J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR-repeat-containing chaperone protein DNAJ, putative

Species:

Leishmania mexicana

UniProt:

E9ASJ6_LEIMU

TriTrypDb:

LmxM.36.0760

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASJ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	194	196	PF00675	0.686
CLV_NRD_NRD_1	349	351	PF00675	0.621
CLV_NRD_NRD_1	651	653	PF00675	0.362
CLV_NRD_NRD_1	665	667	PF00675	0.428
CLV_NRD_NRD_1	721	723	PF00675	0.442
CLV_NRD_NRD_1	767	769	PF00675	0.653
CLV_NRD_NRD_1	96	98	PF00675	0.768
CLV_NRD_NRD_1	99	101	PF00675	0.732
CLV_PCSK_FUR_1	97	101	PF00082	0.701
CLV_PCSK_KEX2_1	349	351	PF00082	0.621
CLV_PCSK_KEX2_1	502	504	PF00082	0.437
CLV_PCSK_KEX2_1	514	516	PF00082	0.478
CLV_PCSK_KEX2_1	651	653	PF00082	0.340
CLV_PCSK_KEX2_1	665	667	PF00082	0.428
CLV_PCSK_KEX2_1	721	723	PF00082	0.442
CLV_PCSK_KEX2_1	767	769	PF00082	0.651
CLV_PCSK_KEX2_1	96	98	PF00082	0.724
CLV_PCSK_KEX2_1	99	101	PF00082	0.683
CLV_PCSK_PC1ET2_1	502	504	PF00082	0.437
CLV_PCSK_PC1ET2_1	514	516	PF00082	0.478
CLV_PCSK_SKI1_1	310	314	PF00082	0.344
CLV_PCSK_SKI1_1	33	37	PF00082	0.524
CLV_PCSK_SKI1_1	393	397	PF00082	0.520
CLV_PCSK_SKI1_1	401	405	PF00082	0.446
CLV_PCSK_SKI1_1	464	468	PF00082	0.489
CLV_PCSK_SKI1_1	489	493	PF00082	0.337
CLV_PCSK_SKI1_1	629	633	PF00082	0.362
CLV_PCSK_SKI1_1	668	672	PF00082	0.425
CLV_PCSK_SKI1_1	722	726	PF00082	0.448
CLV_PCSK_SKI1_1	821	825	PF00082	0.334
CLV_PCSK_SKI1_1	9	13	PF00082	0.704
DEG_APCC_DBOX_1	653	661	PF00400	0.390
DEG_APCC_DBOX_1	99	107	PF00400	0.723
DEG_SPOP_SBC_1	352	356	PF00917	0.534
DEG_SPOP_SBC_1	376	380	PF00917	0.600
DOC_CDC14_PxL_1	481	489	PF14671	0.364
DOC_CKS1_1	85	90	PF01111	0.604
DOC_CYCLIN_RxL_1	500	510	PF00134	0.482
DOC_CYCLIN_RxL_1	779	787	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.665
DOC_MAPK_gen_1	651	659	PF00069	0.363
DOC_MAPK_gen_1	848	855	PF00069	0.473
DOC_MAPK_gen_1	96	106	PF00069	0.627
DOC_MAPK_MEF2A_6	651	659	PF00069	0.407
DOC_PP2B_LxvP_1	138	141	PF13499	0.450
DOC_PP4_FxxP_1	214	217	PF00568	0.597
DOC_USP7_MATH_1	151	155	PF00917	0.745
DOC_USP7_MATH_1	221	225	PF00917	0.614
DOC_USP7_MATH_1	352	356	PF00917	0.696
DOC_USP7_MATH_1	367	371	PF00917	0.609
DOC_USP7_MATH_1	375	379	PF00917	0.662
DOC_USP7_MATH_1	46	50	PF00917	0.615
DOC_USP7_MATH_1	592	596	PF00917	0.460
DOC_USP7_MATH_1	735	739	PF00917	0.622
DOC_USP7_MATH_1	744	748	PF00917	0.598
DOC_USP7_UBL2_3	725	729	PF12436	0.471
DOC_USP7_UBL2_3	804	808	PF12436	0.372
DOC_WW_Pin1_4	186	191	PF00397	0.799
DOC_WW_Pin1_4	217	222	PF00397	0.696
