C3H1-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASJ4_LEIMU

TriTrypDb:

LmxM.36.0740

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASJ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	258	262	PF00656	0.613
CLV_C14_Caspase3-7	360	364	PF00656	0.438
CLV_C14_Caspase3-7	505	509	PF00656	0.487
CLV_NRD_NRD_1	469	471	PF00675	0.469
CLV_NRD_NRD_1	505	507	PF00675	0.464
CLV_PCSK_KEX2_1	471	473	PF00082	0.422
CLV_PCSK_PC1ET2_1	471	473	PF00082	0.422
CLV_PCSK_SKI1_1	274	278	PF00082	0.378
CLV_PCSK_SKI1_1	311	315	PF00082	0.548
DOC_CDC14_PxL_1	416	424	PF14671	0.409
DOC_MAPK_gen_1	202	209	PF00069	0.408
DOC_MAPK_gen_1	271	281	PF00069	0.370
DOC_MAPK_MEF2A_6	202	209	PF00069	0.408
DOC_MAPK_MEF2A_6	271	279	PF00069	0.374
DOC_MAPK_MEF2A_6	421	430	PF00069	0.391
DOC_MAPK_NFAT4_5	274	282	PF00069	0.388
DOC_MAPK_RevD_3	494	507	PF00069	0.417
DOC_PP2B_LxvP_1	371	374	PF13499	0.420
DOC_PP4_FxxP_1	281	284	PF00568	0.389
DOC_USP7_MATH_1	233	237	PF00917	0.668
DOC_USP7_MATH_1	341	345	PF00917	0.359
DOC_USP7_MATH_1	62	66	PF00917	0.668
DOC_USP7_MATH_1	67	71	PF00917	0.615
DOC_USP7_UBL2_3	267	271	PF12436	0.475
DOC_USP7_UBL2_3	311	315	PF12436	0.446
DOC_USP7_UBL2_3	366	370	PF12436	0.456
DOC_USP7_UBL2_3	454	458	PF12436	0.407
DOC_WW_Pin1_4	188	193	PF00397	0.527
DOC_WW_Pin1_4	260	265	PF00397	0.531
DOC_WW_Pin1_4	280	285	PF00397	0.317
DOC_WW_Pin1_4	65	70	PF00397	0.502
DOC_WW_Pin1_4	98	103	PF00397	0.635
LIG_14-3-3_CanoR_1	211	217	PF00244	0.464
LIG_APCC_ABBA_1	355	360	PF00400	0.430
LIG_BRCT_BRCA1_1	321	325	PF00533	0.400
LIG_BRCT_BRCA1_1	489	493	PF00533	0.396
LIG_eIF4E_1	442	448	PF01652	0.436
LIG_FHA_1	189	195	PF00498	0.475
LIG_FHA_1	199	205	PF00498	0.437
LIG_FHA_1	270	276	PF00498	0.430
LIG_FHA_1	425	431	PF00498	0.384
LIG_FHA_2	213	219	PF00498	0.531
LIG_FHA_2	436	442	PF00498	0.459
LIG_FHA_2	497	503	PF00498	0.417
LIG_FHA_2	516	522	PF00498	0.490
LIG_LIR_Apic_2	280	284	PF02991	0.390
LIG_LIR_Apic_2	302	306	PF02991	0.507
LIG_LIR_Apic_2	335	341	PF02991	0.378
LIG_LIR_Gen_1	351	358	PF02991	0.422
LIG_LIR_Gen_1	490	498	PF02991	0.375
LIG_LIR_Nem_3	302	308	PF02991	0.408
LIG_LIR_Nem_3	335	340	PF02991	0.378
LIG_LIR_Nem_3	437	442	PF02991	0.411
LIG_LIR_Nem_3	490	496	PF02991	0.377
LIG_Pex14_2	365	369	PF04695	0.390
LIG_PTB_Apo_2	168	175	PF02174	0.569
LIG_SH2_CRK	338	342	PF00017	0.410
LIG_SH2_GRB2like	354	357	PF00017	0.399
LIG_SH2_STAP1	213	217	PF00017	0.482
LIG_SH2_STAP1	460	464	PF00017	0.622
LIG_SH2_STAT3	125	128	PF00017	0.635
LIG_SH2_STAT3	161	164	PF00017	0.693
LIG_SH2_STAT3	175	178	PF00017	0.492
LIG_SH2_STAT3	456	459	PF00017	0.405
LIG_SH2_STAT3	52	55	PF00017	0.691
LIG_SH2_STAT3	84	87	PF00017	0.583
LIG_SH2_STAT3	95	98	PF00017	0.614
LIG_SH2_STAT5	173	176	PF00017	0.636
LIG_SH2_STAT5	303	306	PF00017	0.434
LIG_SH2_STAT5	346	349	PF00017	0.367
LIG_SH2_STAT5	354	357	PF00017	0.448
LIG_SH2_STAT5	60	63	PF00017	0.612
