Mannosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Mannosyltransferase

Gene product:

GPI anchor biosynthesis protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASP0_LEIMU

TriTrypDb:

LmxM.36.1200

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 4, no: 7
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005789	endoplasmic reticulum membrane	4	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

E9ASP0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASP0

Function

Biological processes
Term	Name	Level	Count
GO:0006497	protein lipidation	5	12
GO:0006505	GPI anchor metabolic process	6	12
GO:0006506	GPI anchor biosynthetic process	6	12
GO:0006629	lipid metabolic process	3	12
GO:0006643	membrane lipid metabolic process	4	12
GO:0006644	phospholipid metabolic process	4	12
GO:0006650	glycerophospholipid metabolic process	5	12
GO:0006661	phosphatidylinositol biosynthetic process	6	12
GO:0006664	glycolipid metabolic process	5	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0008610	lipid biosynthetic process	4	12
GO:0008654	phospholipid biosynthetic process	5	12
GO:0009058	biosynthetic process	2	12
GO:0009247	glycolipid biosynthetic process	5	12
GO:0009987	cellular process	1	12
GO:0019538	protein metabolic process	3	12
GO:0019637	organophosphate metabolic process	3	12
GO:0036211	protein modification process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0043412	macromolecule modification	4	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044249	cellular biosynthetic process	3	12
GO:0044255	cellular lipid metabolic process	3	12
GO:0045017	glycerolipid biosynthetic process	4	12
GO:0046467	membrane lipid biosynthetic process	4	12
GO:0046474	glycerophospholipid biosynthetic process	5	12
GO:0046486	glycerolipid metabolic process	4	12
GO:0046488	phosphatidylinositol metabolic process	6	12
GO:0071704	organic substance metabolic process	2	12
GO:0090407	organophosphate biosynthetic process	4	12
GO:1901135	carbohydrate derivative metabolic process	3	12
GO:1901137	carbohydrate derivative biosynthetic process	4	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901576	organic substance biosynthetic process	3	12
GO:1903509	liposaccharide metabolic process	4	12

