Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ASL6_LEIMU

TriTrypDb:

LmxM.36.0960

Length:

915

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

E9ASL6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASL6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.334
CLV_C14_Caspase3-7	691	695	PF00656	0.653
CLV_C14_Caspase3-7	746	750	PF00656	0.675
CLV_NRD_NRD_1	386	388	PF00675	0.434
CLV_NRD_NRD_1	406	408	PF00675	0.491
CLV_NRD_NRD_1	445	447	PF00675	0.479
CLV_NRD_NRD_1	457	459	PF00675	0.401
CLV_NRD_NRD_1	483	485	PF00675	0.392
CLV_NRD_NRD_1	616	618	PF00675	0.475
CLV_NRD_NRD_1	664	666	PF00675	0.466
CLV_NRD_NRD_1	836	838	PF00675	0.428
CLV_NRD_NRD_1	866	868	PF00675	0.419
CLV_NRD_NRD_1	905	907	PF00675	0.442
CLV_NRD_NRD_1	908	910	PF00675	0.433
CLV_PCSK_FUR_1	613	617	PF00082	0.447
CLV_PCSK_FUR_1	906	910	PF00082	0.441
CLV_PCSK_KEX2_1	386	388	PF00082	0.434
CLV_PCSK_KEX2_1	406	408	PF00082	0.491
CLV_PCSK_KEX2_1	445	447	PF00082	0.476
CLV_PCSK_KEX2_1	457	459	PF00082	0.397
CLV_PCSK_KEX2_1	483	485	PF00082	0.392
CLV_PCSK_KEX2_1	615	617	PF00082	0.475
CLV_PCSK_KEX2_1	664	666	PF00082	0.466
CLV_PCSK_KEX2_1	836	838	PF00082	0.428
CLV_PCSK_KEX2_1	858	860	PF00082	0.431
CLV_PCSK_KEX2_1	868	870	PF00082	0.430
CLV_PCSK_KEX2_1	907	909	PF00082	0.443
CLV_PCSK_PC1ET2_1	858	860	PF00082	0.431
CLV_PCSK_PC1ET2_1	868	870	PF00082	0.430
CLV_PCSK_PC1ET2_1	907	909	PF00082	0.443
CLV_PCSK_PC7_1	382	388	PF00082	0.400
CLV_PCSK_SKI1_1	40	44	PF00082	0.406
CLV_PCSK_SKI1_1	470	474	PF00082	0.392
CLV_PCSK_SKI1_1	651	655	PF00082	0.462
CLV_PCSK_SKI1_1	685	689	PF00082	0.405
DEG_APCC_DBOX_1	141	149	PF00400	0.356
DEG_APCC_DBOX_1	381	389	PF00400	0.605
DEG_Nend_Nbox_1	1	3	PF02207	0.635
DEG_SCF_FBW7_1	15	22	PF00400	0.665
DEG_SPOP_SBC_1	672	676	PF00917	0.688
DOC_CKS1_1	16	21	PF01111	0.664
DOC_CKS1_1	269	274	PF01111	0.532
DOC_CKS1_1	331	336	PF01111	0.340
DOC_CYCLIN_yCln2_LP_2	252	258	PF00134	0.623
DOC_MAPK_gen_1	265	275	PF00069	0.542
DOC_MAPK_MEF2A_6	58	67	PF00069	0.198
DOC_PP2B_LxvP_1	162	165	PF13499	0.313
DOC_PP2B_LxvP_1	252	255	PF13499	0.588
DOC_PP4_FxxP_1	16	19	PF00568	0.601
DOC_PP4_FxxP_1	448	451	PF00568	0.678
DOC_PP4_FxxP_1	521	524	PF00568	0.576
DOC_PP4_FxxP_1	678	681	PF00568	0.668
DOC_USP7_MATH_1	101	105	PF00917	0.451
DOC_USP7_MATH_1	11	15	PF00917	0.604
DOC_USP7_MATH_1	223	227	PF00917	0.199
DOC_USP7_MATH_1	341	345	PF00917	0.321
DOC_USP7_MATH_1	42	46	PF00917	0.622
DOC_USP7_MATH_1	595	599	PF00917	0.596
DOC_USP7_MATH_1	672	676	PF00917	0.711
