LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
SNF1-related protein kinases, putative (fragment)
Species:
Leishmania mexicana
UniProt:
E9ASL0_LEIMU
TriTrypDb:
LmxM.36.0900
Length:
486

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. None of them appear to be TM.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 3
NetGPI no yes: 0, no: 3
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASL0
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASL0

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 4
GO:0006793 phosphorus metabolic process 3 4
GO:0006796 phosphate-containing compound metabolic process 4 4
GO:0006807 nitrogen compound metabolic process 2 4
GO:0008152 metabolic process 1 4
GO:0009987 cellular process 1 4
GO:0016310 phosphorylation 5 4
GO:0019538 protein metabolic process 3 4
GO:0036211 protein modification process 4 4
GO:0043170 macromolecule metabolic process 3 4
GO:0043412 macromolecule modification 4 4
GO:0044237 cellular metabolic process 2 4
GO:0044238 primary metabolic process 2 4
GO:0071704 organic substance metabolic process 2 4
GO:1901564 organonitrogen compound metabolic process 3 4
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 4
GO:0003824 catalytic activity 1 4
GO:0004672 protein kinase activity 3 4
GO:0004674 protein serine/threonine kinase activity 4 2
GO:0005488 binding 1 4
GO:0005524 ATP binding 5 4
GO:0016301 kinase activity 4 4
GO:0016740 transferase activity 2 4
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 4
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 4
GO:0017076 purine nucleotide binding 4 4
GO:0030554 adenyl nucleotide binding 5 4
GO:0032553 ribonucleotide binding 3 4
GO:0032555 purine ribonucleotide binding 4 4
GO:0032559 adenyl ribonucleotide binding 5 4
GO:0035639 purine ribonucleoside triphosphate binding 4 4
GO:0036094 small molecule binding 2 4
GO:0043167 ion binding 2 4
GO:0043168 anion binding 3 4
GO:0097159 organic cyclic compound binding 2 4
GO:0097367 carbohydrate derivative binding 2 4
GO:0140096 catalytic activity, acting on a protein 2 4
GO:1901265 nucleoside phosphate binding 3 4
GO:1901363 heterocyclic compound binding 2 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_MEL_PAP_1 40 46 PF00089 0.597
CLV_NRD_NRD_1 20 22 PF00675 0.705
CLV_NRD_NRD_1 382 384 PF00675 0.654
CLV_NRD_NRD_1 79 81 PF00675 0.314
CLV_PCSK_KEX2_1 382 384 PF00082 0.648
CLV_PCSK_KEX2_1 94 96 PF00082 0.454
CLV_PCSK_PC1ET2_1 94 96 PF00082 0.454
CLV_PCSK_SKI1_1 149 153 PF00082 0.314
CLV_PCSK_SKI1_1 170 174 PF00082 0.314
CLV_PCSK_SKI1_1 184 188 PF00082 0.314
CLV_PCSK_SKI1_1 307 311 PF00082 0.536
CLV_PCSK_SKI1_1 72 76 PF00082 0.366
CLV_PCSK_SKI1_1 88 92 PF00082 0.248
CLV_PCSK_SKI1_1 95 99 PF00082 0.335
