Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASN7_LEIMU

TriTrypDb:

LmxM.36.1170

Length:

637

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

E9ASN7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASN7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0015693	magnesium ion transport	7	2
GO:0030001	metal ion transport	6	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	3
GO:0008324	monoatomic cation transmembrane transporter activity	4	3
GO:0015075	monoatomic ion transmembrane transporter activity	3	3
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	3
GO:0022857	transmembrane transporter activity	2	3
GO:0022890	inorganic cation transmembrane transporter activity	4	3
GO:0046873	metal ion transmembrane transporter activity	5	3
GO:0015095	magnesium ion transmembrane transporter activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.598
CLV_C14_Caspase3-7	242	246	PF00656	0.573
CLV_C14_Caspase3-7	82	86	PF00656	0.739
CLV_NRD_NRD_1	322	324	PF00675	0.554
CLV_NRD_NRD_1	418	420	PF00675	0.364
CLV_NRD_NRD_1	459	461	PF00675	0.427
CLV_NRD_NRD_1	475	477	PF00675	0.276
CLV_NRD_NRD_1	487	489	PF00675	0.311
CLV_NRD_NRD_1	5	7	PF00675	0.494
CLV_NRD_NRD_1	512	514	PF00675	0.415
CLV_NRD_NRD_1	553	555	PF00675	0.434
CLV_NRD_NRD_1	623	625	PF00675	0.413
CLV_NRD_NRD_1	627	629	PF00675	0.431
CLV_PCSK_KEX2_1	294	296	PF00082	0.555
CLV_PCSK_KEX2_1	324	326	PF00082	0.533
CLV_PCSK_KEX2_1	418	420	PF00082	0.408
CLV_PCSK_KEX2_1	475	477	PF00082	0.302
CLV_PCSK_KEX2_1	487	489	PF00082	0.326
CLV_PCSK_KEX2_1	5	7	PF00082	0.495
CLV_PCSK_KEX2_1	512	514	PF00082	0.394
CLV_PCSK_KEX2_1	553	555	PF00082	0.434
CLV_PCSK_KEX2_1	623	625	PF00082	0.289
CLV_PCSK_PC1ET2_1	294	296	PF00082	0.555
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.533
CLV_PCSK_SKI1_1	418	422	PF00082	0.407
CLV_PCSK_SKI1_1	469	473	PF00082	0.370
CLV_PCSK_SKI1_1	488	492	PF00082	0.326
CLV_PCSK_SKI1_1	560	564	PF00082	0.312
CLV_PCSK_SKI1_1	6	10	PF00082	0.471
DEG_Nend_UBRbox_1	1	4	PF02207	0.720
DEG_ODPH_VHL_1	601	613	PF01847	0.448
DEG_SCF_FBW7_2	269	276	PF00400	0.641
DOC_ANK_TNKS_1	58	65	PF00023	0.775
DOC_CDC14_PxL_1	406	414	PF14671	0.526
DOC_CKS1_1	270	275	PF01111	0.549
DOC_CYCLIN_yCln2_LP_2	495	501	PF00134	0.613
DOC_MAPK_DCC_7	356	365	PF00069	0.609
DOC_MAPK_gen_1	553	564	PF00069	0.586
DOC_MAPK_HePTP_8	550	565	PF00069	0.665
