Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASN2_LEIMU

TriTrypDb:

LmxM.36.1120

Length:

363

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 9
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ASN2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASN2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.382
CLV_NRD_NRD_1	142	144	PF00675	0.623
CLV_NRD_NRD_1	37	39	PF00675	0.676
CLV_PCSK_KEX2_1	37	39	PF00082	0.651
CLV_PCSK_SKI1_1	179	183	PF00082	0.604
CLV_PCSK_SKI1_1	71	75	PF00082	0.653
DEG_Nend_Nbox_1	1	3	PF02207	0.689
DEG_SPOP_SBC_1	27	31	PF00917	0.368
DOC_CKS1_1	121	126	PF01111	0.425
DOC_CYCLIN_RxL_1	175	186	PF00134	0.408
DOC_MAPK_FxFP_2	160	163	PF00069	0.431
DOC_MAPK_MEF2A_6	261	269	PF00069	0.210
DOC_PP1_RVXF_1	255	261	PF00149	0.463
DOC_PP4_FxxP_1	160	163	PF00568	0.459
DOC_PP4_FxxP_1	304	307	PF00568	0.608
DOC_USP7_MATH_1	22	26	PF00917	0.386
DOC_USP7_MATH_1	27	31	PF00917	0.385
DOC_USP7_MATH_1	288	292	PF00917	0.586
DOC_USP7_UBL2_3	222	226	PF12436	0.451
DOC_WW_Pin1_4	120	125	PF00397	0.417
DOC_WW_Pin1_4	5	10	PF00397	0.636
LIG_14-3-3_CanoR_1	184	188	PF00244	0.416
LIG_14-3-3_CanoR_1	205	210	PF00244	0.424
LIG_14-3-3_CanoR_1	244	248	PF00244	0.378
LIG_14-3-3_CanoR_1	249	258	PF00244	0.367
LIG_14-3-3_CanoR_1	278	284	PF00244	0.625
LIG_14-3-3_CanoR_1	287	296	PF00244	0.618
LIG_14-3-3_CanoR_1	3	9	PF00244	0.764
LIG_deltaCOP1_diTrp_1	153	160	PF00928	0.401
LIG_deltaCOP1_diTrp_1	165	174	PF00928	0.424
LIG_deltaCOP1_diTrp_1	309	317	PF00928	0.606
LIG_deltaCOP1_diTrp_1	328	338	PF00928	0.591
LIG_FHA_1	9	15	PF00498	0.682
LIG_FHA_2	193	199	PF00498	0.467
LIG_FHA_2	61	67	PF00498	0.414
LIG_LIR_Apic_2	134	139	PF02991	0.390
LIG_LIR_Apic_2	158	163	PF02991	0.455
LIG_LIR_Apic_2	212	216	PF02991	0.435
LIG_LIR_Gen_1	195	204	PF02991	0.472
LIG_LIR_Gen_1	82	90	PF02991	0.437
LIG_LIR_Nem_3	131	136	PF02991	0.411
LIG_LIR_Nem_3	195	200	PF02991	0.469
LIG_LIR_Nem_3	243	248	PF02991	0.332
LIG_LIR_Nem_3	82	86	PF02991	0.448
LIG_Pex14_1	51	55	PF04695	0.433
LIG_Pex14_2	266	270	PF04695	0.239
LIG_REV1ctd_RIR_1	273	282	PF16727	0.321
LIG_REV1ctd_RIR_1	70	76	PF16727	0.468
LIG_SH2_CRK	136	140	PF00017	0.392
LIG_SH2_GRB2like	332	335	PF00017	0.561
LIG_SH2_GRB2like	340	343	PF00017	0.606
LIG_SH2_NCK_1	136	140	PF00017	0.392
LIG_SH2_STAT3	332	335	PF00017	0.661
LIG_SH2_STAT3	343	346	PF00017	0.670
