Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASM2_LEIMU

TriTrypDb:

LmxM.36.1020

Length:

546

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

E9ASM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	122	124	PF00675	0.725
CLV_NRD_NRD_1	141	143	PF00675	0.595
CLV_NRD_NRD_1	253	255	PF00675	0.651
CLV_NRD_NRD_1	338	340	PF00675	0.541
CLV_NRD_NRD_1	443	445	PF00675	0.436
CLV_NRD_NRD_1	527	529	PF00675	0.406
CLV_NRD_NRD_1	540	542	PF00675	0.406
CLV_PCSK_FUR_1	441	445	PF00082	0.462
CLV_PCSK_KEX2_1	122	124	PF00082	0.767
CLV_PCSK_KEX2_1	141	143	PF00082	0.562
CLV_PCSK_KEX2_1	253	255	PF00082	0.651
CLV_PCSK_KEX2_1	324	326	PF00082	0.546
CLV_PCSK_KEX2_1	443	445	PF00082	0.407
CLV_PCSK_KEX2_1	527	529	PF00082	0.406
CLV_PCSK_KEX2_1	539	541	PF00082	0.407
CLV_PCSK_PC1ET2_1	324	326	PF00082	0.583
CLV_PCSK_PC7_1	137	143	PF00082	0.612
CLV_PCSK_PC7_1	439	445	PF00082	0.408
CLV_PCSK_SKI1_1	221	225	PF00082	0.492
CLV_PCSK_SKI1_1	329	333	PF00082	0.553
CLV_PCSK_SKI1_1	339	343	PF00082	0.514
CLV_PCSK_SKI1_1	435	439	PF00082	0.392
CLV_PCSK_SKI1_1	460	464	PF00082	0.417
CLV_PCSK_SKI1_1	527	531	PF00082	0.386
CLV_PCSK_SKI1_1	541	545	PF00082	0.443
DEG_APCC_DBOX_1	220	228	PF00400	0.269
DEG_APCC_DBOX_1	324	332	PF00400	0.376
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SPOP_SBC_1	216	220	PF00917	0.378
DEG_SPOP_SBC_1	452	456	PF00917	0.498
DOC_ANK_TNKS_1	164	171	PF00023	0.313
DOC_CDC14_PxL_1	387	395	PF14671	0.298
DOC_CYCLIN_yCln2_LP_2	17	23	PF00134	0.635
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.325
DOC_CYCLIN_yCln2_LP_2	445	451	PF00134	0.609
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.202
DOC_MAPK_gen_1	122	130	PF00069	0.485
DOC_MAPK_gen_1	441	451	PF00069	0.676
DOC_MAPK_MEF2A_6	221	229	PF00069	0.294
DOC_MAPK_MEF2A_6	443	451	PF00069	0.716
DOC_MAPK_MEF2A_6	460	468	PF00069	0.487
DOC_MAPK_MEF2A_6	505	514	PF00069	0.229
DOC_MAPK_NFAT4_5	444	452	PF00069	0.607
DOC_MAPK_RevD_3	530	546	PF00069	0.585
DOC_PP2B_LxvP_1	225	228	PF13499	0.394
DOC_PP2B_LxvP_1	445	448	PF13499	0.616
DOC_PP2B_LxvP_1	449	452	PF13499	0.615
DOC_PP2B_LxvP_1	471	474	PF13499	0.348
DOC_PP4_FxxP_1	71	74	PF00568	0.413
DOC_USP7_MATH_1	182	186	PF00917	0.471
DOC_USP7_MATH_1	214	218	PF00917	0.443
DOC_USP7_MATH_1	260	264	PF00917	0.476
DOC_USP7_MATH_1	452	456	PF00917	0.690
DOC_USP7_UBL2_3	329	333	PF12436	0.344
DOC_WW_Pin1_4	110	115	PF00397	0.528
DOC_WW_Pin1_4	16	21	PF00397	0.615
