ADP-ribosylation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ADP-ribosylation factor-like protein

Species:

Leishmania mexicana

UniProt:

E9ASK2_LEIMU

TriTrypDb:

LmxM.36.0820

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASK2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	11
GO:0003824	catalytic activity	1	11
GO:0003924	GTPase activity	7	11
GO:0005488	binding	1	11
GO:0005525	GTP binding	5	11
GO:0016462	pyrophosphatase activity	5	11
GO:0016787	hydrolase activity	2	11
GO:0016817	hydrolase activity, acting on acid anhydrides	3	11
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	11
GO:0017076	purine nucleotide binding	4	11
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	11
GO:0019001	guanyl nucleotide binding	5	11
GO:0032553	ribonucleotide binding	3	11
GO:0032555	purine ribonucleotide binding	4	11
GO:0032561	guanyl ribonucleotide binding	5	11
GO:0035639	purine ribonucleoside triphosphate binding	4	11
GO:0036094	small molecule binding	2	11
GO:0043167	ion binding	2	11
GO:0043168	anion binding	3	11
GO:0097159	organic cyclic compound binding	2	11
GO:0097367	carbohydrate derivative binding	2	11
GO:1901265	nucleoside phosphate binding	3	11
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	12	14	PF00082	0.443
CLV_PCSK_KEX2_1	272	274	PF00082	0.493
CLV_PCSK_KEX2_1	96	98	PF00082	0.414
CLV_PCSK_PC1ET2_1	12	14	PF00082	0.464
CLV_PCSK_PC1ET2_1	272	274	PF00082	0.493
CLV_PCSK_PC1ET2_1	96	98	PF00082	0.414
CLV_PCSK_SKI1_1	202	206	PF00082	0.300
CLV_PCSK_SKI1_1	26	30	PF00082	0.604
CLV_PCSK_SKI1_1	273	277	PF00082	0.504
CLV_PCSK_SKI1_1	40	44	PF00082	0.388
CLV_PCSK_SKI1_1	97	101	PF00082	0.305
DEG_APCC_DBOX_1	39	47	PF00400	0.508
DOC_CYCLIN_RxL_1	23	33	PF00134	0.598
DOC_CYCLIN_RxL_1	37	47	PF00134	0.453
DOC_MAPK_gen_1	200	207	PF00069	0.360
DOC_MAPK_gen_1	93	101	PF00069	0.411
DOC_MAPK_MEF2A_6	126	133	PF00069	0.371
DOC_MAPK_MEF2A_6	200	207	PF00069	0.319
DOC_USP7_MATH_1	275	279	PF00917	0.527
DOC_USP7_MATH_1	74	78	PF00917	0.663
DOC_USP7_UBL2_3	272	276	PF12436	0.538
DOC_WW_Pin1_4	125	130	PF00397	0.311
DOC_WW_Pin1_4	131	136	PF00397	0.286
DOC_WW_Pin1_4	85	90	PF00397	0.563
LIG_14-3-3_CanoR_1	97	102	PF00244	0.414
LIG_BIR_II_1	1	5	PF00653	0.576
LIG_EH_1	33	37	PF12763	0.536
LIG_FHA_1	110	116	PF00498	0.277
LIG_FHA_1	126	132	PF00498	0.249
LIG_FHA_1	23	29	PF00498	0.530
LIG_FHA_1	241	247	PF00498	0.387
LIG_FHA_1	96	102	PF00498	0.306
LIG_FHA_2	249	255	PF00498	0.447
LIG_GBD_Chelix_1	252	260	PF00786	0.411
LIG_LIR_Gen_1	264	275	PF02991	0.413
