Ch36-1990 protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Ch36-1990 protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ASN3_LEIMU

TriTrypDb:

LmxM.36.1130

Length:

454

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASN3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASN3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.395
CLV_NRD_NRD_1	269	271	PF00675	0.503
CLV_PCSK_KEX2_1	269	271	PF00082	0.507
CLV_PCSK_SKI1_1	233	237	PF00082	0.520
CLV_PCSK_SKI1_1	391	395	PF00082	0.589
CLV_PCSK_SKI1_1	6	10	PF00082	0.688
CLV_PCSK_SKI1_1	89	93	PF00082	0.618
DEG_APCC_DBOX_1	232	240	PF00400	0.566
DEG_Nend_UBRbox_3	1	3	PF02207	0.609
DEG_SPOP_SBC_1	52	56	PF00917	0.513
DOC_CDC14_PxL_1	135	143	PF14671	0.567
DOC_CYCLIN_RxL_1	3	12	PF00134	0.396
DOC_CYCLIN_RxL_1	332	343	PF00134	0.493
DOC_CYCLIN_yCln2_LP_2	389	395	PF00134	0.612
DOC_CYCLIN_yCln2_LP_2	91	97	PF00134	0.544
DOC_MAPK_DCC_7	194	202	PF00069	0.561
DOC_MAPK_HePTP_8	191	203	PF00069	0.485
DOC_MAPK_HePTP_8	349	361	PF00069	0.491
DOC_MAPK_MEF2A_6	194	203	PF00069	0.560
DOC_MAPK_MEF2A_6	337	346	PF00069	0.452
DOC_MAPK_MEF2A_6	352	361	PF00069	0.351
DOC_PP2B_LxvP_1	91	94	PF13499	0.571
DOC_PP4_FxxP_1	177	180	PF00568	0.553
DOC_USP7_MATH_1	148	152	PF00917	0.595
DOC_USP7_MATH_1	214	218	PF00917	0.699
DOC_USP7_MATH_1	442	446	PF00917	0.545
DOC_USP7_MATH_1	50	54	PF00917	0.543
DOC_USP7_UBL2_3	36	40	PF12436	0.287
DOC_WW_Pin1_4	150	155	PF00397	0.525
DOC_WW_Pin1_4	80	85	PF00397	0.556
LIG_14-3-3_CanoR_1	188	198	PF00244	0.522
LIG_14-3-3_CanoR_1	222	228	PF00244	0.518
LIG_14-3-3_CanoR_1	424	430	PF00244	0.672
LIG_14-3-3_CanoR_1	6	11	PF00244	0.679
LIG_Actin_WH2_2	23	38	PF00022	0.303
LIG_BRCT_BRCA1_1	160	164	PF00533	0.414
LIG_BRCT_BRCA1_1	38	42	PF00533	0.383
LIG_Clathr_ClatBox_1	359	363	PF01394	0.482
LIG_EH1_1	271	279	PF00400	0.591
LIG_eIF4E_1	272	278	PF01652	0.511
LIG_FHA_1	117	123	PF00498	0.560
LIG_FHA_1	242	248	PF00498	0.505
LIG_FHA_1	406	412	PF00498	0.506
LIG_FHA_2	417	423	PF00498	0.679
LIG_FHA_2	52	58	PF00498	0.518
LIG_FHA_2	81	87	PF00498	0.684
LIG_GBD_Chelix_1	103	111	PF00786	0.278
LIG_LIR_Gen_1	383	393	PF02991	0.513
LIG_LIR_Gen_1	39	50	PF02991	0.490
LIG_LIR_LC3C_4	358	361	PF02991	0.550
LIG_LIR_Nem_3	167	173	PF02991	0.472
LIG_LIR_Nem_3	372	376	PF02991	0.614
LIG_LIR_Nem_3	383	389	PF02991	0.422
LIG_LIR_Nem_3	39	45	PF02991	0.450
LIG_LRP6_Inhibitor_1	331	337	PF00058	0.296
LIG_LYPXL_yS_3	138	141	PF13949	0.501
LIG_MYND_3	434	438	PF01753	0.621
LIG_PDZ_Class_3	449	454	PF00595	0.720