LIG_SH2_STAT5	95	98	PF00017	0.635
LIG_SH3_2	119	124	PF14604	0.630
LIG_SH3_3	108	114	PF00018	0.641
LIG_SH3_3	115	121	PF00018	0.572
LIG_SH3_3	417	423	PF00018	0.438
LIG_TRAF2_1	499	502	PF00917	0.468
LIG_TRAF2_1	518	521	PF00917	0.417
LIG_TYR_ITSM	333	340	PF00017	0.369
LIG_UBA3_1	204	208	PF00899	0.369
MOD_CDK_SPK_2	280	285	PF00069	0.398
MOD_CDK_SPxxK_3	260	267	PF00069	0.521
MOD_CK1_1	131	137	PF00069	0.636
MOD_CK1_1	260	266	PF00069	0.549
MOD_CK1_1	280	286	PF00069	0.312
MOD_CK1_1	435	441	PF00069	0.479
MOD_CK1_1	466	472	PF00069	0.466
MOD_CK1_1	65	71	PF00069	0.648
MOD_CK2_1	237	243	PF00069	0.650
MOD_CK2_1	248	254	PF00069	0.581
MOD_CK2_1	496	502	PF00069	0.418
MOD_CK2_1	515	521	PF00069	0.566
MOD_Cter_Amidation	316	319	PF01082	0.425
MOD_GlcNHglycan	158	161	PF01048	0.666
MOD_GlcNHglycan	233	236	PF01048	0.662
MOD_GlcNHglycan	250	253	PF01048	0.508
MOD_GlcNHglycan	290	293	PF01048	0.452
MOD_GlcNHglycan	321	324	PF01048	0.408
MOD_GlcNHglycan	341	344	PF01048	0.288
MOD_GlcNHglycan	350	353	PF01048	0.345
MOD_GlcNHglycan	402	406	PF01048	0.446
MOD_GlcNHglycan	69	72	PF01048	0.608
MOD_GlcNHglycan	8	11	PF01048	0.609
MOD_GSK3_1	227	234	PF00069	0.616
MOD_GSK3_1	244	251	PF00069	0.538
MOD_GSK3_1	341	348	PF00069	0.353
MOD_GSK3_1	401	408	PF00069	0.480
MOD_GSK3_1	63	70	PF00069	0.504
MOD_N-GLC_1	131	136	PF02516	0.652
MOD_N-GLC_1	405	410	PF02516	0.403
MOD_NEK2_1	277	282	PF00069	0.412
MOD_NEK2_1	288	293	PF00069	0.463
MOD_NEK2_1	301	306	PF00069	0.350
MOD_NEK2_1	487	492	PF00069	0.382
MOD_NEK2_2	341	346	PF00069	0.357
MOD_NEK2_2	424	429	PF00069	0.421
MOD_OFUCOSY	485	491	PF10250	0.369
MOD_PIKK_1	113	119	PF00454	0.669
MOD_PIKK_1	47	53	PF00454	0.727
MOD_PIKK_1	78	84	PF00454	0.735
MOD_PIKK_1	93	99	PF00454	0.533
MOD_PK_1	203	209	PF00069	0.401
MOD_Plk_1	301	307	PF00069	0.416
MOD_Plk_1	405	411	PF00069	0.400
MOD_Plk_1	424	430	PF00069	0.394
MOD_Plk_4	107	113	PF00069	0.703
MOD_Plk_4	237	243	PF00069	0.607
MOD_Plk_4	277	283	PF00069	0.414
MOD_Plk_4	341	347	PF00069	0.355
MOD_ProDKin_1	188	194	PF00069	0.514
MOD_ProDKin_1	260	266	PF00069	0.526
MOD_ProDKin_1	280	286	PF00069	0.312
MOD_ProDKin_1	65	71	PF00069	0.502
MOD_ProDKin_1	98	104	PF00069	0.634
MOD_SUMO_for_1	313	316	PF00179	0.452
MOD_SUMO_for_1	537	540	PF00179	0.470
MOD_SUMO_rev_2	240	247	PF00179	0.657
MOD_SUMO_rev_2	263	273	PF00179	0.562
MOD_SUMO_rev_2	312	320	PF00179	0.467
MOD_SUMO_rev_2	500	509	PF00179	0.456
TRG_DiLeu_BaEn_2	488	494	PF01217	0.380
TRG_ENDOCYTIC_2	213	216	PF00928	0.469
TRG_ENDOCYTIC_2	337	340	PF00928	0.371
TRG_ENDOCYTIC_2	354	357	PF00928	0.426
TRG_ER_diArg_1	470	473	PF00400	0.440
TRG_NLS_MonoExtN_4	468	474	PF00514	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7W2	Leptomonas seymouri	69%	100%
A0A3S7XAD2	Leishmania donovani	93%	100%
A4HNT4	Leishmania braziliensis	85%	100%
A4ICR0	Leishmania infantum	93%	99%
Q4Q202	Leishmania major	94%	100%