Putative endonuclease/exonuclease/phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

endonuclease/exonuclease/phosphatase, putative

Species:

Leishmania mexicana

UniProt:

E9ASN5_LEIMU

TriTrypDb:

LmxM.36.1150

Length:

927

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASN5

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	7
GO:0006644	phospholipid metabolic process	4	7
GO:0006650	glycerophospholipid metabolic process	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016311	dephosphorylation	5	7
GO:0019637	organophosphate metabolic process	3	7
GO:0030258	lipid modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044255	cellular lipid metabolic process	3	7
GO:0046486	glycerolipid metabolic process	4	7
GO:0046488	phosphatidylinositol metabolic process	6	7
GO:0046839	phospholipid dephosphorylation	5	7
GO:0046856	phosphatidylinositol dephosphorylation	6	7
GO:0071704	organic substance metabolic process	2	7
GO:0005975	carbohydrate metabolic process	3	1
GO:0006066	alcohol metabolic process	3	1
GO:0009056	catabolic process	2	1
GO:0019751	polyol metabolic process	4	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044282	small molecule catabolic process	3	1
GO:0046164	alcohol catabolic process	4	1
GO:0046174	polyol catabolic process	5	1
GO:0046434	organophosphate catabolic process	4	1
GO:0046838	obsolete phosphorylated carbohydrate dephosphorylation	4	1
GO:0046855	obsolete inositol phosphate dephosphorylation	5	1
GO:0071545	inositol phosphate catabolic process	5	1
GO:1901575	organic substance catabolic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901616	organic hydroxy compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004518	nuclease activity	4	7
GO:0004519	endonuclease activity	5	7
GO:0004527	exonuclease activity	5	7
GO:0016787	hydrolase activity	2	7
GO:0016788	hydrolase activity, acting on ester bonds	3	7
GO:0016791	phosphatase activity	5	7
GO:0042578	phosphoric ester hydrolase activity	4	7
GO:0004439	phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	8	1
GO:0034593	phosphatidylinositol bisphosphate phosphatase activity	7	1
GO:0034595	phosphatidylinositol phosphate 5-phosphatase activity	7	1
GO:0052866	phosphatidylinositol phosphate phosphatase activity	6	1
GO:0106019	phosphatidylinositol-4,5-bisphosphate phosphatase activity	8	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.611
CLV_C14_Caspase3-7	326	330	PF00656	0.631
CLV_C14_Caspase3-7	339	343	PF00656	0.559
CLV_C14_Caspase3-7	598	602	PF00656	0.648
CLV_C14_Caspase3-7	615	619	PF00656	0.487
CLV_NRD_NRD_1	140	142	PF00675	0.567
CLV_NRD_NRD_1	184	186	PF00675	0.533
