EOG090X093U

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

EOG090X093U

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASQ7_LEIMU

TriTrypDb:

LmxM.36.1380

Length:

622

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASQ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASQ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.614
CLV_PCSK_KEX2_1	242	244	PF00082	0.439
CLV_PCSK_KEX2_1	416	418	PF00082	0.262
CLV_PCSK_PC1ET2_1	242	244	PF00082	0.439
CLV_PCSK_PC1ET2_1	416	418	PF00082	0.262
CLV_PCSK_SKI1_1	303	307	PF00082	0.327
CLV_PCSK_SKI1_1	463	467	PF00082	0.411
CLV_PCSK_SKI1_1	483	487	PF00082	0.380
CLV_PCSK_SKI1_1	521	525	PF00082	0.459
CLV_Separin_Metazoa	246	250	PF03568	0.379
DEG_APCC_DBOX_1	609	617	PF00400	0.354
DEG_Nend_Nbox_1	1	3	PF02207	0.390
DEG_SPOP_SBC_1	72	76	PF00917	0.517
DOC_ANK_TNKS_1	284	291	PF00023	0.493
DOC_CYCLIN_RxL_1	291	300	PF00134	0.451
DOC_MAPK_gen_1	136	144	PF00069	0.393
DOC_MAPK_gen_1	249	256	PF00069	0.486
DOC_MAPK_gen_1	519	528	PF00069	0.388
DOC_MAPK_MEF2A_6	136	144	PF00069	0.393
DOC_MAPK_MEF2A_6	521	530	PF00069	0.326
DOC_MAPK_MEF2A_6	604	613	PF00069	0.399
DOC_PP2B_LxvP_1	105	108	PF13499	0.346
DOC_USP7_MATH_1	119	123	PF00917	0.485
DOC_USP7_MATH_1	37	41	PF00917	0.436
DOC_USP7_MATH_1	554	558	PF00917	0.488
DOC_USP7_MATH_1	72	76	PF00917	0.571
DOC_WW_Pin1_4	172	177	PF00397	0.406
DOC_WW_Pin1_4	216	221	PF00397	0.504
DOC_WW_Pin1_4	46	51	PF00397	0.446
LIG_14-3-3_CanoR_1	123	131	PF00244	0.402
LIG_14-3-3_CanoR_1	251	257	PF00244	0.385
LIG_14-3-3_CanoR_1	294	299	PF00244	0.412
LIG_14-3-3_CanoR_1	42	50	PF00244	0.465
LIG_14-3-3_CanoR_1	610	614	PF00244	0.361
LIG_14-3-3_CanoR_1	94	100	PF00244	0.282
LIG_BRCT_BRCA1_1	3	7	PF00533	0.358
LIG_deltaCOP1_diTrp_1	322	328	PF00928	0.333
LIG_deltaCOP1_diTrp_1	5	11	PF00928	0.353
LIG_EH1_1	559	567	PF00400	0.452
LIG_eIF4E_1	560	566	PF01652	0.417
LIG_FHA_1	123	129	PF00498	0.459
LIG_FHA_1	21	27	PF00498	0.407
LIG_FHA_1	325	331	PF00498	0.366
LIG_FHA_1	333	339	PF00498	0.371
LIG_FHA_1	352	358	PF00498	0.248
LIG_FHA_1	540	546	PF00498	0.472
LIG_FHA_1	557	563	PF00498	0.274
LIG_FHA_1	72	78	PF00498	0.538
LIG_FHA_2	128	134	PF00498	0.513
LIG_FHA_2	220	226	PF00498	0.489
LIG_FHA_2	318	324	PF00498	0.443
LIG_FHA_2	43	49	PF00498	0.445
LIG_FHA_2	433	439	PF00498	0.437
LIG_IRF3_LxIS_1	606	612	PF10401	0.441
LIG_LIR_Gen_1	158	169	PF02991	0.377
LIG_LIR_Gen_1	228	239	PF02991	0.541
LIG_LIR_Gen_1	318	329	PF02991	0.359