LIG_LIR_Gen_1	33	43	PF02991	0.518
LIG_LIR_Nem_3	130	136	PF02991	0.383
LIG_LIR_Nem_3	166	171	PF02991	0.443
LIG_LIR_Nem_3	264	270	PF02991	0.392
LIG_LIR_Nem_3	33	39	PF02991	0.501
LIG_NRBOX	38	44	PF00104	0.593
LIG_Pex14_1	160	164	PF04695	0.300
LIG_Pex14_2	156	160	PF04695	0.300
LIG_PTAP_UEV_1	233	238	PF05743	0.153
LIG_SH2_CRK	267	271	PF00017	0.526
LIG_SH2_STAP1	267	271	PF00017	0.493
LIG_SH2_STAT5	127	130	PF00017	0.444
LIG_SH2_STAT5	172	175	PF00017	0.334
LIG_SH2_STAT5	198	201	PF00017	0.361
LIG_SH2_STAT5	38	41	PF00017	0.524
LIG_SH3_2	234	239	PF14604	0.250
LIG_SH3_3	231	237	PF00018	0.374
LIG_SH3_3	29	35	PF00018	0.555
LIG_SH3_3	52	58	PF00018	0.621
LIG_SH3_5	139	143	PF00018	0.409
LIG_SUMO_SIM_par_1	257	264	PF11976	0.197
LIG_SUMO_SIM_par_1	97	103	PF11976	0.446
LIG_UBA3_1	19	26	PF00899	0.545
LIG_UBA3_1	204	211	PF00899	0.343
LIG_WRC_WIRS_1	101	106	PF05994	0.296
MOD_CDC14_SPxK_1	134	137	PF00782	0.153
MOD_CDK_SPxK_1	131	137	PF00069	0.177
MOD_CK1_1	176	182	PF00069	0.411
MOD_CK1_1	77	83	PF00069	0.742
MOD_CK2_1	113	119	PF00069	0.444
MOD_CK2_1	248	254	PF00069	0.305
MOD_GlcNHglycan	119	122	PF01048	0.315
MOD_GlcNHglycan	175	178	PF01048	0.299
MOD_GlcNHglycan	66	70	PF01048	0.708
MOD_GlcNHglycan	76	79	PF01048	0.704
MOD_GlcNHglycan	90	93	PF01048	0.714
MOD_GSK3_1	109	116	PF00069	0.319
MOD_GSK3_1	127	134	PF00069	0.284
MOD_N-GLC_2	144	146	PF02516	0.411
MOD_NEK2_1	190	195	PF00069	0.389
MOD_NEK2_1	22	27	PF00069	0.514
MOD_PIKK_1	56	62	PF00454	0.668
MOD_Plk_1	4	10	PF00069	0.604
MOD_Plk_2-3	248	254	PF00069	0.347
MOD_Plk_4	113	119	PF00069	0.355
MOD_Plk_4	248	254	PF00069	0.231
MOD_ProDKin_1	125	131	PF00069	0.311
MOD_ProDKin_1	85	91	PF00069	0.558
MOD_SUMO_for_1	281	284	PF00179	0.493
MOD_SUMO_for_1	92	95	PF00179	0.347
MOD_SUMO_rev_2	119	128	PF00179	0.444
TRG_DiLeu_BaEn_1	266	271	PF01217	0.237
TRG_DiLeu_BaLyEn_6	200	205	PF01217	0.343
TRG_ENDOCYTIC_2	267	270	PF00928	0.379
TRG_Pf-PMV_PEXEL_1	188	192	PF00026	0.418
TRG_Pf-PMV_PEXEL_1	211	215	PF00026	0.383
TRG_Pf-PMV_PEXEL_1	40	45	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P886	Leptomonas seymouri	67%	99%
A0A0S4JWF1	Bodo saltans	42%	100%
A0A1X0P850	Trypanosomatidae	52%	100%
A0A3S7XAE0	Leishmania donovani	93%	100%
A0A422NK26	Trypanosoma rangeli	52%	94%
A4HNU2	Leishmania braziliensis	80%	95%
A4ICQ2	Leishmania infantum	93%	100%
D0A2Q7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
D0A3V1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q3SXY8	Homo sapiens	36%	70%
Q4Q1Z4	Leishmania major	92%	100%
Q640N2	Mus musculus	37%	70%