HORMA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HORMA domain containing protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASN1_LEIMU

TriTrypDb:

LmxM.36.1110

Length:

552

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	121	125	PF00656	0.436
CLV_NRD_NRD_1	144	146	PF00675	0.424
CLV_NRD_NRD_1	147	149	PF00675	0.398
CLV_NRD_NRD_1	524	526	PF00675	0.716
CLV_NRD_NRD_1	548	550	PF00675	0.721
CLV_PCSK_FUR_1	145	149	PF00082	0.411
CLV_PCSK_KEX2_1	146	148	PF00082	0.416
CLV_PCSK_KEX2_1	524	526	PF00082	0.716
CLV_PCSK_KEX2_1	547	549	PF00082	0.721
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.513
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.721
CLV_PCSK_PC7_1	520	526	PF00082	0.691
CLV_PCSK_SKI1_1	179	183	PF00082	0.411
CLV_PCSK_SKI1_1	43	47	PF00082	0.411
CLV_PCSK_SKI1_1	436	440	PF00082	0.410
CLV_PCSK_SKI1_1	528	532	PF00082	0.713
CLV_PCSK_SKI1_1	69	73	PF00082	0.408
CLV_PCSK_SKI1_1	93	97	PF00082	0.383
DEG_APCC_DBOX_1	76	84	PF00400	0.411
DOC_CKS1_1	273	278	PF01111	0.687
DOC_CYCLIN_RxL_1	90	98	PF00134	0.338
DOC_CYCLIN_yCln2_LP_2	387	393	PF00134	0.511
DOC_CYCLIN_yCln2_LP_2	427	433	PF00134	0.547
DOC_MAPK_MEF2A_6	43	50	PF00069	0.411
DOC_PP2B_LxvP_1	46	49	PF13499	0.407
DOC_PP4_FxxP_1	450	453	PF00568	0.545
DOC_USP7_MATH_1	129	133	PF00917	0.464
DOC_USP7_MATH_1	23	27	PF00917	0.393
DOC_USP7_MATH_1	271	275	PF00917	0.783
DOC_USP7_MATH_1	279	283	PF00917	0.702
DOC_USP7_MATH_1	293	297	PF00917	0.795
DOC_USP7_MATH_1	339	343	PF00917	0.724
DOC_USP7_MATH_1	355	359	PF00917	0.532
DOC_WW_Pin1_4	189	194	PF00397	0.411
DOC_WW_Pin1_4	272	277	PF00397	0.662
DOC_WW_Pin1_4	469	474	PF00397	0.699
LIG_14-3-3_CanoR_1	111	117	PF00244	0.411
LIG_14-3-3_CanoR_1	179	184	PF00244	0.411
LIG_14-3-3_CanoR_1	22	30	PF00244	0.407
LIG_14-3-3_CanoR_1	32	40	PF00244	0.410
LIG_14-3-3_CanoR_1	444	453	PF00244	0.613
LIG_14-3-3_CanoR_1	457	462	PF00244	0.521
LIG_14-3-3_CterR_2	548	552	PF00244	0.713
LIG_BRCT_BRCA1_1	97	101	PF00533	0.396
LIG_Clathr_ClatBox_1	493	497	PF01394	0.547
LIG_deltaCOP1_diTrp_1	65	72	PF00928	0.357
LIG_FHA_1	126	132	PF00498	0.513
LIG_FHA_1	157	163	PF00498	0.411
LIG_FHA_1	180	186	PF00498	0.411
LIG_FHA_1	304	310	PF00498	0.720
LIG_FHA_1	392	398	PF00498	0.555
LIG_FHA_1	416	422	PF00498	0.349
LIG_FHA_1	435	441	PF00498	0.369
LIG_FHA_1	498	504	PF00498	0.525
LIG_FHA_1	56	62	PF00498	0.411
LIG_FHA_1	9	15	PF00498	0.493
LIG_FHA_2	119	125	PF00498	0.436
LIG_FHA_2	148	154	PF00498	0.397
LIG_FHA_2	184	190	PF00498	0.411