DOC_USP7_MATH_1	681	685	PF00917	0.647
DOC_USP7_MATH_1	800	804	PF00917	0.696
DOC_USP7_UBL2_3	761	765	PF12436	0.683
DOC_WW_Pin1_4	113	118	PF00397	0.408
DOC_WW_Pin1_4	15	20	PF00397	0.668
DOC_WW_Pin1_4	188	193	PF00397	0.373
DOC_WW_Pin1_4	236	241	PF00397	0.551
DOC_WW_Pin1_4	268	273	PF00397	0.545
DOC_WW_Pin1_4	330	335	PF00397	0.340
DOC_WW_Pin1_4	412	417	PF00397	0.614
DOC_WW_Pin1_4	420	425	PF00397	0.617
DOC_WW_Pin1_4	774	779	PF00397	0.628
DOC_WW_Pin1_4	792	797	PF00397	0.631
DOC_WW_Pin1_4	891	896	PF00397	0.643
DOC_WW_Pin1_4	900	905	PF00397	0.619
LIG_14-3-3_CanoR_1	193	202	PF00244	0.284
LIG_14-3-3_CanoR_1	407	417	PF00244	0.596
LIG_14-3-3_CanoR_1	457	463	PF00244	0.633
LIG_14-3-3_CanoR_1	616	622	PF00244	0.630
LIG_14-3-3_CanoR_1	625	634	PF00244	0.632
LIG_14-3-3_CanoR_1	787	793	PF00244	0.657
LIG_14-3-3_CanoR_1	798	806	PF00244	0.648
LIG_14-3-3_CanoR_1	830	835	PF00244	0.660
LIG_14-3-3_CanoR_1	869	874	PF00244	0.642
LIG_Actin_RPEL_3	261	280	PF02755	0.474
LIG_Actin_WH2_2	485	503	PF00022	0.537
LIG_BIR_III_4	105	109	PF00653	0.411
LIG_BRCT_BRCA1_1	12	16	PF00533	0.610
LIG_BRCT_BRCA1_1	424	428	PF00533	0.582
LIG_BRCT_BRCA1_1	432	436	PF00533	0.604
LIG_BRCT_BRCA1_1	490	494	PF00533	0.600
LIG_BRCT_BRCA1_1	597	601	PF00533	0.595
LIG_BRCT_BRCA1_1	674	678	PF00533	0.697
LIG_EVH1_1	16	20	PF00568	0.665
LIG_FHA_1	125	131	PF00498	0.302
LIG_FHA_1	157	163	PF00498	0.354
LIG_FHA_1	194	200	PF00498	0.341
LIG_FHA_1	20	26	PF00498	0.638
LIG_FHA_1	229	235	PF00498	0.562
LIG_FHA_1	269	275	PF00498	0.458
LIG_FHA_1	289	295	PF00498	0.211
LIG_FHA_1	349	355	PF00498	0.227
LIG_FHA_1	361	367	PF00498	0.191
LIG_FHA_1	412	418	PF00498	0.628
LIG_FHA_1	487	493	PF00498	0.578
LIG_FHA_1	546	552	PF00498	0.622
LIG_HCF-1_HBM_1	318	321	PF13415	0.283
LIG_Integrin_isoDGR_2	666	668	PF01839	0.450
LIG_LIR_Apic_2	13	19	PF02991	0.606
LIG_LIR_Apic_2	519	524	PF02991	0.543
LIG_LIR_Apic_2	675	681	PF02991	0.684
LIG_LIR_Apic_2	872	876	PF02991	0.644
LIG_LIR_Gen_1	174	185	PF02991	0.343
LIG_LIR_Gen_1	343	352	PF02991	0.282
LIG_LIR_Gen_1	482	492	PF02991	0.602
LIG_LIR_Gen_1	656	663	PF02991	0.589
LIG_LIR_Gen_1	846	854	PF02991	0.682
LIG_LIR_Nem_3	118	124	PF02991	0.393
LIG_LIR_Nem_3	174	180	PF02991	0.331
LIG_LIR_Nem_3	239	244	PF02991	0.630
LIG_LIR_Nem_3	318	323	PF02991	0.321
LIG_LIR_Nem_3	343	348	PF02991	0.282
LIG_LIR_Nem_3	41	46	PF02991	0.593
LIG_LIR_Nem_3	467	472	PF02991	0.669
LIG_LIR_Nem_3	491	497	PF02991	0.588
LIG_LIR_Nem_3	656	661	PF02991	0.585
