J domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASQ2_LEIMU

TriTrypDb:

LmxM.36.1330

Length:

467

Annotations

LeishMANIAdb annotations

Apparently a chaperone for some membrane-associated process unique to Kinetoplastids.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ASQ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASQ2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	404	408	PF00656	0.685
CLV_NRD_NRD_1	156	158	PF00675	0.573
CLV_NRD_NRD_1	266	268	PF00675	0.532
CLV_NRD_NRD_1	292	294	PF00675	0.397
CLV_NRD_NRD_1	449	451	PF00675	0.421
CLV_NRD_NRD_1	6	8	PF00675	0.383
CLV_PCSK_FUR_1	207	211	PF00082	0.361
CLV_PCSK_KEX2_1	156	158	PF00082	0.573
CLV_PCSK_KEX2_1	209	211	PF00082	0.361
CLV_PCSK_KEX2_1	262	264	PF00082	0.361
CLV_PCSK_KEX2_1	266	268	PF00082	0.571
CLV_PCSK_KEX2_1	291	293	PF00082	0.399
CLV_PCSK_KEX2_1	6	8	PF00082	0.383
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.361
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.238
CLV_PCSK_SKI1_1	130	134	PF00082	0.682
CLV_PCSK_SKI1_1	182	186	PF00082	0.485
CLV_PCSK_SKI1_1	424	428	PF00082	0.385
CLV_PCSK_SKI1_1	451	455	PF00082	0.427
DEG_APCC_DBOX_1	54	62	PF00400	0.331
DEG_MDM2_SWIB_1	35	42	PF02201	0.213
DEG_SPOP_SBC_1	143	147	PF00917	0.252
DOC_CKS1_1	2	7	PF01111	0.578
DOC_CYCLIN_RxL_1	124	137	PF00134	0.437
DOC_MAPK_gen_1	291	298	PF00069	0.598
DOC_MAPK_gen_1	378	387	PF00069	0.550
DOC_MAPK_gen_1	89	98	PF00069	0.344
DOC_MAPK_MEF2A_6	391	400	PF00069	0.605
DOC_MAPK_MEF2A_6	55	62	PF00069	0.330
DOC_MAPK_NFAT4_5	55	63	PF00069	0.325
DOC_PP1_RVXF_1	192	198	PF00149	0.568
DOC_PP1_RVXF_1	241	248	PF00149	0.447
DOC_PP2B_LxvP_1	431	434	PF13499	0.629
DOC_PP4_FxxP_1	429	432	PF00568	0.623
DOC_USP7_MATH_1	224	228	PF00917	0.580
DOC_USP7_MATH_1	354	358	PF00917	0.487
DOC_USP7_MATH_1	434	438	PF00917	0.643
DOC_WW_Pin1_4	1	6	PF00397	0.578
DOC_WW_Pin1_4	159	164	PF00397	0.699
LIG_14-3-3_CanoR_1	136	140	PF00244	0.343
LIG_14-3-3_CanoR_1	157	163	PF00244	0.660
LIG_14-3-3_CanoR_1	17	23	PF00244	0.565
LIG_14-3-3_CanoR_1	291	299	PF00244	0.576
LIG_14-3-3_CanoR_1	381	386	PF00244	0.592
LIG_14-3-3_CanoR_1	415	421	PF00244	0.604
LIG_14-3-3_CanoR_1	457	464	PF00244	0.695
LIG_14-3-3_CanoR_1	89	98	PF00244	0.402
LIG_14-3-3_CterR_2	462	467	PF00244	0.622
LIG_Actin_WH2_2	41	57	PF00022	0.402
LIG_BRCT_BRCA1_1	187	191	PF00533	0.684
LIG_BRCT_BRCA1_1	28	32	PF00533	0.213
