Zinc_finger_protein_family_member_-_putative

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASJ3_LEIMU

TriTrypDb:

LmxM.36.0730

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASJ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	100	104	PF00656	0.493
CLV_C14_Caspase3-7	320	324	PF00656	0.836
CLV_NRD_NRD_1	438	440	PF00675	0.757
CLV_PCSK_KEX2_1	438	440	PF00082	0.757
CLV_PCSK_SKI1_1	57	61	PF00082	0.567
DEG_Nend_UBRbox_4	1	3	PF02207	0.280
DEG_SPOP_SBC_1	253	257	PF00917	0.710
DEG_SPOP_SBC_1	447	451	PF00917	0.839
DOC_CKS1_1	170	175	PF01111	0.577
DOC_CKS1_1	398	403	PF01111	0.686
DOC_MAPK_DCC_7	155	165	PF00069	0.528
DOC_MAPK_DCC_7	387	397	PF00069	0.733
DOC_MAPK_FxFP_2	60	63	PF00069	0.468
DOC_MAPK_MEF2A_6	227	236	PF00069	0.478
DOC_MAPK_MEF2A_6	391	399	PF00069	0.685
DOC_PP2B_LxvP_1	356	359	PF13499	0.520
DOC_PP4_FxxP_1	60	63	PF00568	0.468
DOC_USP7_MATH_1	327	331	PF00917	0.757
DOC_USP7_MATH_2	241	247	PF00917	0.752
DOC_WW_Pin1_4	169	174	PF00397	0.530
DOC_WW_Pin1_4	235	240	PF00397	0.542
DOC_WW_Pin1_4	247	252	PF00397	0.698
DOC_WW_Pin1_4	265	270	PF00397	0.670
DOC_WW_Pin1_4	273	278	PF00397	0.699
DOC_WW_Pin1_4	379	384	PF00397	0.801
DOC_WW_Pin1_4	390	395	PF00397	0.626
DOC_WW_Pin1_4	397	402	PF00397	0.559
DOC_WW_Pin1_4	410	415	PF00397	0.509
DOC_WW_Pin1_4	422	427	PF00397	0.735
DOC_WW_Pin1_4	432	437	PF00397	0.709
DOC_WW_Pin1_4	443	448	PF00397	0.738
DOC_WW_Pin1_4	48	53	PF00397	0.593
DOC_WW_Pin1_4	68	73	PF00397	0.225
LIG_APCC_ABBA_1	50	55	PF00400	0.500
LIG_APCC_ABBA_1	74	79	PF00400	0.446
LIG_APCC_ABBA_1	95	100	PF00400	0.494
LIG_CtBP_PxDLS_1	371	375	PF00389	0.728
LIG_FHA_1	198	204	PF00498	0.615
LIG_FHA_1	214	220	PF00498	0.341
LIG_FHA_1	278	284	PF00498	0.729
LIG_FHA_1	338	344	PF00498	0.736
LIG_FHA_1	432	438	PF00498	0.852
LIG_FHA_2	11	17	PF00498	0.629
LIG_FHA_2	170	176	PF00498	0.527
LIG_FHA_2	189	195	PF00498	0.602
LIG_IBAR_NPY_1	441	443	PF08397	0.732
LIG_LIR_Apic_2	58	63	PF02991	0.471
LIG_LIR_Gen_1	91	98	PF02991	0.483
LIG_LIR_Nem_3	138	143	PF02991	0.500
LIG_LIR_Nem_3	91	97	PF02991	0.571
LIG_MYND_1	354	358	PF01753	0.535
LIG_MYND_2	160	164	PF01753	0.534
LIG_NRBOX	45	51	PF00104	0.581
LIG_SH2_CRK	369	373	PF00017	0.689
LIG_SH2_CRK	78	82	PF00017	0.448
LIG_SH2_NCK_1	193	197	PF00017	0.500
LIG_SH2_NCK_1	78	82	PF00017	0.448
LIG_SH2_PTP2	38	41	PF00017	0.542
LIG_SH2_PTP2	94	97	PF00017	0.485
LIG_SH2_SRC	193	196	PF00017	0.500
LIG_SH2_SRC	38	41	PF00017	0.542
LIG_SH2_SRC	78	81	PF00017	0.449
LIG_SH2_STAP1	193	197	PF00017	0.500
LIG_SH2_STAT3	338	341	PF00017	0.842
LIG_SH2_STAT5	317	320	PF00017	0.829
LIG_SH2_STAT5	38	41	PF00017	0.453
LIG_SH2_STAT5	45	48	PF00017	0.435
LIG_SH2_STAT5	70	73	PF00017	0.512
LIG_SH2_STAT5	94	97	PF00017	0.532
LIG_SH3_1	357	363	PF00018	0.632
LIG_SH3_3	164	170	PF00018	0.465
LIG_SH3_3	357	363	PF00018	0.691
LIG_SH3_3	36	42	PF00018	0.450
LIG_SH3_3	365	371	PF00018	0.658
