Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASP1_LEIMU

TriTrypDb:

LmxM.36.1210

Length:

254

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASP1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	141	145	PF00656	0.434
CLV_C14_Caspase3-7	205	209	PF00656	0.669
CLV_PCSK_SKI1_1	113	117	PF00082	0.442
CLV_PCSK_SKI1_1	125	129	PF00082	0.453
CLV_PCSK_SKI1_1	60	64	PF00082	0.377
DOC_USP7_MATH_1	107	111	PF00917	0.461
DOC_USP7_MATH_1	152	156	PF00917	0.413
DOC_USP7_MATH_1	187	191	PF00917	0.665
DOC_USP7_UBL2_3	241	245	PF12436	0.467
DOC_WW_Pin1_4	181	186	PF00397	0.735
DOC_WW_Pin1_4	2	7	PF00397	0.533
LIG_14-3-3_CanoR_1	188	196	PF00244	0.735
LIG_14-3-3_CanoR_1	91	97	PF00244	0.390
LIG_BIR_II_1	1	5	PF00653	0.550
LIG_BIR_III_2	167	171	PF00653	0.427
LIG_FHA_1	56	62	PF00498	0.378
LIG_FHA_1	84	90	PF00498	0.592
LIG_FHA_1	99	105	PF00498	0.385
LIG_FHA_2	141	147	PF00498	0.516
LIG_FHA_2	169	175	PF00498	0.584
LIG_FHA_2	218	224	PF00498	0.513
LIG_GBD_Chelix_1	104	112	PF00786	0.314
LIG_LIR_Gen_1	131	140	PF02991	0.391
LIG_LIR_Gen_1	85	93	PF02991	0.483
LIG_LIR_Nem_3	131	137	PF02991	0.392
LIG_LIR_Nem_3	167	172	PF02991	0.507
LIG_LIR_Nem_3	220	225	PF02991	0.394
LIG_LIR_Nem_3	53	59	PF02991	0.347
LIG_LIR_Nem_3	85	90	PF02991	0.454
LIG_PCNA_PIPBox_1	112	121	PF02747	0.391
LIG_PCNA_PIPBox_1	240	249	PF02747	0.630
LIG_PCNA_yPIPBox_3	240	250	PF02747	0.551
LIG_PTB_Apo_2	78	85	PF02174	0.398
LIG_SH2_CRK	222	226	PF00017	0.414
LIG_SH2_GRB2like	246	249	PF00017	0.481
LIG_SH2_STAP1	57	61	PF00017	0.514
LIG_SH2_STAT3	19	22	PF00017	0.551
LIG_SH2_STAT3	237	240	PF00017	0.584
LIG_SH2_STAT5	118	121	PF00017	0.433
LIG_SH2_STAT5	19	22	PF00017	0.483
LIG_SH2_STAT5	237	240	PF00017	0.541
LIG_SH2_STAT5	36	39	PF00017	0.267
LIG_SH2_STAT5	57	60	PF00017	0.467
LIG_SH3_3	236	242	PF00018	0.481
LIG_SH3_4	241	248	PF00018	0.472
LIG_TYR_ITSM	218	225	PF00017	0.427
LIG_WRC_WIRS_1	169	174	PF05994	0.445
MOD_CDK_SPK_2	2	7	PF00069	0.490
MOD_CDK_SPxxK_3	181	188	PF00069	0.552
MOD_CK1_1	138	144	PF00069	0.544
MOD_CK1_1	192	198	PF00069	0.573
MOD_CK1_1	48	54	PF00069	0.419
MOD_CK1_1	5	11	PF00069	0.524
MOD_CK1_1	85	91	PF00069	0.527
MOD_CK2_1	140	146	PF00069	0.347
MOD_CK2_1	168	174	PF00069	0.578
MOD_GlcNHglycan	109	112	PF01048	0.429
MOD_GlcNHglycan	12	15	PF01048	0.636
MOD_GlcNHglycan	189	192	PF01048	0.662
MOD_GlcNHglycan	50	53	PF01048	0.449
MOD_GSK3_1	1	8	PF00069	0.573
MOD_GSK3_1	138	145	PF00069	0.434
MOD_GSK3_1	152	159	PF00069	0.386
MOD_GSK3_1	187	194	PF00069	0.676
MOD_N-GLC_1	156	161	PF02516	0.541
MOD_NEK2_1	1	6	PF00069	0.719
MOD_NEK2_1	10	15	PF00069	0.395
MOD_NEK2_1	106	111	PF00069	0.297
MOD_NEK2_1	150	155	PF00069	0.503
MOD_NEK2_1	199	204	PF00069	0.551
MOD_NEK2_1	229	234	PF00069	0.395
MOD_NEK2_1	50	55	PF00069	0.403
MOD_NEK2_1	98	103	PF00069	0.373
MOD_NEK2_2	45	50	PF00069	0.379
MOD_NEK2_2	55	60	PF00069	0.295
MOD_PIKK_1	179	185	PF00454	0.698
MOD_PIKK_1	92	98	PF00454	0.498
MOD_PKA_2	187	193	PF00069	0.760
MOD_Plk_1	210	216	PF00069	0.605
MOD_Plk_4	210	216	PF00069	0.521
MOD_Plk_4	217	223	PF00069	0.411
MOD_Plk_4	229	235	PF00069	0.392
MOD_Plk_4	45	51	PF00069	0.455
MOD_ProDKin_1	181	187	PF00069	0.734
MOD_ProDKin_1	2	8	PF00069	0.531
MOD_SUMO_rev_2	204	212	PF00179	0.612
TRG_DiLeu_BaEn_2	145	151	PF01217	0.320
TRG_DiLeu_BaLyEn_6	57	62	PF01217	0.371
TRG_ENDOCYTIC_2	222	225	PF00928	0.446
TRG_ENDOCYTIC_2	246	249	PF00928	0.562
TRG_ER_diArg_1	122	125	PF00400	0.361
TRG_Pf-PMV_PEXEL_1	60	64	PF00026	0.377
TRG_Pf-PMV_PEXEL_1	91	96	PF00026	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDB2	Leptomonas seymouri	47%	91%
A0A0S4JAI8	Bodo saltans	31%	100%
A0A1X0P886	Trypanosomatidae	38%	100%
A0A3S7XAI3	Leishmania donovani	85%	100%
A4ICL3	Leishmania infantum	85%	100%
D0A2U7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
Q4Q1V5	Leishmania major	83%	100%
V5B9R5	Trypanosoma cruzi	37%	100%