LIG_LIR_Nem_3	846	850	PF02991	0.678
LIG_MLH1_MIPbox_1	433	437	PF16413	0.616
LIG_NRBOX	210	216	PF00104	0.234
LIG_NRBOX	467	473	PF00104	0.536
LIG_PCNA_PIPBox_1	260	269	PF02747	0.553
LIG_Pex14_1	39	43	PF04695	0.628
LIG_Pex14_1	847	851	PF04695	0.652
LIG_Pex14_2	60	64	PF04695	0.199
LIG_SH2_CRK	258	262	PF00017	0.512
LIG_SH2_CRK	469	473	PF00017	0.595
LIG_SH2_NCK_1	172	176	PF00017	0.352
LIG_SH2_NCK_1	321	325	PF00017	0.347
LIG_SH2_PTP2	345	348	PF00017	0.289
LIG_SH2_SRC	172	175	PF00017	0.355
LIG_SH2_SRC	177	180	PF00017	0.333
LIG_SH2_SRC	253	256	PF00017	0.542
LIG_SH2_SRC	720	723	PF00017	0.663
LIG_SH2_STAP1	177	181	PF00017	0.272
LIG_SH2_STAT3	337	340	PF00017	0.299
LIG_SH2_STAT5	179	182	PF00017	0.358
LIG_SH2_STAT5	253	256	PF00017	0.564
LIG_SH2_STAT5	345	348	PF00017	0.321
LIG_SH2_STAT5	485	488	PF00017	0.576
LIG_SH2_STAT5	56	59	PF00017	0.459
LIG_SH3_3	14	20	PF00018	0.667
LIG_SH3_3	328	334	PF00018	0.347
LIG_SUMO_SIM_anti_2	207	213	PF11976	0.319
LIG_SUMO_SIM_anti_2	771	777	PF11976	0.613
LIG_SUMO_SIM_par_1	216	221	PF11976	0.240
LIG_SUMO_SIM_par_1	271	276	PF11976	0.458
LIG_SUMO_SIM_par_1	294	299	PF11976	0.198
LIG_SUMO_SIM_par_1	414	420	PF11976	0.654
LIG_TRAF2_1	171	174	PF00917	0.358
LIG_TRAF2_1	477	480	PF00917	0.621
LIG_Vh1_VBS_1	204	222	PF01044	0.199
LIG_WRC_WIRS_1	349	354	PF05994	0.289
MOD_CDC14_SPxK_1	795	798	PF00782	0.502
MOD_CDC14_SPxK_1	903	906	PF00782	0.488
MOD_CDK_SPK_2	188	193	PF00069	0.375
MOD_CDK_SPK_2	330	335	PF00069	0.403
MOD_CDK_SPxK_1	792	798	PF00069	0.501
MOD_CDK_SPxK_1	900	906	PF00069	0.494
MOD_CDK_SPxxK_3	188	195	PF00069	0.432
MOD_CDK_SPxxK_3	900	907	PF00069	0.495
MOD_CK1_1	207	213	PF00069	0.281
MOD_CK1_1	236	242	PF00069	0.504
MOD_CK1_1	288	294	PF00069	0.333
MOD_CK1_1	402	408	PF00069	0.508
MOD_CK1_1	411	417	PF00069	0.534
MOD_CK1_1	420	426	PF00069	0.529
MOD_CK1_1	676	682	PF00069	0.630
MOD_CK1_1	68	74	PF00069	0.321
MOD_CK1_1	745	751	PF00069	0.506
MOD_CK1_1	779	785	PF00069	0.539
MOD_CK1_1	788	794	PF00069	0.519
MOD_CK1_1	835	841	PF00069	0.609
MOD_CK1_1	879	885	PF00069	0.559
MOD_CK1_1	891	897	PF00069	0.507
MOD_CK1_1	900	906	PF00069	0.514
MOD_CK1_1	96	102	PF00069	0.557
MOD_CK2_1	35	41	PF00069	0.430
MOD_CK2_1	654	660	PF00069	0.523
MOD_Cter_Amidation	865	868	PF01082	0.515
MOD_GlcNHglycan	124	127	PF01048	0.303
MOD_GlcNHglycan	148	151	PF01048	0.584
MOD_GlcNHglycan	206	209	PF01048	0.344
MOD_GlcNHglycan	27	30	PF01048	0.521
MOD_GlcNHglycan	275	278	PF01048	0.357
MOD_GlcNHglycan	354	357	PF01048	0.321