LIG_Pex14_2	398	402	PF04695	0.611
LIG_SH2_CRK	396	400	PF00017	0.494
LIG_SH2_GRB2like	395	398	PF00017	0.462
LIG_SH2_STAT5	146	149	PF00017	0.434
LIG_SH2_STAT5	152	155	PF00017	0.444
LIG_SH2_STAT5	157	160	PF00017	0.387
LIG_SH2_STAT5	373	376	PF00017	0.529
LIG_SH3_3	133	139	PF00018	0.508
LIG_SH3_3	218	224	PF00018	0.552
LIG_SH3_3	27	33	PF00018	0.309
LIG_SH3_3	438	444	PF00018	0.665
LIG_SUMO_SIM_anti_2	358	363	PF11976	0.488
LIG_SUMO_SIM_par_1	295	301	PF11976	0.515
LIG_SUMO_SIM_par_1	337	343	PF11976	0.462
LIG_SUMO_SIM_par_1	358	363	PF11976	0.451
LIG_SxIP_EBH_1	423	436	PF03271	0.645
LIG_UBA3_1	385	394	PF00899	0.591
LIG_WRC_WIRS_1	399	404	PF05994	0.510
LIG_WRC_WIRS_1	42	47	PF05994	0.392
MOD_CK1_1	112	118	PF00069	0.497
MOD_CK1_1	340	346	PF00069	0.418
MOD_CK1_1	53	59	PF00069	0.383
MOD_CK2_1	190	196	PF00069	0.512
MOD_CK2_1	228	234	PF00069	0.554
MOD_CK2_1	443	449	PF00069	0.659
MOD_CK2_1	51	57	PF00069	0.490
MOD_CK2_1	80	86	PF00069	0.669
MOD_GlcNHglycan	205	208	PF01048	0.395
MOD_GlcNHglycan	402	405	PF01048	0.505
MOD_GlcNHglycan	445	448	PF01048	0.675
MOD_GlcNHglycan	69	72	PF01048	0.627
MOD_GSK3_1	105	112	PF00069	0.516
MOD_GSK3_1	146	153	PF00069	0.451
MOD_GSK3_1	222	229	PF00069	0.467
MOD_GSK3_1	237	244	PF00069	0.528
MOD_N-GLC_1	180	185	PF02516	0.525
MOD_N-GLC_1	189	194	PF02516	0.523
MOD_NEK2_1	158	163	PF00069	0.458
MOD_NEK2_1	203	208	PF00069	0.453
MOD_NEK2_1	238	243	PF00069	0.425
MOD_NEK2_1	322	327	PF00069	0.485
MOD_NEK2_1	34	39	PF00069	0.471
MOD_NEK2_1	398	403	PF00069	0.483
MOD_NEK2_1	8	13	PF00069	0.552
MOD_PIKK_1	158	164	PF00454	0.450
MOD_PIKK_1	405	411	PF00454	0.508
MOD_PIKK_1	416	422	PF00454	0.508
MOD_Plk_1	180	186	PF00069	0.502
MOD_Plk_4	180	186	PF00069	0.481
MOD_Plk_4	337	343	PF00069	0.429
MOD_Plk_4	355	361	PF00069	0.564
MOD_Plk_4	425	431	PF00069	0.661
MOD_ProDKin_1	150	156	PF00069	0.520
MOD_ProDKin_1	80	86	PF00069	0.570
MOD_SUMO_for_1	285	288	PF00179	0.366
TRG_DiLeu_BaEn_1	196	201	PF01217	0.456
TRG_DiLeu_BaEn_2	233	239	PF01217	0.495
TRG_DiLeu_BaLyEn_6	30	35	PF01217	0.459
TRG_ENDOCYTIC_2	138	141	PF00928	0.431
TRG_ENDOCYTIC_2	157	160	PF00928	0.465
TRG_ENDOCYTIC_2	373	376	PF00928	0.507
TRG_ENDOCYTIC_2	395	398	PF00928	0.509
TRG_ER_diArg_1	269	271	PF00400	0.503
TRG_NLS_MonoExtN_4	313	318	PF00514	0.599

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q9	Leptomonas seymouri	53%	88%
A0A0S4JAW3	Bodo saltans	26%	100%
A4HNX3	Leishmania braziliensis	75%	100%
A4ICM1	Leishmania infantum	88%	100%
H2ALR9	Leishmania donovani	88%	100%
Q4Q1W3	Leishmania major	88%	100%