DOC_WW_Pin1_4	377	382	PF00397	0.520
DOC_WW_Pin1_4	44	49	PF00397	0.641
DOC_WW_Pin1_4	702	707	PF00397	0.488
DOC_WW_Pin1_4	731	736	PF00397	0.610
DOC_WW_Pin1_4	756	761	PF00397	0.720
DOC_WW_Pin1_4	81	86	PF00397	0.762
DOC_WW_Pin1_4	823	828	PF00397	0.372
LIG_14-3-3_CanoR_1	205	214	PF00244	0.640
LIG_14-3-3_CanoR_1	3	8	PF00244	0.668
LIG_14-3-3_CanoR_1	349	357	PF00244	0.622
LIG_14-3-3_CanoR_1	393	403	PF00244	0.540
LIG_14-3-3_CanoR_1	527	537	PF00244	0.390
LIG_14-3-3_CanoR_1	753	762	PF00244	0.716
LIG_14-3-3_CanoR_1	99	104	PF00244	0.763
LIG_BIR_III_4	630	634	PF00653	0.284
LIG_BRCT_BRCA1_1	110	114	PF00533	0.673
LIG_BRCT_BRCA1_1	737	741	PF00533	0.699
LIG_deltaCOP1_diTrp_1	271	281	PF00928	0.345
LIG_FHA_1	126	132	PF00498	0.559
LIG_FHA_1	170	176	PF00498	0.734
LIG_FHA_1	231	237	PF00498	0.456
LIG_FHA_1	259	265	PF00498	0.427
LIG_FHA_1	542	548	PF00498	0.457
LIG_FHA_1	562	568	PF00498	0.291
LIG_FHA_1	596	602	PF00498	0.339
LIG_FHA_1	697	703	PF00498	0.445
LIG_FHA_1	776	782	PF00498	0.448
LIG_FHA_2	257	263	PF00498	0.396
LIG_FHA_2	384	390	PF00498	0.594
LIG_FHA_2	824	830	PF00498	0.372
LIG_GSK3_LRP6_1	217	223	PF00069	0.586
LIG_LIR_Apic_2	213	217	PF02991	0.655
LIG_LIR_Apic_2	42	46	PF02991	0.486
LIG_LIR_Apic_2	441	445	PF02991	0.470
LIG_LIR_Gen_1	415	424	PF02991	0.506
LIG_LIR_Gen_1	449	458	PF02991	0.339
LIG_LIR_Nem_3	284	288	PF02991	0.384
LIG_LIR_Nem_3	415	421	PF02991	0.557
LIG_LIR_Nem_3	449	453	PF02991	0.340
LIG_LIR_Nem_3	471	477	PF02991	0.450
LIG_LIR_Nem_3	482	487	PF02991	0.324
LIG_LIR_Nem_3	550	555	PF02991	0.508
LIG_LIR_Nem_3	796	800	PF02991	0.583
LIG_LIR_Nem_3	834	840	PF02991	0.279
LIG_LYPXL_S_1	483	487	PF13949	0.355
LIG_LYPXL_yS_3	484	487	PF13949	0.354
LIG_PDZ_Class_2	850	855	PF00595	0.483
LIG_Pex14_2	281	285	PF04695	0.385
LIG_PTAP_UEV_1	790	795	PF05743	0.537
LIG_REV1ctd_RIR_1	245	254	PF16727	0.266
LIG_SH2_CRK	43	47	PF00017	0.483
LIG_SH2_CRK	442	446	PF00017	0.463
LIG_SH2_CRK	844	848	PF00017	0.265
LIG_SH2_NCK_1	315	319	PF00017	0.391
LIG_SH2_NCK_1	43	47	PF00017	0.483
LIG_SH2_NCK_1	645	649	PF00017	0.359
LIG_SH2_NCK_1	690	694	PF00017	0.454
LIG_SH2_SRC	287	290	PF00017	0.336
LIG_SH2_SRC	690	693	PF00017	0.462
LIG_SH2_STAP1	222	226	PF00017	0.470
LIG_SH2_STAP1	260	264	PF00017	0.388
LIG_SH2_STAP1	315	319	PF00017	0.407
LIG_SH2_STAP1	597	601	PF00017	0.336
LIG_SH2_STAP1	645	649	PF00017	0.359
LIG_SH2_STAP1	690	694	PF00017	0.481
LIG_SH2_STAT3	664	667	PF00017	0.460
LIG_SH2_STAT5	222	225	PF00017	0.477
LIG_SH2_STAT5	260	263	PF00017	0.475
LIG_SH2_STAT5	287	290	PF00017	0.328
LIG_SH2_STAT5	296	299	PF00017	0.357