DOC_MAPK_MEF2A_6	557	565	PF00069	0.506
DOC_PP1_RVXF_1	486	493	PF00149	0.629
DOC_PP2B_LxvP_1	158	161	PF13499	0.653
DOC_PP4_FxxP_1	420	423	PF00568	0.589
DOC_SPAK_OSR1_1	503	507	PF12202	0.632
DOC_USP7_MATH_1	316	320	PF00917	0.802
DOC_USP7_MATH_1	355	359	PF00917	0.592
DOC_USP7_UBL2_3	314	318	PF12436	0.778
DOC_WW_Pin1_4	14	19	PF00397	0.716
DOC_WW_Pin1_4	194	199	PF00397	0.707
DOC_WW_Pin1_4	269	274	PF00397	0.538
DOC_WW_Pin1_4	410	415	PF00397	0.679
LIG_14-3-3_CanoR_1	220	228	PF00244	0.620
LIG_14-3-3_CanoR_1	356	360	PF00244	0.649
LIG_14-3-3_CanoR_1	418	423	PF00244	0.559
LIG_14-3-3_CanoR_1	5	11	PF00244	0.734
LIG_14-3-3_CanoR_1	51	56	PF00244	0.741
LIG_14-3-3_CanoR_1	623	627	PF00244	0.612
LIG_14-3-3_CanoR_1	628	632	PF00244	0.652
LIG_Actin_WH2_2	544	562	PF00022	0.647
LIG_AP2alpha_1	500	504	PF02296	0.640
LIG_APCC_ABBA_1	27	32	PF00400	0.648
LIG_APCC_ABBA_1	367	372	PF00400	0.514
LIG_BIR_III_4	278	282	PF00653	0.571
LIG_BIR_III_4	448	452	PF00653	0.581
LIG_Clathr_ClatBox_1	116	120	PF01394	0.692
LIG_deltaCOP1_diTrp_1	372	375	PF00928	0.576
LIG_EH1_1	423	431	PF00400	0.596
LIG_FHA_1	162	168	PF00498	0.632
LIG_FHA_1	194	200	PF00498	0.729
LIG_FHA_1	201	207	PF00498	0.624
LIG_FHA_1	220	226	PF00498	0.548
LIG_FHA_1	252	258	PF00498	0.707
LIG_FHA_1	270	276	PF00498	0.478
LIG_FHA_1	32	38	PF00498	0.683
LIG_FHA_1	337	343	PF00498	0.621
LIG_FHA_1	401	407	PF00498	0.707
LIG_FHA_1	533	539	PF00498	0.549
LIG_FHA_1	631	637	PF00498	0.631
LIG_FHA_2	251	257	PF00498	0.726
LIG_FHA_2	258	264	PF00498	0.676
LIG_FHA_2	287	293	PF00498	0.804
LIG_FHA_2	374	380	PF00498	0.521
LIG_FHA_2	64	70	PF00498	0.721
LIG_FHA_2	7	13	PF00498	0.668
LIG_IRF3_LxIS_1	224	231	PF10401	0.633
LIG_LIR_Gen_1	136	146	PF02991	0.645
LIG_LIR_Gen_1	20	29	PF02991	0.637
LIG_LIR_Gen_1	203	210	PF02991	0.574
LIG_LIR_Gen_1	262	270	PF02991	0.589
LIG_LIR_Gen_1	344	355	PF02991	0.641
LIG_LIR_Gen_1	379	389	PF02991	0.529
LIG_LIR_Gen_1	489	500	PF02991	0.622
LIG_LIR_Gen_1	75	81	PF02991	0.660
LIG_LIR_Nem_3	136	142	PF02991	0.597
LIG_LIR_Nem_3	20	24	PF02991	0.645
LIG_LIR_Nem_3	203	208	PF02991	0.572
LIG_LIR_Nem_3	262	267	PF02991	0.578
LIG_LIR_Nem_3	344	350	PF02991	0.625
LIG_LIR_Nem_3	38	42	PF02991	0.644
LIG_LIR_Nem_3	489	495	PF02991	0.613
LIG_LIR_Nem_3	75	79	PF02991	0.643
LIG_MYND_1	410	414	PF01753	0.525
LIG_PCNA_PIPBox_1	431	440	PF02747	0.605
LIG_PDZ_Class_2	632	637	PF00595	0.718
