Zinc_finger_protein_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

zinc finger protein family member, putative

Species:

Leishmania mexicana

UniProt:

E9ASK4_LEIMU

TriTrypDb:

LmxM.36.0840

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASK4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.329
CLV_C14_Caspase3-7	499	503	PF00656	0.533
CLV_C14_Caspase3-7	522	526	PF00656	0.692
CLV_C14_Caspase3-7	752	756	PF00656	0.830
CLV_NRD_NRD_1	403	405	PF00675	0.656
CLV_NRD_NRD_1	489	491	PF00675	0.730
CLV_NRD_NRD_1	567	569	PF00675	0.579
CLV_NRD_NRD_1	88	90	PF00675	0.572
CLV_PCSK_FUR_1	243	247	PF00082	0.588
CLV_PCSK_FUR_1	401	405	PF00082	0.620
CLV_PCSK_KEX2_1	245	247	PF00082	0.611
CLV_PCSK_KEX2_1	403	405	PF00082	0.635
CLV_PCSK_KEX2_1	421	423	PF00082	0.465
CLV_PCSK_KEX2_1	489	491	PF00082	0.730
CLV_PCSK_KEX2_1	567	569	PF00082	0.579
CLV_PCSK_KEX2_1	88	90	PF00082	0.572
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.713
CLV_PCSK_PC1ET2_1	421	423	PF00082	0.580
CLV_PCSK_SKI1_1	201	205	PF00082	0.321
CLV_PCSK_SKI1_1	342	346	PF00082	0.508
CLV_PCSK_SKI1_1	721	725	PF00082	0.716
CLV_PCSK_SKI1_1	748	752	PF00082	0.768
CLV_PCSK_SKI1_1	774	778	PF00082	0.530
CLV_Separin_Metazoa	407	411	PF03568	0.549
DEG_Nend_Nbox_1	1	3	PF02207	0.793
DEG_SPOP_SBC_1	670	674	PF00917	0.828
DEG_SPOP_SBC_1	704	708	PF00917	0.802
DOC_CKS1_1	124	129	PF01111	0.539
DOC_CKS1_1	550	555	PF01111	0.711
DOC_CKS1_1	715	720	PF01111	0.831
DOC_CYCLIN_RxL_1	306	317	PF00134	0.316
DOC_CYCLIN_RxL_1	339	348	PF00134	0.512
DOC_CYCLIN_yCln2_LP_2	119	125	PF00134	0.623
DOC_CYCLIN_yCln2_LP_2	98	104	PF00134	0.513
DOC_MAPK_gen_1	277	287	PF00069	0.487
DOC_MAPK_gen_1	350	357	PF00069	0.500
DOC_MAPK_gen_1	399	408	PF00069	0.642
DOC_MAPK_gen_1	564	572	PF00069	0.595
DOC_MAPK_gen_1	88	98	PF00069	0.641
DOC_MAPK_MEF2A_6	220	227	PF00069	0.486
DOC_MAPK_MEF2A_6	350	359	PF00069	0.600
DOC_PP2B_LxvP_1	119	122	PF13499	0.637
DOC_PP4_FxxP_1	140	143	PF00568	0.506
DOC_USP7_MATH_1	148	152	PF00917	0.447
DOC_USP7_MATH_1	226	230	PF00917	0.454
DOC_USP7_MATH_1	426	430	PF00917	0.687
DOC_USP7_MATH_1	46	50	PF00917	0.623
DOC_USP7_MATH_1	483	487	PF00917	0.734
DOC_USP7_MATH_1	516	520	PF00917	0.698
DOC_USP7_MATH_1	57	61	PF00917	0.726
DOC_USP7_MATH_1	696	700	PF00917	0.769
DOC_USP7_MATH_1	704	708	PF00917	0.701
DOC_USP7_MATH_1	739	743	PF00917	0.818