LIG_FHA_2	273	279	PF00498	0.803
LIG_FHA_2	517	523	PF00498	0.477
LIG_FHA_2	60	66	PF00498	0.367
LIG_LIR_Apic_2	195	199	PF02991	0.513
LIG_LIR_Apic_2	447	453	PF02991	0.501
LIG_LIR_Apic_2	479	483	PF02991	0.468
LIG_LIR_Gen_1	186	196	PF02991	0.411
LIG_LIR_Gen_1	392	403	PF02991	0.453
LIG_LIR_Nem_3	186	191	PF02991	0.400
LIG_LIR_Nem_3	370	376	PF02991	0.321
LIG_LIR_Nem_3	392	398	PF02991	0.453
LIG_LIR_Nem_3	422	427	PF02991	0.553
LIG_NRBOX	371	377	PF00104	0.327
LIG_NRBOX	392	398	PF00104	0.453
LIG_NRBOX	498	504	PF00104	0.544
LIG_NRP_CendR_1	549	552	PF00754	0.718
LIG_Pex14_1	284	288	PF04695	0.707
LIG_SH2_CRK	424	428	PF00017	0.556
LIG_SH2_GRB2like	212	215	PF00017	0.222
LIG_SH2_NCK_1	188	192	PF00017	0.411
LIG_SH2_SRC	188	191	PF00017	0.387
LIG_SH2_SRC	196	199	PF00017	0.438
LIG_SH2_STAT5	105	108	PF00017	0.391
LIG_SH2_STAT5	395	398	PF00017	0.546
LIG_SH2_STAT5	517	520	PF00017	0.538
LIG_SH2_STAT5	79	82	PF00017	0.378
LIG_SH2_STAT5	99	102	PF00017	0.183
LIG_SH3_2	276	281	PF14604	0.813
LIG_SH3_3	270	276	PF00018	0.713
LIG_SH3_3	459	465	PF00018	0.714
LIG_SH3_3	479	485	PF00018	0.610
LIG_SH3_4	464	471	PF00018	0.649
LIG_SUMO_SIM_anti_2	437	443	PF11976	0.510
LIG_SUMO_SIM_par_1	429	434	PF11976	0.346
LIG_TRAF2_1	150	153	PF00917	0.411
LIG_TRAF2_1	334	337	PF00917	0.790
LIG_TRAF2_1	519	522	PF00917	0.653
LIG_TYR_ITSM	184	191	PF00017	0.411
MOD_CK1_1	132	138	PF00069	0.473
MOD_CK1_1	224	230	PF00069	0.411
MOD_CK1_1	26	32	PF00069	0.409
MOD_CK1_1	274	280	PF00069	0.711
MOD_CK1_1	286	292	PF00069	0.623
MOD_CK1_1	3	9	PF00069	0.599
MOD_CK1_1	434	440	PF00069	0.429
MOD_CK2_1	147	153	PF00069	0.411
MOD_CK2_1	157	163	PF00069	0.411
MOD_CK2_1	279	285	PF00069	0.711
MOD_CK2_1	340	346	PF00069	0.704
MOD_CK2_1	378	384	PF00069	0.709
MOD_CK2_1	516	522	PF00069	0.466
MOD_CK2_1	53	59	PF00069	0.353
MOD_Cter_Amidation	545	548	PF01082	0.636
MOD_GlcNHglycan	134	137	PF01048	0.513
MOD_GlcNHglycan	253	256	PF01048	0.624
MOD_GlcNHglycan	269	272	PF01048	0.765
MOD_GlcNHglycan	281	284	PF01048	0.726
MOD_GlcNHglycan	295	298	PF01048	0.604
MOD_GlcNHglycan	380	383	PF01048	0.643
MOD_GlcNHglycan	407	410	PF01048	0.678
MOD_GlcNHglycan	432	436	PF01048	0.615
MOD_GlcNHglycan	459	462	PF01048	0.554
MOD_GlcNHglycan	544	547	PF01048	0.680
MOD_GSK3_1	112	119	PF00069	0.371
MOD_GSK3_1	125	132	PF00069	0.462
MOD_GSK3_1	179	186	PF00069	0.411
MOD_GSK3_1	221	228	PF00069	0.391
MOD_GSK3_1	267	274	PF00069	0.789
MOD_GSK3_1	279	286	PF00069	0.699
MOD_GSK3_1	401	408	PF00069	0.602
