RNA editing complex protein MP67

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA editing complex protein MP67

Species:

Leishmania mexicana

UniProt:

E9ASL2_LEIMU

TriTrypDb:

LmxM.36.0920

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASL2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASL2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006396	RNA processing	6	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0016070	RNA metabolic process	5	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0043170	macromolecule metabolic process	3	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0046483	heterocycle metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0090304	nucleic acid metabolic process	4	10
GO:1901360	organic cyclic compound metabolic process	3	10

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004518	nuclease activity	4	10
GO:0004519	endonuclease activity	5	10
GO:0004521	RNA endonuclease activity	5	10
GO:0004525	ribonuclease III activity	6	10
GO:0004540	RNA nuclease activity	4	10
GO:0016787	hydrolase activity	2	10
GO:0016788	hydrolase activity, acting on ester bonds	3	10
GO:0016891	RNA endonuclease activity, producing 5'-phosphomonoesters	6	10
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	10
GO:0032296	double-stranded RNA-specific ribonuclease activity	5	10
GO:0140098	catalytic activity, acting on RNA	3	10
GO:0140640	catalytic activity, acting on a nucleic acid	2	10
GO:0004129	cytochrome-c oxidase activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0009055	electron transfer activity	3	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016491	oxidoreductase activity	2	2
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	16	18	PF00675	0.651
CLV_NRD_NRD_1	169	171	PF00675	0.562
CLV_NRD_NRD_1	181	183	PF00675	0.512
CLV_NRD_NRD_1	201	203	PF00675	0.447
CLV_NRD_NRD_1	402	404	PF00675	0.649
CLV_NRD_NRD_1	432	434	PF00675	0.705
CLV_NRD_NRD_1	439	441	PF00675	0.701
CLV_NRD_NRD_1	462	464	PF00675	0.740
CLV_NRD_NRD_1	576	578	PF00675	0.742
CLV_PCSK_FUR_1	199	203	PF00082	0.288
CLV_PCSK_FUR_1	403	407	PF00082	0.438
CLV_PCSK_KEX2_1	109	111	PF00082	0.786
CLV_PCSK_KEX2_1	169	171	PF00082	0.433
CLV_PCSK_KEX2_1	181	183	PF00082	0.541
CLV_PCSK_KEX2_1	201	203	PF00082	0.545
CLV_PCSK_KEX2_1	37	39	PF00082	0.535
CLV_PCSK_KEX2_1	398	400	PF00082	0.596
CLV_PCSK_KEX2_1	402	404	PF00082	0.627
CLV_PCSK_KEX2_1	405	407	PF00082	0.631
CLV_PCSK_KEX2_1	431	433	PF00082	0.696
CLV_PCSK_KEX2_1	439	441	PF00082	0.696
CLV_PCSK_KEX2_1	576	578	PF00082	0.742
