Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASK5_LEIMU

TriTrypDb:

LmxM.36.0850

Length:

881

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASK5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	206	210	PF00656	0.418
CLV_C14_Caspase3-7	31	35	PF00656	0.501
CLV_C14_Caspase3-7	53	57	PF00656	0.427
CLV_C14_Caspase3-7	554	558	PF00656	0.668
CLV_C14_Caspase3-7	803	807	PF00656	0.363
CLV_NRD_NRD_1	207	209	PF00675	0.481
CLV_NRD_NRD_1	395	397	PF00675	0.617
CLV_NRD_NRD_1	508	510	PF00675	0.585
CLV_NRD_NRD_1	527	529	PF00675	0.777
CLV_NRD_NRD_1	68	70	PF00675	0.570
CLV_NRD_NRD_1	804	806	PF00675	0.455
CLV_PCSK_KEX2_1	160	162	PF00082	0.461
CLV_PCSK_KEX2_1	207	209	PF00082	0.503
CLV_PCSK_KEX2_1	217	219	PF00082	0.559
CLV_PCSK_KEX2_1	395	397	PF00082	0.625
CLV_PCSK_KEX2_1	508	510	PF00082	0.585
CLV_PCSK_KEX2_1	526	528	PF00082	0.770
CLV_PCSK_KEX2_1	68	70	PF00082	0.578
CLV_PCSK_KEX2_1	804	806	PF00082	0.455
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.461
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.554
CLV_PCSK_SKI1_1	137	141	PF00082	0.471
CLV_PCSK_SKI1_1	161	165	PF00082	0.362
CLV_PCSK_SKI1_1	48	52	PF00082	0.529
CLV_PCSK_SKI1_1	548	552	PF00082	0.595
CLV_PCSK_SKI1_1	650	654	PF00082	0.595
CLV_PCSK_SKI1_1	842	846	PF00082	0.335
CLV_PCSK_SKI1_1	857	861	PF00082	0.377
DEG_APCC_DBOX_1	302	310	PF00400	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.680
DEG_SCF_FBW7_1	737	744	PF00400	0.549
DEG_SCF_FBW7_2	273	280	PF00400	0.479
DEG_SCF_SKP2-CKS1_1	585	592	PF00560	0.577
DEG_SPOP_SBC_1	101	105	PF00917	0.531
DEG_SPOP_SBC_1	603	607	PF00917	0.510
DOC_CKS1_1	641	646	PF01111	0.598
DOC_CKS1_1	738	743	PF01111	0.554
DOC_CYCLIN_RxL_1	141	155	PF00134	0.586
DOC_MAPK_gen_1	272	281	PF00069	0.495
DOC_MAPK_gen_1	395	405	PF00069	0.509
DOC_MAPK_gen_1	838	847	PF00069	0.349
DOC_MAPK_MEF2A_6	272	281	PF00069	0.544
DOC_PP2B_PxIxI_1	276	282	PF00149	0.547
DOC_PP4_FxxP_1	122	125	PF00568	0.585
DOC_PP4_FxxP_1	532	535	PF00568	0.613
DOC_PP4_FxxP_1	799	802	PF00568	0.410
DOC_USP7_MATH_1	107	111	PF00917	0.726
DOC_USP7_MATH_1	135	139	PF00917	0.388
DOC_USP7_MATH_1	230	234	PF00917	0.496
DOC_USP7_MATH_1	290	294	PF00917	0.486
DOC_USP7_MATH_1	404	408	PF00917	0.486
DOC_USP7_MATH_1	464	468	PF00917	0.526
DOC_USP7_MATH_1	552	556	PF00917	0.644
DOC_USP7_MATH_1	598	602	PF00917	0.607
DOC_USP7_MATH_1	661	665	PF00917	0.580
DOC_USP7_MATH_1	673	677	PF00917	0.518
DOC_USP7_MATH_1	707	711	PF00917	0.641
DOC_USP7_MATH_1	720	724	PF00917	0.679
DOC_USP7_MATH_1	95	99	PF00917	0.634
DOC_USP7_UBL2_3	48	52	PF12436	0.595
DOC_WW_Pin1_4	113	118	PF00397	0.554
DOC_WW_Pin1_4	273	278	PF00397	0.562
DOC_WW_Pin1_4	319	324	PF00397	0.558
DOC_WW_Pin1_4	443	448	PF00397	0.606