LIG_SH2_STAT5	132	135	PF00017	0.423
LIG_SH2_STAT5	136	139	PF00017	0.402
LIG_SH2_STAT5	230	233	PF00017	0.502
LIG_SH2_STAT5	274	277	PF00017	0.362
LIG_SH2_STAT5	33	36	PF00017	0.501
LIG_SH2_STAT5	340	343	PF00017	0.547
LIG_SH3_3	208	214	PF00018	0.442
LIG_SUMO_SIM_anti_2	11	16	PF11976	0.613
LIG_TRAF2_1	320	323	PF00917	0.601
LIG_TRAF2_1	63	66	PF00917	0.431
LIG_WRC_WIRS_1	45	50	PF05994	0.504
LIG_WW_1	215	218	PF00397	0.421
MOD_CDK_SPxK_1	120	126	PF00069	0.447
MOD_CK1_1	114	120	PF00069	0.559
MOD_CK1_1	4	10	PF00069	0.736
MOD_CK2_1	237	243	PF00069	0.388
MOD_CK2_1	60	66	PF00069	0.437
MOD_CK2_1	89	95	PF00069	0.462
MOD_CMANNOS	187	190	PF00535	0.604
MOD_GlcNHglycan	17	20	PF01048	0.556
MOD_GlcNHglycan	24	27	PF01048	0.387
MOD_GlcNHglycan	3	6	PF01048	0.525
MOD_GlcNHglycan	30	33	PF01048	0.170
MOD_GSK3_1	1	8	PF00069	0.759
MOD_GSK3_1	188	195	PF00069	0.481
MOD_GSK3_1	22	29	PF00069	0.473
MOD_GSK3_1	243	250	PF00069	0.424
MOD_GSK3_1	56	63	PF00069	0.486
MOD_GSK3_1	91	98	PF00069	0.462
MOD_LATS_1	69	75	PF00433	0.361
MOD_N-GLC_1	112	117	PF02516	0.665
MOD_NEK2_1	1	6	PF00069	0.664
MOD_NEK2_1	15	20	PF00069	0.604
MOD_NEK2_1	269	274	PF00069	0.342
MOD_NEK2_1	281	286	PF00069	0.566
MOD_PIKK_1	89	95	PF00454	0.521
MOD_PKA_2	183	189	PF00069	0.403
MOD_PKA_2	243	249	PF00069	0.374
MOD_PKA_2	60	66	PF00069	0.445
MOD_Plk_1	111	117	PF00069	0.553
MOD_Plk_4	183	189	PF00069	0.403
MOD_Plk_4	243	249	PF00069	0.447
MOD_Plk_4	269	275	PF00069	0.342
MOD_ProDKin_1	120	126	PF00069	0.416
MOD_ProDKin_1	5	11	PF00069	0.637
TRG_DiLeu_BaEn_1	234	239	PF01217	0.418
TRG_DiLeu_BaEn_2	261	267	PF01217	0.410
TRG_ENDOCYTIC_2	130	133	PF00928	0.431
TRG_ENDOCYTIC_2	230	233	PF00928	0.535
TRG_ENDOCYTIC_2	245	248	PF00928	0.302
TRG_ENDOCYTIC_2	40	43	PF00928	0.418
TRG_ENDOCYTIC_2	83	86	PF00928	0.440
TRG_ER_diArg_1	169	172	PF00400	0.460
TRG_ER_diArg_1	204	207	PF00400	0.442
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.399

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P652	Leptomonas seymouri	86%	100%
A0A0S4JBL9	Bodo saltans	62%	100%
A0A1X0P846	Trypanosomatidae	71%	100%
A0A3S7XAH0	Leishmania donovani	90%	100%
A4HNX2	Leishmania braziliensis	87%	100%
A4ICM2	Leishmania infantum	91%	100%
D0A2T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	70%	100%
Q4Q1W4	Leishmania major	94%	100%
V5BZU2	Trypanosoma cruzi	70%	97%