MOD_GlcNHglycan	395	398	PF01048	0.461
MOD_GlcNHglycan	401	404	PF01048	0.492
MOD_GlcNHglycan	410	413	PF01048	0.526
MOD_GlcNHglycan	628	631	PF01048	0.550
MOD_GlcNHglycan	690	693	PF01048	0.576
MOD_GlcNHglycan	694	698	PF01048	0.557
MOD_GlcNHglycan	70	73	PF01048	0.321
MOD_GlcNHglycan	711	714	PF01048	0.593
MOD_GlcNHglycan	753	757	PF01048	0.706
MOD_GlcNHglycan	778	781	PF01048	0.635
MOD_GlcNHglycan	841	844	PF01048	0.753
MOD_GlcNHglycan	879	882	PF01048	0.557
MOD_GSK3_1	107	114	PF00069	0.458
MOD_GSK3_1	11	18	PF00069	0.562
MOD_GSK3_1	156	163	PF00069	0.399
MOD_GSK3_1	191	198	PF00069	0.446
MOD_GSK3_1	284	291	PF00069	0.297
MOD_GSK3_1	292	299	PF00069	0.302
MOD_GSK3_1	348	355	PF00069	0.212
MOD_GSK3_1	402	409	PF00069	0.601
MOD_GSK3_1	422	429	PF00069	0.467
MOD_GSK3_1	48	55	PF00069	0.453
MOD_GSK3_1	597	604	PF00069	0.523
MOD_GSK3_1	617	624	PF00069	0.530
MOD_GSK3_1	672	679	PF00069	0.640
MOD_GSK3_1	688	695	PF00069	0.555
MOD_GSK3_1	764	771	PF00069	0.700
MOD_GSK3_1	776	783	PF00069	0.671
MOD_GSK3_1	788	795	PF00069	0.519
MOD_GSK3_1	835	842	PF00069	0.607
MOD_GSK3_1	876	883	PF00069	0.559
MOD_GSK3_1	893	900	PF00069	0.489
MOD_LATS_1	623	629	PF00433	0.558
MOD_N-GLC_1	111	116	PF02516	0.442
MOD_N-GLC_1	329	334	PF02516	0.447
MOD_N-GLC_1	412	417	PF02516	0.527
MOD_N-GLC_1	644	649	PF02516	0.397
MOD_N-GLC_1	768	773	PF02516	0.548
MOD_N-GLC_1	839	844	PF02516	0.597
MOD_N-GLC_1	860	865	PF02516	0.515
MOD_N-GLC_1	96	101	PF02516	0.571
MOD_N-GLC_2	509	511	PF02516	0.390
MOD_N-GLC_2	705	707	PF02516	0.573
MOD_NEK2_1	107	112	PF00069	0.669
MOD_NEK2_1	124	129	PF00069	0.307
MOD_NEK2_1	140	145	PF00069	0.404
MOD_NEK2_1	218	223	PF00069	0.267
MOD_NEK2_1	233	238	PF00069	0.465
MOD_NEK2_1	273	278	PF00069	0.278
MOD_NEK2_1	285	290	PF00069	0.273
MOD_NEK2_1	292	297	PF00069	0.382
MOD_NEK2_1	298	303	PF00069	0.386
MOD_NEK2_1	323	328	PF00069	0.450
MOD_NEK2_1	352	357	PF00069	0.436
MOD_NEK2_1	417	422	PF00069	0.585
MOD_NEK2_1	488	493	PF00069	0.474
MOD_NEK2_1	597	602	PF00069	0.512
MOD_NEK2_1	621	626	PF00069	0.488
MOD_NEK2_1	644	649	PF00069	0.462
MOD_NEK2_1	654	659	PF00069	0.514
MOD_NEK2_1	752	757	PF00069	0.588
MOD_NEK2_1	786	791	PF00069	0.557
MOD_NEK2_1	899	904	PF00069	0.496
MOD_NEK2_2	11	16	PF00069	0.495
MOD_PIKK_1	193	199	PF00454	0.384
MOD_PIKK_1	296	302	PF00454	0.306
MOD_PIKK_1	422	428	PF00454	0.555
MOD_PIKK_1	470	476	PF00454	0.397
MOD_PIKK_1	530	536	PF00454	0.480
MOD_PIKK_1	560	566	PF00454	0.558
MOD_PIKK_1	635	641	PF00454	0.416
