LRRcap domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein C21orf2 homolog, putative

Species:

Leishmania mexicana

UniProt:

E9ASJ1_LEIMU

TriTrypDb:

LmxM.36.0710

Length:

259

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

E9ASJ1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	132	134	PF00675	0.296
CLV_NRD_NRD_1	73	75	PF00675	0.235
CLV_PCSK_KEX2_1	138	140	PF00082	0.308
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.300
CLV_PCSK_SKI1_1	10	14	PF00082	0.450
CLV_PCSK_SKI1_1	138	142	PF00082	0.273
CLV_PCSK_SKI1_1	203	207	PF00082	0.592
CLV_PCSK_SKI1_1	214	218	PF00082	0.398
CLV_PCSK_SKI1_1	249	253	PF00082	0.453
CLV_PCSK_SKI1_1	82	86	PF00082	0.247
DEG_APCC_DBOX_1	213	221	PF00400	0.534
DOC_CDC14_PxL_1	40	48	PF14671	0.341
DOC_CDC14_PxL_1	87	95	PF14671	0.434
DOC_MAPK_gen_1	42	51	PF00069	0.500
DOC_MAPK_MEF2A_6	88	95	PF00069	0.484
DOC_PP1_RVXF_1	201	208	PF00149	0.606
DOC_USP7_MATH_1	163	167	PF00917	0.710
DOC_USP7_MATH_1	179	183	PF00917	0.620
DOC_USP7_MATH_1	188	192	PF00917	0.518
DOC_USP7_UBL2_3	134	138	PF12436	0.500
DOC_USP7_UBL2_3	15	19	PF12436	0.458
DOC_USP7_UBL2_3	245	249	PF12436	0.557
DOC_WW_Pin1_4	157	162	PF00397	0.662
DOC_WW_Pin1_4	169	174	PF00397	0.574
DOC_WW_Pin1_4	177	182	PF00397	0.714
LIG_14-3-3_CanoR_1	139	145	PF00244	0.517
LIG_FHA_1	1	7	PF00498	0.512
LIG_FHA_1	140	146	PF00498	0.488
LIG_FHA_1	190	196	PF00498	0.683
LIG_FHA_1	90	96	PF00498	0.444
LIG_FHA_2	127	133	PF00498	0.459
LIG_FHA_2	192	198	PF00498	0.723
LIG_LIR_Gen_1	204	215	PF02991	0.483
LIG_LIR_Nem_3	204	210	PF02991	0.503
LIG_MYND_3	43	47	PF01753	0.485
LIG_SH2_STAT5	253	256	PF00017	0.475
LIG_SH2_STAT5	72	75	PF00017	0.417
LIG_SUMO_SIM_anti_2	219	226	PF11976	0.510
LIG_SUMO_SIM_anti_2	230	236	PF11976	0.451
LIG_SUMO_SIM_anti_2	35	41	PF11976	0.434
LIG_SUMO_SIM_anti_2	92	97	PF11976	0.471
LIG_SUMO_SIM_par_1	216	222	PF11976	0.480
LIG_TRAF2_1	129	132	PF00917	0.397
LIG_TRAF2_1	194	197	PF00917	0.614
LIG_UBA3_1	67	75	PF00899	0.471
MOD_CDC14_SPxK_1	172	175	PF00782	0.610
MOD_CDK_SPK_2	157	162	PF00069	0.630
MOD_CDK_SPxK_1	169	175	PF00069	0.613
MOD_CDK_SPxxK_3	157	164	PF00069	0.631
MOD_CK1_1	189	195	PF00069	0.605
MOD_CK1_1	201	207	PF00069	0.475
MOD_CK1_1	219	225	PF00069	0.405
MOD_CK2_1	126	132	PF00069	0.417
MOD_CK2_1	191	197	PF00069	0.644
MOD_GlcNHglycan	151	154	PF01048	0.588
MOD_GlcNHglycan	200	203	PF01048	0.525
MOD_GSK3_1	13	20	PF00069	0.447
MOD_GSK3_1	164	171	PF00069	0.630
MOD_GSK3_1	177	184	PF00069	0.653
MOD_GSK3_1	201	208	PF00069	0.603
MOD_N-GLC_1	198	203	PF02516	0.526
MOD_N-GLC_1	54	59	PF02516	0.300
MOD_NEK2_1	13	18	PF00069	0.372
MOD_NEK2_1	149	154	PF00069	0.549
MOD_NEK2_1	206	211	PF00069	0.531
MOD_NEK2_1	216	221	PF00069	0.479
MOD_PIKK_1	101	107	PF00454	0.341
MOD_PKA_1	138	144	PF00069	0.467
MOD_PKA_1	164	170	PF00069	0.703
MOD_PKA_2	138	144	PF00069	0.500
MOD_Plk_1	225	231	PF00069	0.459
MOD_Plk_1	35	41	PF00069	0.417
MOD_Plk_1	54	60	PF00069	0.500
MOD_Plk_1	82	88	PF00069	0.500
MOD_Plk_4	216	222	PF00069	0.424
MOD_Plk_4	91	97	PF00069	0.466
MOD_ProDKin_1	157	163	PF00069	0.659
MOD_ProDKin_1	169	175	PF00069	0.556
MOD_ProDKin_1	177	183	PF00069	0.715
MOD_SUMO_rev_2	127	136	PF00179	0.485
TRG_DiLeu_BaEn_1	230	235	PF01217	0.548
TRG_ENDOCYTIC_2	109	112	PF00928	0.441
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.229
TRG_Pf-PMV_PEXEL_1	5	9	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7V8	Leptomonas seymouri	65%	100%
A0A0S4JS78	Bodo saltans	43%	100%
A0A3S7XAD6	Leishmania donovani	95%	100%
A4HNT1	Leishmania braziliensis	80%	100%
A4ICR3	Leishmania infantum	95%	100%
D0A2P1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	94%
O43822	Homo sapiens	32%	100%
Q4Q205	Leishmania major	93%	100%
Q8C6G1	Mus musculus	36%	100%
Q9BV99	Homo sapiens	31%	100%
V5DRP5	Trypanosoma cruzi	40%	94%