LIG_LIR_Gen_1	4	14	PF02991	0.361
LIG_LIR_Gen_1	487	495	PF02991	0.334
LIG_LIR_Nem_3	158	164	PF02991	0.350
LIG_LIR_Nem_3	228	234	PF02991	0.605
LIG_LIR_Nem_3	318	324	PF02991	0.365
LIG_LIR_Nem_3	4	10	PF02991	0.352
LIG_LIR_Nem_3	438	442	PF02991	0.348
LIG_LIR_Nem_3	487	492	PF02991	0.321
LIG_LIR_Nem_3	571	575	PF02991	0.554
LIG_LYPXL_S_1	468	472	PF13949	0.441
LIG_NRBOX	560	566	PF00104	0.358
LIG_NRBOX	574	580	PF00104	0.380
LIG_PALB2_WD40_1	2	10	PF16756	0.360
LIG_Pex14_1	325	329	PF04695	0.329
LIG_Pex14_2	321	325	PF04695	0.325
LIG_Pex14_2	484	488	PF04695	0.287
LIG_Pex14_2	7	11	PF04695	0.347
LIG_Rb_LxCxE_1	160	175	PF01857	0.407
LIG_SH2_CRK	161	165	PF00017	0.348
LIG_SH2_NCK_1	553	557	PF00017	0.406
LIG_SH2_STAT3	238	241	PF00017	0.627
LIG_SH2_STAT5	150	153	PF00017	0.392
LIG_SH2_STAT5	161	164	PF00017	0.338
LIG_SH2_STAT5	238	241	PF00017	0.599
LIG_SH2_STAT5	329	332	PF00017	0.364
LIG_SH2_STAT5	560	563	PF00017	0.426
LIG_SH3_2	143	148	PF14604	0.248
LIG_SH3_3	137	143	PF00018	0.283
LIG_SH3_3	195	201	PF00018	0.375
LIG_SH3_3	231	237	PF00018	0.608
LIG_SH3_3	306	312	PF00018	0.464
LIG_SH3_5	157	161	PF00018	0.352
LIG_SUMO_SIM_anti_2	193	199	PF11976	0.350
LIG_SUMO_SIM_anti_2	297	303	PF11976	0.480
LIG_SUMO_SIM_anti_2	542	547	PF11976	0.536
LIG_SUMO_SIM_par_1	193	199	PF11976	0.494
LIG_SUMO_SIM_par_1	294	300	PF11976	0.316
LIG_SxIP_EBH_1	111	123	PF03271	0.353
LIG_TRAF2_1	165	168	PF00917	0.429
LIG_TRAF2_1	188	191	PF00917	0.476
LIG_TYR_ITIM	570	575	PF00017	0.449
LIG_UBA3_1	295	303	PF00899	0.458
LIG_UBA3_1	337	345	PF00899	0.467
LIG_UBA3_1	512	521	PF00899	0.397
LIG_UBA3_1	564	573	PF00899	0.363
LIG_WRC_WIRS_1	128	133	PF05994	0.499
MOD_CK1_1	122	128	PF00069	0.425
MOD_CK1_1	219	225	PF00069	0.713
MOD_CK1_1	259	265	PF00069	0.433
MOD_CK1_1	297	303	PF00069	0.371
MOD_CK1_1	369	375	PF00069	0.475
MOD_CK1_1	75	81	PF00069	0.497
MOD_CK2_1	127	133	PF00069	0.449
MOD_CK2_1	162	168	PF00069	0.503
MOD_CK2_1	219	225	PF00069	0.664
MOD_CK2_1	401	407	PF00069	0.339
MOD_CK2_1	432	438	PF00069	0.443
MOD_CMANNOS	325	328	PF00535	0.331
MOD_GlcNHglycan	101	104	PF01048	0.462
MOD_GlcNHglycan	113	116	PF01048	0.368
MOD_GlcNHglycan	580	583	PF01048	0.410
MOD_GlcNHglycan	7	10	PF01048	0.341
MOD_GSK3_1	1	8	PF00069	0.369
MOD_GSK3_1	113	120	PF00069	0.554
MOD_GSK3_1	215	222	PF00069	0.698
MOD_GSK3_1	226	233	PF00069	0.522
MOD_GSK3_1	252	259	PF00069	0.425
MOD_GSK3_1	324	331	PF00069	0.434
MOD_GSK3_1	38	45	PF00069	0.461
MOD_GSK3_1	381	388	PF00069	0.493