DEG_APCC_DBOX_1 71 79 PF00400 0.454
DEG_Nend_Nbox_1 1 2 PF02207 0.766
DOC_CKS1_1 402 407 PF01111 0.627
DOC_CYCLIN_RxL_1 146 156 PF00134 0.454
DOC_CYCLIN_RxL_1 302 311 PF00134 0.530
DOC_MAPK_DCC_7 400 408 PF00069 0.489
DOC_MAPK_gen_1 116 124 PF00069 0.454
DOC_MAPK_gen_1 70 77 PF00069 0.454
DOC_MAPK_gen_1 92 102 PF00069 0.366
DOC_MAPK_MEF2A_6 116 125 PF00069 0.373
DOC_MAPK_MEF2A_6 70 77 PF00069 0.454
DOC_MAPK_NFAT4_5 118 126 PF00069 0.366
DOC_SPAK_OSR1_1 345 349 PF12202 0.639
DOC_USP7_MATH_1 265 269 PF00917 0.454
DOC_USP7_MATH_1 35 39 PF00917 0.700
DOC_USP7_MATH_1 444 448 PF00917 0.639
DOC_USP7_MATH_1 8 12 PF00917 0.760
DOC_USP7_MATH_2 350 356 PF00917 0.640
DOC_USP7_UBL2_3 432 436 PF12436 0.627
DOC_USP7_UBL2_3 94 98 PF12436 0.387
DOC_WW_Pin1_4 206 211 PF00397 0.288
DOC_WW_Pin1_4 268 273 PF00397 0.366
DOC_WW_Pin1_4 346 351 PF00397 0.633
DOC_WW_Pin1_4 401 406 PF00397 0.541
LIG_14-3-3_CanoR_1 164 174 PF00244 0.454
LIG_14-3-3_CanoR_1 289 293 PF00244 0.314
LIG_14-3-3_CanoR_1 307 313 PF00244 0.406
LIG_14-3-3_CanoR_1 322 328 PF00244 0.461
LIG_14-3-3_CanoR_1 368 377 PF00244 0.740
LIG_14-3-3_CanoR_1 9 18 PF00244 0.759
LIG_FHA_1 154 160 PF00498 0.413
LIG_FHA_1 324 330 PF00498 0.674
LIG_FHA_1 66 72 PF00498 0.454
LIG_FHA_2 115 121 PF00498 0.314
LIG_FHA_2 166 172 PF00498 0.454
LIG_FHA_2 402 408 PF00498 0.624
LIG_LIR_Apic_2 209 215 PF02991 0.280
LIG_LIR_Apic_2 261 267 PF02991 0.318
LIG_LIR_Apic_2 399 405 PF02991 0.636
LIG_LIR_Gen_1 311 318 PF02991 0.460
LIG_LIR_Gen_1 391 401 PF02991 0.659
LIG_LIR_Gen_1 57 65 PF02991 0.366
LIG_LIR_Nem_3 109 115 PF02991 0.454
LIG_LIR_Nem_3 132 137 PF02991 0.314
LIG_LIR_Nem_3 311 317 PF02991 0.439
LIG_LIR_Nem_3 391 396 PF02991 0.586
LIG_LIR_Nem_3 421 426 PF02991 0.495
LIG_LIR_Nem_3 479 484 PF02991 0.647
LIG_LIR_Nem_3 57 61 PF02991 0.354
LIG_MYND_1 299 303 PF01753 0.454
LIG_PCNA_yPIPBox_3 275 289 PF02747 0.454
LIG_PDZ_Class_2 481 486 PF00595 0.722
LIG_PTB_Apo_2 442 449 PF02174 0.757
LIG_Rb_pABgroove_1 106 114 PF01858 0.366
LIG_SH2_CRK 112 116 PF00017 0.314
LIG_SH2_CRK 238 242 PF00017 0.314
LIG_SH2_CRK 264 268 PF00017 0.366
LIG_SH2_CRK 314 318 PF00017 0.414
LIG_SH2_CRK 393 397 PF00017 0.658
LIG_SH2_CRK 464 468 PF00017 0.606
LIG_SH2_CRK 481 485 PF00017 0.474
LIG_SH2_GRB2like 31 34 PF00017 0.705
LIG_SH2_GRB2like 393 396 PF00017 0.573
LIG_SH2_NCK_1 212 216 PF00017 0.314
LIG_SH2_NCK_1 264 268 PF00017 0.366
LIG_SH2_PTP2 426 429 PF00017 0.663
LIG_SH2_SRC 264 267 PF00017 0.454
LIG_SH2_STAP1 314 318 PF00017 0.414
LIG_SH2_STAP1 393 397 PF00017 0.581
LIG_SH2_STAT5 127 130 PF00017 0.314
LIG_SH2_STAT5 136 139 PF00017 0.314
LIG_SH2_STAT5 161 164 PF00017 0.314
LIG_SH2_STAT5 308 311 PF00017 0.453
LIG_SH2_STAT5 328 331 PF00017 0.345
LIG_SH2_STAT5 389 392 PF00017 0.661