DOC_WW_Pin1_4	527	532	PF00397	0.635
DOC_WW_Pin1_4	548	553	PF00397	0.761
DOC_WW_Pin1_4	578	583	PF00397	0.614
DOC_WW_Pin1_4	586	591	PF00397	0.592
DOC_WW_Pin1_4	604	609	PF00397	0.559
DOC_WW_Pin1_4	617	622	PF00397	0.712
DOC_WW_Pin1_4	640	645	PF00397	0.668
DOC_WW_Pin1_4	695	700	PF00397	0.567
DOC_WW_Pin1_4	718	723	PF00397	0.805
DOC_WW_Pin1_4	737	742	PF00397	0.482
DOC_WW_Pin1_4	747	752	PF00397	0.591
LIG_14-3-3_CanoR_1	128	134	PF00244	0.486
LIG_14-3-3_CanoR_1	179	187	PF00244	0.460
LIG_14-3-3_CanoR_1	193	199	PF00244	0.407
LIG_14-3-3_CanoR_1	218	225	PF00244	0.372
LIG_14-3-3_CanoR_1	23	29	PF00244	0.668
LIG_14-3-3_CanoR_1	297	306	PF00244	0.418
LIG_14-3-3_CanoR_1	395	403	PF00244	0.538
LIG_14-3-3_CanoR_1	667	671	PF00244	0.534
LIG_14-3-3_CanoR_1	705	713	PF00244	0.606
LIG_Actin_WH2_2	177	195	PF00022	0.439
LIG_Actin_WH2_2	260	276	PF00022	0.422
LIG_Actin_WH2_2	302	320	PF00022	0.429
LIG_BIR_III_4	623	627	PF00653	0.632
LIG_BRCT_BRCA1_1	92	96	PF00533	0.632
LIG_EVH1_1	729	733	PF00568	0.632
LIG_FHA_1	101	107	PF00498	0.617
LIG_FHA_1	134	140	PF00498	0.466
LIG_FHA_1	274	280	PF00498	0.617
LIG_FHA_1	348	354	PF00498	0.506
LIG_FHA_1	417	423	PF00498	0.375
LIG_FHA_1	450	456	PF00498	0.545
LIG_FHA_1	480	486	PF00498	0.437
LIG_FHA_1	49	55	PF00498	0.541
LIG_FHA_1	495	501	PF00498	0.475
LIG_FHA_1	565	571	PF00498	0.658
LIG_FHA_1	633	639	PF00498	0.732
LIG_FHA_1	677	683	PF00498	0.597
LIG_FHA_1	687	693	PF00498	0.656
LIG_FHA_1	713	719	PF00498	0.682
LIG_FHA_1	77	83	PF00498	0.602
LIG_FHA_1	818	824	PF00498	0.472
LIG_FHA_2	29	35	PF00498	0.609
LIG_FHA_2	383	389	PF00498	0.453
LIG_FHA_2	432	438	PF00498	0.684
LIG_FHA_2	489	495	PF00498	0.354
LIG_FHA_2	51	57	PF00498	0.442
LIG_FHA_2	641	647	PF00498	0.652
LIG_FHA_2	801	807	PF00498	0.347
LIG_GBD_Chelix_1	309	317	PF00786	0.489
LIG_LIR_Apic_2	121	125	PF02991	0.557
LIG_LIR_Apic_2	530	535	PF02991	0.608
LIG_LIR_Apic_2	726	732	PF02991	0.653
LIG_LIR_Apic_2	796	802	PF02991	0.420
LIG_LIR_Gen_1	209	216	PF02991	0.481
LIG_LIR_Gen_1	59	67	PF02991	0.514
LIG_LIR_Gen_1	828	837	PF02991	0.382
LIG_LIR_Nem_3	209	214	PF02991	0.488
LIG_LIR_Nem_3	511	516	PF02991	0.618
LIG_LIR_Nem_3	59	64	PF02991	0.516
LIG_LIR_Nem_3	828	834	PF02991	0.405
LIG_MYND_1	578	582	PF01753	0.685
LIG_PTAP_UEV_1	721	726	PF05743	0.578
LIG_RPA_C_Fungi	382	394	PF08784	0.463
LIG_SH2_CRK	211	215	PF00017	0.482
LIG_SH2_CRK	26	30	PF00017	0.659
LIG_SH2_CRK	513	517	PF00017	0.574
LIG_SH2_NCK_1	26	30	PF00017	0.597
LIG_SH2_STAP1	335	339	PF00017	0.457
LIG_SH3_3	12	18	PF00018	0.529
LIG_SH3_3	698	704	PF00018	0.590
LIG_SH3_3	719	725	PF00018	0.586
LIG_SH3_3	727	733	PF00018	0.615
LIG_SH3_3	735	741	PF00018	0.663
LIG_SUMO_SIM_par_1	452	459	PF11976	0.447
