RNA editing complex protein MP61

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP61

Species:

Leishmania mexicana

UniProt:

E9ASM5_LEIMU

TriTrypDb:

LmxM.36.1050

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASM5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASM5

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006396	RNA processing	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004518	nuclease activity	4	11
GO:0004519	endonuclease activity	5	11
GO:0004521	RNA endonuclease activity	5	11
GO:0004525	ribonuclease III activity	6	11
GO:0004540	RNA nuclease activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	11
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	11
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	298	302	PF00656	0.408
CLV_C14_Caspase3-7	428	432	PF00656	0.475
CLV_MEL_PAP_1	554	560	PF00089	0.572
CLV_NRD_NRD_1	112	114	PF00675	0.507
CLV_NRD_NRD_1	137	139	PF00675	0.570
CLV_NRD_NRD_1	17	19	PF00675	0.761
CLV_NRD_NRD_1	218	220	PF00675	0.393
CLV_NRD_NRD_1	221	223	PF00675	0.408
CLV_NRD_NRD_1	425	427	PF00675	0.771
CLV_NRD_NRD_1	50	52	PF00675	0.666
CLV_NRD_NRD_1	521	523	PF00675	0.672
CLV_NRD_NRD_1	78	80	PF00675	0.700
CLV_NRD_NRD_1	81	83	PF00675	0.720
CLV_PCSK_FUR_1	219	223	PF00082	0.417
CLV_PCSK_FUR_1	79	83	PF00082	0.782
CLV_PCSK_KEX2_1	112	114	PF00082	0.621
CLV_PCSK_KEX2_1	137	139	PF00082	0.479
CLV_PCSK_KEX2_1	149	151	PF00082	0.327
CLV_PCSK_KEX2_1	17	19	PF00082	0.760
CLV_PCSK_KEX2_1	220	222	PF00082	0.421
CLV_PCSK_KEX2_1	425	427	PF00082	0.767
CLV_PCSK_KEX2_1	482	484	PF00082	0.559
CLV_PCSK_KEX2_1	521	523	PF00082	0.653
CLV_PCSK_KEX2_1	78	80	PF00082	0.700
CLV_PCSK_KEX2_1	81	83	PF00082	0.720
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.405
CLV_PCSK_PC1ET2_1	220	222	PF00082	0.439
CLV_PCSK_PC1ET2_1	482	484	PF00082	0.559
CLV_PCSK_SKI1_1	137	141	PF00082	0.530
CLV_PCSK_SKI1_1	221	225	PF00082	0.473
CLV_PCSK_SKI1_1	228	232	PF00082	0.411
CLV_PCSK_SKI1_1	233	237	PF00082	0.405
CLV_PCSK_SKI1_1	268	272	PF00082	0.379
CLV_Separin_Metazoa	179	183	PF03568	0.396
DEG_APCC_DBOX_1	220	228	PF00400	0.511
DEG_APCC_DBOX_1	496	504	PF00400	0.688
DEG_Nend_UBRbox_1	1	4	PF02207	0.449
DEG_SCF_FBW7_1	447	453	PF00400	0.586
DOC_ANK_TNKS_1	482	489	PF00023	0.685
DOC_CDC14_PxL_1	205	213	PF14671	0.422
DOC_CKS1_1	447	452	PF01111	0.514