DOC_USP7_MATH_1	746	750	PF00917	0.658
DOC_USP7_MATH_1	754	758	PF00917	0.530
DOC_WW_Pin1_4	123	128	PF00397	0.543
DOC_WW_Pin1_4	5	10	PF00397	0.684
DOC_WW_Pin1_4	549	554	PF00397	0.715
DOC_WW_Pin1_4	571	576	PF00397	0.625
DOC_WW_Pin1_4	658	663	PF00397	0.670
DOC_WW_Pin1_4	714	719	PF00397	0.835
LIG_14-3-3_CanoR_1	309	314	PF00244	0.480
LIG_14-3-3_CanoR_1	490	496	PF00244	0.681
LIG_14-3-3_CanoR_1	504	514	PF00244	0.594
LIG_14-3-3_CanoR_1	748	754	PF00244	0.830
LIG_BIR_III_2	394	398	PF00653	0.476
LIG_BRCT_BRCA1_1	190	194	PF00533	0.486
LIG_BRCT_BRCA1_1	228	232	PF00533	0.465
LIG_BRCT_BRCA1_1	510	514	PF00533	0.662
LIG_BRCT_BRCA1_1	656	660	PF00533	0.794
LIG_BRCT_BRCA1_2	228	234	PF00533	0.461
LIG_Clathr_ClatBox_1	665	669	PF01394	0.811
LIG_deltaCOP1_diTrp_1	655	660	PF00928	0.794
LIG_FHA_1	127	133	PF00498	0.318
LIG_FHA_1	209	215	PF00498	0.482
LIG_FHA_1	231	237	PF00498	0.438
LIG_FHA_1	269	275	PF00498	0.558
LIG_FHA_1	316	322	PF00498	0.529
LIG_FHA_1	661	667	PF00498	0.706
LIG_FHA_2	165	171	PF00498	0.342
LIG_FHA_2	183	189	PF00498	0.540
LIG_FHA_2	202	208	PF00498	0.330
LIG_FHA_2	318	324	PF00498	0.497
LIG_IBAR_NPY_1	100	102	PF08397	0.562
LIG_IBAR_NPY_1	515	517	PF08397	0.695
LIG_LIR_Apic_2	20	25	PF02991	0.790
LIG_LIR_Apic_2	699	704	PF02991	0.810
LIG_LIR_Gen_1	209	219	PF02991	0.607
LIG_LIR_Gen_1	300	311	PF02991	0.480
LIG_LIR_Gen_1	385	393	PF02991	0.520
LIG_LIR_Gen_1	527	534	PF02991	0.785
LIG_LIR_Nem_3	16	22	PF02991	0.730
LIG_LIR_Nem_3	209	215	PF02991	0.501
LIG_LIR_Nem_3	300	306	PF02991	0.480
LIG_LIR_Nem_3	385	389	PF02991	0.408
LIG_LIR_Nem_3	511	517	PF02991	0.622
LIG_LIR_Nem_3	527	533	PF02991	0.674
LIG_PALB2_WD40_1	298	306	PF16756	0.502
LIG_Pex14_2	299	303	PF04695	0.496
LIG_Pex14_2	654	658	PF04695	0.794
LIG_SH2_CRK	22	26	PF00017	0.783
LIG_SH2_CRK	517	521	PF00017	0.804
LIG_SH2_CRK	623	627	PF00017	0.777
LIG_SH2_NCK_1	22	26	PF00017	0.796
LIG_SH2_PTP2	237	240	PF00017	0.640
LIG_SH2_PTP2	701	704	PF00017	0.735
LIG_SH2_SRC	22	25	PF00017	0.783
LIG_SH2_SRC	237	240	PF00017	0.640
LIG_SH2_SRC	28	31	PF00017	0.687
LIG_SH2_SRC	701	704	PF00017	0.735
LIG_SH2_STAP1	104	108	PF00017	0.597
LIG_SH2_STAP1	19	23	PF00017	0.807
LIG_SH2_STAT3	104	107	PF00017	0.795
LIG_SH2_STAT5	181	184	PF00017	0.612
LIG_SH2_STAT5	237	240	PF00017	0.640
LIG_SH2_STAT5	28	31	PF00017	0.708
LIG_SH2_STAT5	310	313	PF00017	0.499