LIG_TRAF2_1	813	816	PF00917	0.396
LIG_TRAF2_1	825	828	PF00917	0.508
MOD_CDC14_SPxK_1	581	584	PF00782	0.621
MOD_CDK_SPK_2	700	705	PF00069	0.508
MOD_CDK_SPxK_1	578	584	PF00069	0.623
MOD_CDK_SPxK_1	586	592	PF00069	0.607
MOD_CK1_1	118	124	PF00069	0.598
MOD_CK1_1	182	188	PF00069	0.447
MOD_CK1_1	233	239	PF00069	0.619
MOD_CK1_1	241	247	PF00069	0.516
MOD_CK1_1	340	346	PF00069	0.466
MOD_CK1_1	407	413	PF00069	0.380
MOD_CK1_1	441	447	PF00069	0.612
MOD_CK1_1	617	623	PF00069	0.572
MOD_CK1_1	645	651	PF00069	0.626
MOD_CK1_1	676	682	PF00069	0.677
MOD_CK1_1	723	729	PF00069	0.631
MOD_CK1_1	745	751	PF00069	0.781
MOD_CK2_1	38	44	PF00069	0.545
MOD_CK2_1	382	388	PF00069	0.453
MOD_CK2_1	640	646	PF00069	0.625
MOD_CK2_1	657	663	PF00069	0.557
MOD_CK2_1	765	771	PF00069	0.374
MOD_CK2_1	810	816	PF00069	0.362
MOD_CK2_1	822	828	PF00069	0.460
MOD_Cter_Amidation	524	527	PF01082	0.624
MOD_DYRK1A_RPxSP_1	548	552	PF00069	0.595
MOD_GlcNHglycan	117	120	PF01048	0.663
MOD_GlcNHglycan	129	132	PF01048	0.450
MOD_GlcNHglycan	2	5	PF01048	0.569
MOD_GlcNHglycan	233	236	PF01048	0.508
MOD_GlcNHglycan	291	295	PF01048	0.573
MOD_GlcNHglycan	300	303	PF01048	0.451
MOD_GlcNHglycan	510	513	PF01048	0.539
MOD_GlcNHglycan	547	551	PF01048	0.713
MOD_GlcNHglycan	554	557	PF01048	0.608
MOD_GlcNHglycan	559	562	PF01048	0.550
MOD_GlcNHglycan	659	662	PF01048	0.770
MOD_GlcNHglycan	683	686	PF01048	0.616
MOD_GlcNHglycan	70	74	PF01048	0.547
MOD_GlcNHglycan	722	725	PF01048	0.633
MOD_GlcNHglycan	812	815	PF01048	0.348
MOD_GlcNHglycan	82	85	PF01048	0.610
MOD_GlcNHglycan	824	827	PF01048	0.404
MOD_GlcNHglycan	853	856	PF01048	0.472
MOD_GlcNHglycan	864	867	PF01048	0.413
MOD_GlcNHglycan	93	96	PF01048	0.570
MOD_GSK3_1	102	109	PF00069	0.714
MOD_GSK3_1	111	118	PF00069	0.553
MOD_GSK3_1	135	142	PF00069	0.615
MOD_GSK3_1	178	185	PF00069	0.497
MOD_GSK3_1	226	233	PF00069	0.480
MOD_GSK3_1	235	242	PF00069	0.511
MOD_GSK3_1	24	31	PF00069	0.644
MOD_GSK3_1	34	41	PF00069	0.638
MOD_GSK3_1	431	438	PF00069	0.635
MOD_GSK3_1	456	463	PF00069	0.486
MOD_GSK3_1	48	55	PF00069	0.578
MOD_GSK3_1	488	495	PF00069	0.392
MOD_GSK3_1	527	534	PF00069	0.604
MOD_GSK3_1	548	555	PF00069	0.594
MOD_GSK3_1	562	569	PF00069	0.597
MOD_GSK3_1	598	605	PF00069	0.632
MOD_GSK3_1	657	664	PF00069	0.735
MOD_GSK3_1	707	714	PF00069	0.771
MOD_GSK3_1	737	744	PF00069	0.577
MOD_GSK3_1	76	83	PF00069	0.665
MOD_GSK3_1	815	822	PF00069	0.382
MOD_GSK3_1	91	98	PF00069	0.629
MOD_N-GLC_1	230	235	PF02516	0.599
MOD_N-GLC_1	516	521	PF02516	0.536
MOD_N-GLC_1	673	678	PF02516	0.663
MOD_N-GLC_1	851	856	PF02516	0.468
MOD_NEK2_1	106	111	PF00069	0.582
MOD_NEK2_1	187	192	PF00069	0.495
MOD_NEK2_1	337	342	PF00069	0.442
MOD_NEK2_1	394	399	PF00069	0.676
