PPM-type phosphatase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASP3_LEIMU

TriTrypDb:

LmxM.36.1230

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASP3

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004721	phosphoprotein phosphatase activity	3	12
GO:0004722	protein serine/threonine phosphatase activity	4	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016791	phosphatase activity	5	12
GO:0042578	phosphoric ester hydrolase activity	4	12
GO:0140096	catalytic activity, acting on a protein	2	12
GO:0017018	myosin phosphatase activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	296	300	PF00656	0.609
CLV_C14_Caspase3-7	336	340	PF00656	0.361
CLV_NRD_NRD_1	123	125	PF00675	0.537
CLV_NRD_NRD_1	143	145	PF00675	0.297
CLV_NRD_NRD_1	230	232	PF00675	0.477
CLV_NRD_NRD_1	321	323	PF00675	0.361
CLV_NRD_NRD_1	360	362	PF00675	0.435
CLV_NRD_NRD_1	489	491	PF00675	0.496
CLV_NRD_NRD_1	508	510	PF00675	0.376
CLV_PCSK_KEX2_1	142	144	PF00082	0.566
CLV_PCSK_KEX2_1	230	232	PF00082	0.477
CLV_PCSK_KEX2_1	321	323	PF00082	0.361
CLV_PCSK_KEX2_1	360	362	PF00082	0.367
CLV_PCSK_KEX2_1	488	490	PF00082	0.504
CLV_PCSK_KEX2_1	507	509	PF00082	0.268
CLV_PCSK_KEX2_1	572	574	PF00082	0.530
CLV_PCSK_PC1ET2_1	572	574	PF00082	0.530
CLV_PCSK_SKI1_1	230	234	PF00082	0.636
CLV_PCSK_SKI1_1	260	264	PF00082	0.541
CLV_PCSK_SKI1_1	287	291	PF00082	0.494
CLV_PCSK_SKI1_1	514	518	PF00082	0.481
CLV_PCSK_SKI1_1	553	557	PF00082	0.606
CLV_PCSK_SKI1_1	569	573	PF00082	0.430
CLV_Separin_Metazoa	550	554	PF03568	0.563
DEG_APCC_DBOX_1	12	20	PF00400	0.421
DEG_APCC_DBOX_1	519	527	PF00400	0.475
DEG_Nend_UBRbox_1	1	4	PF02207	0.601
DOC_CYCLIN_RxL_1	408	417	PF00134	0.278
DOC_MAPK_DCC_7	13	21	PF00069	0.491
DOC_MAPK_gen_1	13	21	PF00069	0.435
DOC_MAPK_gen_1	302	310	PF00069	0.393
DOC_MAPK_MEF2A_6	13	21	PF00069	0.465
DOC_MAPK_MEF2A_6	302	310	PF00069	0.393
DOC_MAPK_RevD_3	131	144	PF00069	0.537
DOC_PIKK_1	399	406	PF02985	0.434
DOC_PP1_RVXF_1	210	217	PF00149	0.395
DOC_PP2B_LxvP_1	14	17	PF13499	0.404
DOC_PP2B_LxvP_1	416	419	PF13499	0.362
DOC_PP2B_PxIxI_1	16	22	PF00149	0.482
DOC_USP7_MATH_1	149	153	PF00917	0.387
DOC_USP7_MATH_1	181	185	PF00917	0.574
DOC_USP7_MATH_1	206	210	PF00917	0.524
DOC_USP7_MATH_1	436	440	PF00917	0.356
DOC_USP7_MATH_1	58	62	PF00917	0.511
DOC_USP7_MATH_2	117	123	PF00917	0.304
DOC_WW_Pin1_4	199	204	PF00397	0.759
DOC_WW_Pin1_4	218	223	PF00397	0.286
DOC_WW_Pin1_4	240	245	PF00397	0.623
DOC_WW_Pin1_4	359	364	PF00397	0.389
DOC_WW_Pin1_4	54	59	PF00397	0.686
DOC_WW_Pin1_4	60	65	PF00397	0.683
LIG_14-3-3_CanoR_1	144	154	PF00244	0.591
LIG_14-3-3_CanoR_1	230	240	PF00244	0.646