DOC_CKS1_1	59	64	PF01111	0.723
DOC_CKS1_1	96	101	PF01111	0.723
DOC_CYCLIN_yClb1_LxF_4	397	403	PF00134	0.520
DOC_CYCLIN_yCln2_LP_2	5	11	PF00134	0.550
DOC_MAPK_DCC_7	2	12	PF00069	0.535
DOC_MAPK_gen_1	219	229	PF00069	0.393
DOC_MAPK_gen_1	26	34	PF00069	0.472
DOC_MAPK_gen_1	393	402	PF00069	0.451
DOC_MAPK_gen_1	78	86	PF00069	0.482
DOC_MAPK_MEF2A_6	123	132	PF00069	0.546
DOC_MAPK_MEF2A_6	173	180	PF00069	0.381
DOC_MAPK_MEF2A_6	26	34	PF00069	0.568
DOC_MAPK_MEF2A_6	511	520	PF00069	0.639
DOC_MAPK_MEF2A_6	557	565	PF00069	0.503
DOC_MAPK_NFAT4_5	173	181	PF00069	0.380
DOC_PP1_RVXF_1	256	262	PF00149	0.394
DOC_PP2B_LxvP_1	5	8	PF13499	0.651
DOC_PP2B_LxvP_1	565	568	PF13499	0.603
DOC_PP2B_LxvP_1	93	96	PF13499	0.753
DOC_PP4_FxxP_1	59	62	PF00568	0.724
DOC_USP7_MATH_1	316	320	PF00917	0.301
DOC_USP7_MATH_1	35	39	PF00917	0.700
DOC_USP7_MATH_1	71	75	PF00917	0.572
DOC_WW_Pin1_4	132	137	PF00397	0.283
DOC_WW_Pin1_4	184	189	PF00397	0.428
DOC_WW_Pin1_4	435	440	PF00397	0.767
DOC_WW_Pin1_4	446	451	PF00397	0.494
DOC_WW_Pin1_4	552	557	PF00397	0.639
DOC_WW_Pin1_4	58	63	PF00397	0.654
DOC_WW_Pin1_4	95	100	PF00397	0.703
LIG_14-3-3_CanoR_1	198	205	PF00244	0.399
LIG_14-3-3_CanoR_1	2	6	PF00244	0.698
LIG_14-3-3_CanoR_1	26	31	PF00244	0.471
LIG_14-3-3_CanoR_1	532	538	PF00244	0.428
LIG_APCC_ABBA_1	140	145	PF00400	0.388
LIG_BRCT_BRCA1_1	252	256	PF00533	0.435
LIG_BRCT_BRCA1_1	275	279	PF00533	0.526
LIG_DLG_GKlike_1	416	424	PF00625	0.691
LIG_eIF4E_1	362	368	PF01652	0.547
LIG_FHA_1	348	354	PF00498	0.644
LIG_FHA_1	356	362	PF00498	0.590
LIG_FHA_1	382	388	PF00498	0.373
LIG_FHA_1	41	47	PF00498	0.586
LIG_FHA_1	415	421	PF00498	0.571
LIG_FHA_1	449	455	PF00498	0.694
LIG_FHA_1	553	559	PF00498	0.647
LIG_FHA_2	185	191	PF00498	0.422
LIG_FHA_2	342	348	PF00498	0.525
LIG_FHA_2	474	480	PF00498	0.727
LIG_FXI_DFP_1	143	147	PF00024	0.406
LIG_GBD_Chelix_1	329	337	PF00786	0.348
LIG_Integrin_RGD_1	426	428	PF01839	0.690
LIG_Integrin_RGDW_4	426	429	PF00362	0.692
LIG_LIR_Apic_2	433	439	PF02991	0.686
LIG_LIR_Apic_2	441	445	PF02991	0.602
LIG_LIR_Gen_1	114	122	PF02991	0.673
LIG_LIR_Gen_1	141	148	PF02991	0.385
LIG_LIR_Gen_1	193	204	PF02991	0.460
LIG_LIR_Gen_1	253	262	PF02991	0.402
LIG_LIR_Gen_1	291	297	PF02991	0.539
LIG_LIR_Gen_1	331	341	PF02991	0.505
LIG_LIR_Gen_1	475	486	PF02991	0.694
LIG_LIR_Gen_1	527	536	PF02991	0.452
LIG_LIR_Nem_3	114	118	PF02991	0.642
