Ras-GAP domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASK1_LEIMU

TriTrypDb:

LmxM.36.0810

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASK1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASK1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.316
CLV_C14_Caspase3-7	240	244	PF00656	0.376
CLV_C14_Caspase3-7	276	280	PF00656	0.326
CLV_NRD_NRD_1	157	159	PF00675	0.572
CLV_NRD_NRD_1	230	232	PF00675	0.531
CLV_NRD_NRD_1	3	5	PF00675	0.417
CLV_NRD_NRD_1	54	56	PF00675	0.588
CLV_PCSK_FUR_1	155	159	PF00082	0.470
CLV_PCSK_KEX2_1	157	159	PF00082	0.522
CLV_PCSK_KEX2_1	230	232	PF00082	0.531
CLV_PCSK_KEX2_1	3	5	PF00082	0.417
CLV_PCSK_KEX2_1	442	444	PF00082	0.671
CLV_PCSK_KEX2_1	54	56	PF00082	0.619
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.471
CLV_PCSK_PC1ET2_1	442	444	PF00082	0.671
CLV_PCSK_SKI1_1	139	143	PF00082	0.495
CLV_PCSK_SKI1_1	159	163	PF00082	0.411
CLV_PCSK_SKI1_1	213	217	PF00082	0.569
CLV_PCSK_SKI1_1	230	234	PF00082	0.524
CLV_PCSK_SKI1_1	353	357	PF00082	0.593
CLV_PCSK_SKI1_1	430	434	PF00082	0.541
CLV_PCSK_SKI1_1	442	446	PF00082	0.624
CLV_PCSK_SKI1_1	55	59	PF00082	0.574
CLV_PCSK_SKI1_1	94	98	PF00082	0.514
DEG_APCC_DBOX_1	54	62	PF00400	0.408
DEG_APCC_DBOX_1	93	101	PF00400	0.325
DOC_CDC14_PxL_1	175	183	PF14671	0.298
DOC_CYCLIN_RxL_1	208	221	PF00134	0.299
DOC_CYCLIN_RxL_1	52	62	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	83	89	PF00134	0.388
DOC_MAPK_gen_1	155	163	PF00069	0.338
DOC_MAPK_MEF2A_6	189	196	PF00069	0.289
DOC_PP1_RVXF_1	157	164	PF00149	0.325
DOC_PP2B_LxvP_1	123	126	PF13499	0.374
DOC_PP2B_LxvP_1	76	79	PF13499	0.406
DOC_PP4_FxxP_1	162	165	PF00568	0.270
DOC_PP4_FxxP_1	447	450	PF00568	0.464
DOC_USP7_MATH_1	177	181	PF00917	0.305
DOC_USP7_MATH_1	211	215	PF00917	0.274
DOC_USP7_MATH_1	26	30	PF00917	0.430
DOC_USP7_MATH_1	312	316	PF00917	0.427
DOC_USP7_UBL2_3	153	157	PF12436	0.275
DOC_USP7_UBL2_3	271	275	PF12436	0.335
DOC_USP7_UBL2_3	379	383	PF12436	0.251
DOC_USP7_UBL2_3	433	437	PF12436	0.309
LIG_14-3-3_CanoR_1	213	218	PF00244	0.362
LIG_BIR_III_4	279	283	PF00653	0.308
LIG_BIR_III_4	44	48	PF00653	0.369
LIG_FHA_1	219	225	PF00498	0.411
LIG_FHA_1	257	263	PF00498	0.303
LIG_FHA_1	346	352	PF00498	0.415
LIG_FHA_1	393	399	PF00498	0.307
LIG_FHA_1	429	435	PF00498	0.395
LIG_FHA_1	71	77	PF00498	0.426
LIG_FHA_2	238	244	PF00498	0.390
LIG_FHA_2	338	344	PF00498	0.415
LIG_GBD_Chelix_1	111	119	PF00786	0.525
LIG_GBD_Chelix_1	398	406	PF00786	0.572
LIG_IBAR_NPY_1	204	206	PF08397	0.406
LIG_LIR_Apic_2	445	450	PF02991	0.409
LIG_LIR_Gen_1	166	176	PF02991	0.271
LIG_LIR_Gen_1	422	429	PF02991	0.390
LIG_LIR_Gen_1	60	71	PF02991	0.416
LIG_LIR_Nem_3	166	171	PF02991	0.281
LIG_LIR_Nem_3	17	22	PF02991	0.581
LIG_LIR_Nem_3	193	199	PF02991	0.323
LIG_LIR_Nem_3	254	260	PF02991	0.336
LIG_LIR_Nem_3	327	333	PF02991	0.290