LIG_Pex14_2	420	424	PF04695	0.550
LIG_Pex14_2	500	504	PF04695	0.640
LIG_PTB_Apo_2	55	62	PF02174	0.689
LIG_REV1ctd_RIR_1	53	62	PF16727	0.549
LIG_SH2_CRK	139	143	PF00017	0.645
LIG_SH2_CRK	21	25	PF00017	0.715
LIG_SH2_CRK	614	618	PF00017	0.431
LIG_SH2_PTP2	264	267	PF00017	0.559
LIG_SH2_SRC	152	155	PF00017	0.535
LIG_SH2_SRC	28	31	PF00017	0.687
LIG_SH2_SRC	408	411	PF00017	0.541
LIG_SH2_STAP1	139	143	PF00017	0.648
LIG_SH2_STAP1	582	586	PF00017	0.383
LIG_SH2_STAT5	152	155	PF00017	0.615
LIG_SH2_STAT5	21	24	PF00017	0.691
LIG_SH2_STAT5	240	243	PF00017	0.585
LIG_SH2_STAT5	264	267	PF00017	0.510
LIG_SH2_STAT5	28	31	PF00017	0.664
LIG_SH2_STAT5	614	617	PF00017	0.382
LIG_SH2_STAT5	76	79	PF00017	0.644
LIG_SH3_3	10	16	PF00018	0.730
LIG_SH3_3	164	170	PF00018	0.634
LIG_SH3_3	195	201	PF00018	0.634
LIG_SH3_3	356	362	PF00018	0.634
LIG_SH3_3	503	509	PF00018	0.623
LIG_SH3_3	583	589	PF00018	0.385
LIG_Sin3_3	364	371	PF02671	0.599
LIG_SUMO_SIM_anti_2	248	254	PF11976	0.621
LIG_SUMO_SIM_par_1	534	539	PF11976	0.547
LIG_SUMO_SIM_par_1	574	580	PF11976	0.382
LIG_TRAF2_1	9	12	PF00917	0.739
LIG_UBA3_1	374	380	PF00899	0.568
LIG_WRC_WIRS_1	52	57	PF05994	0.718
LIG_WW_3	104	108	PF00397	0.784
MOD_CK1_1	165	171	PF00069	0.752
MOD_CK1_1	188	194	PF00069	0.763
MOD_CK1_1	231	237	PF00069	0.549
MOD_CK1_1	250	256	PF00069	0.610
MOD_CK1_1	259	265	PF00069	0.641
MOD_CK1_1	31	37	PF00069	0.688
MOD_CK1_1	319	325	PF00069	0.809
MOD_CK1_1	332	338	PF00069	0.665
MOD_CK1_1	399	405	PF00069	0.617
MOD_CK1_1	630	636	PF00069	0.721
MOD_CK1_1	92	98	PF00069	0.714
MOD_CK2_1	148	154	PF00069	0.589
MOD_CK2_1	250	256	PF00069	0.707
MOD_CK2_1	338	344	PF00069	0.653
MOD_CK2_1	355	361	PF00069	0.605
MOD_CK2_1	373	379	PF00069	0.452
MOD_CK2_1	6	12	PF00069	0.769
MOD_CK2_1	63	69	PF00069	0.724
MOD_GlcNHglycan	109	112	PF01048	0.588
MOD_GlcNHglycan	120	124	PF01048	0.373
MOD_GlcNHglycan	216	219	PF01048	0.393
MOD_GlcNHglycan	318	321	PF01048	0.584
MOD_GlcNHglycan	38	42	PF01048	0.484
MOD_GSK3_1	107	114	PF00069	0.732
MOD_GSK3_1	161	168	PF00069	0.630
MOD_GSK3_1	186	193	PF00069	0.781
MOD_GSK3_1	210	217	PF00069	0.593
MOD_GSK3_1	239	246	PF00069	0.630
MOD_GSK3_1	247	254	PF00069	0.655
MOD_GSK3_1	255	262	PF00069	0.682
MOD_GSK3_1	332	339	PF00069	0.717
MOD_GSK3_1	396	403	PF00069	0.619
MOD_GSK3_1	532	539	PF00069	0.533
MOD_GSK3_1	618	625	PF00069	0.401
MOD_GSK3_1	85	92	PF00069	0.783