LIG_LIR_Nem_3	141	146	PF02991	0.395
LIG_LIR_Nem_3	193	199	PF02991	0.425
LIG_LIR_Nem_3	253	259	PF02991	0.409
LIG_LIR_Nem_3	291	296	PF02991	0.546
LIG_LIR_Nem_3	331	337	PF02991	0.348
LIG_LIR_Nem_3	475	481	PF02991	0.581
LIG_LIR_Nem_3	527	531	PF02991	0.449
LIG_NRBOX	222	228	PF00104	0.390
LIG_PCNA_yPIPBox_3	385	395	PF02747	0.524
LIG_PDZ_Class_3	575	580	PF00595	0.561
LIG_Pex14_2	111	115	PF04695	0.658
LIG_Pex14_2	139	143	PF04695	0.385
LIG_PTB_Apo_2	152	159	PF02174	0.402
LIG_SH2_CRK	436	440	PF00017	0.742
LIG_SH2_CRK	442	446	PF00017	0.734
LIG_SH2_GRB2like	478	481	PF00017	0.606
LIG_SH2_GRB2like	56	59	PF00017	0.704
LIG_SH2_STAP1	362	366	PF00017	0.533
LIG_SH2_STAP1	373	377	PF00017	0.457
LIG_SH2_STAT5	184	187	PF00017	0.443
LIG_SH2_STAT5	225	228	PF00017	0.396
LIG_SH2_STAT5	269	272	PF00017	0.371
LIG_SH2_STAT5	340	343	PF00017	0.473
LIG_SH2_STAT5	362	365	PF00017	0.515
LIG_SH3_1	442	448	PF00018	0.680
LIG_SH3_3	442	448	PF00018	0.742
LIG_SH3_3	5	11	PF00018	0.558
LIG_SH3_3	93	99	PF00018	0.638
LIG_SUMO_SIM_anti_2	498	504	PF11976	0.691
LIG_SUMO_SIM_anti_2	61	68	PF11976	0.653
LIG_SUMO_SIM_par_1	128	135	PF11976	0.589
LIG_UBA3_1	223	231	PF00899	0.394
MOD_CDC14_SPxK_1	135	138	PF00782	0.295
MOD_CDK_SPK_2	132	137	PF00069	0.283
MOD_CDK_SPK_2	435	440	PF00069	0.474
MOD_CDK_SPK_2	552	557	PF00069	0.747
MOD_CDK_SPxK_1	132	138	PF00069	0.286
MOD_CK1_1	116	122	PF00069	0.727
MOD_CK1_1	131	137	PF00069	0.494
MOD_CK1_1	247	253	PF00069	0.656
MOD_CK1_1	273	279	PF00069	0.534
MOD_CK1_1	38	44	PF00069	0.694
MOD_CK1_1	438	444	PF00069	0.710
MOD_CK2_1	184	190	PF00069	0.495
MOD_CK2_1	82	88	PF00069	0.475
MOD_Cter_Amidation	49	52	PF01082	0.744
MOD_GlcNHglycan	120	123	PF01048	0.698
MOD_GlcNHglycan	249	252	PF01048	0.549
MOD_GlcNHglycan	406	409	PF01048	0.712
MOD_GlcNHglycan	466	469	PF01048	0.515
MOD_GlcNHglycan	48	51	PF01048	0.631
MOD_GlcNHglycan	528	531	PF01048	0.692
MOD_GlcNHglycan	550	553	PF01048	0.701
MOD_GSK3_1	113	120	PF00069	0.693
MOD_GSK3_1	128	135	PF00069	0.509
MOD_GSK3_1	22	29	PF00069	0.725
MOD_GSK3_1	240	247	PF00069	0.569
MOD_GSK3_1	316	323	PF00069	0.450
MOD_GSK3_1	35	42	PF00069	0.667
MOD_GSK3_1	416	423	PF00069	0.722
MOD_GSK3_1	446	453	PF00069	0.592
MOD_GSK3_1	526	533	PF00069	0.644
MOD_GSK3_1	548	555	PF00069	0.657
MOD_N-GLC_1	154	159	PF02516	0.413
MOD_N-GLC_1	240	245	PF02516	0.583
MOD_N-GLC_1	524	529	PF02516	0.500