MOD_GSK3_1	497	504	PF00069	0.530
MOD_GSK3_1	512	519	PF00069	0.525
MOD_GSK3_1	53	60	PF00069	0.352
MOD_GSK3_1	538	545	PF00069	0.664
MOD_N-GLC_1	103	108	PF02516	0.411
MOD_N-GLC_1	116	121	PF02516	0.411
MOD_N-GLC_1	8	13	PF02516	0.481
MOD_NEK2_1	1	6	PF00069	0.640
MOD_NEK2_1	116	121	PF00069	0.356
MOD_NEK2_1	157	162	PF00069	0.509
MOD_NEK2_1	183	188	PF00069	0.411
MOD_NEK2_1	225	230	PF00069	0.340
MOD_NEK2_1	376	381	PF00069	0.582
MOD_NEK2_1	401	406	PF00069	0.500
MOD_NEK2_1	95	100	PF00069	0.396
MOD_PIKK_1	116	122	PF00454	0.371
MOD_PIKK_1	129	135	PF00454	0.462
MOD_PIKK_1	303	309	PF00454	0.593
MOD_PIKK_1	8	14	PF00454	0.490
MOD_PKA_1	147	153	PF00069	0.411
MOD_PKA_2	147	153	PF00069	0.411
MOD_PKA_2	183	189	PF00069	0.400
MOD_PKA_2	21	27	PF00069	0.494
MOD_PKA_2	250	256	PF00069	0.661
MOD_PKA_2	443	449	PF00069	0.618
MOD_PKA_2	537	543	PF00069	0.818
MOD_PKB_1	145	153	PF00069	0.411
MOD_Plk_1	284	290	PF00069	0.682
MOD_Plk_1	391	397	PF00069	0.563
MOD_Plk_1	512	518	PF00069	0.545
MOD_Plk_1	81	87	PF00069	0.411
MOD_Plk_2-3	415	421	PF00069	0.352
MOD_Plk_2-3	59	65	PF00069	0.411
MOD_Plk_4	157	163	PF00069	0.513
MOD_Plk_4	183	189	PF00069	0.411
MOD_Plk_4	391	397	PF00069	0.488
MOD_Plk_4	434	440	PF00069	0.412
MOD_Plk_4	485	491	PF00069	0.510
MOD_Plk_4	512	518	PF00069	0.545
MOD_ProDKin_1	189	195	PF00069	0.411
MOD_ProDKin_1	272	278	PF00069	0.661
MOD_ProDKin_1	469	475	PF00069	0.693
TRG_DiLeu_BaEn_1	153	158	PF01217	0.513
TRG_DiLeu_BaEn_1	392	397	PF01217	0.455
TRG_DiLeu_BaEn_2	40	46	PF01217	0.407
TRG_DiLeu_BaLyEn_6	171	176	PF01217	0.431
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.499
TRG_DiLeu_BaLyEn_6	371	376	PF01217	0.482
TRG_DiLeu_BaLyEn_6	383	388	PF01217	0.653
TRG_ENDOCYTIC_2	188	191	PF00928	0.404
TRG_ENDOCYTIC_2	373	376	PF00928	0.425
TRG_ENDOCYTIC_2	395	398	PF00928	0.546
TRG_ENDOCYTIC_2	424	427	PF00928	0.550
TRG_ER_diArg_1	144	147	PF00400	0.411
TRG_ER_diArg_1	523	525	PF00400	0.640
TRG_NLS_MonoCore_2	144	149	PF00514	0.513
TRG_NLS_MonoCore_2	462	467	PF00514	0.653
TRG_NLS_MonoExtN_4	142	149	PF00514	0.513
TRG_NLS_MonoExtN_4	462	467	PF00514	0.641
TRG_Pf-PMV_PEXEL_1	318	323	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	32	37	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.383

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6U4	Leptomonas seymouri	55%	100%
A0A3S7XAH4	Leishmania donovani	87%	100%
A4HNX1	Leishmania braziliensis	72%	99%
A4ICM3	Leishmania infantum	88%	100%
Q4Q1W5	Leishmania major	88%	100%