Cilia- and flagella-associated protein 36

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

The ARF-like 2 binding protein BART, putative

Species:

Leishmania mexicana

UniProt:

E9ASR0_LEIMU

TriTrypDb:

LmxM.36.1400

Length:

443

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	11
GO:0120025	plasma membrane bounded cell projection	3	10
GO:0005930	axoneme	2	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0097014	ciliary plasm	5	1
GO:0097546	ciliary base	2	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ASR0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASR0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	184	188	PF00656	0.584
CLV_NRD_NRD_1	178	180	PF00675	0.566
CLV_NRD_NRD_1	428	430	PF00675	0.521
CLV_NRD_NRD_1	438	440	PF00675	0.596
CLV_PCSK_KEX2_1	120	122	PF00082	0.288
CLV_PCSK_KEX2_1	178	180	PF00082	0.602
CLV_PCSK_KEX2_1	370	372	PF00082	0.646
CLV_PCSK_KEX2_1	428	430	PF00082	0.521
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.334
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.679
CLV_PCSK_SKI1_1	103	107	PF00082	0.328
CLV_PCSK_SKI1_1	5	9	PF00082	0.386
CLV_PCSK_SKI1_1	96	100	PF00082	0.352
DEG_SCF_FBW7_1	359	364	PF00400	0.587
DEG_SPOP_SBC_1	403	407	PF00917	0.561
DOC_CKS1_1	20	25	PF01111	0.496
DOC_CYCLIN_RxL_1	115	126	PF00134	0.566
DOC_MAPK_gen_1	120	127	PF00069	0.488
DOC_MAPK_gen_1	178	185	PF00069	0.612
DOC_MAPK_gen_1	249	258	PF00069	0.477
DOC_MAPK_MEF2A_6	120	127	PF00069	0.496
DOC_MAPK_MEF2A_6	178	185	PF00069	0.584
DOC_MAPK_NFAT4_5	120	128	PF00069	0.496
DOC_PP1_RVXF_1	252	259	PF00149	0.479
DOC_PP4_FxxP_1	284	287	PF00568	0.736
DOC_USP7_MATH_1	132	136	PF00917	0.607
DOC_USP7_MATH_1	144	148	PF00917	0.668
DOC_USP7_MATH_1	287	291	PF00917	0.702
DOC_USP7_MATH_1	300	304	PF00917	0.696
DOC_USP7_MATH_1	314	318	PF00917	0.695
DOC_USP7_MATH_1	327	331	PF00917	0.598
DOC_USP7_MATH_1	334	338	PF00917	0.711
DOC_USP7_MATH_1	351	355	PF00917	0.647
DOC_USP7_MATH_1	438	442	PF00917	0.452
DOC_USP7_MATH_1	77	81	PF00917	0.572
DOC_USP7_UBL2_3	99	103	PF12436	0.591
DOC_WW_Pin1_4	14	19	PF00397	0.482
DOC_WW_Pin1_4	283	288	PF00397	0.763
DOC_WW_Pin1_4	357	362	PF00397	0.649
DOC_WW_Pin1_4	399	404	PF00397	0.519
LIG_14-3-3_CanoR_1	5	14	PF00244	0.586
LIG_14-3-3_CterR_2	439	443	PF00244	0.756
LIG_Actin_WH2_2	164	180	PF00022	0.579
LIG_BIR_II_1	1	5	PF00653	0.200
LIG_FHA_1	156	162	PF00498	0.633
LIG_FHA_1	331	337	PF00498	0.709
LIG_FHA_1	421	427	PF00498	0.536
LIG_FHA_1	59	65	PF00498	0.476
LIG_FHA_1	6	12	PF00498	0.526
LIG_FHA_2	144	150	PF00498	0.534
LIG_FHA_2	20	26	PF00498	0.513
LIG_FHA_2	362	368	PF00498	0.598
LIG_FHA_2	71	77	PF00498	0.521
LIG_FHA_2	86	92	PF00498	0.567
LIG_GBD_Chelix_1	426	434	PF00786	0.594
LIG_Integrin_RGD_1	431	433	PF01839	0.651
LIG_LIR_Apic_2	17	23	PF02991	0.482
LIG_LIR_Apic_2	283	287	PF02991	0.715
LIG_LIR_Gen_1	109	119	PF02991	0.502
LIG_LIR_Gen_1	255	266	PF02991	0.347
LIG_LIR_Gen_1	44	52	PF02991	0.512
LIG_LIR_Nem_3	109	114	PF02991	0.496
LIG_LIR_Nem_3	255	261	PF02991	0.386
LIG_LIR_Nem_3	44	48	PF02991	0.512
LIG_PCNA_PIPBox_1	391	400	PF02747	0.646