MOD_N-GLC_2	200	202	PF02516	0.550
MOD_NEK2_1	1	6	PF00069	0.561
MOD_NEK2_1	118	123	PF00069	0.430
MOD_NEK2_1	315	320	PF00069	0.485
MOD_NEK2_1	341	346	PF00069	0.541
MOD_NEK2_1	381	386	PF00069	0.371
MOD_NEK2_1	420	425	PF00069	0.630
MOD_NEK2_1	45	50	PF00069	0.706
MOD_NEK2_1	464	469	PF00069	0.678
MOD_NEK2_1	472	477	PF00069	0.654
MOD_NEK2_1	531	536	PF00069	0.708
MOD_NEK2_2	288	293	PF00069	0.567
MOD_NEK2_2	514	519	PF00069	0.641
MOD_PIKK_1	341	347	PF00454	0.548
MOD_PIKK_1	456	462	PF00454	0.659
MOD_PK_1	26	32	PF00069	0.568
MOD_PK_1	557	563	PF00069	0.453
MOD_PK_1	82	88	PF00069	0.475
MOD_PKA_2	1	7	PF00069	0.685
MOD_PKA_2	531	537	PF00069	0.424
MOD_Plk_1	154	160	PF00069	0.416
MOD_Plk_1	498	504	PF00069	0.732
MOD_Plk_1	524	530	PF00069	0.505
MOD_Plk_1	82	88	PF00069	0.475
MOD_Plk_4	154	160	PF00069	0.393
MOD_Plk_4	270	276	PF00069	0.423
MOD_Plk_4	329	335	PF00069	0.330
MOD_Plk_4	41	47	PF00069	0.659
MOD_Plk_4	450	456	PF00069	0.707
MOD_Plk_4	498	504	PF00069	0.614
MOD_Plk_4	61	67	PF00069	0.649
MOD_ProDKin_1	132	138	PF00069	0.286
MOD_ProDKin_1	184	190	PF00069	0.430
MOD_ProDKin_1	435	441	PF00069	0.769
MOD_ProDKin_1	446	452	PF00069	0.493
MOD_ProDKin_1	552	558	PF00069	0.636
MOD_ProDKin_1	58	64	PF00069	0.652
MOD_ProDKin_1	95	101	PF00069	0.701
MOD_SUMO_for_1	570	573	PF00179	0.673
TRG_AP2beta_CARGO_1	141	150	PF09066	0.409
TRG_DiLeu_BaEn_1	88	93	PF01217	0.688
TRG_DiLeu_BaEn_2	256	262	PF01217	0.516
TRG_DiLeu_BaLyEn_6	219	224	PF01217	0.539
TRG_ENDOCYTIC_2	307	310	PF00928	0.379
TRG_ENDOCYTIC_2	478	481	PF00928	0.580
TRG_ENDOCYTIC_2	56	59	PF00928	0.704
TRG_ER_diArg_1	111	113	PF00400	0.610
TRG_ER_diArg_1	136	138	PF00400	0.572
TRG_ER_diArg_1	16	18	PF00400	0.763
TRG_ER_diArg_1	219	222	PF00400	0.410
TRG_ER_diArg_1	520	522	PF00400	0.661
TRG_ER_diArg_1	78	81	PF00400	0.710
TRG_NLS_Bipartite_1	137	153	PF00514	0.402
TRG_NLS_MonoExtN_4	219	224	PF00514	0.395
TRG_Pf-PMV_PEXEL_1	365	369	PF00026	0.489

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3V7	Leptomonas seymouri	48%	98%
A0A1X0P9H0	Trypanosomatidae	49%	100%
A0A3R7KSN8	Trypanosoma rangeli	46%	100%
A0A3S7XAI5	Leishmania donovani	90%	99%
A4HNW5	Leishmania braziliensis	79%	100%
A4ICM9	Leishmania infantum	90%	99%
D0A2T3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
Q6T449	Leishmania major	88%	100%
V5BZU7	Trypanosoma cruzi	48%	100%