Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASP9_LEIMU

TriTrypDb:

LmxM.36.1300

Length:

614

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0032797	SMN complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0120114	Sm-like protein family complex	2	1

Expansion

Sequence features

E9ASP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASP9

Function

Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	9
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	9
GO:0022607	cellular component assembly	4	9
GO:0022618	ribonucleoprotein complex assembly	6	9
GO:0043933	protein-containing complex organization	4	9
GO:0065003	protein-containing complex assembly	5	9
GO:0071826	ribonucleoprotein complex subunit organization	5	9
GO:0071840	cellular component organization or biogenesis	2	9

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	110	114	PF00656	0.698
CLV_C14_Caspase3-7	296	300	PF00656	0.719
CLV_C14_Caspase3-7	336	340	PF00656	0.526
CLV_C14_Caspase3-7	424	428	PF00656	0.718
CLV_C14_Caspase3-7	439	443	PF00656	0.675
CLV_NRD_NRD_1	239	241	PF00675	0.684
CLV_NRD_NRD_1	307	309	PF00675	0.647
CLV_NRD_NRD_1	360	362	PF00675	0.526
CLV_NRD_NRD_1	6	8	PF00675	0.444
CLV_PCSK_FUR_1	358	362	PF00082	0.548
CLV_PCSK_KEX2_1	150	152	PF00082	0.676
CLV_PCSK_KEX2_1	154	156	PF00082	0.675
CLV_PCSK_KEX2_1	307	309	PF00082	0.655
CLV_PCSK_KEX2_1	358	360	PF00082	0.510
CLV_PCSK_KEX2_1	6	8	PF00082	0.444
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.663
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.660
CLV_PCSK_PC7_1	354	360	PF00082	0.567
CLV_PCSK_SKI1_1	151	155	PF00082	0.739
CLV_PCSK_SKI1_1	196	200	PF00082	0.544
CLV_PCSK_SKI1_1	487	491	PF00082	0.459
CLV_PCSK_SKI1_1	560	564	PF00082	0.565
CLV_PCSK_SKI1_1	6	10	PF00082	0.442
CLV_Separin_Metazoa	320	324	PF03568	0.403
DEG_APCC_DBOX_1	486	494	PF00400	0.498
DEG_Nend_Nbox_1	1	3	PF02207	0.489
DEG_SCF_FBW7_1	177	184	PF00400	0.611
DEG_SIAH_1	211	219	PF03145	0.768
DEG_SPOP_SBC_1	181	185	PF00917	0.731
DEG_SPOP_SBC_1	398	402	PF00917	0.505
DOC_CYCLIN_yCln2_LP_2	43	49	PF00134	0.428
DOC_CYCLIN_yCln2_LP_2	472	478	PF00134	0.449
DOC_CYCLIN_yCln2_LP_2	523	529	PF00134	0.534
DOC_MAPK_gen_1	259	269	PF00069	0.498
DOC_PP1_RVXF_1	194	201	PF00149	0.707
DOC_PP2B_LxvP_1	43	46	PF13499	0.501
DOC_PP2B_LxvP_1	472	475	PF13499	0.476