MOD_PIKK_1	800	806	PF00454	0.611
MOD_PIKK_1	880	886	PF00454	0.507
MOD_PK_1	458	464	PF00069	0.513
MOD_PKA_1	406	412	PF00069	0.607
MOD_PKA_1	616	622	PF00069	0.557
MOD_PKA_2	406	412	PF00069	0.607
MOD_PKA_2	616	622	PF00069	0.561
MOD_PKA_2	786	792	PF00069	0.570
MOD_PKA_2	835	841	PF00069	0.519
MOD_PKB_1	615	623	PF00069	0.467
MOD_PKB_1	867	875	PF00069	0.546
MOD_Plk_1	173	179	PF00069	0.392
MOD_Plk_1	644	650	PF00069	0.489
MOD_Plk_1	768	774	PF00069	0.548
MOD_Plk_1	886	892	PF00069	0.549
MOD_Plk_1	96	102	PF00069	0.568
MOD_Plk_2-3	173	179	PF00069	0.303
MOD_Plk_2-3	768	774	PF00069	0.507
MOD_Plk_4	11	17	PF00069	0.579
MOD_Plk_4	115	121	PF00069	0.500
MOD_Plk_4	207	213	PF00069	0.282
MOD_Plk_4	223	229	PF00069	0.282
MOD_Plk_4	341	347	PF00069	0.369
MOD_Plk_4	52	58	PF00069	0.410
MOD_Plk_4	846	852	PF00069	0.526
MOD_Plk_4	860	866	PF00069	0.551
MOD_ProDKin_1	113	119	PF00069	0.490
MOD_ProDKin_1	15	21	PF00069	0.580
MOD_ProDKin_1	188	194	PF00069	0.455
MOD_ProDKin_1	236	242	PF00069	0.420
MOD_ProDKin_1	268	274	PF00069	0.402
MOD_ProDKin_1	330	336	PF00069	0.405
MOD_ProDKin_1	412	418	PF00069	0.506
MOD_ProDKin_1	420	426	PF00069	0.510
MOD_ProDKin_1	774	780	PF00069	0.525
MOD_ProDKin_1	792	798	PF00069	0.534
MOD_ProDKin_1	891	897	PF00069	0.546
MOD_ProDKin_1	900	906	PF00069	0.514
TRG_DiLeu_BaEn_1	467	472	PF01217	0.490
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.383
TRG_DiLeu_BaLyEn_6	413	418	PF01217	0.477
TRG_DiLeu_LyEn_5	467	472	PF01217	0.490
TRG_ENDOCYTIC_2	137	140	PF00928	0.373
TRG_ENDOCYTIC_2	177	180	PF00928	0.395
TRG_ENDOCYTIC_2	241	244	PF00928	0.441
TRG_ENDOCYTIC_2	258	261	PF00928	0.352
TRG_ENDOCYTIC_2	345	348	PF00928	0.321
TRG_ENDOCYTIC_2	469	472	PF00928	0.599
TRG_ENDOCYTIC_2	485	488	PF00928	0.496
TRG_ER_diArg_1	141	144	PF00400	0.424
TRG_ER_diArg_1	385	387	PF00400	0.503
TRG_ER_diArg_1	457	460	PF00400	0.494
TRG_ER_diArg_1	483	485	PF00400	0.474
TRG_ER_diArg_1	613	616	PF00400	0.583
TRG_ER_diArg_1	663	665	PF00400	0.568
TRG_ER_diArg_1	867	870	PF00400	0.509
TRG_ER_diArg_1	905	908	PF00400	0.548
TRG_NES_CRM1_1	508	519	PF08389	0.423
TRG_NLS_Bipartite_1	857	871	PF00514	0.511
TRG_Pf-PMV_PEXEL_1	470	474	PF00026	0.475
TRG_Pf-PMV_PEXEL_1	580	584	PF00026	0.399
TRG_Pf-PMV_PEXEL_1	728	732	PF00026	0.609

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1X5	Leptomonas seymouri	32%	100%
A0A3S7XAF2	Leishmania donovani	77%	100%
A4HNV5	Leishmania braziliensis	49%	100%
A4ICN8	Leishmania infantum	77%	100%
Q4Q1Y0	Leishmania major	75%	100%