Molecular functions
Term	Name	Level	Count
GO:0000026	alpha-1,2-mannosyltransferase activity	6	12
GO:0000030	mannosyltransferase activity	5	12
GO:0003824	catalytic activity	1	12
GO:0004376	glycolipid mannosyltransferase activity	6	12
GO:0016740	transferase activity	2	12
GO:0016757	glycosyltransferase activity	3	12
GO:0016758	hexosyltransferase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.382
CLV_NRD_NRD_1	130	132	PF00675	0.302
CLV_NRD_NRD_1	154	156	PF00675	0.231
CLV_NRD_NRD_1	428	430	PF00675	0.288
CLV_NRD_NRD_1	450	452	PF00675	0.424
CLV_PCSK_KEX2_1	130	132	PF00082	0.305
CLV_PCSK_KEX2_1	153	155	PF00082	0.228
CLV_PCSK_KEX2_1	268	270	PF00082	0.340
CLV_PCSK_KEX2_1	428	430	PF00082	0.286
CLV_PCSK_KEX2_1	450	452	PF00082	0.424
CLV_PCSK_KEX2_1	624	626	PF00082	0.668
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.182
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.340
CLV_PCSK_PC1ET2_1	624	626	PF00082	0.532
CLV_PCSK_SKI1_1	135	139	PF00082	0.273
CLV_PCSK_SKI1_1	239	243	PF00082	0.268
CLV_PCSK_SKI1_1	269	273	PF00082	0.493
CLV_PCSK_SKI1_1	357	361	PF00082	0.350
CLV_PCSK_SKI1_1	428	432	PF00082	0.294
CLV_PCSK_SKI1_1	514	518	PF00082	0.534
CLV_PCSK_SKI1_1	52	56	PF00082	0.504
DEG_APCC_DBOX_1	497	505	PF00400	0.272
DEG_Nend_UBRbox_2	1	3	PF02207	0.473
DEG_SPOP_SBC_1	141	145	PF00917	0.433
DOC_CDC14_PxL_1	360	368	PF14671	0.286
DOC_CDC14_PxL_1	381	389	PF14671	0.321
DOC_CKS1_1	271	276	PF01111	0.256
DOC_CYCLIN_RxL_1	234	244	PF00134	0.387
DOC_CYCLIN_RxL_1	265	273	PF00134	0.180
DOC_CYCLIN_RxL_1	425	434	PF00134	0.516
DOC_MAPK_DCC_7	378	388	PF00069	0.265
DOC_MAPK_gen_1	413	421	PF00069	0.526
DOC_MAPK_gen_1	527	537	PF00069	0.382
DOC_MAPK_MEF2A_6	27	34	PF00069	0.283
DOC_MAPK_NFAT4_5	27	35	PF00069	0.367
DOC_PP1_RVXF_1	237	244	PF00149	0.407
DOC_PP1_RVXF_1	266	273	PF00149	0.259
DOC_PP1_RVXF_1	376	383	PF00149	0.323
DOC_PP1_RVXF_1	489	495	PF00149	0.343
DOC_PP2B_LxvP_1	419	422	PF13499	0.516
DOC_PP4_FxxP_1	138	141	PF00568	0.432
DOC_PP4_FxxP_1	382	385	PF00568	0.323
DOC_PP4_FxxP_1	587	590	PF00568	0.178
DOC_PP4_FxxP_1	77	80	PF00568	0.420
DOC_USP7_MATH_1	13	17	PF00917	0.466
DOC_USP7_MATH_1	141	145	PF00917	0.484
DOC_USP7_MATH_1	420	424	PF00917	0.457
DOC_USP7_MATH_1	459	463	PF00917	0.140
DOC_USP7_MATH_1	67	71	PF00917	0.232
DOC_WW_Pin1_4	270	275	PF00397	0.230
DOC_WW_Pin1_4	36	41	PF00397	0.238
DOC_WW_Pin1_4	476	481	PF00397	0.266
LIG_14-3-3_CanoR_1	12	18	PF00244	0.484
LIG_14-3-3_CanoR_1	213	221	PF00244	0.235
LIG_14-3-3_CanoR_1	27	31	PF00244	0.376
LIG_14-3-3_CanoR_1	337	343	PF00244	0.448
LIG_14-3-3_CanoR_1	413	418	PF00244	0.541