DOC_PP2B_LxvP_1	523	526	PF13499	0.529
DOC_PP4_FxxP_1	495	498	PF00568	0.517
DOC_PP4_FxxP_1	56	59	PF00568	0.514
DOC_USP7_MATH_1	109	113	PF00917	0.685
DOC_USP7_MATH_1	153	157	PF00917	0.774
DOC_USP7_MATH_1	170	174	PF00917	0.700
DOC_USP7_MATH_1	181	185	PF00917	0.580
DOC_USP7_MATH_1	399	403	PF00917	0.450
DOC_USP7_MATH_1	407	411	PF00917	0.399
DOC_USP7_MATH_1	434	438	PF00917	0.551
DOC_USP7_MATH_1	443	447	PF00917	0.575
DOC_USP7_MATH_1	569	573	PF00917	0.470
DOC_USP7_UBL2_3	150	154	PF12436	0.772
DOC_USP7_UBL2_3	79	83	PF12436	0.621
DOC_WW_Pin1_4	166	171	PF00397	0.648
DOC_WW_Pin1_4	177	182	PF00397	0.641
DOC_WW_Pin1_4	191	196	PF00397	0.755
DOC_WW_Pin1_4	208	213	PF00397	0.677
DOC_WW_Pin1_4	480	485	PF00397	0.602
LIG_14-3-3_CanoR_1	196	201	PF00244	0.481
LIG_14-3-3_CanoR_1	285	292	PF00244	0.670
LIG_14-3-3_CanoR_1	389	396	PF00244	0.563
LIG_14-3-3_CanoR_1	414	423	PF00244	0.525
LIG_14-3-3_CanoR_1	487	493	PF00244	0.528
LIG_14-3-3_CanoR_1	506	511	PF00244	0.579
LIG_14-3-3_CanoR_1	544	550	PF00244	0.451
LIG_14-3-3_CanoR_1	570	578	PF00244	0.515
LIG_14-3-3_CanoR_1	6	15	PF00244	0.445
LIG_Actin_WH2_2	256	273	PF00022	0.518
LIG_Actin_WH2_2	64	81	PF00022	0.529
LIG_BIR_III_2	573	577	PF00653	0.545
LIG_BRCT_BRCA1_1	248	252	PF00533	0.588
LIG_BRCT_BRCA1_1	401	405	PF00533	0.482
LIG_BRCT_BRCA1_1	85	89	PF00533	0.647
LIG_EVH1_1	56	60	PF00568	0.507
LIG_FHA_1	114	120	PF00498	0.758
LIG_FHA_1	125	131	PF00498	0.628
LIG_FHA_1	211	217	PF00498	0.698
LIG_FHA_1	22	28	PF00498	0.476
LIG_FHA_1	3	9	PF00498	0.440
LIG_FHA_1	329	335	PF00498	0.510
LIG_FHA_1	471	477	PF00498	0.603
LIG_FHA_1	505	511	PF00498	0.563
LIG_FHA_1	529	535	PF00498	0.514
LIG_FHA_1	557	563	PF00498	0.548
LIG_FHA_1	593	599	PF00498	0.347
LIG_FHA_2	197	203	PF00498	0.736
LIG_LIR_Apic_2	55	59	PF02991	0.508
LIG_LIR_Gen_1	265	274	PF02991	0.498
LIG_LIR_Gen_1	491	498	PF02991	0.438
LIG_LIR_LC3C_4	127	132	PF02991	0.760
LIG_LIR_Nem_3	265	269	PF02991	0.514
LIG_LIR_Nem_3	309	313	PF02991	0.477
LIG_LIR_Nem_3	491	495	PF02991	0.428
LIG_LIR_Nem_3	609	614	PF02991	0.642
LIG_PCNA_PIPBox_1	486	495	PF02747	0.531
LIG_PCNA_yPIPBox_3	486	494	PF02747	0.531
LIG_Pex14_2	342	346	PF04695	0.513
LIG_PTAP_UEV_1	211	216	PF05743	0.775
LIG_REV1ctd_RIR_1	601	609	PF16727	0.519
LIG_SH2_CRK	353	357	PF00017	0.551
LIG_SH2_CRK	594	598	PF00017	0.433
LIG_SH2_GRB2like	376	379	PF00017	0.582