CLV_NRD_NRD_1	388	390	PF00675	0.319
CLV_NRD_NRD_1	425	427	PF00675	0.515
CLV_NRD_NRD_1	459	461	PF00675	0.387
CLV_NRD_NRD_1	722	724	PF00675	0.400
CLV_NRD_NRD_1	731	733	PF00675	0.508
CLV_NRD_NRD_1	776	778	PF00675	0.587
CLV_NRD_NRD_1	780	782	PF00675	0.413
CLV_NRD_NRD_1	803	805	PF00675	0.462
CLV_NRD_NRD_1	893	895	PF00675	0.384
CLV_PCSK_KEX2_1	184	186	PF00082	0.533
CLV_PCSK_KEX2_1	388	390	PF00082	0.459
CLV_PCSK_KEX2_1	425	427	PF00082	0.406
CLV_PCSK_KEX2_1	458	460	PF00082	0.378
CLV_PCSK_KEX2_1	536	538	PF00082	0.543
CLV_PCSK_KEX2_1	596	598	PF00082	0.555
CLV_PCSK_KEX2_1	776	778	PF00082	0.585
CLV_PCSK_KEX2_1	780	782	PF00082	0.421
CLV_PCSK_KEX2_1	886	888	PF00082	0.435
CLV_PCSK_KEX2_1	893	895	PF00082	0.376
CLV_PCSK_PC1ET2_1	536	538	PF00082	0.543
CLV_PCSK_PC1ET2_1	596	598	PF00082	0.570
CLV_PCSK_PC1ET2_1	776	778	PF00082	0.583
CLV_PCSK_PC1ET2_1	886	888	PF00082	0.458
CLV_PCSK_SKI1_1	247	251	PF00082	0.552
CLV_PCSK_SKI1_1	537	541	PF00082	0.537
CLV_PCSK_SKI1_1	723	727	PF00082	0.411
CLV_PCSK_SKI1_1	733	737	PF00082	0.554
CLV_PCSK_SKI1_1	781	785	PF00082	0.387
CLV_PCSK_SKI1_1	818	822	PF00082	0.395
CLV_PCSK_SKI1_1	886	890	PF00082	0.353
DEG_SPOP_SBC_1	118	122	PF00917	0.529
DEG_SPOP_SBC_1	315	319	PF00917	0.503
DEG_SPOP_SBC_1	78	82	PF00917	0.518
DEG_SPOP_SBC_1	89	93	PF00917	0.517
DOC_ANK_TNKS_1	596	603	PF00023	0.549
DOC_MAPK_gen_1	425	436	PF00069	0.392
DOC_MAPK_gen_1	723	730	PF00069	0.385
DOC_MAPK_gen_1	893	899	PF00069	0.375
DOC_MAPK_MEF2A_6	104	111	PF00069	0.532
DOC_MAPK_MEF2A_6	486	495	PF00069	0.348
DOC_PP1_RVXF_1	245	252	PF00149	0.514
DOC_PP2B_LxvP_1	225	228	PF13499	0.524
DOC_PP2B_LxvP_1	765	768	PF13499	0.593
DOC_PP4_FxxP_1	352	355	PF00568	0.494
DOC_USP7_MATH_1	118	122	PF00917	0.541
DOC_USP7_MATH_1	143	147	PF00917	0.664
DOC_USP7_MATH_1	183	187	PF00917	0.647
DOC_USP7_MATH_1	229	233	PF00917	0.763
DOC_USP7_MATH_1	284	288	PF00917	0.527
DOC_USP7_MATH_1	304	308	PF00917	0.578
DOC_USP7_MATH_1	34	38	PF00917	0.615
DOC_USP7_MATH_1	416	420	PF00917	0.390
DOC_USP7_MATH_1	469	473	PF00917	0.395
DOC_USP7_MATH_1	522	526	PF00917	0.578
DOC_USP7_MATH_1	566	570	PF00917	0.618
DOC_USP7_MATH_1	575	579	PF00917	0.570
DOC_USP7_MATH_1	768	772	PF00917	0.559
DOC_USP7_MATH_1	89	93	PF00917	0.649
DOC_USP7_MATH_2	625	631	PF00917	0.577
DOC_WW_Pin1_4	114	119	PF00397	0.662
DOC_WW_Pin1_4	121	126	PF00397	0.623
DOC_WW_Pin1_4	16	21	PF00397	0.623
DOC_WW_Pin1_4	260	265	PF00397	0.648
DOC_WW_Pin1_4	333	338	PF00397	0.589
DOC_WW_Pin1_4	495	500	PF00397	0.432
DOC_WW_Pin1_4	538	543	PF00397	0.597
DOC_WW_Pin1_4	621	626	PF00397	0.632
DOC_WW_Pin1_4	677	682	PF00397	0.719
DOC_WW_Pin1_4	754	759	PF00397	0.536
