LeishMANIAdb
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Protein kinase domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Protein kinase domain-containing protein
Gene product:
mitogen-activated protein kinase kinase 5
Species:
Leishmania mexicana
UniProt:
E9ASK6_LEIMU
TriTrypDb:
LmxM.36.0860
Length:
525

Annotations

LeishMANIAdb annotations

A large and apprently artificial collection of diverse kinetoplastid protein kinases. A subfamily has 2TM regions, but the majority is cytoplasmic.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 9
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 34
NetGPI no yes: 0, no: 34
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 2
GO:0005737 cytoplasm 2 6
GO:0005829 cytosol 2 1
GO:0031974 membrane-enclosed lumen 2 1
GO:0031981 nuclear lumen 5 1
GO:0032838 plasma membrane bounded cell projection cytoplasm 4 1
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0043233 organelle lumen 3 1
GO:0070013 intracellular organelle lumen 4 1
GO:0097014 ciliary plasm 5 1
GO:0099568 cytoplasmic region 3 1
GO:0110165 cellular anatomical entity 1 6

Expansion

Sequence features

E9ASK6
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK6

Function

Biological processes
Term Name Level Count
GO:0006468 protein phosphorylation 5 35
GO:0006793 phosphorus metabolic process 3 35
GO:0006796 phosphate-containing compound metabolic process 4 35
GO:0006807 nitrogen compound metabolic process 2 35
GO:0008152 metabolic process 1 35
GO:0009987 cellular process 1 35
GO:0016310 phosphorylation 5 35
GO:0019538 protein metabolic process 3 35
GO:0036211 protein modification process 4 35
GO:0043170 macromolecule metabolic process 3 35
GO:0043412 macromolecule modification 4 35
GO:0044237 cellular metabolic process 2 35
GO:0044238 primary metabolic process 2 35
GO:0071704 organic substance metabolic process 2 35
GO:1901564 organonitrogen compound metabolic process 3 35
GO:0000281 mitotic cytokinesis 4 1
GO:0000910 cytokinesis 3 1
GO:0007165 signal transduction 2 3
GO:0022402 cell cycle process 2 1
GO:0035556 intracellular signal transduction 3 3
GO:0050789 regulation of biological process 2 3
GO:0050794 regulation of cellular process 3 3
GO:0061640 cytoskeleton-dependent cytokinesis 4 1
GO:0065007 biological regulation 1 3
GO:1903047 mitotic cell cycle process 3 1
GO:0000165 MAPK cascade 4 1
GO:0001932 regulation of protein phosphorylation 7 1
GO:0001934 positive regulation of protein phosphorylation 8 1
GO:0009893 positive regulation of metabolic process 4 1
GO:0009966 regulation of signal transduction 4 1
GO:0009967 positive regulation of signal transduction 5 1
GO:0010562 positive regulation of phosphorus metabolic process 6 1
GO:0010604 positive regulation of macromolecule metabolic process 5 1
GO:0010646 regulation of cell communication 4 1
GO:0010647 positive regulation of cell communication 5 1
GO:0019220 regulation of phosphate metabolic process 6 1
GO:0019222 regulation of metabolic process 3 1
GO:0023051 regulation of signaling 3 1
GO:0023056 positive regulation of signaling 4 1
GO:0031323 regulation of cellular metabolic process 4 1
GO:0031325 positive regulation of cellular metabolic process 5 1
GO:0031399 regulation of protein modification process 6 1
GO:0031401 positive regulation of protein modification process 7 1