MOD_NEK2_1	416	421	PF00069	0.428
MOD_NEK2_1	460	465	PF00069	0.601
MOD_NEK2_1	492	497	PF00069	0.572
MOD_NEK2_1	597	602	PF00069	0.648
MOD_NEK2_1	819	824	PF00069	0.471
MOD_NEK2_1	82	87	PF00069	0.513
MOD_NEK2_1	862	867	PF00069	0.424
MOD_PIKK_1	217	223	PF00454	0.529
MOD_PIKK_1	236	242	PF00454	0.622
MOD_PIKK_1	404	410	PF00454	0.584
MOD_PIKK_1	673	679	PF00454	0.642
MOD_PKA_1	217	223	PF00069	0.398
MOD_PKA_1	508	514	PF00069	0.550
MOD_PKA_2	127	133	PF00069	0.495
MOD_PKA_2	178	184	PF00069	0.497
MOD_PKA_2	187	193	PF00069	0.494
MOD_PKA_2	217	223	PF00069	0.398
MOD_PKA_2	394	400	PF00069	0.682
MOD_PKA_2	416	422	PF00069	0.435
MOD_PKA_2	492	498	PF00069	0.469
MOD_PKA_2	500	506	PF00069	0.386
MOD_PKA_2	508	514	PF00069	0.506
MOD_PKA_2	666	672	PF00069	0.531
MOD_PKB_1	544	552	PF00069	0.585
MOD_Plk_1	337	343	PF00069	0.423
MOD_Plk_1	673	679	PF00069	0.673
MOD_Plk_1	857	863	PF00069	0.402
MOD_Plk_2-3	488	494	PF00069	0.364
MOD_Plk_2-3	765	771	PF00069	0.374
MOD_Plk_4	187	193	PF00069	0.476
MOD_Plk_4	363	369	PF00069	0.500
MOD_Plk_4	389	395	PF00069	0.607
MOD_Plk_4	418	424	PF00069	0.418
MOD_Plk_4	456	462	PF00069	0.476
MOD_Plk_4	857	863	PF00069	0.395
MOD_ProDKin_1	113	119	PF00069	0.553
MOD_ProDKin_1	273	279	PF00069	0.563
MOD_ProDKin_1	319	325	PF00069	0.559
MOD_ProDKin_1	443	449	PF00069	0.591
MOD_ProDKin_1	527	533	PF00069	0.630
MOD_ProDKin_1	548	554	PF00069	0.760
MOD_ProDKin_1	578	584	PF00069	0.615
MOD_ProDKin_1	586	592	PF00069	0.594
MOD_ProDKin_1	604	610	PF00069	0.563
MOD_ProDKin_1	617	623	PF00069	0.713
MOD_ProDKin_1	640	646	PF00069	0.666
MOD_ProDKin_1	695	701	PF00069	0.563
MOD_ProDKin_1	718	724	PF00069	0.805
MOD_ProDKin_1	737	743	PF00069	0.484
MOD_ProDKin_1	747	753	PF00069	0.586
MOD_SUMO_for_1	432	435	PF00179	0.399
MOD_SUMO_rev_2	155	162	PF00179	0.520
MOD_SUMO_rev_2	645	651	PF00179	0.587
MOD_SUMO_rev_2	660	666	PF00179	0.522
TRG_DiLeu_BaEn_1	305	310	PF01217	0.478
TRG_ENDOCYTIC_2	211	214	PF00928	0.485
TRG_ENDOCYTIC_2	428	431	PF00928	0.541
TRG_ENDOCYTIC_2	513	516	PF00928	0.572
TRG_ER_diArg_1	394	396	PF00400	0.616
TRG_ER_diArg_1	498	501	PF00400	0.447
TRG_ER_diArg_1	508	510	PF00400	0.512
TRG_ER_diArg_1	526	528	PF00400	0.721
TRG_ER_diArg_1	543	546	PF00400	0.612
TRG_ER_diArg_1	58	61	PF00400	0.496
TRG_ER_diArg_1	67	69	PF00400	0.517
TRG_ER_diArg_1	759	762	PF00400	0.356
TRG_Pf-PMV_PEXEL_1	147	152	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	65	70	PF00026	0.579
TRG_Pf-PMV_PEXEL_1	767	771	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM17	Leptomonas seymouri	35%	95%
A0A3Q8IIS1	Leishmania donovani	80%	99%
A4HNU5	Leishmania braziliensis	61%	100%
A4ICP9	Leishmania infantum	80%	99%
Q4Q1Z1	Leishmania major	80%	100%