Putative MP18 RNA editing complex protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MP18 RNA editing complex protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASJ0_LEIMU

TriTrypDb:

LmxM.36.0700

Length:

229

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0031019	mitochondrial mRNA editing complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045293	mRNA editing complex	3	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:1902494	catalytic complex	2	1

Expansion

Sequence features

E9ASJ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASJ0

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009451	RNA modification	5	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	7
GO:0003677	DNA binding	4	7
GO:0003697	single-stranded DNA binding	5	7
GO:0005488	binding	1	7
GO:0097159	organic cyclic compound binding	2	7
GO:1901363	heterocyclic compound binding	2	7
GO:0003723	RNA binding	4	1
GO:0003824	catalytic activity	1	1
GO:0004518	nuclease activity	4	1
GO:0004519	endonuclease activity	5	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	106	110	PF00656	0.475
CLV_C14_Caspase3-7	217	221	PF00656	0.599
CLV_NRD_NRD_1	188	190	PF00675	0.535
CLV_NRD_NRD_1	3	5	PF00675	0.575
CLV_PCSK_KEX2_1	188	190	PF00082	0.535
CLV_PCSK_KEX2_1	3	5	PF00082	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.638
DOC_MAPK_DCC_7	188	197	PF00069	0.443
DOC_MAPK_MEF2A_6	165	174	PF00069	0.431
DOC_PP2B_PxIxI_1	169	175	PF00149	0.373
DOC_USP7_MATH_1	20	24	PF00917	0.681
DOC_USP7_MATH_1	35	39	PF00917	0.477
DOC_WW_Pin1_4	187	192	PF00397	0.607
LIG_14-3-3_CanoR_1	138	147	PF00244	0.392
LIG_14-3-3_CanoR_1	3	13	PF00244	0.550
LIG_FHA_1	103	109	PF00498	0.446
LIG_FHA_1	20	26	PF00498	0.526
LIG_FHA_1	88	94	PF00498	0.395
LIG_FHA_2	104	110	PF00498	0.425
LIG_Integrin_isoDGR_2	150	152	PF01839	0.390
LIG_SH2_PTP2	171	174	PF00017	0.352
LIG_SH2_STAT5	168	171	PF00017	0.399
LIG_SH2_STAT5	92	95	PF00017	0.442
LIG_SH3_1	188	194	PF00018	0.538
LIG_SH3_3	171	177	PF00018	0.407
LIG_SH3_3	188	194	PF00018	0.538
MOD_CK1_1	190	196	PF00069	0.663
MOD_CK1_1	209	215	PF00069	0.508
MOD_CK1_1	222	228	PF00069	0.749
MOD_CK1_1	29	35	PF00069	0.555
MOD_CK1_1	46	52	PF00069	0.581
MOD_GlcNHglycan	211	214	PF01048	0.635
MOD_GlcNHglycan	22	25	PF01048	0.693
MOD_GlcNHglycan	48	51	PF01048	0.761
MOD_GlcNHglycan	52	55	PF01048	0.757
MOD_GlcNHglycan	6	9	PF01048	0.532
MOD_GlcNHglycan	64	67	PF01048	0.723
MOD_GSK3_1	26	33	PF00069	0.712
MOD_GSK3_1	4	11	PF00069	0.634
MOD_GSK3_1	44	51	PF00069	0.629
MOD_GSK3_1	99	106	PF00069	0.390
MOD_N-GLC_1	207	212	PF02516	0.554
MOD_NEK2_1	101	106	PF00069	0.374
MOD_NEK2_1	64	69	PF00069	0.564
MOD_NEK2_2	219	224	PF00069	0.522
MOD_PIKK_1	222	228	PF00454	0.696
MOD_PIKK_1	96	102	PF00454	0.364
MOD_PK_1	72	78	PF00069	0.438
MOD_PKA_1	3	9	PF00069	0.515
MOD_PKA_2	3	9	PF00069	0.515
MOD_Plk_1	219	225	PF00069	0.520
MOD_Plk_4	179	185	PF00069	0.462
MOD_Plk_4	77	83	PF00069	0.413
MOD_ProDKin_1	187	193	PF00069	0.608
TRG_ENDOCYTIC_2	129	132	PF00928	0.434
TRG_ENDOCYTIC_2	166	169	PF00928	0.418
TRG_ENDOCYTIC_2	171	174	PF00928	0.352
TRG_ER_diArg_1	152	155	PF00400	0.422
TRG_ER_diArg_1	2	4	PF00400	0.589

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM19	Leptomonas seymouri	75%	100%
A0A3S7XAD1	Leishmania donovani	90%	100%
A4HNT0	Leishmania braziliensis	78%	100%
A4ICR4	Leishmania infantum	90%	100%
Q6T456	Leishmania major	90%	100%