DOC_WW_Pin1_4	760	765	PF00397	0.534
DOC_WW_Pin1_4	90	95	PF00397	0.532
LIG_14-3-3_CanoR_1	108	114	PF00244	0.639
LIG_14-3-3_CanoR_1	11	17	PF00244	0.566
LIG_14-3-3_CanoR_1	184	193	PF00244	0.759
LIG_14-3-3_CanoR_1	207	216	PF00244	0.567
LIG_14-3-3_CanoR_1	26	30	PF00244	0.510
LIG_14-3-3_CanoR_1	278	283	PF00244	0.578
LIG_14-3-3_CanoR_1	468	478	PF00244	0.382
LIG_14-3-3_CanoR_1	537	542	PF00244	0.654
LIG_14-3-3_CanoR_1	631	637	PF00244	0.679
LIG_14-3-3_CanoR_1	887	895	PF00244	0.466
LIG_14-3-3_CanoR_1	898	906	PF00244	0.326
LIG_14-3-3_CanoR_1	907	915	PF00244	0.237
LIG_14-3-3_CterR_2	923	927	PF00244	0.515
LIG_APCC_ABBA_1	897	902	PF00400	0.376
LIG_BIR_III_2	501	505	PF00653	0.563
LIG_BRCT_BRCA1_1	555	559	PF00533	0.608
LIG_eIF4E_1	401	407	PF01652	0.376
LIG_FHA_1	220	226	PF00498	0.654
LIG_FHA_1	292	298	PF00498	0.704
LIG_FHA_1	349	355	PF00498	0.552
LIG_FHA_1	36	42	PF00498	0.549
LIG_FHA_1	390	396	PF00498	0.427
LIG_FHA_1	426	432	PF00498	0.498
LIG_FHA_1	474	480	PF00498	0.512
LIG_FHA_1	512	518	PF00498	0.544
LIG_FHA_1	688	694	PF00498	0.352
LIG_FHA_2	233	239	PF00498	0.608
LIG_FHA_2	337	343	PF00498	0.761
LIG_FHA_2	496	502	PF00498	0.521
LIG_FHA_2	613	619	PF00498	0.592
LIG_FHA_2	631	637	PF00498	0.516
LIG_FHA_2	777	783	PF00498	0.382
LIG_FHA_2	860	866	PF00498	0.441
LIG_FHA_2	96	102	PF00498	0.632
LIG_GBD_Chelix_1	489	497	PF00786	0.358
LIG_HP1_1	913	917	PF01393	0.345
LIG_Integrin_RGD_1	364	366	PF01839	0.496
LIG_LIR_Apic_2	350	355	PF02991	0.499
LIG_LIR_Gen_1	248	258	PF02991	0.578
LIG_LIR_Gen_1	527	535	PF02991	0.554
LIG_LIR_Gen_1	680	691	PF02991	0.385
LIG_LIR_Nem_3	396	401	PF02991	0.406
LIG_LIR_Nem_3	527	532	PF02991	0.577
LIG_LIR_Nem_3	587	593	PF02991	0.620
LIG_LIR_Nem_3	680	686	PF02991	0.412
LIG_LIR_Nem_3	706	710	PF02991	0.378
LIG_Rb_pABgroove_1	912	920	PF01858	0.345
LIG_REV1ctd_RIR_1	723	731	PF16727	0.400
LIG_SH2_CRK	683	687	PF00017	0.366
LIG_SH2_CRK	707	711	PF00017	0.390
LIG_SH2_NCK_1	440	444	PF00017	0.364
LIG_SH2_NCK_1	900	904	PF00017	0.370
LIG_SH2_STAP1	853	857	PF00017	0.473
LIG_SH2_STAT3	712	715	PF00017	0.412
LIG_SH2_STAT3	809	812	PF00017	0.382
LIG_SH2_STAT5	199	202	PF00017	0.537
LIG_SH2_STAT5	380	383	PF00017	0.346
LIG_SH2_STAT5	398	401	PF00017	0.381
LIG_SH2_STAT5	417	420	PF00017	0.674
LIG_SH2_STAT5	465	468	PF00017	0.396
LIG_SH2_STAT5	809	812	PF00017	0.404
LIG_SH2_STAT5	878	881	PF00017	0.332
LIG_SH2_STAT5	900	903	PF00017	0.360
LIG_SH3_2	372	377	PF14604	0.381
LIG_SH3_3	108	114	PF00018	0.652
LIG_SH3_3	137	143	PF00018	0.683
LIG_SH3_3	147	153	PF00018	0.581
LIG_SH3_3	24	30	PF00018	0.551
LIG_SH3_3	369	375	PF00018	0.395
LIG_SH3_3	567	573	PF00018	0.612
LIG_SH3_5	195	199	PF00018	0.523