LIG_SH2_STAT5 423 426 PF00017 0.565
LIG_SH2_STAT5 481 484 PF00017 0.723
LIG_SH3_3 280 286 PF00018 0.314
LIG_SH3_3 300 306 PF00018 0.177
LIG_SUMO_SIM_anti_2 120 126 PF11976 0.366
LIG_SUMO_SIM_par_1 120 126 PF11976 0.366
LIG_TRAF2_1 349 352 PF00917 0.611
LIG_TRAF2_1 359 362 PF00917 0.429
LIG_TRAF2_1 438 441 PF00917 0.753
LIG_TRAF2_2 46 51 PF00917 0.454
LIG_TYR_ITIM 236 241 PF00017 0.314
LIG_TYR_ITIM 312 317 PF00017 0.407
LIG_TYR_ITIM 424 429 PF00017 0.520
MOD_CK1_1 11 17 PF00069 0.758
MOD_CK1_1 194 200 PF00069 0.342
MOD_CK1_1 206 212 PF00069 0.265
MOD_CK1_1 268 274 PF00069 0.454
MOD_CK1_1 451 457 PF00069 0.680
MOD_CK1_1 479 485 PF00069 0.599
MOD_CK2_1 11 17 PF00069 0.758
MOD_CK2_1 126 132 PF00069 0.314
MOD_CK2_1 346 352 PF00069 0.548
MOD_CK2_1 356 362 PF00069 0.498
MOD_CK2_1 401 407 PF00069 0.611
MOD_CK2_1 444 450 PF00069 0.688
MOD_GlcNHglycan 128 131 PF01048 0.314
MOD_GlcNHglycan 218 221 PF01048 0.314
MOD_GlcNHglycan 450 453 PF01048 0.757
MOD_GlcNHglycan 88 91 PF01048 0.454
MOD_GSK3_1 182 189 PF00069 0.454
MOD_GSK3_1 202 209 PF00069 0.104
MOD_GSK3_1 318 325 PF00069 0.532
MOD_GSK3_1 352 359 PF00069 0.554
MOD_GSK3_1 440 447 PF00069 0.640
MOD_GSK3_1 451 458 PF00069 0.562
MOD_GSK3_1 473 480 PF00069 0.567
MOD_GSK3_1 82 89 PF00069 0.337
MOD_N-GLC_1 477 482 PF02516 0.646
MOD_NEK2_1 191 196 PF00069 0.314
MOD_NEK2_1 202 207 PF00069 0.314
MOD_NEK2_1 241 246 PF00069 0.387
MOD_NEK2_1 247 252 PF00069 0.341
MOD_NEK2_1 323 328 PF00069 0.576
MOD_NEK2_1 448 453 PF00069 0.647
MOD_NEK2_1 455 460 PF00069 0.568
MOD_NEK2_2 182 187 PF00069 0.404
MOD_NEK2_2 308 313 PF00069 0.451
MOD_PIKK_1 427 433 PF00454 0.672
MOD_PIKK_1 455 461 PF00454 0.741
MOD_PKA_2 165 171 PF00069 0.454
MOD_PKA_2 288 294 PF00069 0.314
MOD_PKA_2 54 60 PF00069 0.314
MOD_PKA_2 8 14 PF00069 0.761
MOD_Plk_1 318 324 PF00069 0.586
MOD_Plk_1 477 483 PF00069 0.645
MOD_Plk_2-3 288 294 PF00069 0.314
MOD_Plk_4 323 329 PF00069 0.619
MOD_Plk_4 352 358 PF00069 0.652
MOD_Plk_4 422 428 PF00069 0.567
MOD_Plk_4 451 457 PF00069 0.607
MOD_ProDKin_1 206 212 PF00069 0.288
MOD_ProDKin_1 268 274 PF00069 0.366
MOD_ProDKin_1 346 352 PF00069 0.636
MOD_ProDKin_1 401 407 PF00069 0.540
MOD_SUMO_for_1 172 175 PF00179 0.314
MOD_SUMO_for_1 93 96 PF00179 0.454
MOD_SUMO_rev_2 394 401 PF00179 0.576
TRG_ENDOCYTIC_2 112 115 PF00928 0.314
TRG_ENDOCYTIC_2 238 241 PF00928 0.314
TRG_ENDOCYTIC_2 314 317 PF00928 0.383
TRG_ENDOCYTIC_2 389 392 PF00928 0.661
TRG_ENDOCYTIC_2 393 396 PF00928 0.591
TRG_ENDOCYTIC_2 426 429 PF00928 0.488
TRG_ENDOCYTIC_2 464 467 PF00928 0.605
TRG_ENDOCYTIC_2 481 484 PF00928 0.478
TRG_ER_diArg_1 18 21 PF00400 0.718
TRG_ER_diArg_1 382 384 PF00400 0.654
TRG_NES_CRM1_1 337 352 PF08389 0.636
TRG_Pf-PMV_PEXEL_1 149 153 PF00026 0.314