LIG_SH2_STAT5	442	445	PF00017	0.428
LIG_SH2_STAT5	528	531	PF00017	0.363
LIG_SH2_STAT5	557	560	PF00017	0.571
LIG_SH2_STAT5	597	600	PF00017	0.359
LIG_SH2_STAT5	615	618	PF00017	0.476
LIG_SH2_STAT5	658	661	PF00017	0.366
LIG_SH2_STAT5	79	82	PF00017	0.668
LIG_SH3_1	82	88	PF00018	0.659
LIG_SH3_2	86	91	PF14604	0.630
LIG_SH3_3	215	221	PF00018	0.554
LIG_SH3_3	788	794	PF00018	0.545
LIG_SH3_3	80	86	PF00018	0.736
LIG_SH3_CIN85_PxpxPR_1	86	91	PF14604	0.630
LIG_SUMO_SIM_par_1	102	108	PF11976	0.610
LIG_SUMO_SIM_par_1	434	441	PF11976	0.432
LIG_SUMO_SIM_par_1	9	14	PF11976	0.666
LIG_TRAF2_1	143	146	PF00917	0.700
LIG_TRAF2_1	405	408	PF00917	0.405
LIG_TYR_ITIM	842	847	PF00017	0.265
LIG_UBA3_1	458	465	PF00899	0.396
LIG_WRC_WIRS_1	282	287	PF05994	0.403
LIG_WW_3	88	92	PF00397	0.691
MOD_CDK_SPK_2	731	736	PF00069	0.587
MOD_CDK_SPxxK_3	823	830	PF00069	0.308
MOD_CDK_SPxxK_3	84	91	PF00069	0.599
MOD_CK1_1	102	108	PF00069	0.642
MOD_CK1_1	110	116	PF00069	0.600
MOD_CK1_1	181	187	PF00069	0.610
MOD_CK1_1	220	226	PF00069	0.695
MOD_CK1_1	344	350	PF00069	0.729
MOD_CK1_1	353	359	PF00069	0.592
MOD_CK1_1	438	444	PF00069	0.483
MOD_CK1_1	49	55	PF00069	0.699
MOD_CK1_1	595	601	PF00069	0.397
MOD_CK1_1	742	748	PF00069	0.683
MOD_CK1_1	756	762	PF00069	0.693
MOD_CK1_1	81	87	PF00069	0.758
MOD_CK2_1	119	125	PF00069	0.617
MOD_CK2_1	152	158	PF00069	0.647
MOD_CK2_1	179	185	PF00069	0.555
MOD_CK2_1	224	230	PF00069	0.568
MOD_CK2_1	256	262	PF00069	0.393
MOD_CK2_1	383	389	PF00069	0.536
MOD_CK2_1	394	400	PF00069	0.334
MOD_CK2_1	465	471	PF00069	0.413
MOD_CK2_1	59	65	PF00069	0.651
MOD_CK2_1	744	750	PF00069	0.683
MOD_CK2_1	823	829	PF00069	0.372
MOD_GlcNHglycan	110	113	PF01048	0.635
MOD_GlcNHglycan	134	137	PF01048	0.574
MOD_GlcNHglycan	181	184	PF01048	0.628
MOD_GlcNHglycan	29	32	PF01048	0.628
MOD_GlcNHglycan	343	346	PF01048	0.790
MOD_GlcNHglycan	51	54	PF01048	0.649
MOD_GlcNHglycan	594	597	PF01048	0.399
MOD_GlcNHglycan	62	65	PF01048	0.742
MOD_GlcNHglycan	636	639	PF01048	0.365
MOD_GlcNHglycan	679	682	PF01048	0.461
MOD_GlcNHglycan	741	744	PF01048	0.630
MOD_GlcNHglycan	755	758	PF01048	0.706
MOD_GlcNHglycan	770	773	PF01048	0.575
MOD_GlcNHglycan	791	794	PF01048	0.603
MOD_GlcNHglycan	849	853	PF01048	0.456
MOD_GSK3_1	11	18	PF00069	0.654
MOD_GSK3_1	158	165	PF00069	0.673
MOD_GSK3_1	175	182	PF00069	0.557
MOD_GSK3_1	201	208	PF00069	0.702
MOD_GSK3_1	217	224	PF00069	0.646
MOD_GSK3_1	341	348	PF00069	0.723
MOD_GSK3_1	352	359	PF00069	0.602
MOD_GSK3_1	44	51	PF00069	0.594
MOD_GSK3_1	538	545	PF00069	0.448
MOD_GSK3_1	55	62	PF00069	0.577