MOD_LATS_1	4	10	PF00433	0.672
MOD_N-GLC_1	57	62	PF02516	0.488
MOD_NEK2_1	19	24	PF00069	0.672
MOD_NEK2_1	239	244	PF00069	0.611
MOD_NEK2_1	305	310	PF00069	0.740
MOD_NEK2_1	336	341	PF00069	0.711
MOD_NEK2_1	424	429	PF00069	0.516
MOD_NEK2_1	491	496	PF00069	0.527
MOD_NEK2_2	373	378	PF00069	0.486
MOD_PIKK_1	219	225	PF00454	0.629
MOD_PIKK_1	228	234	PF00454	0.622
MOD_PIKK_1	329	335	PF00454	0.701
MOD_PKA_1	418	424	PF00069	0.592
MOD_PKA_2	219	225	PF00069	0.660
MOD_PKA_2	355	361	PF00069	0.654
MOD_PKA_2	418	424	PF00069	0.566
MOD_PKA_2	45	51	PF00069	0.640
MOD_PKA_2	532	538	PF00069	0.565
MOD_PKA_2	622	628	PF00069	0.604
MOD_PKB_1	49	57	PF00069	0.689
MOD_Plk_1	19	25	PF00069	0.695
MOD_Plk_1	247	253	PF00069	0.628
MOD_Plk_1	57	63	PF00069	0.689
MOD_Plk_2-3	148	154	PF00069	0.586
MOD_Plk_2-3	85	91	PF00069	0.722
MOD_Plk_4	148	154	PF00069	0.607
MOD_Plk_4	162	168	PF00069	0.644
MOD_Plk_4	19	25	PF00069	0.685
MOD_Plk_4	424	430	PF00069	0.495
MOD_Plk_4	491	497	PF00069	0.510
MOD_Plk_4	51	57	PF00069	0.728
MOD_Plk_4	577	583	PF00069	0.487
MOD_Plk_4	72	78	PF00069	0.679
MOD_ProDKin_1	14	20	PF00069	0.714
MOD_ProDKin_1	194	200	PF00069	0.694
MOD_ProDKin_1	269	275	PF00069	0.546
MOD_ProDKin_1	410	416	PF00069	0.673
MOD_SUMO_rev_2	231	237	PF00179	0.646
MOD_SUMO_rev_2	291	296	PF00179	0.751
TRG_DiLeu_BaEn_1	124	129	PF01217	0.507
TRG_DiLeu_BaLyEn_6	631	636	PF01217	0.662
TRG_ENDOCYTIC_2	139	142	PF00928	0.648
TRG_ENDOCYTIC_2	21	24	PF00928	0.642
TRG_ENDOCYTIC_2	264	267	PF00928	0.519
TRG_ENDOCYTIC_2	614	617	PF00928	0.374
TRG_ENDOCYTIC_2	76	79	PF00928	0.636
TRG_ER_diArg_1	418	420	PF00400	0.595
TRG_ER_diArg_1	474	476	PF00400	0.541
TRG_ER_diArg_1	49	52	PF00400	0.736
TRG_ER_diArg_1	511	513	PF00400	0.609
TRG_ER_diArg_1	552	554	PF00400	0.640
TRG_ER_diArg_1	622	624	PF00400	0.525
TRG_NLS_Bipartite_1	312	327	PF00514	0.608
TRG_NLS_MonoExtN_4	321	327	PF00514	0.784
TRG_Pf-PMV_PEXEL_1	527	531	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWZ8	Leptomonas seymouri	57%	96%
A0A0S4J7H4	Bodo saltans	22%	87%
A0A1X0NDD2	Trypanosomatidae	33%	100%
A0A3R7L723	Trypanosoma rangeli	30%	100%
A0A3S7XAL7	Leishmania donovani	91%	100%
A4HNX7	Leishmania braziliensis	71%	99%
A4ICL7	Leishmania infantum	90%	100%
B6DT97	Bodo saltans	23%	76%
D0A2U3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q1V9	Leishmania major	89%	100%
V5B9T6	Trypanosoma cruzi	33%	100%