TRG_Pf-PMV_PEXEL_1 80 84 PF00026 0.454

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1HZY0 Leptomonas seymouri 28% 81%
A0A0N1I6Q7 Leptomonas seymouri 29% 100%
A0A0S4JNA1 Bodo saltans 26% 98%
A0A1X0NUQ4 Trypanosomatidae 29% 100%
A0A3Q8IAQ1 Leishmania donovani 29% 100%
A0A3Q8IB30 Leishmania donovani 28% 100%
A0A3Q8IB74 Leishmania donovani 26% 100%
A0A3Q8IC87 Leishmania donovani 34% 100%
A0A3Q8IHH8 Leishmania donovani 28% 97%
A0A3Q8II44 Leishmania donovani 28% 100%
A0A3Q8IJ66 Leishmania donovani 27% 100%
A0A3Q8INQ4 Leishmania donovani 33% 100%
A0A3R7KDE9 Trypanosoma rangeli 59% 67%
A0A3S5H5G0 Leishmania donovani 28% 100%
A0A3S5H5U5 Leishmania donovani 26% 100%
A0A3S7WRG1 Leishmania donovani 27% 100%
A0A3S7WTN9 Leishmania donovani 33% 100%
A0A3S7WWE7 Leishmania donovani 26% 100%
A0A3S7X2W9 Leishmania donovani 27% 100%
A0A3S7X7D5 Leishmania donovani 27% 100%
A0A3S7X7Y2 Leishmania donovani 28% 100%
A0A3S7X9R4 Leishmania donovani 30% 100%
A0A3S7X9S2 Leishmania donovani 30% 100%
A0A451EJH2 Leishmania donovani 26% 100%
A2ZVI7 Oryza sativa subsp. japonica 33% 94%
A4H3D2 Leishmania braziliensis 25% 100%
A4H436 Leishmania braziliensis 24% 100%
A4H459 Leishmania braziliensis 28% 100%
A4H4S9 Leishmania braziliensis 26% 100%
A4H8C4 Leishmania braziliensis 33% 100%
A4H9L8 Leishmania braziliensis 28% 100%
A4H9U7 Leishmania braziliensis 27% 100%
A4H9X5 Leishmania braziliensis 25% 100%
A4HAS1 Leishmania braziliensis 26% 100%
A4HBL4 Leishmania braziliensis 25% 100%
A4HCE6 Leishmania braziliensis 29% 100%
A4HED7 Leishmania braziliensis 32% 100%
A4HFI2 Leishmania braziliensis 27% 100%
A4HH03 Leishmania braziliensis 28% 100%
A4HHS9 Leishmania braziliensis 26% 100%
A4HMD1 Leishmania braziliensis 27% 100%
A4HN71 Leishmania braziliensis 29% 100%
A4HQG8 Leishmania braziliensis 27% 100%
A4HRN3 Leishmania infantum 26% 100%
A4HSE2 Leishmania infantum 28% 100%
A4HUS3 Leishmania infantum 27% 100%
A4HWP5 Leishmania infantum 33% 100%
A4HXY2 Leishmania infantum 28% 100%
A4HZA2 Leishmania infantum 26% 100%
A4HZV1 Leishmania infantum 34% 100%
A4HZW8 Leishmania infantum 29% 100%
A4I1T4 Leishmania infantum 33% 100%
A4I4X0 Leishmania infantum 28% 97%
A4I4Y0 Leishmania infantum 27% 100%
A4I9H1 Leishmania infantum 27% 100%
A4I9Y5 Leishmania infantum 28% 100%
A4IAZ8 Leishmania infantum 27% 100%
A4IBT4 Leishmania infantum 29% 100%
A4IBT9 Leishmania infantum 29% 100%
A4ICA4 Leishmania infantum 28% 100%
D0A2R8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 56% 67%
E8NHS0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ACB1 Leishmania major 25% 100%
E9AEB9 Leishmania major 28% 97%
E9AED4 Leishmania major 28% 100%
E9AFM1 Leishmania major 29% 100%
E9AG71 Leishmania infantum 26% 100%
E9AGS0 Leishmania infantum 25% 100%