LIG_SUMO_SIM_par_1	405	411	PF11976	0.338
LIG_SUMO_SIM_par_1	493	498	PF11976	0.384
LIG_SUMO_SIM_par_1	913	919	PF11976	0.346
LIG_TRAF2_1	757	760	PF00917	0.490
MOD_CDK_SPK_2	495	500	PF00069	0.426
MOD_CDK_SPxK_1	760	766	PF00069	0.542
MOD_CDK_SPxxK_3	260	267	PF00069	0.497
MOD_CDK_SPxxK_3	90	97	PF00069	0.536
MOD_CK1_1	117	123	PF00069	0.554
MOD_CK1_1	124	130	PF00069	0.530
MOD_CK1_1	15	21	PF00069	0.672
MOD_CK1_1	232	238	PF00069	0.721
MOD_CK1_1	307	313	PF00069	0.656
MOD_CK1_1	319	325	PF00069	0.550
MOD_CK1_1	336	342	PF00069	0.627
MOD_CK1_1	562	568	PF00069	0.569
MOD_CK1_1	630	636	PF00069	0.654
MOD_CK1_1	7	13	PF00069	0.614
MOD_CK1_1	79	85	PF00069	0.560
MOD_CK1_1	92	98	PF00069	0.637
MOD_CK2_1	256	262	PF00069	0.558
MOD_CK2_1	344	350	PF00069	0.638
MOD_CK2_1	36	42	PF00069	0.502
MOD_CK2_1	416	422	PF00069	0.484
MOD_CK2_1	621	627	PF00069	0.557
MOD_CK2_1	754	760	PF00069	0.534
MOD_CK2_1	768	774	PF00069	0.555
MOD_CK2_1	859	865	PF00069	0.446
MOD_Cter_Amidation	730	733	PF01082	0.508
MOD_GlcNHglycan	131	134	PF01048	0.663
MOD_GlcNHglycan	286	289	PF01048	0.610
MOD_GlcNHglycan	394	398	PF01048	0.404
MOD_GlcNHglycan	554	558	PF01048	0.537
MOD_GlcNHglycan	564	567	PF01048	0.691
MOD_GlcNHglycan	64	67	PF01048	0.621
MOD_GlcNHglycan	71	75	PF01048	0.556
MOD_GlcNHglycan	770	773	PF01048	0.526
MOD_GlcNHglycan	854	858	PF01048	0.501
MOD_GlcNHglycan	889	892	PF01048	0.387
MOD_GSK3_1	114	121	PF00069	0.592
MOD_GSK3_1	12	19	PF00069	0.686
MOD_GSK3_1	245	252	PF00069	0.602
MOD_GSK3_1	256	263	PF00069	0.556
MOD_GSK3_1	30	37	PF00069	0.597
MOD_GSK3_1	300	307	PF00069	0.570
MOD_GSK3_1	315	322	PF00069	0.579
MOD_GSK3_1	344	351	PF00069	0.539
MOD_GSK3_1	389	396	PF00069	0.465
MOD_GSK3_1	425	432	PF00069	0.521
MOD_GSK3_1	469	476	PF00069	0.393
MOD_GSK3_1	513	520	PF00069	0.558
MOD_GSK3_1	55	62	PF00069	0.652
MOD_GSK3_1	562	569	PF00069	0.575
MOD_GSK3_1	627	634	PF00069	0.600
MOD_GSK3_1	644	651	PF00069	0.667
MOD_GSK3_1	687	694	PF00069	0.366
MOD_GSK3_1	77	84	PF00069	0.578
MOD_GSK3_1	812	819	PF00069	0.444
MOD_GSK3_1	88	95	PF00069	0.600
MOD_GSK3_1	919	926	PF00069	0.451
MOD_LATS_1	423	429	PF00433	0.354
MOD_N-GLC_1	166	171	PF02516	0.507
MOD_N-GLC_1	22	27	PF02516	0.513
MOD_N-GLC_1	278	283	PF02516	0.489
MOD_N-GLC_1	315	320	PF02516	0.572
MOD_N-GLC_1	566	571	PF02516	0.518
MOD_N-GLC_1	59	64	PF02516	0.656
MOD_N-GLC_1	602	607	PF02516	0.643
MOD_N-GLC_1	631	636	PF02516	0.584
MOD_N-GLC_1	76	81	PF02516	0.522
MOD_N-GLC_1	800	805	PF02516	0.398
MOD_N-GLC_1	866	871	PF02516	0.461
MOD_NEK2_1	119	124	PF00069	0.585
MOD_NEK2_1	173	178	PF00069	0.601
MOD_NEK2_1	250	255	PF00069	0.609
MOD_NEK2_1	272	277	PF00069	0.608
MOD_NEK2_1	300	305	PF00069	0.718