LIG_14-3-3_CanoR_1	428	434	PF00244	0.484
LIG_14-3-3_CanoR_1	458	467	PF00244	0.149
LIG_14-3-3_CanoR_1	514	523	PF00244	0.344
LIG_14-3-3_CanoR_1	57	63	PF00244	0.316
LIG_Actin_WH2_2	21	37	PF00022	0.193
LIG_Actin_WH2_2	391	409	PF00022	0.275
LIG_BRCT_BRCA1_1	186	190	PF00533	0.300
LIG_BRCT_BRCA1_1	339	343	PF00533	0.432
LIG_BRCT_BRCA1_1	69	73	PF00533	0.265
LIG_CSL_BTD_1	314	317	PF09270	0.376
LIG_eIF4E_1	381	387	PF01652	0.376
LIG_FHA_1	161	167	PF00498	0.367
LIG_FHA_1	213	219	PF00498	0.228
LIG_FHA_1	242	248	PF00498	0.223
LIG_FHA_1	27	33	PF00498	0.421
LIG_FHA_1	363	369	PF00498	0.376
LIG_FHA_1	583	589	PF00498	0.358
LIG_FHA_2	85	91	PF00498	0.465
LIG_IRF3_LxIS_1	384	391	PF10401	0.275
LIG_LIR_Apic_2	136	141	PF02991	0.382
LIG_LIR_Apic_2	584	590	PF02991	0.184
LIG_LIR_Apic_2	70	74	PF02991	0.344
LIG_LIR_Apic_2	8	13	PF02991	0.422
LIG_LIR_Gen_1	16	26	PF02991	0.216
LIG_LIR_Gen_1	180	189	PF02991	0.324
LIG_LIR_Gen_1	273	283	PF02991	0.343
LIG_LIR_Gen_1	376	387	PF02991	0.281
LIG_LIR_Gen_1	438	449	PF02991	0.286
LIG_LIR_Gen_1	479	489	PF02991	0.255
LIG_LIR_Gen_1	610	620	PF02991	0.341
LIG_LIR_Nem_3	122	128	PF02991	0.429
LIG_LIR_Nem_3	16	21	PF02991	0.398
LIG_LIR_Nem_3	170	174	PF02991	0.212
LIG_LIR_Nem_3	180	184	PF02991	0.299
LIG_LIR_Nem_3	186	192	PF02991	0.267
LIG_LIR_Nem_3	197	202	PF02991	0.191
LIG_LIR_Nem_3	263	267	PF02991	0.262
LIG_LIR_Nem_3	273	278	PF02991	0.282
LIG_LIR_Nem_3	287	292	PF02991	0.238
LIG_LIR_Nem_3	376	382	PF02991	0.310
LIG_LIR_Nem_3	438	444	PF02991	0.286
LIG_LIR_Nem_3	455	460	PF02991	0.330
LIG_LIR_Nem_3	464	470	PF02991	0.323
LIG_LIR_Nem_3	479	485	PF02991	0.238
LIG_LIR_Nem_3	48	54	PF02991	0.217
LIG_LIR_Nem_3	610	616	PF02991	0.419
LIG_LIR_Nem_3	70	76	PF02991	0.285
LIG_MLH1_MIPbox_1	186	190	PF16413	0.300
LIG_NRBOX	18	24	PF00104	0.370
LIG_NRBOX	187	193	PF00104	0.243
LIG_Pex14_2	311	315	PF04695	0.382
LIG_Pex14_2	431	435	PF04695	0.419
LIG_Pex14_2	73	77	PF04695	0.382
LIG_Pex14_2	82	86	PF04695	0.413
LIG_SH2_CRK	181	185	PF00017	0.268
LIG_SH2_CRK	267	271	PF00017	0.316
LIG_SH2_CRK	275	279	PF00017	0.316
LIG_SH2_CRK	51	55	PF00017	0.238
LIG_SH2_CRK	593	597	PF00017	0.316
LIG_SH2_CRK	600	604	PF00017	0.277
LIG_SH2_GRB2like	181	184	PF00017	0.286
LIG_SH2_NCK_1	181	185	PF00017	0.316
LIG_SH2_PTP2	71	74	PF00017	0.376
LIG_SH2_STAT5	264	267	PF00017	0.318
LIG_SH2_STAT5	298	301	PF00017	0.243
LIG_SH2_STAT5	381	384	PF00017	0.391
LIG_SH2_STAT5	528	531	PF00017	0.294
LIG_SH2_STAT5	613	616	PF00017	0.352
LIG_SH2_STAT5	71	74	PF00017	0.321
LIG_SH3_3	268	274	PF00018	0.234
LIG_SH3_3	289	295	PF00018	0.288