DOC_WW_Pin1_4	256	261	PF00397	0.480
LIG_14-3-3_CanoR_1	199	206	PF00244	0.325
LIG_14-3-3_CanoR_1	31	37	PF00244	0.517
LIG_Actin_WH2_2	324	341	PF00022	0.332
LIG_APCC_ABBA_1	235	240	PF00400	0.358
LIG_APCC_ABBA_1	514	519	PF00400	0.173
LIG_BIR_III_4	157	161	PF00653	0.401
LIG_BRCT_BRCA1_1	218	222	PF00533	0.398
LIG_Clathr_ClatBox_1	515	519	PF01394	0.173
LIG_deltaCOP1_diTrp_1	58	63	PF00928	0.508
LIG_FHA_1	142	148	PF00498	0.416
LIG_FHA_1	33	39	PF00498	0.504
LIG_FHA_1	394	400	PF00498	0.395
LIG_FHA_1	420	426	PF00498	0.230
LIG_FHA_2	185	191	PF00498	0.319
LIG_FHA_2	307	313	PF00498	0.406
LIG_LIR_Apic_2	68	74	PF02991	0.414
LIG_LIR_Gen_1	174	182	PF02991	0.347
LIG_LIR_Gen_1	190	201	PF02991	0.255
LIG_LIR_Gen_1	219	230	PF02991	0.450
LIG_LIR_Gen_1	346	356	PF02991	0.298
LIG_LIR_LC3C_4	470	473	PF02991	0.355
LIG_LIR_Nem_3	174	179	PF02991	0.390
LIG_LIR_Nem_3	190	196	PF02991	0.343
LIG_LIR_Nem_3	219	225	PF02991	0.456
LIG_LIR_Nem_3	346	351	PF02991	0.403
LIG_MAD2	354	362	PF02301	0.245
LIG_MYND_1	474	478	PF01753	0.322
LIG_NRBOX	327	333	PF00104	0.371
LIG_NRBOX	464	470	PF00104	0.419
LIG_PAM2_1	360	372	PF00658	0.386
LIG_Pex14_1	59	63	PF04695	0.506
LIG_SH2_CRK	348	352	PF00017	0.324
LIG_SH2_NCK_1	348	352	PF00017	0.248
LIG_SH2_STAP1	143	147	PF00017	0.368
LIG_SH2_STAP1	348	352	PF00017	0.317
LIG_SH2_STAT5	133	136	PF00017	0.421
LIG_SH2_STAT5	143	146	PF00017	0.438
LIG_SH2_STAT5	520	523	PF00017	0.437
LIG_SH3_3	111	117	PF00018	0.552
LIG_SH3_3	408	414	PF00018	0.344
LIG_SH3_3	469	475	PF00018	0.414
LIG_SUMO_SIM_anti_2	192	198	PF11976	0.270
LIG_SUMO_SIM_anti_2	467	473	PF11976	0.355
LIG_SUMO_SIM_anti_2	511	516	PF11976	0.357
LIG_SUMO_SIM_par_1	227	232	PF11976	0.380
LIG_SUMO_SIM_par_1	33	40	PF11976	0.473
LIG_SUMO_SIM_par_1	464	470	PF11976	0.437
LIG_SUMO_SIM_par_1	508	513	PF11976	0.484
LIG_TRAF2_1	65	68	PF00917	0.476
LIG_TRAF2_1	94	97	PF00917	0.486
LIG_UBA3_1	368	376	PF00899	0.334
MOD_CK1_1	181	187	PF00069	0.462
MOD_CK1_1	19	25	PF00069	0.705
MOD_CK1_1	217	223	PF00069	0.406
MOD_CK1_1	456	462	PF00069	0.617
MOD_CK2_1	260	266	PF00069	0.470
MOD_CK2_1	273	279	PF00069	0.424
MOD_CK2_1	306	312	PF00069	0.419
MOD_CK2_1	464	470	PF00069	0.355
MOD_CMANNOS	82	85	PF00535	0.659
MOD_GlcNHglycan	180	183	PF01048	0.583
MOD_GlcNHglycan	208	211	PF01048	0.659
MOD_GlcNHglycan	21	24	PF01048	0.684
MOD_GlcNHglycan	275	278	PF01048	0.605
MOD_GlcNHglycan	381	386	PF01048	0.633
MOD_GlcNHglycan	39	42	PF01048	0.656