MOD_NEK2_1	493	498	PF00069	0.442
MOD_NEK2_1	545	550	PF00069	0.575
MOD_NEK2_1	559	564	PF00069	0.760
MOD_NEK2_1	687	692	PF00069	0.348
MOD_NEK2_1	787	792	PF00069	0.336
MOD_PIKK_1	184	190	PF00454	0.648
MOD_PIKK_1	256	262	PF00454	0.494
MOD_PIKK_1	4	10	PF00454	0.664
MOD_PIKK_1	408	414	PF00454	0.357
MOD_PIKK_1	429	435	PF00454	0.385
MOD_PIKK_1	648	654	PF00454	0.669
MOD_PK_1	278	284	PF00069	0.596
MOD_PKA_1	184	190	PF00069	0.529
MOD_PKA_1	425	431	PF00069	0.402
MOD_PKA_1	776	782	PF00069	0.414
MOD_PKA_1	886	892	PF00069	0.451
MOD_PKA_2	183	189	PF00069	0.660
MOD_PKA_2	218	224	PF00069	0.578
MOD_PKA_2	25	31	PF00069	0.618
MOD_PKA_2	348	354	PF00069	0.521
MOD_PKA_2	425	431	PF00069	0.402
MOD_PKA_2	552	558	PF00069	0.590
MOD_PKA_2	630	636	PF00069	0.626
MOD_PKA_2	776	782	PF00069	0.414
MOD_PKA_2	847	853	PF00069	0.469
MOD_PKA_2	886	892	PF00069	0.451
MOD_PKA_2	906	912	PF00069	0.241
MOD_PKB_1	217	225	PF00069	0.537
MOD_Plk_1	22	28	PF00069	0.515
MOD_Plk_1	278	284	PF00069	0.491
MOD_Plk_1	315	321	PF00069	0.618
MOD_Plk_1	393	399	PF00069	0.339
MOD_Plk_1	545	551	PF00069	0.585
MOD_Plk_1	566	572	PF00069	0.537
MOD_Plk_1	787	793	PF00069	0.334
MOD_Plk_2-3	741	747	PF00069	0.716
MOD_Plk_2-3	825	831	PF00069	0.354
MOD_Plk_4	545	551	PF00069	0.612
MOD_Plk_4	612	618	PF00069	0.621
MOD_Plk_4	682	688	PF00069	0.374
MOD_Plk_4	787	793	PF00069	0.334
MOD_ProDKin_1	114	120	PF00069	0.665
MOD_ProDKin_1	121	127	PF00069	0.624
MOD_ProDKin_1	16	22	PF00069	0.620
MOD_ProDKin_1	260	266	PF00069	0.649
MOD_ProDKin_1	333	339	PF00069	0.588
MOD_ProDKin_1	495	501	PF00069	0.448
MOD_ProDKin_1	538	544	PF00069	0.601
MOD_ProDKin_1	621	627	PF00069	0.632
MOD_ProDKin_1	677	683	PF00069	0.702
MOD_ProDKin_1	754	760	PF00069	0.536
MOD_ProDKin_1	90	96	PF00069	0.534
MOD_SUMO_rev_2	360	369	PF00179	0.468
MOD_SUMO_rev_2	667	676	PF00179	0.520
TRG_DiLeu_BaEn_1	589	594	PF01217	0.611
TRG_ENDOCYTIC_2	440	443	PF00928	0.357
TRG_ENDOCYTIC_2	590	593	PF00928	0.619
TRG_ENDOCYTIC_2	683	686	PF00928	0.370
TRG_ENDOCYTIC_2	707	710	PF00928	0.383
TRG_ENDOCYTIC_2	900	903	PF00928	0.360
TRG_ER_diArg_1	216	219	PF00400	0.599
TRG_ER_diArg_1	388	391	PF00400	0.362
TRG_ER_diArg_1	425	427	PF00400	0.463
TRG_ER_diArg_1	458	460	PF00400	0.432
TRG_ER_diArg_1	893	895	PF00400	0.384
TRG_NLS_Bipartite_1	871	889	PF00514	0.442
TRG_NLS_MonoExtC_3	731	737	PF00514	0.545
TRG_NLS_MonoExtC_3	775	780	PF00514	0.609
TRG_NLS_MonoExtN_4	776	781	PF00514	0.579

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEB1	Leptomonas seymouri	54%	100%
A0A3S7XAJ4	Leishmania donovani	79%	100%
A4HNX5	Leishmania braziliensis	54%	98%
A4ICL9	Leishmania infantum	79%	73%
Q4Q1W1	Leishmania major	77%	100%