PARP-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASQ4_LEIMU

TriTrypDb:

LmxM.36.1350

Length:

239

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1

Expansion

Sequence features

E9ASQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003677	DNA binding	4	10
GO:0005488	binding	1	10
GO:0008270	zinc ion binding	6	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0046914	transition metal ion binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10
GO:0003824	catalytic activity	1	2
GO:0016874	ligase activity	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.750
CLV_C14_Caspase3-7	167	171	PF00656	0.683
CLV_C14_Caspase3-7	215	219	PF00656	0.769
CLV_NRD_NRD_1	154	156	PF00675	0.763
CLV_NRD_NRD_1	236	238	PF00675	0.706
CLV_PCSK_KEX2_1	148	150	PF00082	0.707
CLV_PCSK_KEX2_1	235	237	PF00082	0.664
CLV_PCSK_PC1ET2_1	148	150	PF00082	0.707
CLV_PCSK_PC1ET2_1	235	237	PF00082	0.664
CLV_PCSK_SKI1_1	123	127	PF00082	0.689
DEG_Kelch_Keap1_1	142	147	PF01344	0.510
DOC_MAPK_gen_1	23	32	PF00069	0.561
DOC_USP7_MATH_1	131	135	PF00917	0.801
DOC_USP7_MATH_1	14	18	PF00917	0.508
DOC_USP7_MATH_1	141	145	PF00917	0.742
DOC_USP7_MATH_1	220	224	PF00917	0.781
DOC_USP7_MATH_1	64	68	PF00917	0.551
DOC_USP7_UBL2_3	126	130	PF12436	0.765
DOC_USP7_UBL2_3	23	27	PF12436	0.512
DOC_USP7_UBL2_3	231	235	PF12436	0.727
LIG_deltaCOP1_diTrp_1	46	50	PF00928	0.561
LIG_FHA_1	32	38	PF00498	0.513
LIG_FHA_1	97	103	PF00498	0.587
LIG_FHA_2	197	203	PF00498	0.531
LIG_FHA_2	206	212	PF00498	0.531
LIG_FHA_2	213	219	PF00498	0.706
LIG_LIR_Nem_3	202	207	PF02991	0.529
LIG_LIR_Nem_3	47	53	PF02991	0.486
LIG_SH2_STAP1	177	181	PF00017	0.618
LIG_SH2_STAT5	207	210	PF00017	0.561
LIG_SH3_2	150	155	PF14604	0.790
LIG_SH3_3	147	153	PF00018	0.762
LIG_SH3_3	185	191	PF00018	0.324
LIG_SH3_4	126	133	PF00018	0.717
LIG_SH3_4	231	238	PF00018	0.727
LIG_SH3_CIN85_PxpxPR_1	150	155	PF14604	0.712
LIG_TRAF2_1	199	202	PF00917	0.591
LIG_WRC_WIRS_1	37	42	PF05994	0.500
LIG_WW_3	152	156	PF00397	0.713
MOD_CK1_1	142	148	PF00069	0.568
MOD_CK1_1	17	23	PF00069	0.531
MOD_CK1_1	171	177	PF00069	0.609
MOD_CK2_1	141	147	PF00069	0.719
MOD_CK2_1	196	202	PF00069	0.531
MOD_CK2_1	36	42	PF00069	0.461
MOD_Cter_Amidation	21	24	PF01082	0.361
MOD_GlcNHglycan	10	13	PF01048	0.276
MOD_GlcNHglycan	110	113	PF01048	0.621
MOD_GlcNHglycan	131	134	PF01048	0.803
MOD_GlcNHglycan	141	144	PF01048	0.551
MOD_GlcNHglycan	66	69	PF01048	0.336
MOD_GSK3_1	59	66	PF00069	0.536
MOD_LATS_1	203	209	PF00433	0.591
MOD_N-GLC_1	17	22	PF02516	0.391
MOD_N-GLC_1	212	217	PF02516	0.785
MOD_OFUCOSY	16	21	PF10250	0.331
MOD_PKA_2	154	160	PF00069	0.713
MOD_PKA_2	64	70	PF00069	0.551
MOD_Plk_1	97	103	PF00069	0.567
MOD_Plk_4	97	103	PF00069	0.567
TRG_NLS_MonoCore_2	234	239	PF00514	0.730
TRG_NLS_MonoExtC_3	234	239	PF00514	0.480
TRG_NLS_MonoExtN_4	153	159	PF00514	0.700
TRG_NLS_MonoExtN_4	232	239	PF00514	0.732

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA52	Leptomonas seymouri	71%	100%
A0A0S4J2P2	Bodo saltans	41%	87%
A0A1X0P7R0	Trypanosomatidae	42%	96%
A0A3S5H819	Leishmania donovani	90%	84%
A4HNZ2	Leishmania braziliensis	81%	100%
A4ICK1	Leishmania infantum	90%	84%
D0A369	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
Q4Q1U1	Leishmania major	88%	100%