CLV_PCSK_KEX2_1	76	78	PF00082	0.510
CLV_PCSK_PC1ET2_1	109	111	PF00082	0.791
CLV_PCSK_PC1ET2_1	37	39	PF00082	0.611
CLV_PCSK_PC1ET2_1	398	400	PF00082	0.458
CLV_PCSK_PC1ET2_1	405	407	PF00082	0.469
CLV_PCSK_PC1ET2_1	76	78	PF00082	0.510
CLV_PCSK_SKI1_1	109	113	PF00082	0.805
CLV_PCSK_SKI1_1	148	152	PF00082	0.663
CLV_PCSK_SKI1_1	206	210	PF00082	0.406
CLV_PCSK_SKI1_1	215	219	PF00082	0.393
CLV_PCSK_SKI1_1	25	29	PF00082	0.624
CLV_PCSK_SKI1_1	257	261	PF00082	0.535
CLV_PCSK_SKI1_1	327	331	PF00082	0.506
CLV_PCSK_SKI1_1	402	406	PF00082	0.502
CLV_PCSK_SKI1_1	419	423	PF00082	0.520
CLV_PCSK_SKI1_1	548	552	PF00082	0.708
CLV_PCSK_SKI1_1	71	75	PF00082	0.480
DEG_APCC_DBOX_1	205	213	PF00400	0.444
DEG_APCC_DBOX_1	547	555	PF00400	0.707
DEG_SPOP_SBC_1	570	574	PF00917	0.803
DOC_CDC14_PxL_1	420	428	PF14671	0.611
DOC_CYCLIN_yCln2_LP_2	422	425	PF00134	0.481
DOC_MAPK_gen_1	156	166	PF00069	0.320
DOC_MAPK_gen_1	181	187	PF00069	0.692
DOC_MAPK_gen_1	201	211	PF00069	0.413
DOC_MAPK_gen_1	431	438	PF00069	0.691
DOC_MAPK_gen_1	439	445	PF00069	0.630
DOC_MAPK_gen_1	76	83	PF00069	0.560
DOC_MAPK_MEF2A_6	159	168	PF00069	0.549
DOC_MAPK_MEF2A_6	431	438	PF00069	0.684
DOC_MAPK_MEF2A_6	76	85	PF00069	0.568
DOC_PP1_RVXF_1	325	332	PF00149	0.502
DOC_PP2B_LxvP_1	422	425	PF13499	0.457
DOC_USP7_MATH_1	102	106	PF00917	0.674
DOC_USP7_MATH_1	125	129	PF00917	0.677
DOC_USP7_MATH_1	434	438	PF00917	0.664
DOC_USP7_MATH_1	467	471	PF00917	0.735
DOC_USP7_MATH_1	518	522	PF00917	0.749
DOC_USP7_MATH_1	96	100	PF00917	0.674
DOC_WW_Pin1_4	118	123	PF00397	0.762
DOC_WW_Pin1_4	134	139	PF00397	0.565
DOC_WW_Pin1_4	257	262	PF00397	0.561
DOC_WW_Pin1_4	454	459	PF00397	0.679
DOC_WW_Pin1_4	528	533	PF00397	0.763
DOC_WW_Pin1_4	534	539	PF00397	0.693
DOC_WW_Pin1_4	563	568	PF00397	0.675
DOC_WW_Pin1_4	89	94	PF00397	0.667
LIG_14-3-3_CanoR_1	110	116	PF00244	0.755
LIG_14-3-3_CanoR_1	154	159	PF00244	0.653
LIG_14-3-3_CanoR_1	17	27	PF00244	0.550
LIG_14-3-3_CanoR_1	182	188	PF00244	0.552
LIG_14-3-3_CanoR_1	189	194	PF00244	0.355
LIG_14-3-3_CanoR_1	219	225	PF00244	0.595
LIG_14-3-3_CanoR_1	263	268	PF00244	0.479
LIG_14-3-3_CanoR_1	348	354	PF00244	0.581
LIG_14-3-3_CanoR_1	563	567	PF00244	0.601
LIG_14-3-3_CanoR_1	571	578	PF00244	0.676
LIG_Actin_WH2_2	371	389	PF00022	0.527
LIG_Actin_WH2_2	62	78	PF00022	0.351
LIG_BRCT_BRCA1_1	107	111	PF00533	0.783
LIG_BRCT_BRCA1_1	136	140	PF00533	0.613
LIG_BRCT_BRCA1_1	183	187	PF00533	0.686
LIG_eIF4E_1	134	140	PF01652	0.623
LIG_FHA_1	274	280	PF00498	0.454
LIG_FHA_1	331	337	PF00498	0.609
LIG_FHA_1	537	543	PF00498	0.517
LIG_FHA_1	573	579	PF00498	0.758
