Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASJ7_LEIMU

TriTrypDb:

LmxM.36.0770

Length:

437

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASJ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	124	128	PF00656	0.562
CLV_C14_Caspase3-7	163	167	PF00656	0.557
CLV_NRD_NRD_1	102	104	PF00675	0.586
CLV_NRD_NRD_1	410	412	PF00675	0.773
CLV_NRD_NRD_1	422	424	PF00675	0.641
CLV_PCSK_FUR_1	100	104	PF00082	0.533
CLV_PCSK_FUR_1	420	424	PF00082	0.461
CLV_PCSK_KEX2_1	100	102	PF00082	0.600
CLV_PCSK_KEX2_1	420	422	PF00082	0.668
CLV_PCSK_SKI1_1	138	142	PF00082	0.546
CLV_PCSK_SKI1_1	281	285	PF00082	0.482
DEG_SPOP_SBC_1	372	376	PF00917	0.638
DOC_CKS1_1	203	208	PF01111	0.572
DOC_CKS1_1	60	65	PF01111	0.553
DOC_CYCLIN_yCln2_LP_2	110	116	PF00134	0.456
DOC_CYCLIN_yCln2_LP_2	329	335	PF00134	0.676
DOC_MAPK_HePTP_8	19	31	PF00069	0.432
DOC_MAPK_MEF2A_6	22	31	PF00069	0.450
DOC_PP2B_LxvP_1	248	251	PF13499	0.701
DOC_PP4_FxxP_1	23	26	PF00568	0.349
DOC_USP7_MATH_1	114	118	PF00917	0.685
DOC_USP7_MATH_1	121	125	PF00917	0.755
DOC_USP7_MATH_1	179	183	PF00917	0.731
DOC_USP7_MATH_1	187	191	PF00917	0.777
DOC_USP7_MATH_1	228	232	PF00917	0.495
DOC_USP7_MATH_1	252	256	PF00917	0.765
DOC_USP7_MATH_1	267	271	PF00917	0.784
DOC_USP7_MATH_1	371	375	PF00917	0.784
DOC_USP7_MATH_1	382	386	PF00917	0.507
DOC_USP7_MATH_1	403	407	PF00917	0.691
DOC_WW_Pin1_4	109	114	PF00397	0.713
DOC_WW_Pin1_4	202	207	PF00397	0.681
DOC_WW_Pin1_4	366	371	PF00397	0.591
DOC_WW_Pin1_4	375	380	PF00397	0.740
DOC_WW_Pin1_4	59	64	PF00397	0.548
LIG_14-3-3_CanoR_1	61	71	PF00244	0.476
LIG_Actin_WH2_2	320	336	PF00022	0.669
LIG_BIR_II_1	1	5	PF00653	0.564
LIG_FHA_1	130	136	PF00498	0.616
LIG_FHA_1	178	184	PF00498	0.644
LIG_FHA_1	355	361	PF00498	0.683
LIG_FHA_2	1	7	PF00498	0.479
LIG_FHA_2	161	167	PF00498	0.697
LIG_FHA_2	203	209	PF00498	0.503
LIG_FHA_2	63	69	PF00498	0.419
LIG_FHA_2	8	14	PF00498	0.332
LIG_Integrin_RGD_1	103	105	PF01839	0.462
LIG_LIR_Gen_1	193	203	PF02991	0.588
LIG_LIR_Nem_3	150	156	PF02991	0.442
LIG_LIR_Nem_3	193	198	PF02991	0.592
LIG_LIR_Nem_3	231	237	PF02991	0.568
LIG_LIR_Nem_3	6	11	PF02991	0.379
LIG_NRBOX	14	20	PF00104	0.441
LIG_SH2_CRK	153	157	PF00017	0.436
LIG_SH2_GRB2like	304	307	PF00017	0.581
LIG_SH2_SRC	11	14	PF00017	0.451
LIG_SH2_SRC	304	307	PF00017	0.497
LIG_SH2_STAT5	11	14	PF00017	0.331
LIG_SH2_STAT5	304	307	PF00017	0.581
LIG_SH3_3	110	116	PF00018	0.693
LIG_SH3_3	244	250	PF00018	0.586
LIG_SH3_3	290	296	PF00018	0.667
LIG_SH3_3	329	335	PF00018	0.574
LIG_SH3_CIN85_PxpxPR_1	294	299	PF14604	0.551
LIG_SUMO_SIM_anti_2	13	19	PF11976	0.442
LIG_SUMO_SIM_par_1	25	30	PF11976	0.557
LIG_TRAF2_1	207	210	PF00917	0.507
LIG_TRAF2_1	65	68	PF00917	0.491