LIG_SH2_STAT5	379	382	PF00017	0.455
LIG_SH2_STAT5	551	554	PF00017	0.816
LIG_SH2_STAT5	701	704	PF00017	0.689
LIG_SH3_3	121	127	PF00018	0.546
LIG_SH3_3	140	146	PF00018	0.376
LIG_SH3_3	220	226	PF00018	0.434
LIG_SH3_3	318	324	PF00018	0.445
LIG_SH3_3	623	629	PF00018	0.745
LIG_SUMO_SIM_par_1	121	126	PF11976	0.498
LIG_SUMO_SIM_par_1	128	133	PF11976	0.479
LIG_SUMO_SIM_par_1	568	574	PF11976	0.636
LIG_SxIP_EBH_1	763	774	PF03271	0.652
LIG_TRAF2_1	453	456	PF00917	0.725
MOD_CDK_SPxxK_3	714	721	PF00069	0.833
MOD_CK1_1	13	19	PF00069	0.713
MOD_CK1_1	208	214	PF00069	0.491
MOD_CK1_1	328	334	PF00069	0.506
MOD_CK1_1	482	488	PF00069	0.698
MOD_CK1_1	508	514	PF00069	0.645
MOD_CK1_1	519	525	PF00069	0.577
MOD_CK1_1	560	566	PF00069	0.783
MOD_CK1_1	574	580	PF00069	0.557
MOD_CK1_1	671	677	PF00069	0.833
MOD_CK1_1	697	703	PF00069	0.813
MOD_CK1_1	706	712	PF00069	0.597
MOD_CK1_1	725	731	PF00069	0.809
MOD_CK1_1	738	744	PF00069	0.817
MOD_CK1_1	749	755	PF00069	0.798
MOD_CK1_1	756	762	PF00069	0.793
MOD_CK1_1	766	772	PF00069	0.718
MOD_CK1_1	83	89	PF00069	0.553
MOD_CK2_1	107	113	PF00069	0.600
MOD_CK2_1	182	188	PF00069	0.535
MOD_CMANNOS	278	281	PF00535	0.507
MOD_GlcNHglycan	12	15	PF01048	0.675
MOD_GlcNHglycan	135	138	PF01048	0.609
MOD_GlcNHglycan	428	431	PF01048	0.654
MOD_GlcNHglycan	48	51	PF01048	0.683
MOD_GlcNHglycan	481	484	PF01048	0.799
MOD_GlcNHglycan	493	496	PF01048	0.626
MOD_GlcNHglycan	538	541	PF01048	0.844
MOD_GlcNHglycan	576	579	PF01048	0.753
MOD_GlcNHglycan	725	728	PF01048	0.591
MOD_GlcNHglycan	737	740	PF01048	0.713
MOD_GlcNHglycan	748	751	PF01048	0.730
MOD_GlcNHglycan	755	759	PF01048	0.719
MOD_GlcNHglycan	82	85	PF01048	0.542
MOD_GSK3_1	126	133	PF00069	0.509
MOD_GSK3_1	13	20	PF00069	0.654
MOD_GSK3_1	201	208	PF00069	0.394
MOD_GSK3_1	226	233	PF00069	0.456
MOD_GSK3_1	424	431	PF00069	0.704
MOD_GSK3_1	475	482	PF00069	0.756
MOD_GSK3_1	521	528	PF00069	0.558
MOD_GSK3_1	545	552	PF00069	0.760
MOD_GSK3_1	57	64	PF00069	0.680
MOD_GSK3_1	654	661	PF00069	0.693
MOD_GSK3_1	668	675	PF00069	0.726
MOD_GSK3_1	703	710	PF00069	0.815
MOD_GSK3_1	721	728	PF00069	0.815
MOD_GSK3_1	735	742	PF00069	0.738
MOD_GSK3_1	749	756	PF00069	0.629
MOD_GSK3_1	759	766	PF00069	0.755
MOD_N-GLC_1	10	15	PF02516	0.635
MOD_N-GLC_1	442	447	PF02516	0.513
MOD_N-GLC_1	483	488	PF02516	0.686
MOD_N-GLC_1	491	496	PF02516	0.636
MOD_N-GLC_1	545	550	PF02516	0.668