LIG_SH3_3	297	303	PF00018	0.244
LIG_SH3_3	358	364	PF00018	0.425
LIG_SH3_3	394	400	PF00018	0.245
LIG_SH3_3	564	570	PF00018	0.402
LIG_SUMO_SIM_anti_2	161	168	PF11976	0.205
LIG_SUMO_SIM_anti_2	391	398	PF11976	0.394
LIG_SUMO_SIM_par_1	165	170	PF11976	0.282
LIG_SUMO_SIM_par_1	364	370	PF11976	0.275
LIG_SUMO_SIM_par_1	385	392	PF11976	0.346
LIG_SUMO_SIM_par_1	533	539	PF11976	0.239
LIG_TRAF2_1	605	608	PF00917	0.322
LIG_TRFH_1	381	385	PF08558	0.376
LIG_TYR_ITIM	265	270	PF00017	0.260
LIG_TYR_ITIM	49	54	PF00017	0.214
LIG_UBA3_1	261	268	PF00899	0.403
LIG_UBA3_1	283	288	PF00899	0.207
LIG_UBA3_1	81	85	PF00899	0.436
LIG_WRC_WIRS_1	199	204	PF05994	0.228
MOD_CK1_1	144	150	PF00069	0.444
MOD_CK1_1	182	188	PF00069	0.140
MOD_CK1_1	198	204	PF00069	0.127
MOD_CK1_1	331	337	PF00069	0.479
MOD_CK1_1	344	350	PF00069	0.518
MOD_CK1_1	362	368	PF00069	0.300
MOD_CK1_1	423	429	PF00069	0.363
MOD_CK1_1	618	624	PF00069	0.421
MOD_CK2_1	142	148	PF00069	0.559
MOD_CK2_1	36	42	PF00069	0.226
MOD_CK2_1	602	608	PF00069	0.450
MOD_GlcNHglycan	132	135	PF01048	0.252
MOD_GlcNHglycan	138	141	PF01048	0.212
MOD_GlcNHglycan	255	258	PF01048	0.399
MOD_GlcNHglycan	331	334	PF01048	0.319
MOD_GlcNHglycan	343	346	PF01048	0.341
MOD_GlcNHglycan	361	364	PF01048	0.326
MOD_GlcNHglycan	369	372	PF01048	0.171
MOD_GlcNHglycan	403	406	PF01048	0.332
MOD_GlcNHglycan	422	425	PF01048	0.301
MOD_GlcNHglycan	461	464	PF01048	0.499
MOD_GlcNHglycan	504	507	PF01048	0.536
MOD_GlcNHglycan	543	546	PF01048	0.522
MOD_GSK3_1	136	143	PF00069	0.509
MOD_GSK3_1	155	162	PF00069	0.457
MOD_GSK3_1	173	180	PF00069	0.376
MOD_GSK3_1	190	197	PF00069	0.260
MOD_GSK3_1	241	248	PF00069	0.295
MOD_GSK3_1	26	33	PF00069	0.312
MOD_GSK3_1	337	344	PF00069	0.540
MOD_GSK3_1	407	414	PF00069	0.534
MOD_GSK3_1	431	438	PF00069	0.398
MOD_GSK3_1	84	91	PF00069	0.376
MOD_N-GLC_1	182	187	PF02516	0.550
MOD_N-GLC_2	99	101	PF02516	0.173
MOD_NEK2_1	142	147	PF00069	0.523
MOD_NEK2_1	173	178	PF00069	0.317
MOD_NEK2_1	190	195	PF00069	0.264
MOD_NEK2_1	212	217	PF00069	0.244
MOD_NEK2_1	241	246	PF00069	0.279
MOD_NEK2_1	284	289	PF00069	0.327
MOD_NEK2_1	30	35	PF00069	0.279
MOD_NEK2_1	343	348	PF00069	0.541
MOD_NEK2_1	359	364	PF00069	0.300
MOD_NEK2_1	367	372	PF00069	0.352
MOD_NEK2_1	388	393	PF00069	0.347
MOD_NEK2_1	406	411	PF00069	0.524
MOD_NEK2_1	431	436	PF00069	0.293
MOD_NEK2_1	84	89	PF00069	0.358
MOD_PIKK_1	508	514	PF00454	0.381
MOD_PK_1	530	536	PF00069	0.222
MOD_PKA_1	130	136	PF00069	0.340
MOD_PKA_2	130	136	PF00069	0.520
MOD_PKA_2	212	218	PF00069	0.235
MOD_PKA_2	26	32	PF00069	0.275
MOD_PKA_2	618	624	PF00069	0.349