GO:0033674 positive regulation of kinase activity 6 1
GO:0042325 regulation of phosphorylation 7 1
GO:0042327 positive regulation of phosphorylation 8 1
GO:0043085 positive regulation of catalytic activity 4 1
GO:0043405 regulation of MAP kinase activity 8 1
GO:0043406 positive regulation of MAP kinase activity 8 1
GO:0043408 regulation of MAPK cascade 6 1
GO:0043410 positive regulation of MAPK cascade 7 1
GO:0043549 regulation of kinase activity 5 1
GO:0044093 positive regulation of molecular function 3 1
GO:0045859 regulation of protein kinase activity 6 1
GO:0045860 positive regulation of protein kinase activity 7 1
GO:0045937 positive regulation of phosphate metabolic process 7 1
GO:0046777 protein autophosphorylation 6 1
GO:0048518 positive regulation of biological process 3 1
GO:0048522 positive regulation of cellular process 4 1
GO:0048583 regulation of response to stimulus 3 1
GO:0048584 positive regulation of response to stimulus 4 1
GO:0050790 regulation of catalytic activity 3 1
GO:0051171 regulation of nitrogen compound metabolic process 4 1
GO:0051173 positive regulation of nitrogen compound metabolic process 5 1
GO:0051174 regulation of phosphorus metabolic process 5 1
GO:0051246 regulation of protein metabolic process 5 1
GO:0051247 positive regulation of protein metabolic process 6 1
GO:0051338 regulation of transferase activity 4 1
GO:0051347 positive regulation of transferase activity 5 1
GO:0060255 regulation of macromolecule metabolic process 4 1
GO:0065009 regulation of molecular function 2 1
GO:0071900 regulation of protein serine/threonine kinase activity 7 1
GO:0071902 positive regulation of protein serine/threonine kinase activity 8 1
GO:0080090 regulation of primary metabolic process 4 1
GO:1902531 regulation of intracellular signal transduction 5 1
GO:1902533 positive regulation of intracellular signal transduction 6 1
Molecular functions
Term Name Level Count
GO:0000166 nucleotide binding 3 35
GO:0003824 catalytic activity 1 35
GO:0004672 protein kinase activity 3 35
GO:0005488 binding 1 35
GO:0005524 ATP binding 5 35
GO:0016301 kinase activity 4 35
GO:0016740 transferase activity 2 35
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 35
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 35
GO:0017076 purine nucleotide binding 4 35
GO:0030554 adenyl nucleotide binding 5 35
GO:0032553 ribonucleotide binding 3 35
GO:0032555 purine ribonucleotide binding 4 35
GO:0032559 adenyl ribonucleotide binding 5 35
GO:0035639 purine ribonucleoside triphosphate binding 4 35
GO:0036094 small molecule binding 2 35
GO:0043167 ion binding 2 35
GO:0043168 anion binding 3 35
GO:0097159 organic cyclic compound binding 2 35
GO:0097367 carbohydrate derivative binding 2 35
GO:0140096 catalytic activity, acting on a protein 2 35
GO:1901265 nucleoside phosphate binding 3 35
GO:1901363 heterocyclic compound binding 2 35
GO:0004674 protein serine/threonine kinase activity 4 16
GO:0004707 MAP kinase activity 5 10
GO:0043169 cation binding 3 1
GO:0046872 metal ion binding 4 1
GO:0004140 dephospho-CoA kinase activity 5 1
GO:0004708 MAP kinase kinase activity 5 1
GO:0004712 protein serine/threonine/tyrosine kinase activity 4 1
GO:0005515 protein binding 2 1
GO:0019899 enzyme binding 3 1
GO:0019900 kinase binding 4 1
GO:0019901 protein kinase binding 5 1
GO:0051019 mitogen-activated protein kinase binding 6 1

