403	410	PF00069	0.706
MOD_GSK3_1	44	51	PF00069	0.718
MOD_GSK3_1	445	452	PF00069	0.622
MOD_GSK3_1	465	472	PF00069	0.675
MOD_GSK3_1	533	540	PF00069	0.648
MOD_GSK3_1	541	548	PF00069	0.734
MOD_GSK3_1	649	656	PF00069	0.581
MOD_GSK3_1	664	671	PF00069	0.564
MOD_GSK3_1	738	745	PF00069	0.437
MOD_GSK3_1	764	771	PF00069	0.490
MOD_GSK3_1	78	85	PF00069	0.636
MOD_GSK3_1	796	803	PF00069	0.454
MOD_GSK3_1	830	837	PF00069	0.425
MOD_GSK3_1	96	103	PF00069	0.619
MOD_N-GLC_1	257	262	PF02516	0.572
MOD_N-GLC_1	669	674	PF02516	0.349
MOD_N-GLC_1	780	785	PF02516	0.402
MOD_N-GLC_1	837	842	PF02516	0.683
MOD_NEK2_1	14	19	PF00069	0.694
MOD_NEK2_1	219	224	PF00069	0.619
MOD_NEK2_1	338	343	PF00069	0.527
MOD_NEK2_1	378	383	PF00069	0.451
MOD_NEK2_1	409	414	PF00069	0.797
MOD_NEK2_1	429	434	PF00069	0.683
MOD_NEK2_1	531	536	PF00069	0.642
MOD_NEK2_1	580	585	PF00069	0.541
MOD_NEK2_1	684	689	PF00069	0.480
MOD_NEK2_1	780	785	PF00069	0.368
MOD_NEK2_1	800	805	PF00069	0.239
MOD_NEK2_2	189	194	PF00069	0.643
MOD_OFUCOSY	801	806	PF10250	0.328
MOD_PIKK_1	108	114	PF00454	0.677
MOD_PIKK_1	313	319	PF00454	0.536
MOD_PIKK_1	580	586	PF00454	0.439
MOD_PIKK_1	757	763	PF00454	0.348
MOD_PK_1	659	665	PF00069	0.454
MOD_PKA_2	14	20	PF00069	0.691
MOD_PKA_2	363	369	PF00069	0.412
MOD_PKA_2	445	451	PF00069	0.619
MOD_PKA_2	48	54	PF00069	0.738
MOD_PKA_2	531	537	PF00069	0.535
MOD_PKA_2	621	627	PF00069	0.544
MOD_PKA_2	658	664	PF00069	0.668
MOD_PKA_2	783	789	PF00069	0.432
MOD_PKA_2	819	825	PF00069	0.365
MOD_PKB_1	30	38	PF00069	0.613
MOD_PKB_1	456	464	PF00069	0.494
MOD_PKB_1	794	802	PF00069	0.502
MOD_Plk_1	229	235	PF00069	0.393
MOD_Plk_1	610	616	PF00069	0.483
MOD_Plk_1	669	675	PF00069	0.396
MOD_Plk_1	780	786	PF00069	0.543
MOD_Plk_1	837	843	PF00069	0.617
MOD_Plk_2-3	858	864	PF00069	0.507
MOD_Plk_4	338	344	PF00069	0.529
MOD_Plk_4	358	364	PF00069	0.347
MOD_Plk_4	385	391	PF00069	0.500
MOD_Plk_4	431	437	PF00069	0.727
MOD_ProDKin_1	112	118	PF00069	0.741
MOD_ProDKin_1	291	297	PF00069	0.384
MOD_ProDKin_1	393	399	PF00069	0.651
MOD_ProDKin_1	403	409	PF00069	0.635
MOD_ProDKin_1	465	471	PF00069	0.729
MOD_ProDKin_1	534	540	PF00069	0.661
MOD_ProDKin_1	541	547	PF00069	0.620
MOD_ProDKin_1	55	61	PF00069	0.735
MOD_ProDKin_1	649	655	PF00069	0.601
MOD_ProDKin_1	738	744	PF00069	0.561
MOD_ProDKin_1	810	816	PF00069	0.447
MOD_ProDKin_1	842	848	PF00069	0.604
TRG_DiLeu_BaEn_4	462	468	PF01217	0.558
TRG_DiLeu_BaLyEn_6	215	220	PF01217	0.323
TRG_DiLeu_BaLyEn_6	23	28	PF01217	0.599
TRG_ENDOCYTIC_2	216	219	PF00928	0.437
TRG_ER_diArg_1	193	196	PF00400	0.615
TRG_ER_diArg_1	28	30	PF00400	0.655
TRG_ER_diArg_1	38	41	PF00400	0.519
TRG_ER_diArg_1	455	458	PF00400	0.506
TRG_ER_diArg_1	482	485	PF00400	0.662
TRG_ER_diArg_1	520	523	PF00400	0.428
TRG_ER_diArg_1	690	693	PF00400	0.453
TRG_ER_diArg_1	782	785	PF00400	0.452
TRG_ER_diArg_1	794	796	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.762
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.540

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS2	Leptomonas seymouri	42%	100%
A0A0S4JGK3	Bodo saltans	28%	100%
A0A1X0P808	Trypanosomatidae	30%	82%
A0A3Q8IJ60	Leishmania donovani	83%	100%
A4HP01	Leishmania braziliensis	68%	100%
A4ICJ5	Leishmania infantum	83%	100%
D0A2X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	87%
Q4Q1T5	Leishmania major	83%	100%
V5B4G3	Trypanosoma cruzi	30%	86%