BILBO1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASQ0_LEIMU

TriTrypDb:

LmxM.36.1310

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASQ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASQ0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	228	232	PF00656	0.555
CLV_MEL_PAP_1	145	151	PF00089	0.578
CLV_NRD_NRD_1	176	178	PF00675	0.507
CLV_NRD_NRD_1	190	192	PF00675	0.480
CLV_NRD_NRD_1	210	212	PF00675	0.427
CLV_PCSK_FUR_1	208	212	PF00082	0.590
CLV_PCSK_KEX2_1	176	178	PF00082	0.503
CLV_PCSK_KEX2_1	190	192	PF00082	0.493
CLV_PCSK_KEX2_1	208	210	PF00082	0.438
CLV_PCSK_SKI1_1	217	221	PF00082	0.542
CLV_PCSK_SKI1_1	230	234	PF00082	0.477
CLV_PCSK_SKI1_1	241	245	PF00082	0.467
CLV_PCSK_SKI1_1	78	82	PF00082	0.243
DEG_Nend_Nbox_1	1	3	PF02207	0.400
DOC_CYCLIN_yClb5_NLxxxL_5	13	21	PF00134	0.449
DOC_MAPK_gen_1	13	21	PF00069	0.307
DOC_MAPK_MEF2A_6	13	21	PF00069	0.346
DOC_PP2B_LxvP_1	106	109	PF13499	0.335
DOC_USP7_MATH_1	112	116	PF00917	0.581
DOC_USP7_MATH_1	126	130	PF00917	0.603
DOC_USP7_MATH_1	157	161	PF00917	0.657
DOC_WW_Pin1_4	135	140	PF00397	0.621
DOC_WW_Pin1_4	163	168	PF00397	0.555
DOC_WW_Pin1_4	251	256	PF00397	0.691
LIG_14-3-3_CanoR_1	114	124	PF00244	0.680
LIG_14-3-3_CanoR_1	135	139	PF00244	0.607
LIG_14-3-3_CanoR_1	148	155	PF00244	0.682
LIG_14-3-3_CanoR_1	208	214	PF00244	0.599
LIG_14-3-3_CanoR_1	73	78	PF00244	0.423
LIG_Actin_WH2_2	57	75	PF00022	0.349
LIG_APCC_ABBA_1	64	69	PF00400	0.363
LIG_FHA_1	119	125	PF00498	0.739
LIG_FHA_1	213	219	PF00498	0.573
LIG_LIR_Gen_1	56	67	PF02991	0.449
LIG_LIR_Gen_1	85	94	PF02991	0.337
LIG_LIR_Nem_3	214	219	PF02991	0.520
LIG_LIR_Nem_3	237	243	PF02991	0.484
LIG_LIR_Nem_3	85	89	PF02991	0.337
LIG_Rb_LxCxE_1	214	231	PF01857	0.514
LIG_Rb_LxCxE_1	23	45	PF01857	0.300
LIG_SH2_CRK	216	220	PF00017	0.517
LIG_SH2_CRK	86	90	PF00017	0.344
LIG_SH2_SRC	67	70	PF00017	0.344
LIG_SH2_STAP1	67	71	PF00017	0.344
LIG_SH2_STAP1	86	90	PF00017	0.145
LIG_SH2_STAT3	90	93	PF00017	0.328
LIG_SH2_STAT5	90	93	PF00017	0.344
LIG_SH3_2	109	114	PF14604	0.621
LIG_SH3_3	105	111	PF00018	0.145
LIG_SH3_3	88	94	PF00018	0.349
LIG_TRAF2_1	236	239	PF00917	0.478
LIG_WW_3	107	111	PF00397	0.545
MOD_CDC14_SPxK_1	166	169	PF00782	0.571
MOD_CDK_SPxK_1	163	169	PF00069	0.595
MOD_CDK_SPxxK_3	135	142	PF00069	0.654
MOD_CK1_1	115	121	PF00069	0.753
MOD_CK1_1	143	149	PF00069	0.700
MOD_CK1_1	158	164	PF00069	0.565
MOD_CK1_1	212	218	PF00069	0.523
MOD_CK2_1	51	57	PF00069	0.262
MOD_Cter_Amidation	11	14	PF01082	0.278
MOD_DYRK1A_RPxSP_1	135	139	PF00069	0.553
MOD_GlcNHglycan	142	145	PF01048	0.700
MOD_GlcNHglycan	149	152	PF01048	0.669
MOD_GlcNHglycan	44	48	PF01048	0.409
MOD_GSK3_1	112	119	PF00069	0.626
MOD_GSK3_1	140	147	PF00069	0.655
MOD_GSK3_1	157	164	PF00069	0.638
MOD_GSK3_1	20	27	PF00069	0.430
MOD_GSK3_1	49	56	PF00069	0.365
MOD_GSK3_1	72	79	PF00069	0.423
MOD_NEK2_1	120	125	PF00069	0.728
MOD_NEK2_1	72	77	PF00069	0.451
MOD_NEK2_2	126	131	PF00069	0.567
MOD_PIKK_1	225	231	PF00454	0.592
MOD_PIKK_1	78	84	PF00454	0.250
MOD_PIKK_1	93	99	PF00454	0.470
MOD_PKA_1	209	215	PF00069	0.530
MOD_PKA_2	115	121	PF00069	0.769
MOD_PKA_2	134	140	PF00069	0.419
MOD_PKA_2	147	153	PF00069	0.680
MOD_PKA_2	209	215	PF00069	0.601
MOD_PKA_2	72	78	PF00069	0.461
MOD_PKB_1	114	122	PF00069	0.761
MOD_Plk_4	60	66	PF00069	0.417
MOD_ProDKin_1	135	141	PF00069	0.620
MOD_ProDKin_1	163	169	PF00069	0.550
MOD_ProDKin_1	251	257	PF00069	0.724
TRG_DiLeu_BaEn_1	246	251	PF01217	0.609
TRG_DiLeu_BaEn_3	238	244	PF01217	0.521
TRG_ENDOCYTIC_2	216	219	PF00928	0.521
TRG_ENDOCYTIC_2	67	70	PF00928	0.393
TRG_ENDOCYTIC_2	86	89	PF00928	0.145
TRG_ER_diArg_1	189	191	PF00400	0.587
TRG_ER_diArg_1	208	211	PF00400	0.400
TRG_Pf-PMV_PEXEL_1	29	34	PF00026	0.442

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2R9	Leptomonas seymouri	49%	93%
A0A0S4J2G2	Bodo saltans	42%	100%
A0A0S4JNL3	Bodo saltans	24%	100%
A0A1X0P9F2	Trypanosomatidae	44%	100%
A0A3Q8IH20	Leishmania donovani	89%	100%
A0A422N0I0	Trypanosoma rangeli	42%	100%
A4HNY8	Leishmania braziliensis	75%	100%
A4ICK5	Leishmania infantum	89%	100%
Q4Q1U5	Leishmania major	86%	100%
V5BQB2	Trypanosoma cruzi	43%	100%