LIG_SH3_3	395	401	PF00018	0.645
LIG_SUMO_SIM_par_1	413	419	PF11976	0.708
LIG_TRAF2_1	241	244	PF00917	0.735
LIG_TRAF2_1	311	314	PF00917	0.682
LIG_TRFH_1	443	447	PF08558	0.737
MOD_CDC14_SPxK_1	393	396	PF00782	0.585
MOD_CDC14_SPxK_1	435	438	PF00782	0.750
MOD_CDK_SPxK_1	390	396	PF00069	0.619
MOD_CDK_SPxK_1	432	438	PF00069	0.751
MOD_CDK_SPxxK_3	432	439	PF00069	0.752
MOD_CK1_1	114	120	PF00069	0.310
MOD_CK1_1	246	252	PF00069	0.797
MOD_CK1_1	262	268	PF00069	0.535
MOD_CK1_1	373	379	PF00069	0.545
MOD_CK1_1	413	419	PF00069	0.723
MOD_CK1_1	422	428	PF00069	0.735
MOD_CK1_1	432	438	PF00069	0.751
MOD_CK1_1	446	452	PF00069	0.631
MOD_CK2_1	10	16	PF00069	0.422
MOD_CK2_1	188	194	PF00069	0.598
MOD_CK2_1	373	379	PF00069	0.515
MOD_GlcNHglycan	261	264	PF01048	0.761
MOD_GlcNHglycan	31	34	PF01048	0.535
MOD_GlcNHglycan	388	391	PF01048	0.756
MOD_GlcNHglycan	418	421	PF01048	0.721
MOD_GlcNHglycan	422	425	PF01048	0.735
MOD_GSK3_1	142	149	PF00069	0.490
MOD_GSK3_1	184	191	PF00069	0.588
MOD_GSK3_1	243	250	PF00069	0.779
MOD_GSK3_1	254	261	PF00069	0.628
MOD_GSK3_1	265	272	PF00069	0.600
MOD_GSK3_1	273	280	PF00069	0.603
MOD_GSK3_1	317	324	PF00069	0.577
MOD_GSK3_1	386	393	PF00069	0.760
MOD_GSK3_1	416	423	PF00069	0.828
MOD_GSK3_1	441	448	PF00069	0.831
MOD_N-GLC_2	34	36	PF02516	0.477
MOD_NEK2_1	21	26	PF00069	0.472
MOD_NEK2_1	282	287	PF00069	0.612
MOD_PIKK_1	188	194	PF00454	0.598
MOD_PIKK_1	337	343	PF00454	0.773
MOD_PIKK_1	424	430	PF00454	0.838
MOD_PKA_2	146	152	PF00069	0.443
MOD_PKA_2	315	321	PF00069	0.602
MOD_PKA_2	386	392	PF00069	0.688
MOD_Plk_1	243	249	PF00069	0.699
MOD_Plk_1	322	328	PF00069	0.733
MOD_Plk_4	21	27	PF00069	0.458
MOD_Plk_4	362	368	PF00069	0.734
MOD_Plk_4	55	61	PF00069	0.450
MOD_ProDKin_1	169	175	PF00069	0.532
MOD_ProDKin_1	235	241	PF00069	0.548
MOD_ProDKin_1	247	253	PF00069	0.699
MOD_ProDKin_1	265	271	PF00069	0.665
MOD_ProDKin_1	273	279	PF00069	0.698
MOD_ProDKin_1	379	385	PF00069	0.801
MOD_ProDKin_1	390	396	PF00069	0.619
MOD_ProDKin_1	397	403	PF00069	0.574
MOD_ProDKin_1	410	416	PF00069	0.506
MOD_ProDKin_1	422	428	PF00069	0.735
MOD_ProDKin_1	432	438	PF00069	0.710
MOD_ProDKin_1	443	449	PF00069	0.738
MOD_ProDKin_1	48	54	PF00069	0.588
MOD_ProDKin_1	68	74	PF00069	0.223
MOD_SUMO_rev_2	51	59	PF00179	0.588
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.577
TRG_ENDOCYTIC_2	156	159	PF00928	0.596
TRG_ENDOCYTIC_2	369	372	PF00928	0.816
TRG_ENDOCYTIC_2	38	41	PF00928	0.542
TRG_ENDOCYTIC_2	62	65	PF00928	0.431
TRG_ENDOCYTIC_2	77	80	PF00928	0.415
TRG_ENDOCYTIC_2	94	97	PF00928	0.485
TRG_ER_diArg_1	437	439	PF00400	0.758
TRG_Pf-PMV_PEXEL_1	290	294	PF00026	0.689

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P889	Leptomonas seymouri	59%	95%
A0A3S7XAD0	Leishmania donovani	92%	90%
A4HNT3	Leishmania braziliensis	84%	100%
A4ICR1	Leishmania infantum	92%	90%
Q4Q203	Leishmania major	93%	100%