LIG_SH2_PTP2	266	269	PF00017	0.560
LIG_SH2_STAP1	107	111	PF00017	0.663
LIG_SH2_STAP1	594	598	PF00017	0.424
LIG_SH2_STAT5	120	123	PF00017	0.482
LIG_SH2_STAT5	266	269	PF00017	0.490
LIG_SH2_STAT5	376	379	PF00017	0.458
LIG_SH2_STAT5	594	597	PF00017	0.392
LIG_SH2_STAT5	77	80	PF00017	0.567
LIG_SH3_1	54	60	PF00018	0.505
LIG_SH3_3	206	212	PF00018	0.713
LIG_SH3_3	322	328	PF00018	0.573
LIG_SH3_3	359	365	PF00018	0.545
LIG_SH3_3	473	479	PF00018	0.625
LIG_SH3_3	523	529	PF00018	0.452
LIG_SH3_3	54	60	PF00018	0.505
LIG_SUMO_SIM_anti_2	125	134	PF11976	0.749
LIG_SUMO_SIM_anti_2	265	271	PF11976	0.552
LIG_SUMO_SIM_anti_2	595	601	PF11976	0.351
LIG_SUMO_SIM_par_1	187	192	PF11976	0.598
LIG_SUMO_SIM_par_1	588	595	PF11976	0.378
LIG_TRAF2_1	236	239	PF00917	0.631
LIG_TRAF2_1	458	461	PF00917	0.752
LIG_TRAF2_1	95	98	PF00917	0.705
LIG_WRC_WIRS_1	327	332	PF05994	0.402
LIG_WRC_WIRS_1	489	494	PF05994	0.423
LIG_WW_1	576	579	PF00397	0.529
LIG_WW_3	58	62	PF00397	0.506
MOD_CDC14_SPxK_1	169	172	PF00782	0.486
MOD_CDK_SPK_2	191	196	PF00069	0.489
MOD_CDK_SPxK_1	166	172	PF00069	0.495
MOD_CDK_SPxxK_3	480	487	PF00069	0.456
MOD_CK1_1	123	129	PF00069	0.708
MOD_CK1_1	344	350	PF00069	0.460
MOD_CK1_1	397	403	PF00069	0.426
MOD_CK1_1	426	432	PF00069	0.666
MOD_CK1_1	500	506	PF00069	0.621
MOD_CK1_1	556	562	PF00069	0.573
MOD_CK2_1	233	239	PF00069	0.584
MOD_CK2_1	415	421	PF00069	0.414
MOD_CK2_1	434	440	PF00069	0.745
MOD_CK2_1	499	505	PF00069	0.676
MOD_Cter_Amidation	80	83	PF01082	0.670
MOD_GlcNHglycan	10	13	PF01048	0.455
MOD_GlcNHglycan	109	112	PF01048	0.699
MOD_GlcNHglycan	116	119	PF01048	0.793
MOD_GlcNHglycan	127	130	PF01048	0.701
MOD_GlcNHglycan	157	160	PF01048	0.772
MOD_GlcNHglycan	19	22	PF01048	0.471
MOD_GlcNHglycan	29	32	PF01048	0.412
MOD_GlcNHglycan	346	349	PF01048	0.490
MOD_GlcNHglycan	396	399	PF01048	0.444
MOD_GlcNHglycan	401	404	PF01048	0.355
MOD_GlcNHglycan	436	439	PF01048	0.652
MOD_GlcNHglycan	520	523	PF01048	0.424
MOD_GlcNHglycan	555	558	PF01048	0.601
MOD_GSK3_1	109	116	PF00069	0.721
MOD_GSK3_1	119	126	PF00069	0.692
MOD_GSK3_1	153	160	PF00069	0.727
MOD_GSK3_1	166	173	PF00069	0.632
MOD_GSK3_1	17	24	PF00069	0.485
MOD_GSK3_1	177	184	PF00069	0.758
MOD_GSK3_1	187	194	PF00069	0.728
MOD_GSK3_1	204	211	PF00069	0.742
MOD_GSK3_1	299	306	PF00069	0.492
MOD_GSK3_1	340	347	PF00069	0.483
MOD_GSK3_1	394	401	PF00069	0.427