MOD_GSK3_1	484	491	PF00069	0.315
MOD_GSK3_1	574	581	PF00069	0.453
MOD_GSK3_1	71	78	PF00069	0.563
MOD_N-GLC_1	172	177	PF02516	0.381
MOD_N-GLC_1	252	257	PF02516	0.419
MOD_N-GLC_1	259	264	PF02516	0.399
MOD_N-GLC_1	381	386	PF02516	0.470
MOD_N-GLC_1	401	406	PF02516	0.205
MOD_N-GLC_1	432	437	PF02516	0.391
MOD_N-GLC_1	454	459	PF02516	0.406
MOD_N-GLC_1	94	99	PF02516	0.506
MOD_NEK2_1	110	115	PF00069	0.332
MOD_NEK2_1	132	137	PF00069	0.483
MOD_NEK2_1	179	184	PF00069	0.298
MOD_NEK2_1	256	261	PF00069	0.522
MOD_NEK2_1	366	371	PF00069	0.391
MOD_NEK2_1	475	480	PF00069	0.346
MOD_NEK2_1	484	489	PF00069	0.299
MOD_NEK2_1	578	583	PF00069	0.375
MOD_NEK2_1	609	614	PF00069	0.330
MOD_NEK2_1	616	621	PF00069	0.352
MOD_NEK2_1	73	78	PF00069	0.477
MOD_PIKK_1	117	123	PF00454	0.370
MOD_PIKK_1	279	285	PF00454	0.417
MOD_PKA_2	122	128	PF00069	0.364
MOD_PKA_2	475	481	PF00069	0.461
MOD_PKA_2	609	615	PF00069	0.376
MOD_PKA_2	65	71	PF00069	0.498
MOD_PKA_2	93	99	PF00069	0.404
MOD_PKB_1	92	100	PF00069	0.450
MOD_Plk_1	252	258	PF00069	0.637
MOD_Plk_1	317	323	PF00069	0.407
MOD_Plk_1	332	338	PF00069	0.266
MOD_Plk_1	381	387	PF00069	0.470
MOD_Plk_1	401	407	PF00069	0.294
MOD_Plk_1	432	438	PF00069	0.375
MOD_Plk_2-3	317	323	PF00069	0.504
MOD_Plk_4	127	133	PF00069	0.495
MOD_Plk_4	252	258	PF00069	0.635
MOD_Plk_4	294	300	PF00069	0.376
MOD_Plk_4	324	330	PF00069	0.343
MOD_Plk_4	381	387	PF00069	0.436
MOD_Plk_4	419	425	PF00069	0.300
MOD_Plk_4	432	438	PF00069	0.342
MOD_Plk_4	475	481	PF00069	0.341
MOD_Plk_4	484	490	PF00069	0.299
MOD_Plk_4	556	562	PF00069	0.286
MOD_Plk_4	574	580	PF00069	0.367
MOD_ProDKin_1	172	178	PF00069	0.411
MOD_ProDKin_1	216	222	PF00069	0.505
MOD_ProDKin_1	46	52	PF00069	0.446
MOD_SUMO_for_1	415	418	PF00179	0.550
MOD_SUMO_rev_2	384	393	PF00179	0.335
TRG_DiLeu_BaEn_1	273	278	PF01217	0.471
TRG_ENDOCYTIC_2	161	164	PF00928	0.343
TRG_ENDOCYTIC_2	469	472	PF00928	0.445
TRG_ENDOCYTIC_2	572	575	PF00928	0.361
TRG_ER_diArg_1	248	251	PF00400	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1E7	Leptomonas seymouri	68%	100%
A0A0S4JC36	Bodo saltans	40%	100%
A0A1X0P7Z1	Trypanosomatidae	44%	100%
A0A3Q8IIW2	Leishmania donovani	94%	100%
A0A422MZU5	Trypanosoma rangeli	47%	100%
A4HNZ3	Leishmania braziliensis	80%	100%
A4HNZ7	Leishmania braziliensis	79%	100%
A4ICJ8	Leishmania infantum	93%	100%
D0A2X3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
Q4Q1T8	Leishmania major	91%	100%
V5BU60	Trypanosoma cruzi	46%	100%