Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Secreted protein

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ASM9_LEIMU

TriTrypDb:

LmxM.36.1090

Length:

153

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 6, no: 2
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	143	145	PF00675	0.632
CLV_PCSK_KEX2_1	143	145	PF00082	0.573
CLV_PCSK_SKI1_1	46	50	PF00082	0.582
DOC_CYCLIN_RxL_1	132	142	PF00134	0.358
DOC_MAPK_MEF2A_6	6	13	PF00069	0.372
DOC_USP7_MATH_1	30	34	PF00917	0.555
DOC_USP7_UBL2_3	99	103	PF12436	0.528
DOC_WW_Pin1_4	128	133	PF00397	0.470
LIG_14-3-3_CanoR_1	117	125	PF00244	0.495
LIG_14-3-3_CanoR_1	29	35	PF00244	0.477
LIG_14-3-3_CanoR_1	83	89	PF00244	0.373
LIG_EH1_1	7	15	PF00400	0.602
LIG_eIF4E_1	89	95	PF01652	0.433
LIG_FHA_1	106	112	PF00498	0.499
LIG_FHA_1	5	11	PF00498	0.573
LIG_FHA_1	59	65	PF00498	0.388
LIG_FHA_1	89	95	PF00498	0.398
LIG_LIR_Apic_2	91	96	PF02991	0.468
LIG_LIR_Gen_1	35	44	PF02991	0.497
LIG_LIR_Gen_1	7	15	PF02991	0.605
LIG_LIR_Nem_3	131	137	PF02991	0.443
LIG_LIR_Nem_3	35	41	PF02991	0.530
LIG_LIR_Nem_3	7	11	PF02991	0.527
LIG_Pex14_2	4	8	PF04695	0.538
LIG_SH2_CRK	134	138	PF00017	0.352
LIG_SH2_CRK	89	93	PF00017	0.433
LIG_SH2_NCK_1	89	93	PF00017	0.382
LIG_SH2_SRC	93	96	PF00017	0.308
LIG_SH2_STAP1	89	93	PF00017	0.382
LIG_SH2_STAT5	93	96	PF00017	0.385
LIG_WRC_WIRS_1	1	6	PF05994	0.542
LIG_WW_3	26	30	PF00397	0.560
MOD_CDK_SPxxK_3	128	135	PF00069	0.476
MOD_CK1_1	33	39	PF00069	0.436
MOD_CMANNOS	79	82	PF00535	0.425
MOD_GSK3_1	33	40	PF00069	0.525
MOD_GSK3_1	48	55	PF00069	0.425
MOD_GSK3_1	78	85	PF00069	0.408
MOD_NEK2_1	139	144	PF00069	0.550
MOD_NEK2_1	4	9	PF00069	0.630
MOD_NEK2_1	78	83	PF00069	0.481
MOD_NEK2_2	82	87	PF00069	0.387
MOD_NEK2_2	88	93	PF00069	0.393
MOD_PIKK_1	39	45	PF00454	0.386
MOD_PK_1	37	43	PF00069	0.438
MOD_PKA_2	116	122	PF00069	0.591
MOD_PKA_2	139	145	PF00069	0.505
MOD_PKA_2	82	88	PF00069	0.379
MOD_Plk_4	88	94	PF00069	0.456
MOD_ProDKin_1	128	134	PF00069	0.468
MOD_SUMO_rev_2	33	38	PF00179	0.373
MOD_SUMO_rev_2	70	78	PF00179	0.455
TRG_ENDOCYTIC_2	134	137	PF00928	0.380
TRG_ENDOCYTIC_2	89	92	PF00928	0.384
TRG_ER_diArg_1	143	145	PF00400	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R1	Leptomonas seymouri	44%	100%
A0A1X0P821	Trypanosomatidae	32%	100%
A0A3Q8IJY0	Leishmania donovani	90%	100%
A0A3R7NU99	Trypanosoma rangeli	29%	85%
A4HNW9	Leishmania braziliensis	67%	100%
A4ICM5	Leishmania infantum	90%	100%
Q4Q1W7	Leishmania major	90%	100%