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 136 140 PF00656 0.230
CLV_C14_Caspase3-7 207 211 PF00656 0.230
CLV_NRD_NRD_1 102 104 PF00675 0.233
CLV_NRD_NRD_1 304 306 PF00675 0.492
CLV_NRD_NRD_1 74 76 PF00675 0.296
CLV_PCSK_KEX2_1 102 104 PF00082 0.266
CLV_PCSK_KEX2_1 304 306 PF00082 0.379
CLV_PCSK_KEX2_1 414 416 PF00082 0.379
CLV_PCSK_KEX2_1 74 76 PF00082 0.311
CLV_PCSK_PC1ET2_1 414 416 PF00082 0.379
CLV_PCSK_SKI1_1 159 163 PF00082 0.292
CLV_PCSK_SKI1_1 177 181 PF00082 0.314
CLV_PCSK_SKI1_1 415 419 PF00082 0.521
CLV_PCSK_SKI1_1 497 501 PF00082 0.484
CLV_PCSK_SKI1_1 88 92 PF00082 0.282
CLV_Separin_Metazoa 310 314 PF03568 0.204
DEG_APCC_DBOX_1 101 109 PF00400 0.230
DEG_APCC_DBOX_1 158 166 PF00400 0.224
DEG_SPOP_SBC_1 331 335 PF00917 0.555
DOC_CKS1_1 113 118 PF01111 0.210
DOC_CYCLIN_yClb1_LxF_4 520 525 PF00134 0.441
DOC_CYCLIN_yCln2_LP_2 145 151 PF00134 0.204
DOC_CYCLIN_yCln2_LP_2 312 318 PF00134 0.321
DOC_PP2B_LxvP_1 280 283 PF13499 0.276
DOC_PP4_FxxP_1 113 116 PF00568 0.221
DOC_USP7_MATH_1 355 359 PF00917 0.604
DOC_USP7_MATH_1 361 365 PF00917 0.715
DOC_USP7_MATH_1 435 439 PF00917 0.618
DOC_USP7_MATH_1 442 446 PF00917 0.627
DOC_USP7_MATH_1 452 456 PF00917 0.573
DOC_USP7_MATH_2 283 289 PF00917 0.196
DOC_WW_Pin1_4 112 117 PF00397 0.281
DOC_WW_Pin1_4 219 224 PF00397 0.286
DOC_WW_Pin1_4 298 303 PF00397 0.216
DOC_WW_Pin1_4 333 338 PF00397 0.683
DOC_WW_Pin1_4 350 355 PF00397 0.605
DOC_WW_Pin1_4 365 370 PF00397 0.639
DOC_WW_Pin1_4 372 377 PF00397 0.623
LIG_14-3-3_CanoR_1 258 267 PF00244 0.303
LIG_14-3-3_CanoR_1 305 315 PF00244 0.321
LIG_14-3-3_CanoR_1 497 506 PF00244 0.657
LIG_Actin_WH2_2 244 260 PF00022 0.239
LIG_Actin_WH2_2 492 507 PF00022 0.484
LIG_APCC_ABBAyCdc20_2 172 178 PF00400 0.286
LIG_APCC_ABBAyCdc20_2 426 432 PF00400 0.499
LIG_BIR_II_1 1 5 PF00653 0.540
LIG_FHA_1 113 119 PF00498 0.331
LIG_FHA_1 188 194 PF00498 0.396
LIG_FHA_1 307 313 PF00498 0.497
LIG_FHA_1 334 340 PF00498 0.724
LIG_FHA_1 491 497 PF00498 0.482
LIG_FHA_2 205 211 PF00498 0.266
LIG_FHA_2 276 282 PF00498 0.167
LIG_FHA_2 305 311 PF00498 0.283
LIG_FHA_2 393 399 PF00498 0.356
LIG_FHA_2 498 504 PF00498 0.673
LIG_GBD_Chelix_1 405 413 PF00786 0.295
LIG_LIR_Apic_2 112 116 PF02991 0.204
LIG_LIR_Apic_2 217 223 PF02991 0.325
LIG_LIR_Gen_1 130 138 PF02991 0.297
LIG_LIR_LC3C_4 239 244 PF02991 0.329
LIG_LIR_Nem_3 120 125 PF02991 0.336
LIG_LIR_Nem_3 144 149 PF02991 0.396
LIG_LIR_Nem_3 263 269 PF02991 0.274
LIG_NRBOX 344 350 PF00104 0.454
LIG_NRBOX 519 525 PF00104 0.513
LIG_PDZ_Class_2 520 525 PF00595 0.513
LIG_Pex14_2 121 125 PF04695 0.230
LIG_SH2_CRK 146 150 PF00017 0.204
LIG_SH2_CRK 254 258 PF00017 0.219
LIG_SH2_STAT5 117 120 PF00017 0.318
LIG_SH2_STAT5 167 170 PF00017 0.311
LIG_SH2_STAT5 320 323 PF00017 0.438
LIG_SH3_3 145 151 PF00018 0.271
LIG_SH3_3 296 302 PF00018 0.329
LIG_SH3_3 336 342 PF00018 0.600
LIG_SH3_3 375 381 PF00018 0.536