MOD_GlcNHglycan	455	458	PF01048	0.406
MOD_GSK3_1	178	185	PF00069	0.419
MOD_GSK3_1	201	208	PF00069	0.450
MOD_GSK3_1	212	219	PF00069	0.482
MOD_GSK3_1	256	263	PF00069	0.477
MOD_GSK3_1	30	37	PF00069	0.564
MOD_GSK3_1	303	310	PF00069	0.301
MOD_GSK3_1	393	400	PF00069	0.390
MOD_GSK3_1	452	459	PF00069	0.618
MOD_N-GLC_1	153	158	PF02516	0.626
MOD_N-GLC_1	206	211	PF02516	0.609
MOD_NEK2_1	201	206	PF00069	0.383
MOD_NEK2_1	249	254	PF00069	0.451
MOD_NEK2_1	273	278	PF00069	0.394
MOD_NEK2_1	305	310	PF00069	0.280
MOD_NEK2_1	32	37	PF00069	0.464
MOD_NEK2_1	392	397	PF00069	0.406
MOD_NEK2_1	464	469	PF00069	0.468
MOD_NEK2_2	364	369	PF00069	0.343
MOD_PIKK_1	266	272	PF00454	0.366
MOD_PIKK_1	500	506	PF00454	0.350
MOD_PKA_1	141	147	PF00069	0.480
MOD_PKA_2	141	147	PF00069	0.410
MOD_PKA_2	30	36	PF00069	0.532
MOD_PKA_2	500	506	PF00069	0.411
MOD_PKA_2	99	105	PF00069	0.504
MOD_Plk_1	148	154	PF00069	0.394
MOD_Plk_1	364	370	PF00069	0.360
MOD_Plk_4	171	177	PF00069	0.275
MOD_Plk_4	201	207	PF00069	0.313
MOD_Plk_4	364	370	PF00069	0.286
MOD_Plk_4	464	470	PF00069	0.433
MOD_Plk_4	510	516	PF00069	0.292
MOD_Plk_4	533	539	PF00069	0.610
MOD_ProDKin_1	110	116	PF00069	0.530
MOD_ProDKin_1	16	22	PF00069	0.621
MOD_ProDKin_1	256	262	PF00069	0.481
MOD_SUMO_rev_2	275	284	PF00179	0.275
MOD_SUMO_rev_2	318	326	PF00179	0.413
MOD_SUMO_rev_2	39	49	PF00179	0.464
TRG_DiLeu_BaEn_1	192	197	PF01217	0.376
TRG_DiLeu_BaEn_1	287	292	PF01217	0.277
TRG_DiLeu_BaEn_1	327	332	PF01217	0.401
TRG_DiLeu_BaEn_2	233	239	PF01217	0.313
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.421
TRG_DiLeu_LyEn_5	388	393	PF01217	0.350
TRG_ENDOCYTIC_2	348	351	PF00928	0.391
TRG_ENDOCYTIC_2	352	355	PF00928	0.390
TRG_ER_diArg_1	141	143	PF00400	0.408
TRG_ER_diArg_1	440	443	PF00400	0.624
TRG_ER_diArg_1	52	55	PF00400	0.416
TRG_ER_diArg_1	527	529	PF00400	0.607
TRG_ER_diArg_1	538	541	PF00400	0.632
TRG_NLS_Bipartite_1	324	343	PF00514	0.332
TRG_NLS_MonoExtC_3	338	343	PF00514	0.324
TRG_NLS_MonoExtN_4	337	343	PF00514	0.397
TRG_Pf-PMV_PEXEL_1	354	358	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5R2	Leptomonas seymouri	44%	98%
A0A1X0P8Z7	Trypanosomatidae	26%	97%
A0A3Q8INF1	Leishmania donovani	86%	100%
A0A3R7NN64	Trypanosoma rangeli	25%	97%
A4HNW2	Leishmania braziliensis	67%	100%
A4ICN2	Leishmania infantum	86%	100%
D0A2T0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	95%
Q4Q1X4	Leishmania major	84%	100%
V5BV13	Trypanosoma cruzi	26%	85%