LIG_14-3-3_CanoR_1	316	324	PF00244	0.397
LIG_14-3-3_CanoR_1	412	417	PF00244	0.435
LIG_14-3-3_CanoR_1	520	526	PF00244	0.551
LIG_14-3-3_CanoR_1	59	64	PF00244	0.660
LIG_14-3-3_CanoR_1	96	102	PF00244	0.405
LIG_Actin_WH2_2	303	318	PF00022	0.362
LIG_AP2alpha_2	78	80	PF02296	0.294
LIG_BRCT_BRCA1_1	279	283	PF00533	0.402
LIG_FHA_1	127	133	PF00498	0.464
LIG_FHA_1	21	27	PF00498	0.454
LIG_FHA_1	303	309	PF00498	0.421
LIG_FHA_1	68	74	PF00498	0.623
LIG_FHA_2	153	159	PF00498	0.570
LIG_FHA_2	331	337	PF00498	0.362
LIG_FHA_2	61	67	PF00498	0.725
LIG_IBAR_NPY_1	341	343	PF08397	0.411
LIG_LIR_Apic_2	469	473	PF02991	0.427
LIG_LIR_Gen_1	564	574	PF02991	0.468
LIG_LIR_Nem_3	317	323	PF02991	0.317
LIG_LIR_Nem_3	36	41	PF02991	0.476
LIG_LIR_Nem_3	376	380	PF02991	0.341
LIG_LIR_Nem_3	564	570	PF02991	0.466
LIG_Pex14_2	430	434	PF04695	0.435
LIG_PTAP_UEV_1	575	580	PF05743	0.572
LIG_PTB_Apo_2	262	269	PF02174	0.280
LIG_PTB_Apo_2	338	345	PF02174	0.361
LIG_PTB_Phospho_1	338	344	PF10480	0.361
LIG_REV1ctd_RIR_1	168	176	PF16727	0.495
LIG_SH2_CRK	320	324	PF00017	0.435
LIG_SH2_GRB2like	343	346	PF00017	0.411
LIG_SH2_PTP2	18	21	PF00017	0.472
LIG_SH2_SRC	162	165	PF00017	0.470
LIG_SH2_STAP1	162	166	PF00017	0.340
LIG_SH2_STAT5	105	108	PF00017	0.355
LIG_SH2_STAT5	18	21	PF00017	0.472
LIG_SH2_STAT5	477	480	PF00017	0.413
LIG_SH2_STAT5	93	96	PF00017	0.469
LIG_SH3_1	125	131	PF00018	0.567
LIG_SH3_1	200	206	PF00018	0.610
LIG_SH3_1	573	579	PF00018	0.526
LIG_SH3_3	125	131	PF00018	0.574
LIG_SH3_3	177	183	PF00018	0.453
LIG_SH3_3	200	206	PF00018	0.673
LIG_SH3_3	555	561	PF00018	0.501
LIG_SH3_3	573	579	PF00018	0.526
LIG_SUMO_SIM_anti_2	522	527	PF11976	0.487
LIG_SUMO_SIM_par_1	305	311	PF11976	0.410
LIG_SUMO_SIM_par_1	367	373	PF11976	0.365
LIG_TRAF2_1	185	188	PF00917	0.553
LIG_TRAF2_1	205	208	PF00917	0.602
LIG_TRAF2_1	253	256	PF00917	0.458
LIG_TYR_ITIM	16	21	PF00017	0.486
LIG_UBA3_1	10	15	PF00899	0.478
LIG_UBA3_1	368	375	PF00899	0.420
LIG_WRC_WIRS_1	35	40	PF05994	0.393
MOD_CDC14_SPxK_1	243	246	PF00782	0.633
MOD_CDK_SPK_2	54	59	PF00069	0.644
MOD_CDK_SPxK_1	240	246	PF00069	0.627
MOD_CK1_1	111	117	PF00069	0.388
MOD_CK1_1	152	158	PF00069	0.547
MOD_CK1_1	460	466	PF00069	0.668
MOD_CK2_1	152	158	PF00069	0.467
MOD_CK2_1	182	188	PF00069	0.575
MOD_CK2_1	359	365	PF00069	0.402
MOD_CK2_1	399	405	PF00069	0.312
MOD_CK2_1	460	466	PF00069	0.605
MOD_Cter_Amidation	358	361	PF01082	0.428
MOD_GlcNHglycan	149	152	PF01048	0.602
MOD_GlcNHglycan	164	167	PF01048	0.491
MOD_GlcNHglycan	184	187	PF01048	0.413
MOD_GlcNHglycan	207	211	PF01048	0.449
MOD_GlcNHglycan	216	219	PF01048	0.401
MOD_GlcNHglycan	448	451	PF01048	0.508
MOD_GlcNHglycan	455	458	PF01048	0.594