LIG_FHA_2	155	161	PF00498	0.604
LIG_FHA_2	26	32	PF00498	0.602
LIG_FHA_2	359	365	PF00498	0.450
LIG_FHA_2	387	393	PF00498	0.584
LIG_FHA_2	82	88	PF00498	0.599
LIG_HP1_1	70	74	PF01393	0.540
LIG_LIR_Apic_2	340	345	PF02991	0.653
LIG_LIR_Gen_1	128	138	PF02991	0.696
LIG_LIR_Gen_1	160	168	PF02991	0.582
LIG_LIR_Gen_1	184	193	PF02991	0.606
LIG_LIR_Gen_1	243	251	PF02991	0.525
LIG_LIR_Nem_3	128	133	PF02991	0.671
LIG_LIR_Nem_3	160	164	PF02991	0.529
LIG_LIR_Nem_3	184	190	PF02991	0.580
LIG_LIR_Nem_3	243	248	PF02991	0.533
LIG_LIR_Nem_3	253	259	PF02991	0.517
LIG_LIR_Nem_3	297	301	PF02991	0.393
LIG_LIR_Nem_3	340	344	PF02991	0.603
LIG_LIR_Nem_3	391	396	PF02991	0.376
LIG_MAD2	25	33	PF02301	0.655
LIG_NRBOX	325	331	PF00104	0.494
LIG_Pex14_1	203	207	PF04695	0.434
LIG_Pex14_1	337	341	PF04695	0.674
LIG_REV1ctd_RIR_1	252	260	PF16727	0.531
LIG_RPA_C_Fungi	197	209	PF08784	0.561
LIG_SH2_CRK	152	156	PF00017	0.641
LIG_SH2_CRK	296	300	PF00017	0.500
LIG_SH2_CRK	342	346	PF00017	0.688
LIG_SH2_CRK	420	424	PF00017	0.608
LIG_SH2_NCK_1	342	346	PF00017	0.688
LIG_SH2_SRC	134	137	PF00017	0.675
LIG_SH2_STAP1	41	45	PF00017	0.527
LIG_SH2_STAP1	59	63	PF00017	0.293
LIG_SH2_STAT5	207	210	PF00017	0.501
LIG_SH2_STAT5	281	284	PF00017	0.445
LIG_SH2_STAT5	298	301	PF00017	0.341
LIG_SH2_STAT5	353	356	PF00017	0.432
LIG_SH2_STAT5	39	42	PF00017	0.419
LIG_SH2_STAT5	393	396	PF00017	0.619
LIG_SH3_2	458	463	PF14604	0.777
LIG_SH3_3	119	125	PF00018	0.685
LIG_SH3_3	452	458	PF00018	0.683
LIG_SH3_3	520	526	PF00018	0.746
LIG_SH3_3	90	96	PF00018	0.714
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.523
LIG_SUMO_SIM_par_1	188	197	PF11976	0.575
LIG_SUMO_SIM_par_1	291	297	PF11976	0.450
LIG_TRAF2_1	389	392	PF00917	0.543
LIG_TRAF2_1	9	12	PF00917	0.721
LIG_TRFH_1	420	424	PF08558	0.519
LIG_UBA3_1	208	213	PF00899	0.535
LIG_WRC_WIRS_1	82	87	PF05994	0.554
LIG_WW_3	178	182	PF00397	0.606
MOD_CDK_SPxK_1	257	263	PF00069	0.556
MOD_CK1_1	105	111	PF00069	0.616
MOD_CK1_1	116	122	PF00069	0.712
MOD_CK1_1	192	198	PF00069	0.470
MOD_CK1_1	220	226	PF00069	0.536
MOD_CK1_1	450	456	PF00069	0.780
MOD_CK1_1	512	518	PF00069	0.694
MOD_CK1_1	537	543	PF00069	0.757
MOD_CK1_1	58	64	PF00069	0.547
MOD_CK1_1	91	97	PF00069	0.706
MOD_CK2_1	101	107	PF00069	0.678
MOD_CK2_1	154	160	PF00069	0.614
MOD_CK2_1	18	24	PF00069	0.492
MOD_CK2_1	191	197	PF00069	0.613
MOD_CK2_1	358	364	PF00069	0.441
MOD_CK2_1	386	392	PF00069	0.522
MOD_CK2_1	81	87	PF00069	0.574
MOD_DYRK1A_RPxSP_1	563	567	PF00069	0.471
MOD_GlcNHglycan	104	107	PF01048	0.627
MOD_GlcNHglycan	414	417	PF01048	0.495
MOD_GlcNHglycan	489	492	PF01048	0.478