LIG_LIR_Nem_3	339	344	PF02991	0.309
LIG_LIR_Nem_3	422	426	PF02991	0.400
LIG_LIR_Nem_3	60	66	PF02991	0.413
LIG_LIR_Nem_3	81	87	PF02991	0.363
LIG_LYPXL_yS_3	178	181	PF13949	0.299
LIG_NRBOX	350	356	PF00104	0.325
LIG_PCNA_PIPBox_1	374	383	PF02747	0.291
LIG_Pex14_2	19	23	PF04695	0.461
LIG_SH2_CRK	206	210	PF00017	0.311
LIG_SH2_CRK	295	299	PF00017	0.356
LIG_SH2_SRC	416	419	PF00017	0.374
LIG_SH2_STAP1	206	210	PF00017	0.352
LIG_SH2_STAT5	110	113	PF00017	0.306
LIG_SH2_STAT5	184	187	PF00017	0.286
LIG_SH2_STAT5	35	38	PF00017	0.467
LIG_SH2_STAT5	381	384	PF00017	0.306
LIG_SUMO_SIM_anti_2	190	196	PF11976	0.334
LIG_SUMO_SIM_par_1	258	264	PF11976	0.289
LIG_SUMO_SIM_par_1	364	370	PF11976	0.379
LIG_UBA3_1	402	410	PF00899	0.303
LIG_UBA3_1	425	433	PF00899	0.383
LIG_UBA3_1	83	91	PF00899	0.366
LIG_WRC_WIRS_1	217	222	PF05994	0.348
MOD_CK1_1	389	395	PF00069	0.397
MOD_CK1_1	419	425	PF00069	0.315
MOD_CK2_1	177	183	PF00069	0.387
MOD_CK2_1	337	343	PF00069	0.428
MOD_Cter_Amidation	316	319	PF01082	0.670
MOD_GlcNHglycan	455	458	PF01048	0.785
MOD_GSK3_1	147	154	PF00069	0.410
MOD_GSK3_1	246	253	PF00069	0.364
MOD_GSK3_1	256	263	PF00069	0.311
MOD_NEK2_1	149	154	PF00069	0.371
MOD_NEK2_1	218	223	PF00069	0.303
MOD_NEK2_1	260	265	PF00069	0.286
MOD_NEK2_1	337	342	PF00069	0.409
MOD_NEK2_1	354	359	PF00069	0.295
MOD_PIKK_1	218	224	PF00454	0.308
MOD_PIKK_1	8	14	PF00454	0.675
MOD_PKA_1	442	448	PF00069	0.482
MOD_PKA_2	199	205	PF00069	0.357
MOD_PKA_2	442	448	PF00069	0.443
MOD_Plk_1	119	125	PF00069	0.368
MOD_Plk_1	142	148	PF00069	0.373
MOD_Plk_1	386	392	PF00069	0.372
MOD_Plk_2-3	72	78	PF00069	0.476
MOD_Plk_4	213	219	PF00069	0.363
MOD_Plk_4	237	243	PF00069	0.387
MOD_Plk_4	256	262	PF00069	0.392
MOD_SUMO_for_1	436	439	PF00179	0.307
TRG_DiLeu_BaEn_2	325	331	PF01217	0.304
TRG_DiLeu_BaEn_4	326	332	PF01217	0.317
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.385
TRG_ENDOCYTIC_2	178	181	PF00928	0.319
TRG_ENDOCYTIC_2	206	209	PF00928	0.338
TRG_ENDOCYTIC_2	295	298	PF00928	0.351
TRG_ENDOCYTIC_2	371	374	PF00928	0.287
TRG_ENDOCYTIC_2	423	426	PF00928	0.397
TRG_ER_diArg_1	2	4	PF00400	0.627
TRG_ER_diArg_1	230	232	PF00400	0.342
TRG_ER_diArg_1	53	55	PF00400	0.408
TRG_ER_FFAT_1	339	350	PF00635	0.360
TRG_NLS_MonoExtN_4	155	161	PF00514	0.311
TRG_Pf-PMV_PEXEL_1	113	117	PF00026	0.526
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	303	307	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM88	Leptomonas seymouri	84%	100%
A0A0S4JVF0	Bodo saltans	59%	100%
A0A1X0P8C7	Trypanosomatidae	70%	100%
A0A3Q8IQJ6	Leishmania donovani	96%	100%
A0A3R7MNS3	Trypanosoma rangeli	70%	100%
A4HNU1	Leishmania braziliensis	90%	100%
A4ICQ3	Leishmania infantum	96%	100%
D0A2Q6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	67%	100%
Q4Q1Z5	Leishmania major	97%	100%