MOD_GSK3_1	403	410	PF00069	0.378
MOD_GSK3_1	432	439	PF00069	0.720
MOD_GSK3_1	452	459	PF00069	0.514
MOD_GSK3_1	496	503	PF00069	0.589
MOD_N-GLC_1	123	128	PF02516	0.687
MOD_N-GLC_1	204	209	PF02516	0.718
MOD_N-GLC_1	299	304	PF02516	0.725
MOD_N-GLC_1	52	57	PF02516	0.496
MOD_NEK2_1	204	209	PF00069	0.718
MOD_NEK2_1	281	286	PF00069	0.566
MOD_NEK2_1	321	326	PF00069	0.548
MOD_NEK2_1	394	399	PF00069	0.499
MOD_NEK2_1	405	410	PF00069	0.422
MOD_NEK2_1	41	46	PF00069	0.418
MOD_NEK2_1	538	543	PF00069	0.469
MOD_NEK2_1	562	567	PF00069	0.528
MOD_PIKK_1	284	290	PF00454	0.564
MOD_PIKK_1	328	334	PF00454	0.469
MOD_PK_1	506	512	PF00069	0.533
MOD_PKA_2	284	290	PF00069	0.572
MOD_PKA_2	388	394	PF00069	0.572
MOD_PKA_2	432	438	PF00069	0.761
MOD_PKA_2	505	511	PF00069	0.595
MOD_PKA_2	569	575	PF00069	0.408
MOD_PKB_1	155	163	PF00069	0.763
MOD_PKB_1	504	512	PF00069	0.560
MOD_Plk_1	253	259	PF00069	0.454
MOD_Plk_1	426	432	PF00069	0.674
MOD_Plk_1	52	58	PF00069	0.500
MOD_Plk_1	97	103	PF00069	0.759
MOD_Plk_2-3	293	299	PF00069	0.468
MOD_Plk_2-3	421	427	PF00069	0.653
MOD_Plk_2-3	456	462	PF00069	0.614
MOD_Plk_4	246	252	PF00069	0.546
MOD_Plk_4	488	494	PF00069	0.405
MOD_Plk_4	592	598	PF00069	0.349
MOD_ProDKin_1	166	172	PF00069	0.648
MOD_ProDKin_1	177	183	PF00069	0.643
MOD_ProDKin_1	191	197	PF00069	0.754
MOD_ProDKin_1	208	214	PF00069	0.674
MOD_ProDKin_1	480	486	PF00069	0.595
MOD_SUMO_rev_2	236	242	PF00179	0.595
TRG_DiLeu_BaLyEn_6	351	356	PF01217	0.480
TRG_DiLeu_BaLyEn_6	408	413	PF01217	0.505
TRG_ENDOCYTIC_2	266	269	PF00928	0.530
TRG_ENDOCYTIC_2	310	313	PF00928	0.554
TRG_ENDOCYTIC_2	353	356	PF00928	0.551
TRG_ENDOCYTIC_2	579	582	PF00928	0.390
TRG_ENDOCYTIC_2	594	597	PF00928	0.347
TRG_ENDOCYTIC_2	77	80	PF00928	0.656
TRG_ER_diArg_1	358	361	PF00400	0.550
TRG_ER_diArg_1	448	451	PF00400	0.771
TRG_ER_diArg_1	6	8	PF00400	0.463
TRG_NLS_MonoCore_2	147	152	PF00514	0.699
TRG_NLS_MonoExtN_4	146	153	PF00514	0.654

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC77	Leptomonas seymouri	47%	100%
A0A0S4IYS2	Bodo saltans	28%	100%
A0A1X0P8B5	Trypanosomatidae	31%	100%
A0A3Q8IJZ4	Leishmania donovani	90%	100%
A0A3R7RAQ0	Trypanosoma rangeli	33%	100%
A4HNY7	Leishmania braziliensis	77%	100%
A4ICK6	Leishmania infantum	84%	100%
D0A2V6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
Q4Q1U6	Leishmania major	87%	100%