MOD_PKB_1	411	419	PF00069	0.390
MOD_Plk_1	110	116	PF00069	0.516
MOD_Plk_4	110	116	PF00069	0.552
MOD_Plk_4	13	19	PF00069	0.324
MOD_Plk_4	184	190	PF00069	0.299
MOD_Plk_4	198	204	PF00069	0.263
MOD_Plk_4	338	344	PF00069	0.515
MOD_Plk_4	362	368	PF00069	0.322
MOD_Plk_4	389	395	PF00069	0.354
MOD_Plk_4	431	437	PF00069	0.262
MOD_Plk_4	452	458	PF00069	0.335
MOD_Plk_4	530	536	PF00069	0.428
MOD_Plk_4	91	97	PF00069	0.510
MOD_ProDKin_1	270	276	PF00069	0.230
MOD_ProDKin_1	36	42	PF00069	0.238
MOD_ProDKin_1	476	482	PF00069	0.266
MOD_SUMO_for_1	562	565	PF00179	0.298
MOD_SUMO_rev_2	370	377	PF00179	0.370
TRG_DiLeu_BaEn_1	556	561	PF01217	0.254
TRG_DiLeu_BaEn_2	185	191	PF01217	0.260
TRG_DiLeu_BaLyEn_6	382	387	PF01217	0.275
TRG_ENDOCYTIC_2	181	184	PF00928	0.262
TRG_ENDOCYTIC_2	199	202	PF00928	0.255
TRG_ENDOCYTIC_2	267	270	PF00928	0.256
TRG_ENDOCYTIC_2	275	278	PF00928	0.259
TRG_ENDOCYTIC_2	289	292	PF00928	0.257
TRG_ENDOCYTIC_2	296	299	PF00928	0.218
TRG_ENDOCYTIC_2	369	372	PF00928	0.260
TRG_ENDOCYTIC_2	381	384	PF00928	0.225
TRG_ENDOCYTIC_2	467	470	PF00928	0.203
TRG_ENDOCYTIC_2	51	54	PF00928	0.217
TRG_ENDOCYTIC_2	593	596	PF00928	0.300
TRG_ENDOCYTIC_2	613	616	PF00928	0.337
TRG_ER_diArg_1	412	415	PF00400	0.478
TRG_ER_diArg_1	427	429	PF00400	0.480
TRG_ER_diArg_1	449	451	PF00400	0.256
TRG_NLS_MonoExtC_3	152	157	PF00514	0.382
TRG_NLS_MonoExtN_4	151	157	PF00514	0.382
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q8	Leptomonas seymouri	56%	100%
A0A0S4J7A7	Bodo saltans	29%	100%
A0A1X0P926	Trypanosomatidae	32%	100%
A0A3Q8IJ48	Leishmania donovani	83%	100%
A0A422NTW3	Trypanosoma rangeli	31%	100%
A4HNY0	Leishmania braziliensis	69%	100%
A4ICL4	Leishmania infantum	84%	100%
D0A2U6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
P86935	Trypanosoma brucei brucei	33%	100%
P86936	Trypanosoma brucei brucei (strain 927/4 GUTat10.1)	33%	100%
Q1LZA0	Bos taurus	26%	100%
Q4Q1V6	Leishmania major	81%	100%
Q4V7R2	Xenopus laevis	24%	100%
Q6BH65	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	22%	100%
Q6CAB8	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	100%
Q6CN76	Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37)	24%	100%
Q6FTY5	Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65)	22%	100%
Q75BG9	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	23%	100%
Q7SXZ1	Danio rerio	25%	100%
Q92521	Homo sapiens	24%	100%
Q94A15	Arabidopsis thaliana	25%	100%
Q9JJQ0	Mus musculus	25%	100%
Q9USN0	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q9VZM5	Drosophila melanogaster	25%	100%
V5DRF7	Trypanosoma cruzi	32%	100%