Eukaryotic translation initiation factor 6

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor 6 (eIF-6), putative

Species:

Leishmania mexicana

UniProt:

E9ASK9_LEIMU

TriTrypDb:

LmxM.36.0890

Length:

249

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	12
GO:0005737	cytoplasm	2	11
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0030684	preribosome	3	1
GO:0030687	preribosome, large subunit precursor	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	12
GO:0043228	non-membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12

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Expansion

Sequence features

E9ASK9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK9

Function

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Biological processes
Term	Name	Level	Count
GO:0000054	ribosomal subunit export from nucleus	3	1
GO:0000460	maturation of 5.8S rRNA	9	1
GO:0000470	maturation of LSU-rRNA	9	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006364	rRNA processing	8	1
GO:0006396	RNA processing	6	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006810	transport	3	1
GO:0006913	nucleocytoplasmic transport	5	1

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Show entries

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0043021	ribonucleoprotein complex binding	3	12
GO:0043022	ribosome binding	4	12
GO:0043023	ribosomal large subunit binding	4	12
GO:0044877	protein-containing complex binding	2	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	52	56	PF00656	0.504
CLV_C14_Caspase3-7	87	91	PF00656	0.458
CLV_NRD_NRD_1	225	227	PF00675	0.562
CLV_PCSK_KEX2_1	225	227	PF00082	0.562
DOC_CKS1_1	163	168	PF01111	0.458
DOC_CYCLIN_yCln2_LP_2	177	183	PF00134	0.458
DOC_PP2B_LxvP_1	177	180	PF13499	0.458
DOC_PP2B_LxvP_1	70	73	PF13499	0.458
DOC_USP7_MATH_1	192	196	PF00917	0.458
DOC_USP7_MATH_1	28	32	PF00917	0.469

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDV4	Leptomonas seymouri	96%	100%
A0A0S4IVB2	Bodo saltans	87%	100%
A0A1X0P9I9	Trypanosomatidae	91%	100%
A0A3Q8IVS9	Leishmania donovani	99%	100%
A0A422NK30	Trypanosoma rangeli	91%	100%
A0RYC3	Cenarchaeum symbiosum (strain A)	28%	100%
A1RXF3	Thermofilum pendens (strain DSM 2475 / Hrk 5)	30%	100%
A2BN57	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	30%	100%
A2STI7	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	27%	100%
A3CWZ4	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	30%	100%

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