LIG_SUMO_SIM_anti_2 52 61 PF11976 0.316
LIG_SUMO_SIM_par_1 380 385 PF11976 0.456
LIG_SUMO_SIM_par_1 47 53 PF11976 0.399
LIG_SUMO_SIM_par_1 83 89 PF11976 0.242
LIG_TRAF2_1 487 490 PF00917 0.503
LIG_WRC_WIRS_1 118 123 PF05994 0.208
MOD_CDC14_SPxK_1 222 225 PF00782 0.276
MOD_CDC14_SPxK_1 301 304 PF00782 0.229
MOD_CDK_SPK_2 365 370 PF00069 0.501
MOD_CDK_SPxK_1 219 225 PF00069 0.276
MOD_CDK_SPxK_1 298 304 PF00069 0.212
MOD_CDK_SPxxK_3 298 305 PF00069 0.209
MOD_CK1_1 333 339 PF00069 0.606
MOD_CK1_1 380 386 PF00069 0.491
MOD_CK1_1 440 446 PF00069 0.574
MOD_CK1_1 455 461 PF00069 0.773
MOD_CK1_1 69 75 PF00069 0.252
MOD_CK2_1 138 144 PF00069 0.293
MOD_CK2_1 14 20 PF00069 0.507
MOD_CK2_1 199 205 PF00069 0.293
MOD_CK2_1 275 281 PF00069 0.389
MOD_CK2_1 304 310 PF00069 0.343
MOD_CK2_1 49 55 PF00069 0.385
MOD_CK2_1 505 511 PF00069 0.554
MOD_GlcNHglycan 16 19 PF01048 0.604
MOD_GlcNHglycan 294 297 PF01048 0.394
MOD_GlcNHglycan 357 360 PF01048 0.517
MOD_GlcNHglycan 437 440 PF01048 0.681
MOD_GlcNHglycan 444 447 PF01048 0.773
MOD_GlcNHglycan 454 457 PF01048 0.553
MOD_GlcNHglycan 479 482 PF01048 0.587
MOD_GlcNHglycan 484 487 PF01048 0.591
MOD_GlcNHglycan 69 72 PF01048 0.277
MOD_GSK3_1 210 217 PF00069 0.350
MOD_GSK3_1 28 35 PF00069 0.421
MOD_GSK3_1 331 338 PF00069 0.598
MOD_GSK3_1 361 368 PF00069 0.516
MOD_GSK3_1 506 513 PF00069 0.491
MOD_N-GLC_2 45 47 PF02516 0.332
MOD_NEK2_1 138 143 PF00069 0.289
MOD_NEK2_1 185 190 PF00069 0.338
MOD_NEK2_1 198 203 PF00069 0.272
MOD_NEK2_1 204 209 PF00069 0.274
MOD_NEK2_1 214 219 PF00069 0.297
MOD_NEK2_1 332 337 PF00069 0.704
MOD_NEK2_1 382 387 PF00069 0.453
MOD_NEK2_1 504 509 PF00069 0.494
MOD_NEK2_2 117 122 PF00069 0.204
MOD_PKA_1 304 310 PF00069 0.356
MOD_PKA_2 304 310 PF00069 0.320
MOD_PKA_2 318 324 PF00069 0.504
MOD_PKA_2 504 510 PF00069 0.630
MOD_PKA_2 78 84 PF00069 0.291
MOD_Plk_1 400 406 PF00069 0.290
MOD_Plk_2-3 392 398 PF00069 0.372
MOD_Plk_4 117 123 PF00069 0.263
MOD_Plk_4 127 133 PF00069 0.245
MOD_Plk_4 163 169 PF00069 0.406
MOD_Plk_4 210 216 PF00069 0.316
MOD_Plk_4 28 34 PF00069 0.399
MOD_Plk_4 335 341 PF00069 0.584
MOD_Plk_4 344 350 PF00069 0.483
MOD_ProDKin_1 112 118 PF00069 0.281
MOD_ProDKin_1 219 225 PF00069 0.286
MOD_ProDKin_1 298 304 PF00069 0.216
MOD_ProDKin_1 333 339 PF00069 0.681
MOD_ProDKin_1 350 356 PF00069 0.551
MOD_ProDKin_1 365 371 PF00069 0.639
MOD_ProDKin_1 372 378 PF00069 0.622
MOD_SUMO_rev_2 188 196 PF00179 0.292
MOD_SUMO_rev_2 326 332 PF00179 0.465
TRG_DiLeu_BaEn_1 519 524 PF01217 0.509
TRG_DiLeu_BaEn_2 127 133 PF01217 0.237
TRG_DiLeu_LyEn_5 519 524 PF01217 0.427
TRG_ENDOCYTIC_2 122 125 PF00928 0.285
TRG_ENDOCYTIC_2 146 149 PF00928 0.354
TRG_ENDOCYTIC_2 254 257 PF00928 0.255
TRG_ER_diArg_1 101 103 PF00400 0.232
TRG_ER_diArg_1 304 306 PF00400 0.306
TRG_ER_diArg_1 73 75 PF00400 0.267
TRG_Pf-PMV_PEXEL_1 497 502 PF00026 0.477