MOD_N-GLC_1	677	682	PF02516	0.866
MOD_N-GLC_1	697	702	PF02516	0.812
MOD_N-GLC_2	76	78	PF02516	0.512
MOD_NEK2_1	182	187	PF00069	0.501
MOD_NEK2_1	230	235	PF00069	0.562
MOD_NEK2_1	326	331	PF00069	0.519
MOD_NEK2_1	345	350	PF00069	0.566
MOD_NEK2_1	491	496	PF00069	0.730
MOD_NEK2_1	558	563	PF00069	0.607
MOD_NEK2_1	654	659	PF00069	0.795
MOD_NEK2_1	668	673	PF00069	0.592
MOD_NEK2_1	694	699	PF00069	0.803
MOD_NEK2_1	735	740	PF00069	0.712
MOD_NEK2_1	763	768	PF00069	0.836
MOD_NEK2_2	34	39	PF00069	0.808
MOD_OFUCOSY	364	369	PF10250	0.623
MOD_PIKK_1	707	713	PF00454	0.814
MOD_PK_1	210	216	PF00069	0.593
MOD_PK_1	351	357	PF00069	0.484
MOD_PK_1	677	683	PF00069	0.794
MOD_PKA_1	421	427	PF00069	0.558
MOD_PKA_2	164	170	PF00069	0.340
MOD_PKA_2	421	427	PF00069	0.558
MOD_PKA_2	536	542	PF00069	0.745
MOD_PKA_2	80	86	PF00069	0.672
MOD_Plk_1	187	193	PF00069	0.575
MOD_Plk_1	208	214	PF00069	0.600
MOD_Plk_1	315	321	PF00069	0.527
MOD_Plk_1	389	395	PF00069	0.385
MOD_Plk_1	483	489	PF00069	0.720
MOD_Plk_1	496	502	PF00069	0.647
MOD_Plk_1	654	660	PF00069	0.795
MOD_Plk_1	697	703	PF00069	0.813
MOD_Plk_2-3	317	323	PF00069	0.495
MOD_Plk_2-3	428	434	PF00069	0.487
MOD_Plk_4	126	132	PF00069	0.497
MOD_Plk_4	17	23	PF00069	0.787
MOD_Plk_4	188	194	PF00069	0.560
MOD_Plk_4	226	232	PF00069	0.415
MOD_Plk_4	697	703	PF00069	0.735
MOD_ProDKin_1	123	129	PF00069	0.537
MOD_ProDKin_1	5	11	PF00069	0.685
MOD_ProDKin_1	549	555	PF00069	0.710
MOD_ProDKin_1	571	577	PF00069	0.632
MOD_ProDKin_1	658	664	PF00069	0.670
MOD_ProDKin_1	714	720	PF00069	0.833
MOD_SUMO_for_1	414	417	PF00179	0.600
MOD_SUMO_rev_2	213	222	PF00179	0.612
MOD_SUMO_rev_2	445	453	PF00179	0.809
TRG_DiLeu_BaLyEn_6	661	666	PF01217	0.797
TRG_ENDOCYTIC_2	310	313	PF00928	0.499
TRG_ENDOCYTIC_2	379	382	PF00928	0.455
TRG_ENDOCYTIC_2	517	520	PF00928	0.701
TRG_ENDOCYTIC_2	530	533	PF00928	0.738
TRG_ENDOCYTIC_2	623	626	PF00928	0.781
TRG_ER_diArg_1	401	404	PF00400	0.644
TRG_ER_diArg_1	489	491	PF00400	0.730
TRG_ER_diArg_1	566	568	PF00400	0.605
TRG_NLS_MonoExtN_4	243	249	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	342	346	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDN9	Leptomonas seymouri	57%	100%
A0A3S7XAM4	Leishmania donovani	91%	100%
A4HNU4	Leishmania braziliensis	80%	100%
A4ICQ0	Leishmania infantum	91%	100%
Q4Q1Z2	Leishmania major	91%	100%