MOD_GlcNHglycan	511	514	PF01048	0.665
MOD_GSK3_1	101	108	PF00069	0.709
MOD_GSK3_1	114	121	PF00069	0.750
MOD_GSK3_1	189	196	PF00069	0.455
MOD_GSK3_1	450	457	PF00069	0.704
MOD_GSK3_1	487	494	PF00069	0.560
MOD_GSK3_1	499	506	PF00069	0.618
MOD_GSK3_1	524	531	PF00069	0.679
MOD_GSK3_1	58	65	PF00069	0.565
MOD_GSK3_1	87	94	PF00069	0.522
MOD_N-GLC_1	102	107	PF02516	0.500
MOD_NEK2_1	111	116	PF00069	0.726
MOD_NEK2_1	191	196	PF00069	0.537
MOD_NEK2_1	211	216	PF00069	0.471
MOD_NEK2_1	255	260	PF00069	0.498
MOD_NEK2_1	365	370	PF00069	0.498
MOD_NEK2_1	374	379	PF00069	0.459
MOD_NEK2_1	449	454	PF00069	0.589
MOD_NEK2_1	499	504	PF00069	0.650
MOD_NEK2_1	55	60	PF00069	0.504
MOD_NEK2_1	569	574	PF00069	0.632
MOD_NEK2_1	75	80	PF00069	0.221
MOD_NEK2_1	81	86	PF00069	0.492
MOD_NEK2_2	434	439	PF00069	0.580
MOD_PIKK_1	18	24	PF00454	0.331
MOD_PIKK_1	501	507	PF00454	0.653
MOD_PKA_1	181	187	PF00069	0.692
MOD_PKA_1	485	491	PF00069	0.617
MOD_PKA_2	181	187	PF00069	0.692
MOD_PKA_2	347	353	PF00069	0.592
MOD_PKA_2	450	456	PF00069	0.728
MOD_PKA_2	562	568	PF00069	0.751
MOD_PKA_2	570	576	PF00069	0.723
MOD_Plk_1	434	440	PF00069	0.465
MOD_Plk_4	263	269	PF00069	0.514
MOD_Plk_4	365	371	PF00069	0.504
MOD_Plk_4	537	543	PF00069	0.673
MOD_Plk_4	81	87	PF00069	0.514
MOD_ProDKin_1	118	124	PF00069	0.758
MOD_ProDKin_1	134	140	PF00069	0.561
MOD_ProDKin_1	257	263	PF00069	0.556
MOD_ProDKin_1	454	460	PF00069	0.678
MOD_ProDKin_1	528	534	PF00069	0.762
MOD_ProDKin_1	563	569	PF00069	0.678
MOD_ProDKin_1	89	95	PF00069	0.681
MOD_SUMO_rev_2	104	111	PF00179	0.497
MOD_SUMO_rev_2	320	329	PF00179	0.518
TRG_DiLeu_BaEn_1	325	330	PF01217	0.488
TRG_DiLeu_BaEn_2	106	112	PF01217	0.498
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.634
TRG_DiLeu_BaLyEn_6	422	427	PF01217	0.572
TRG_ENDOCYTIC_2	296	299	PF00928	0.369
TRG_ENDOCYTIC_2	341	344	PF00928	0.581
TRG_ENDOCYTIC_2	393	396	PF00928	0.374
TRG_ENDOCYTIC_2	420	423	PF00928	0.611
TRG_ER_diArg_1	168	170	PF00400	0.562
TRG_ER_diArg_1	180	182	PF00400	0.513
TRG_ER_diArg_1	198	201	PF00400	0.454
TRG_ER_diArg_1	203	206	PF00400	0.396
TRG_ER_diArg_1	431	433	PF00400	0.713
TRG_ER_diArg_1	438	440	PF00400	0.739
TRG_ER_diArg_1	576	578	PF00400	0.745
TRG_Pf-PMV_PEXEL_1	156	160	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V7	Leptomonas seymouri	40%	92%
A0A1X0P8F1	Trypanosomatidae	36%	90%
A0A3S7XAF0	Leishmania donovani	87%	100%
A0A422MWV0	Trypanosoma rangeli	35%	98%
A4ICP2	Leishmania infantum	87%	100%
E9AIX5	Leishmania braziliensis	75%	100%
Q4Q1Y4	Leishmania major	86%	100%
V5BZV5	Trypanosoma cruzi	35%	98%