MOD_GlcNHglycan	459	462	PF01048	0.559
MOD_GlcNHglycan	576	579	PF01048	0.661
MOD_GSK3_1	111	118	PF00069	0.312
MOD_GSK3_1	145	152	PF00069	0.547
MOD_GSK3_1	195	202	PF00069	0.757
MOD_GSK3_1	214	221	PF00069	0.483
MOD_GSK3_1	240	247	PF00069	0.442
MOD_GSK3_1	298	305	PF00069	0.489
MOD_GSK3_1	446	453	PF00069	0.525
MOD_GSK3_1	54	61	PF00069	0.573
MOD_GSK3_1	67	74	PF00069	0.739
MOD_GSK3_1	96	103	PF00069	0.411
MOD_NEK2_1	101	106	PF00069	0.356
MOD_NEK2_1	216	221	PF00069	0.348
MOD_NEK2_1	277	282	PF00069	0.313
MOD_NEK2_1	29	34	PF00069	0.540
MOD_NEK2_1	48	53	PF00069	0.362
MOD_NEK2_1	89	94	PF00069	0.429
MOD_NEK2_2	351	356	PF00069	0.337
MOD_OFUCOSY	269	276	PF10250	0.207
MOD_PIKK_1	71	77	PF00454	0.601
MOD_PKA_2	315	321	PF00069	0.362
MOD_PKA_2	519	525	PF00069	0.536
MOD_PKA_2	58	64	PF00069	0.559
MOD_Plk_1	302	308	PF00069	0.435
MOD_Plk_1	330	336	PF00069	0.362
MOD_Plk_1	398	404	PF00069	0.318
MOD_Plk_1	436	442	PF00069	0.487
MOD_Plk_1	498	504	PF00069	0.427
MOD_Plk_2-3	399	405	PF00069	0.361
MOD_Plk_4	111	117	PF00069	0.341
MOD_Plk_4	149	155	PF00069	0.631
MOD_Plk_4	220	226	PF00069	0.515
MOD_Plk_4	501	507	PF00069	0.484
MOD_Plk_4	521	527	PF00069	0.269
MOD_Plk_4	97	103	PF00069	0.473
MOD_ProDKin_1	199	205	PF00069	0.746
MOD_ProDKin_1	218	224	PF00069	0.298
MOD_ProDKin_1	240	246	PF00069	0.627
MOD_ProDKin_1	359	365	PF00069	0.389
MOD_ProDKin_1	54	60	PF00069	0.688
MOD_SUMO_rev_2	362	369	PF00179	0.359
TRG_DiLeu_BaEn_1	258	263	PF01217	0.553
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.529
TRG_ENDOCYTIC_2	18	21	PF00928	0.479
TRG_ENDOCYTIC_2	320	323	PF00928	0.435
TRG_ENDOCYTIC_2	343	346	PF00928	0.427
TRG_ER_diArg_1	142	144	PF00400	0.573
TRG_ER_diArg_1	320	322	PF00400	0.356
TRG_ER_diArg_1	487	490	PF00400	0.503
TRG_ER_diArg_1	506	509	PF00400	0.272
TRG_NES_CRM1_1	404	417	PF08389	0.278
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.548
TRG_Pf-PMV_PEXEL_1	231	235	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.397
TRG_Pf-PMV_PEXEL_1	378	383	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	412	417	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	46	50	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	489	493	PF00026	0.449

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q6	Leptomonas seymouri	61%	100%
A0A0S4IM91	Bodo saltans	29%	100%
A0A0S4IRQ5	Bodo saltans	29%	100%
A0A1X0P810	Trypanosomatidae	45%	97%
A0A3S7XAR2	Leishmania donovani	92%	99%
A4HNY3	Leishmania braziliensis	79%	100%
A4ICL1	Leishmania infantum	92%	99%
D0A2U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	97%
Q4Q1V3	Leishmania major	92%	100%
V5BZP6	Trypanosoma cruzi	47%	99%