MOD_GSK3_1	724	731	PF00069	0.589
MOD_GSK3_1	735	742	PF00069	0.782
MOD_GSK3_1	74	81	PF00069	0.720
MOD_GSK3_1	95	102	PF00069	0.720
MOD_N-GLC_1	108	113	PF02516	0.634
MOD_N-GLC_1	119	124	PF02516	0.605
MOD_N-GLC_1	616	621	PF02516	0.340
MOD_NEK2_1	1	6	PF00069	0.703
MOD_NEK2_1	162	167	PF00069	0.628
MOD_NEK2_1	169	174	PF00069	0.592
MOD_NEK2_1	281	286	PF00069	0.433
MOD_NEK2_1	394	399	PF00069	0.426
MOD_NEK2_1	413	418	PF00069	0.322
MOD_NEK2_1	55	60	PF00069	0.670
MOD_NEK2_1	671	676	PF00069	0.356
MOD_NEK2_1	784	789	PF00069	0.449
MOD_NEK2_2	127	132	PF00069	0.632
MOD_PIKK_1	119	125	PF00454	0.500
MOD_PIKK_1	394	400	PF00454	0.423
MOD_PIKK_1	528	534	PF00454	0.369
MOD_PIKK_1	709	715	PF00454	0.461
MOD_PIKK_1	744	750	PF00454	0.503
MOD_PKA_1	99	105	PF00069	0.685
MOD_PKA_2	2	8	PF00069	0.646
MOD_PKA_2	341	347	PF00069	0.611
MOD_PKA_2	348	354	PF00069	0.580
MOD_PKA_2	567	573	PF00069	0.463
MOD_PKA_2	95	101	PF00069	0.732
MOD_PKB_1	751	759	PF00069	0.671
MOD_PKB_1	97	105	PF00069	0.690
MOD_Plk_1	158	164	PF00069	0.694
MOD_Plk_1	367	373	PF00069	0.470
MOD_Plk_1	616	622	PF00069	0.341
MOD_Plk_4	110	116	PF00069	0.567
MOD_Plk_4	164	170	PF00069	0.742
MOD_Plk_4	413	419	PF00069	0.412
MOD_Plk_4	74	80	PF00069	0.675
MOD_Plk_4	784	790	PF00069	0.558
MOD_Plk_4	99	105	PF00069	0.686
MOD_ProDKin_1	186	192	PF00069	0.798
MOD_ProDKin_1	217	223	PF00069	0.698
MOD_ProDKin_1	377	383	PF00069	0.519
MOD_ProDKin_1	44	50	PF00069	0.643
MOD_ProDKin_1	702	708	PF00069	0.494
MOD_ProDKin_1	731	737	PF00069	0.610
MOD_ProDKin_1	756	762	PF00069	0.717
MOD_ProDKin_1	81	87	PF00069	0.762
MOD_ProDKin_1	823	829	PF00069	0.372
MOD_SUMO_rev_2	51	61	PF00179	0.617
MOD_SUMO_rev_2	703	712	PF00179	0.462
MOD_SUMO_rev_2	796	806	PF00179	0.503
TRG_DiLeu_BaLyEn_6	390	395	PF01217	0.585
TRG_DiLeu_BaLyEn_6	503	508	PF01217	0.258
TRG_ENDOCYTIC_2	319	322	PF00928	0.416
TRG_ENDOCYTIC_2	327	330	PF00928	0.466
TRG_ENDOCYTIC_2	484	487	PF00928	0.389
TRG_ENDOCYTIC_2	844	847	PF00928	0.265
TRG_ER_diArg_1	651	654	PF00400	0.407
TRG_ER_diArg_1	664	666	PF00400	0.458
TRG_ER_diArg_1	96	99	PF00400	0.714
TRG_Pf-PMV_PEXEL_1	393	398	PF00026	0.554
TRG_Pf-PMV_PEXEL_1	465	469	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.272
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I741	Leptomonas seymouri	47%	71%
A0A0S4JSA3	Bodo saltans	26%	88%
A0A3S7XAG9	Leishmania donovani	90%	100%
A4HNT6	Leishmania braziliensis	72%	100%
A4ICQ8	Leishmania infantum	89%	100%
D0A2Q0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	88%
Q4Q200	Leishmania major	89%	100%