LIG_FHA_1	145	151	PF00498	0.319
LIG_FHA_1	28	34	PF00498	0.202
LIG_FHA_1	377	383	PF00498	0.498
LIG_FHA_1	39	45	PF00498	0.370
LIG_FHA_1	428	434	PF00498	0.549
LIG_FHA_1	55	61	PF00498	0.310
LIG_FHA_1	75	81	PF00498	0.347
LIG_FHA_1	91	97	PF00498	0.358
LIG_FHA_2	200	206	PF00498	0.565
LIG_FHA_2	363	369	PF00498	0.663
LIG_FHA_2	402	408	PF00498	0.693
LIG_LIR_Apic_2	427	432	PF02991	0.623
LIG_LIR_Gen_1	244	254	PF02991	0.498
LIG_LIR_Gen_1	310	317	PF02991	0.280
LIG_LIR_Gen_1	36	47	PF02991	0.399
LIG_LIR_Gen_1	56	65	PF02991	0.294
LIG_LIR_LC3C_4	57	62	PF02991	0.338
LIG_LIR_Nem_3	103	108	PF02991	0.357
LIG_LIR_Nem_3	244	250	PF02991	0.498
LIG_LIR_Nem_3	252	257	PF02991	0.480
LIG_LIR_Nem_3	29	35	PF02991	0.213
LIG_LIR_Nem_3	310	316	PF02991	0.369
LIG_LIR_Nem_3	36	42	PF02991	0.190
LIG_LIR_Nem_3	56	62	PF02991	0.300
LIG_MAD2	213	221	PF02301	0.516
LIG_Pex14_1	39	43	PF04695	0.213
LIG_Pex14_2	280	284	PF04695	0.697
LIG_Pex14_2	343	347	PF04695	0.408
LIG_Pex14_2	35	39	PF04695	0.209
LIG_SH2_CRK	212	216	PF00017	0.536
LIG_SH2_CRK	254	258	PF00017	0.561
LIG_SH2_NCK_1	19	23	PF00017	0.560
LIG_SH2_NCK_1	254	258	PF00017	0.531
LIG_SH2_STAT5	329	332	PF00017	0.397
LIG_SH2_STAT5	43	46	PF00017	0.330
LIG_SH2_STAT5	47	50	PF00017	0.352
LIG_SH2_STAT5	9	12	PF00017	0.584
LIG_SH3_3	2	8	PF00018	0.578
LIG_SUMO_SIM_par_1	145	154	PF11976	0.375
LIG_SUMO_SIM_par_1	313	319	PF11976	0.194
LIG_SUMO_SIM_par_1	451	456	PF11976	0.632
LIG_TRAF2_1	365	368	PF00917	0.663
LIG_Vh1_VBS_1	27	45	PF01044	0.194
MOD_CDK_SPK_2	1	6	PF00069	0.467
MOD_CDK_SPxK_1	1	7	PF00069	0.468
MOD_CK1_1	138	144	PF00069	0.387
MOD_CK1_1	169	175	PF00069	0.711
MOD_CK1_1	272	278	PF00069	0.689
MOD_CK1_1	418	424	PF00069	0.455
MOD_CK1_1	74	80	PF00069	0.679
MOD_CK2_1	171	177	PF00069	0.687
MOD_CK2_1	186	192	PF00069	0.517
MOD_CK2_1	199	205	PF00069	0.318
MOD_CK2_1	362	368	PF00069	0.495
MOD_Cter_Amidation	154	157	PF01082	0.476
MOD_Cter_Amidation	264	267	PF01082	0.652
MOD_GlcNHglycan	115	118	PF01048	0.567
MOD_GlcNHglycan	140	143	PF01048	0.398
MOD_GlcNHglycan	153	156	PF01048	0.681
MOD_GlcNHglycan	169	172	PF01048	0.733
MOD_GlcNHglycan	20	23	PF01048	0.457
MOD_GlcNHglycan	226	229	PF01048	0.420
MOD_GlcNHglycan	230	233	PF01048	0.404
MOD_GlcNHglycan	238	242	PF01048	0.349
MOD_GlcNHglycan	274	277	PF01048	0.695
MOD_GlcNHglycan	459	462	PF01048	0.565
MOD_GSK3_1	100	107	PF00069	0.494
MOD_GSK3_1	113	120	PF00069	0.483
MOD_GSK3_1	134	141	PF00069	0.358
MOD_GSK3_1	167	174	PF00069	0.749
MOD_GSK3_1	220	227	PF00069	0.420
MOD_GSK3_1	316	323	PF00069	0.522
MOD_GSK3_1	33	40	PF00069	0.212
MOD_GSK3_1	414	421	PF00069	0.514
MOD_GSK3_1	42	49	PF00069	0.384
MOD_GSK3_1	68	75	PF00069	0.515
MOD_N-GLC_1	269	274	PF02516	0.742
MOD_N-GLC_1	320	325	PF02516	0.583
MOD_N-GLC_1	66	71	PF02516	0.450
MOD_NEK2_1	10	15	PF00069	0.483
MOD_NEK2_1	104	109	PF00069	0.474
MOD_NEK2_1	132	137	PF00069	0.633
MOD_NEK2_1	151	156	PF00069	0.426
MOD_NEK2_1	18	23	PF00069	0.450
MOD_NEK2_1	27	32	PF00069	0.172
MOD_NEK2_1	33	38	PF00069	0.169
MOD_NEK2_1	54	59	PF00069	0.564
MOD_NEK2_1	98	103	PF00069	0.477
MOD_NEK2_2	117	122	PF00069	0.450
MOD_NEK2_2	354	359	PF00069	0.537
MOD_NEK2_2	79	84	PF00069	0.485
MOD_PIKK_1	169	175	PF00454	0.691
MOD_PIKK_1	291	297	PF00454	0.581
MOD_PK_1	381	387	PF00069	0.363
MOD_PKA_1	291	297	PF00069	0.581
MOD_PKA_2	135	141	PF00069	0.427
MOD_PKA_2	228	234	PF00069	0.194
MOD_PKA_2	272	278	PF00069	0.573
MOD_PKA_2	291	297	PF00069	0.507
MOD_PKA_2	414	420	PF00069	0.667
MOD_PKA_2	54	60	PF00069	0.406
MOD_Plk_1	320	326	PF00069	0.582
MOD_Plk_1	435	441	PF00069	0.596
MOD_Plk_1	455	461	PF00069	0.438
MOD_Plk_1	66	72	PF00069	0.453
MOD_Plk_2-3	201	207	PF00069	0.485
MOD_Plk_2-3	362	368	PF00069	0.590
MOD_Plk_4	100	106	PF00069	0.522
MOD_Plk_4	135	141	PF00069	0.427
MOD_Plk_4	28	34	PF00069	0.213
MOD_Plk_4	38	44	PF00069	0.181
MOD_Plk_4	54	60	PF00069	0.378
MOD_Plk_4	92	98	PF00069	0.551
MOD_ProDKin_1	1	7	PF00069	0.468
MOD_ProDKin_1	159	165	PF00069	0.640
TRG_DiLeu_BaLyEn_6	294	299	PF01217	0.584
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.450
TRG_ENDOCYTIC_2	212	215	PF00928	0.444
TRG_ENDOCYTIC_2	254	257	PF00928	0.344
TRG_ER_diArg_1	121	124	PF00400	0.735
TRG_ER_diArg_1	156	158	PF00400	0.777
TRG_ER_diArg_1	291	293	PF00400	0.564
TRG_ER_diArg_1	5	7	PF00400	0.471
TRG_Pf-PMV_PEXEL_1	297	301	PF00026	0.344
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.419

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P358	Leptomonas seymouri	57%	100%
A0A1X0P876	Trypanosomatidae	43%	100%
A0A3S7XAJ1	Leishmania donovani	88%	100%
A4HNZ0	Leishmania braziliensis	74%	100%
A4ICK3	Leishmania infantum	91%	100%
D0A2V8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
Q4Q1U3	Leishmania major	91%	100%
V5BUV1	Trypanosoma cruzi	40%	100%