LIG_ULM_U2AF65_1	420	425	PF00076	0.701
MOD_CK1_1	182	188	PF00069	0.730
MOD_CK1_1	190	196	PF00069	0.517
MOD_CK1_1	308	314	PF00069	0.535
MOD_CK1_1	385	391	PF00069	0.627
MOD_CK1_1	401	407	PF00069	0.690
MOD_CK2_1	185	191	PF00069	0.673
MOD_CK2_1	202	208	PF00069	0.466
MOD_CK2_1	274	280	PF00069	0.638
MOD_CK2_1	402	408	PF00069	0.494
MOD_CK2_1	62	68	PF00069	0.419
MOD_GlcNHglycan	129	132	PF01048	0.652
MOD_GlcNHglycan	187	190	PF01048	0.775
MOD_GlcNHglycan	191	195	PF01048	0.610
MOD_GlcNHglycan	269	272	PF01048	0.647
MOD_GlcNHglycan	307	310	PF01048	0.761
MOD_GlcNHglycan	335	338	PF01048	0.658
MOD_GlcNHglycan	363	366	PF01048	0.729
MOD_GlcNHglycan	384	387	PF01048	0.696
MOD_GlcNHglycan	405	408	PF01048	0.498
MOD_GlcNHglycan	41	44	PF01048	0.566
MOD_GlcNHglycan	80	83	PF01048	0.418
MOD_GSK3_1	119	126	PF00069	0.687
MOD_GSK3_1	156	163	PF00069	0.586
MOD_GSK3_1	166	173	PF00069	0.692
MOD_GSK3_1	35	42	PF00069	0.625
MOD_GSK3_1	350	357	PF00069	0.431
MOD_GSK3_1	361	368	PF00069	0.732
MOD_GSK3_1	371	378	PF00069	0.769
MOD_GSK3_1	398	405	PF00069	0.705
MOD_N-GLC_1	305	310	PF02516	0.607
MOD_N-GLC_1	39	44	PF02516	0.715
MOD_N-GLC_2	359	361	PF02516	0.617
MOD_NEK2_1	80	85	PF00069	0.417
MOD_NEK2_2	228	233	PF00069	0.413
MOD_PIKK_1	221	227	PF00454	0.615
MOD_PIKK_1	297	303	PF00454	0.679
MOD_PIKK_1	398	404	PF00454	0.662
MOD_PKA_1	411	417	PF00069	0.671
MOD_PKA_2	119	125	PF00069	0.645
MOD_PKA_2	274	280	PF00069	0.474
MOD_PKA_2	333	339	PF00069	0.551
MOD_PKB_1	348	356	PF00069	0.544
MOD_Plk_1	147	153	PF00069	0.495
MOD_Plk_1	27	33	PF00069	0.501
MOD_Plk_2-3	166	172	PF00069	0.606
MOD_Plk_4	148	154	PF00069	0.555
MOD_Plk_4	228	234	PF00069	0.510
MOD_Plk_4	243	249	PF00069	0.508
MOD_Plk_4	319	325	PF00069	0.631
MOD_Plk_4	342	348	PF00069	0.572
MOD_Plk_4	385	391	PF00069	0.452
MOD_Plk_4	7	13	PF00069	0.415
MOD_ProDKin_1	109	115	PF00069	0.715
MOD_ProDKin_1	202	208	PF00069	0.675
MOD_ProDKin_1	366	372	PF00069	0.594
MOD_ProDKin_1	375	381	PF00069	0.739
MOD_ProDKin_1	59	65	PF00069	0.549
TRG_DiLeu_BaEn_1	210	215	PF01217	0.540
TRG_DiLeu_BaEn_1	280	285	PF01217	0.586
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.470
TRG_ENDOCYTIC_2	153	156	PF00928	0.434
TRG_ER_diArg_1	100	103	PF00400	0.499
TRG_ER_diArg_1	347	350	PF00400	0.580
TRG_ER_diArg_1	420	423	PF00400	0.695
TRG_ER_diArg_1	88	91	PF00400	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PFS7	Leptomonas seymouri	43%	98%
A0A1X0P881	Trypanosomatidae	28%	94%
A0A3Q8IFT7	Leishmania donovani	86%	100%
A0A422NK60	Trypanosoma rangeli	28%	100%
A4HNT7	Leishmania braziliensis	67%	100%
A4ICQ7	Leishmania infantum	86%	100%
D0A2Q4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
Q4Q1Z9	Leishmania major	86%	100%
V5BZW6	Trypanosoma cruzi	28%	100%