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I0B6 Leptomonas seymouri 57% 98%
A0A0S4JP91 Bodo saltans 28% 87%
A0A1X0P919 Trypanosomatidae 54% 100%
A0A3Q8IIG1 Leishmania donovani 30% 100%
A0A3Q8IND3 Leishmania donovani 90% 100%
A0A3R7K5U6 Trypanosoma rangeli 25% 90%
A0A3S7WYP4 Leishmania donovani 33% 100%
A0A3S7X2W3 Leishmania donovani 37% 100%
A0A3S7X7Y2 Leishmania donovani 35% 100%
A0A422NT49 Trypanosoma rangeli 27% 74%
A4H4S9 Leishmania braziliensis 22% 100%
A4H7V0 Leishmania braziliensis 25% 74%
A4HA94 Leishmania braziliensis 29% 100%
A4HAS1 Leishmania braziliensis 34% 100%
A4HCE6 Leishmania braziliensis 31% 100%
A4HDU3 Leishmania braziliensis 35% 100%
A4HHN1 Leishmania braziliensis 36% 100%
A4HNU6 Leishmania braziliensis 77% 100%
A4HYH4 Leishmania infantum 29% 100%
A4I140 Leishmania infantum 33% 100%
A4I435 Leishmania infantum 30% 100%
A4I4U6 Leishmania infantum 37% 100%
A4I9Y5 Leishmania infantum 35% 100%
A4ICP8 Leishmania infantum 90% 100%
C9ZKU8 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 25% 90%
E9ALJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9APX7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 25% 74%
E9AS98 Leishmania mexicana (strain MHOM/GT/2001/U1103) 29% 100%
E9AX78 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
E9B4Z4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 35% 100%
P51137 Medicago sativa 26% 100%
P53350 Homo sapiens 26% 87%
Q0PKV7 Leishmania mexicana 100% 100%
Q12701 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 27% 89%
Q13555 Homo sapiens 25% 94%
Q4Q1Z0 Leishmania major 90% 98%
Q4Q204 Leishmania major 28% 100%
Q4Q2Z2 Leishmania major 35% 100%
Q4Q7W2 Leishmania major 31% 100%
Q4QA98 Leishmania major 34% 100%
Q4QD66 Leishmania major 29% 100%
Q4QFK4 Leishmania major 26% 84%
Q6DGS3 Danio rerio 26% 95%
Q923T9 Mus musculus 25% 99%
Q9U6V4 Leishmania donovani 29% 100%
Q9V3Q6 Drosophila melanogaster 26% 77%
Q9Y077 Leishmania major 37% 100%
Q9Z1J2 Mus musculus 25% 66%
V5BDF5 Trypanosoma cruzi 26% 80%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS