Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASQ1_LEIMU

TriTrypDb:

LmxM.36.1320

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASQ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASQ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	384	388	PF00656	0.600
CLV_MEL_PAP_1	133	139	PF00089	0.626
CLV_NRD_NRD_1	145	147	PF00675	0.483
CLV_NRD_NRD_1	151	153	PF00675	0.483
CLV_NRD_NRD_1	17	19	PF00675	0.761
CLV_NRD_NRD_1	206	208	PF00675	0.758
CLV_NRD_NRD_1	233	235	PF00675	0.635
CLV_NRD_NRD_1	343	345	PF00675	0.686
CLV_NRD_NRD_1	356	358	PF00675	0.581
CLV_PCSK_KEX2_1	145	147	PF00082	0.487
CLV_PCSK_KEX2_1	17	19	PF00082	0.761
CLV_PCSK_KEX2_1	206	208	PF00082	0.648
CLV_PCSK_KEX2_1	233	235	PF00082	0.649
CLV_PCSK_KEX2_1	343	345	PF00082	0.686
CLV_PCSK_KEX2_1	356	358	PF00082	0.581
CLV_PCSK_KEX2_1	40	42	PF00082	0.630
CLV_PCSK_KEX2_1	80	82	PF00082	0.739
CLV_PCSK_PC1ET2_1	343	345	PF00082	0.686
CLV_PCSK_PC1ET2_1	40	42	PF00082	0.559
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.525
DOC_MAPK_gen_1	17	27	PF00069	0.641
DOC_MAPK_RevD_3	133	146	PF00069	0.529
DOC_PP2B_LxvP_1	86	89	PF13499	0.622
DOC_USP7_MATH_1	390	394	PF00917	0.752
DOC_USP7_MATH_1	398	402	PF00917	0.713
DOC_USP7_MATH_1	8	12	PF00917	0.694
DOC_USP7_UBL2_3	36	40	PF12436	0.715
DOC_WW_Pin1_4	100	105	PF00397	0.697
DOC_WW_Pin1_4	248	253	PF00397	0.549
DOC_WW_Pin1_4	294	299	PF00397	0.727
DOC_WW_Pin1_4	357	362	PF00397	0.788
DOC_WW_Pin1_4	56	61	PF00397	0.745
DOC_WW_Pin1_4	93	98	PF00397	0.676
LIG_14-3-3_CanoR_1	10	16	PF00244	0.698
LIG_14-3-3_CanoR_1	136	142	PF00244	0.599
LIG_14-3-3_CanoR_1	17	27	PF00244	0.728
LIG_14-3-3_CanoR_1	218	224	PF00244	0.563
LIG_14-3-3_CanoR_1	259	268	PF00244	0.643
LIG_14-3-3_CanoR_1	301	305	PF00244	0.726
LIG_14-3-3_CanoR_1	334	339	PF00244	0.653
LIG_14-3-3_CanoR_1	344	350	PF00244	0.739
LIG_14-3-3_CanoR_1	41	47	PF00244	0.527
LIG_14-3-3_CanoR_1	81	86	PF00244	0.632
LIG_14-3-3_CanoR_1	93	97	PF00244	0.630
LIG_14-3-3_CanoR_1	99	104	PF00244	0.560
LIG_Actin_WH2_2	254	271	PF00022	0.526
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_2	285	289	PF00653	0.720
LIG_BRCT_BRCA1_1	240	244	PF00533	0.589
LIG_FHA_1	224	230	PF00498	0.429
LIG_FHA_1	249	255	PF00498	0.565
LIG_FHA_1	261	267	PF00498	0.534
LIG_FHA_1	66	72	PF00498	0.711
LIG_FHA_1	80	86	PF00498	0.577
LIG_FHA_2	172	178	PF00498	0.435
LIG_FHA_2	235	241	PF00498	0.594
LIG_FHA_2	366	372	PF00498	0.829
LIG_FHA_2	382	388	PF00498	0.511
LIG_FHA_2	46	52	PF00498	0.647
LIG_LIR_Gen_1	245	255	PF02991	0.671
LIG_LIR_Gen_1	374	382	PF02991	0.517
LIG_LIR_Gen_1	5	13	PF02991	0.619
LIG_LIR_Nem_3	2	6	PF02991	0.739
LIG_LIR_Nem_3	231	235	PF02991	0.544
LIG_LIR_Nem_3	241	247	PF02991	0.601
LIG_LIR_Nem_3	374	378	PF02991	0.524
LIG_LIR_Nem_3	59	65	PF02991	0.652
LIG_PDZ_Class_2	418	423	PF00595	0.567
LIG_Pex14_2	312	316	PF04695	0.503
LIG_SH2_CRK	6	10	PF00017	0.507
LIG_SH2_NCK_1	407	411	PF00017	0.509
LIG_SH2_NCK_1	47	51	PF00017	0.718
LIG_SH2_SRC	407	410	PF00017	0.515
LIG_SH2_STAP1	407	411	PF00017	0.492
LIG_SH2_STAT5	47	50	PF00017	0.648
LIG_SH3_3	287	293	PF00018	0.772
LIG_SH3_3	57	63	PF00018	0.778
LIG_SH3_3	68	74	PF00018	0.698
LIG_SH3_5	19	23	PF00018	0.648
LIG_SUMO_SIM_anti_2	336	342	PF11976	0.490
LIG_SUMO_SIM_par_1	225	231	PF11976	0.356
MOD_CDK_SPK_2	100	105	PF00069	0.553
MOD_CDK_SPK_2	56	61	PF00069	0.685
MOD_CDK_SPxK_1	93	99	PF00069	0.569
MOD_CDK_SPxxK_3	294	301	PF00069	0.682
MOD_CK1_1	2	8	PF00069	0.728
MOD_CK1_1	260	266	PF00069	0.534
MOD_CK1_1	393	399	PF00069	0.644
MOD_CK1_1	401	407	PF00069	0.617
MOD_CK1_1	412	418	PF00069	0.537
MOD_CK1_1	43	49	PF00069	0.728
MOD_CK1_1	84	90	PF00069	0.594
MOD_CK2_1	234	240	PF00069	0.650
MOD_CK2_1	357	363	PF00069	0.793
MOD_CK2_1	365	371	PF00069	0.735
MOD_CK2_1	402	408	PF00069	0.716
MOD_CK2_1	45	51	PF00069	0.746
MOD_GlcNHglycan	11	14	PF01048	0.681
MOD_GlcNHglycan	123	126	PF01048	0.644
MOD_GlcNHglycan	200	203	PF01048	0.480
MOD_GlcNHglycan	219	222	PF01048	0.565
MOD_GlcNHglycan	244	247	PF01048	0.672
MOD_GlcNHglycan	302	305	PF01048	0.789
MOD_GlcNHglycan	318	321	PF01048	0.561
MOD_GlcNHglycan	42	45	PF01048	0.704
MOD_GlcNHglycan	86	89	PF01048	0.618
MOD_GSK3_1	108	115	PF00069	0.647
MOD_GSK3_1	121	128	PF00069	0.573
MOD_GSK3_1	198	205	PF00069	0.560
MOD_GSK3_1	234	241	PF00069	0.571
MOD_GSK3_1	300	307	PF00069	0.719
MOD_GSK3_1	316	323	PF00069	0.525
MOD_GSK3_1	35	42	PF00069	0.684
MOD_GSK3_1	357	364	PF00069	0.667
MOD_GSK3_1	398	405	PF00069	0.686
MOD_GSK3_1	80	87	PF00069	0.560
MOD_N-GLC_1	280	285	PF02516	0.599
MOD_N-GLC_1	316	321	PF02516	0.775
MOD_N-GLC_1	357	362	PF02516	0.741
MOD_N-GLC_1	398	403	PF02516	0.572
MOD_NEK2_1	300	305	PF00069	0.744
MOD_NEK2_1	316	321	PF00069	0.526
MOD_NEK2_1	9	14	PF00069	0.669
MOD_PIKK_1	181	187	PF00454	0.422
MOD_PIKK_1	260	266	PF00454	0.534
MOD_PIKK_1	30	36	PF00454	0.461
MOD_PK_1	334	340	PF00069	0.550
MOD_PKA_1	206	212	PF00069	0.474
MOD_PKA_1	233	239	PF00069	0.580
MOD_PKA_1	344	350	PF00069	0.685
MOD_PKA_1	40	46	PF00069	0.700
MOD_PKA_1	80	86	PF00069	0.525
MOD_PKA_2	135	141	PF00069	0.599
MOD_PKA_2	205	211	PF00069	0.668
MOD_PKA_2	217	223	PF00069	0.551
MOD_PKA_2	233	239	PF00069	0.455
MOD_PKA_2	300	306	PF00069	0.735
MOD_PKA_2	333	339	PF00069	0.500
MOD_PKA_2	40	46	PF00069	0.705
MOD_PKA_2	80	86	PF00069	0.631
MOD_PKA_2	9	15	PF00069	0.652
MOD_PKA_2	92	98	PF00069	0.655
MOD_Plk_1	181	187	PF00069	0.548
MOD_Plk_1	398	404	PF00069	0.458
MOD_Plk_4	157	163	PF00069	0.411
MOD_Plk_4	223	229	PF00069	0.408
MOD_Plk_4	234	240	PF00069	0.448
MOD_Plk_4	308	314	PF00069	0.794
MOD_Plk_4	345	351	PF00069	0.702
MOD_Plk_4	402	408	PF00069	0.630
MOD_Plk_4	409	415	PF00069	0.544
MOD_Plk_4	81	87	PF00069	0.603
MOD_ProDKin_1	100	106	PF00069	0.722
MOD_ProDKin_1	248	254	PF00069	0.568
MOD_ProDKin_1	294	300	PF00069	0.730
MOD_ProDKin_1	357	363	PF00069	0.793
MOD_ProDKin_1	56	62	PF00069	0.745
MOD_ProDKin_1	93	99	PF00069	0.678
TRG_DiLeu_BaEn_1	182	187	PF01217	0.503
TRG_ENDOCYTIC_2	6	9	PF00928	0.787
TRG_ER_diArg_1	16	18	PF00400	0.780
TRG_ER_diArg_1	232	234	PF00400	0.653
TRG_ER_diArg_1	417	420	PF00400	0.552
TRG_NLS_MonoExtN_4	343	348	PF00514	0.690
TRG_Pf-PMV_PEXEL_1	259	264	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ64	Leptomonas seymouri	35%	100%
A0A3S7XAJ3	Leishmania donovani	77%	100%
A4HNY9	Leishmania braziliensis	59%	100%
A4ICK4	Leishmania infantum	77%	100%
Q4Q1U4	Leishmania major	78%	100%