LIG_PCNA_yPIPBox_3	387	398	PF02747	0.596
LIG_PTAP_UEV_1	301	306	PF05743	0.493
LIG_PTAP_UEV_1	340	345	PF05743	0.710
LIG_SH2_CRK	45	49	PF00017	0.505
LIG_SH2_STAT5	45	48	PF00017	0.534
LIG_SH3_1	338	344	PF00018	0.716
LIG_SH3_3	290	296	PF00018	0.680
LIG_SH3_3	299	305	PF00018	0.604
LIG_SH3_3	307	313	PF00018	0.627
LIG_SH3_3	323	329	PF00018	0.601
LIG_SH3_3	338	344	PF00018	0.532
LIG_SUMO_SIM_anti_2	124	129	PF11976	0.605
LIG_TRAF2_1	364	367	PF00917	0.585
LIG_TRAF2_1	389	392	PF00917	0.575
LIG_TYR_ITIM	43	48	PF00017	0.550
LIG_WRC_WIRS_1	394	399	PF05994	0.644
MOD_CK1_1	232	238	PF00069	0.455
MOD_CK1_1	286	292	PF00069	0.761
MOD_CK1_1	330	336	PF00069	0.710
MOD_CK1_1	339	345	PF00069	0.683
MOD_CK1_1	354	360	PF00069	0.669
MOD_CK1_1	36	42	PF00069	0.559
MOD_CK1_1	402	408	PF00069	0.649
MOD_CK1_1	58	64	PF00069	0.583
MOD_CK1_1	70	76	PF00069	0.515
MOD_CK2_1	143	149	PF00069	0.627
MOD_CK2_1	232	238	PF00069	0.582
MOD_CK2_1	361	367	PF00069	0.606
MOD_CK2_1	386	392	PF00069	0.578
MOD_CK2_1	70	76	PF00069	0.537
MOD_GlcNHglycan	14	17	PF01048	0.386
MOD_GlcNHglycan	146	149	PF01048	0.614
MOD_GlcNHglycan	231	234	PF01048	0.665
MOD_GlcNHglycan	302	305	PF01048	0.702
MOD_GlcNHglycan	338	341	PF01048	0.749
MOD_GlcNHglycan	353	356	PF01048	0.672
MOD_GlcNHglycan	409	412	PF01048	0.704
MOD_GSK3_1	1	8	PF00069	0.479
MOD_GSK3_1	283	290	PF00069	0.614
MOD_GSK3_1	328	335	PF00069	0.689
MOD_GSK3_1	353	360	PF00069	0.707
MOD_GSK3_1	399	406	PF00069	0.648
MOD_N-GLC_1	109	114	PF02516	0.350
MOD_N-GLC_1	36	41	PF02516	0.372
MOD_N-GLC_1	399	404	PF02516	0.668
MOD_N-GLC_2	272	274	PF02516	0.514
MOD_N-GLC_2	31	33	PF02516	0.362
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	332	337	PF00069	0.611
MOD_NEK2_1	413	418	PF00069	0.692
MOD_NEK2_1	43	48	PF00069	0.525
MOD_NEK2_1	55	60	PF00069	0.461
MOD_NEK2_1	78	83	PF00069	0.586
MOD_PIKK_1	152	158	PF00454	0.693
MOD_PKA_1	152	158	PF00069	0.427
MOD_PKA_2	386	392	PF00069	0.553
MOD_Plk_1	109	115	PF00069	0.550
MOD_Plk_1	181	187	PF00069	0.526
MOD_Plk_1	43	49	PF00069	0.513
MOD_Plk_2-3	86	92	PF00069	0.377
MOD_Plk_4	393	399	PF00069	0.649
MOD_Plk_4	43	49	PF00069	0.540
MOD_Plk_4	55	61	PF00069	0.498
MOD_ProDKin_1	14	20	PF00069	0.482
MOD_ProDKin_1	283	289	PF00069	0.765
MOD_ProDKin_1	357	363	PF00069	0.640
MOD_ProDKin_1	399	405	PF00069	0.529
MOD_SUMO_for_1	151	154	PF00179	0.662
MOD_SUMO_rev_2	89	98	PF00179	0.377
TRG_ENDOCYTIC_2	45	48	PF00928	0.505
TRG_ER_diArg_1	177	179	PF00400	0.591
TRG_ER_diArg_1	428	431	PF00400	0.522
TRG_NES_CRM1_1	57	72	PF08389	0.497
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.362
TRG_Pf-PMV_PEXEL_1	428	433	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.386

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3F6	Leptomonas seymouri	47%	100%
A0A0S4JFM0	Bodo saltans	30%	99%
A0A1X0P8V3	Trypanosomatidae	33%	100%
A0A3R7MMF8	Trypanosoma rangeli	30%	100%
A0A3S7XAM0	Leishmania donovani	82%	98%
A4HP00	Leishmania braziliensis	65%	100%
A4ICJ6	Leishmania infantum	82%	98%
Q4Q1T6	Leishmania major	84%	100%
V5DL00	Trypanosoma cruzi	33%	100%