RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

predicted RanGDP binding protein

Species:

Leishmania mexicana

UniProt:

E9ASR1_LEIMU

TriTrypDb:

LmxM.36.1410

Length:

871

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASR1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR1

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.631
CLV_C14_Caspase3-7	638	642	PF00656	0.321
CLV_C14_Caspase3-7	662	666	PF00656	0.735
CLV_C14_Caspase3-7	855	859	PF00656	0.633
CLV_NRD_NRD_1	226	228	PF00675	0.504
CLV_NRD_NRD_1	29	31	PF00675	0.667
CLV_NRD_NRD_1	354	356	PF00675	0.563
CLV_NRD_NRD_1	455	457	PF00675	0.631
CLV_NRD_NRD_1	504	506	PF00675	0.458
CLV_NRD_NRD_1	576	578	PF00675	0.586

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHS2	Leptomonas seymouri	42%	100%
A0A0S4JGK3	Bodo saltans	28%	100%
A0A1X0P808	Trypanosomatidae	30%	82%
A0A3Q8IJ60	Leishmania donovani	83%	100%
A4HP01	Leishmania braziliensis	68%	100%
A4ICJ5	Leishmania infantum	83%	100%
D0A2X7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	87%
Q4Q1T5	Leishmania major	83%	100%
V5B4G3	Trypanosoma cruzi	30%	86%

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