E9AJJ9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AKB7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AKZ7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9ALU0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 83%
E9ANF7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9AQF3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9ARP5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9ARW9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AUY2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 100%
E9AVR5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 100%
E9AVS7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9AXW8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 33% 100%
E9B4G9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
E9B5Y1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 27% 100%
E9B6S4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9B6S9 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
O94168 Candida tropicalis 47% 79%
P06782 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 46% 77%
P28582 Daucus carota 29% 91%
P49101 Zea mays 31% 95%
P53682 Oryza sativa subsp. japonica 29% 91%
P53683 Oryza sativa subsp. japonica 29% 91%
P54645 Rattus norvegicus 46% 87%
Q00372 Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) 46% 79%
Q13131 Homo sapiens 46% 87%
Q27687 Leishmania major 28% 100%
Q2QQR2 Oryza sativa subsp. japonica 29% 79%
Q2QY37 Oryza sativa subsp. japonica 33% 90%
Q2RAV0 Oryza sativa subsp. japonica 33% 90%
Q38871 Arabidopsis thaliana 29% 87%
Q38872 Arabidopsis thaliana 30% 89%
Q42396 Arabidopsis thaliana 32% 99%
Q42438 Arabidopsis thaliana 32% 91%
Q42479 Arabidopsis thaliana 32% 92%
Q4Q0B0 Leishmania major 28% 100%
Q4Q2Z2 Leishmania major 28% 100%
Q4Q5T9 Leishmania major 26% 100%
Q4Q9K2 Leishmania major 33% 100%
Q4QBQ2 Leishmania major 28% 100%
Q4QBR6 Leishmania major 33% 100%
Q4QCK0 Leishmania major 25% 100%
Q4QCR3 Leishmania major 26% 100%
Q4QDK3 Leishmania major 25% 100%
Q4QF23 Leishmania major 33% 100%
Q4QH69 Leishmania major 26% 100%
Q4QIV8 Leishmania major 27% 100%
Q4QJJ0 Leishmania major 27% 100%
Q54YF2 Dictyostelium discoideum 43% 67%
Q5EG47 Mus musculus 46% 87%
Q5RDH5 Pongo abelii 46% 88%
Q6NLQ6 Arabidopsis thaliana 32% 90%
Q6ZI44 Oryza sativa subsp. japonica 38% 100%
Q75GE8 Oryza sativa subsp. japonica 35% 90%
Q7XJR9 Arabidopsis thaliana 31% 85%
Q965G5 Caenorhabditis elegans 30% 100%
Q9FIM9 Arabidopsis thaliana 33% 82%
Q9FX86 Arabidopsis thaliana 30% 80%
Q9GNR4 Leishmania major 29% 100%
Q9LJL9 Arabidopsis thaliana 32% 81%
Q9NHE1 Leishmania major 27% 100%
Q9SG12 Arabidopsis thaliana 33% 82%
Q9SJ61 Arabidopsis thaliana 29% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS