EamA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

EamA-like transporter family, putative

Species:

Leishmania mexicana

UniProt:

E9ASI7_LEIMU

TriTrypDb:

LmxM.36.0670

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 3, no: 7
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0000139	Golgi membrane	5	2
GO:0031090	organelle membrane	3	2
GO:0098588	bounding membrane of organelle	4	2

Expansion

Sequence features

E9ASI7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASI7

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	4
GO:0009987	cellular process	1	3
GO:0051179	localization	1	4
GO:0051234	establishment of localization	2	4
GO:0055085	transmembrane transport	2	3
GO:0008643	carbohydrate transport	5	1
GO:0071702	organic substance transport	4	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	4
GO:0022857	transmembrane transporter activity	2	4
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	35	39	PF00656	0.375
CLV_PCSK_SKI1_1	368	372	PF00082	0.328
DOC_CDC14_PxL_1	243	251	PF14671	0.532
DOC_MAPK_DCC_7	242	251	PF00069	0.519
DOC_MAPK_MEF2A_6	242	251	PF00069	0.519
DOC_MAPK_MEF2A_6	305	313	PF00069	0.328
DOC_MAPK_MEF2A_6	332	339	PF00069	0.422
DOC_PP1_RVXF_1	199	206	PF00149	0.420
DOC_PP2B_LxvP_1	311	314	PF13499	0.409
DOC_PP2B_LxvP_1	377	380	PF13499	0.380
DOC_PP4_FxxP_1	40	43	PF00568	0.472
DOC_PP4_FxxP_1	61	64	PF00568	0.299
DOC_USP7_MATH_2	455	461	PF00917	0.549
DOC_WW_Pin1_4	119	124	PF00397	0.600
LIG_14-3-3_CanoR_1	368	373	PF00244	0.371
LIG_14-3-3_CanoR_1	56	62	PF00244	0.418
LIG_Actin_WH2_2	16	31	PF00022	0.504
LIG_BIR_III_2	423	427	PF00653	0.542
LIG_BRCT_BRCA1_1	340	344	PF00533	0.451
LIG_BRCT_BRCA1_1	36	40	PF00533	0.421
LIG_BRCT_BRCA1_1	6	10	PF00533	0.536
LIG_Clathr_ClatBox_1	282	286	PF01394	0.287
LIG_deltaCOP1_diTrp_1	327	336	PF00928	0.303
LIG_FHA_1	106	112	PF00498	0.685
LIG_FHA_1	23	29	PF00498	0.413
LIG_FHA_1	252	258	PF00498	0.508
LIG_FHA_1	357	363	PF00498	0.533
LIG_FHA_1	369	375	PF00498	0.295
LIG_FHA_1	74	80	PF00498	0.405
LIG_FHA_2	174	180	PF00498	0.571
LIG_FHA_2	409	415	PF00498	0.661
LIG_LIR_Apic_2	115	120	PF02991	0.589
LIG_LIR_Apic_2	124	129	PF02991	0.331
LIG_LIR_Apic_2	37	43	PF02991	0.453
LIG_LIR_Apic_2	60	64	PF02991	0.318
LIG_LIR_Gen_1	147	155	PF02991	0.255
LIG_LIR_Gen_1	159	169	PF02991	0.298
LIG_LIR_Gen_1	384	395	PF02991	0.270
LIG_LIR_Gen_1	411	421	PF02991	0.606
LIG_LIR_Gen_1	7	18	PF02991	0.455
LIG_LIR_Nem_3	147	151	PF02991	0.315
LIG_LIR_Nem_3	159	165	PF02991	0.298
LIG_LIR_Nem_3	167	173	PF02991	0.315
LIG_LIR_Nem_3	384	390	PF02991	0.352
LIG_LIR_Nem_3	411	416	PF02991	0.659
LIG_LIR_Nem_3	66	72	PF02991	0.328
LIG_LIR_Nem_3	7	13	PF02991	0.506
LIG_MLH1_MIPbox_1	340	344	PF16413	0.451
LIG_NRBOX	194	200	PF00104	0.435
LIG_NRBOX	217	223	PF00104	0.419
LIG_NRBOX	373	379	PF00104	0.469
LIG_PCNA_yPIPBox_3	212	222	PF02747	0.293
LIG_Pex14_2	383	387	PF04695	0.345
LIG_Pex14_2	61	65	PF04695	0.311
LIG_PTB_Apo_2	399	406	PF02174	0.419
LIG_SH2_CRK	117	121	PF00017	0.618
LIG_SH2_CRK	148	152	PF00017	0.305
LIG_SH2_CRK	232	236	PF00017	0.317
LIG_SH2_CRK	244	248	PF00017	0.497
LIG_SH2_NCK_1	148	152	PF00017	0.316
LIG_SH2_PTP2	91	94	PF00017	0.569
LIG_SH2_SRC	315	318	PF00017	0.361
LIG_SH2_STAP1	148	152	PF00017	0.316
LIG_SH2_STAP1	315	319	PF00017	0.367
LIG_SH2_STAT5	168	171	PF00017	0.319
LIG_SH2_STAT5	338	341	PF00017	0.331
LIG_SH2_STAT5	91	94	PF00017	0.562
LIG_SH3_1	117	123	PF00018	0.651
LIG_SH3_3	117	123	PF00018	0.582
LIG_SUMO_SIM_anti_2	263	268	PF11976	0.380
LIG_SUMO_SIM_par_1	281	287	PF11976	0.448
LIG_SUMO_SIM_par_1	359	366	PF11976	0.559
LIG_TRAF2_1	284	287	PF00917	0.427
LIG_TRAF2_2	418	423	PF00917	0.535
LIG_TYR_ITIM	146	151	PF00017	0.318
LIG_TYR_ITIM	166	171	PF00017	0.204
LIG_TYR_ITIM	313	318	PF00017	0.369
LIG_UBA3_1	240	245	PF00899	0.563
LIG_UBA3_1	81	90	PF00899	0.364
LIG_WRC_WIRS_1	58	63	PF05994	0.343
MOD_CK2_1	173	179	PF00069	0.551
MOD_CK2_1	378	384	PF00069	0.382
MOD_GlcNHglycan	129	132	PF01048	0.400
MOD_GlcNHglycan	290	293	PF01048	0.653
MOD_GlcNHglycan	340	343	PF01048	0.414
MOD_GlcNHglycan	356	359	PF01048	0.250
MOD_GlcNHglycan	44	47	PF01048	0.709
MOD_GlcNHglycan	6	9	PF01048	0.620
MOD_GSK3_1	30	37	PF00069	0.387
MOD_GSK3_1	354	361	PF00069	0.548
MOD_GSK3_1	38	45	PF00069	0.447
MOD_GSK3_1	4	11	PF00069	0.479
MOD_GSK3_1	443	450	PF00069	0.614
MOD_GSK3_1	96	103	PF00069	0.647
MOD_N-GLC_1	299	304	PF02516	0.624
MOD_N-GLC_1	368	373	PF02516	0.390
MOD_N-GLC_1	443	448	PF02516	0.297
MOD_N-GLC_2	346	348	PF02516	0.351
MOD_NEK2_1	134	139	PF00069	0.296
MOD_NEK2_1	144	149	PF00069	0.329
MOD_NEK2_1	155	160	PF00069	0.327
MOD_NEK2_1	19	24	PF00069	0.385
MOD_NEK2_1	205	210	PF00069	0.466
MOD_NEK2_1	262	267	PF00069	0.386
MOD_NEK2_1	363	368	PF00069	0.389
MOD_NEK2_1	57	62	PF00069	0.359
MOD_PIKK_1	63	69	PF00454	0.363
MOD_PKA_2	173	179	PF00069	0.534
MOD_PKA_2	325	331	PF00069	0.388
MOD_PKB_1	445	453	PF00069	0.658
MOD_Plk_1	299	305	PF00069	0.425
MOD_Plk_1	368	374	PF00069	0.405
MOD_Plk_1	447	453	PF00069	0.709
MOD_Plk_4	121	127	PF00069	0.499
MOD_Plk_4	134	140	PF00069	0.278
MOD_Plk_4	147	153	PF00069	0.277
MOD_Plk_4	156	162	PF00069	0.327
MOD_Plk_4	262	268	PF00069	0.384
MOD_Plk_4	299	305	PF00069	0.431
MOD_Plk_4	348	354	PF00069	0.440
MOD_Plk_4	358	364	PF00069	0.509
MOD_Plk_4	368	374	PF00069	0.122
MOD_Plk_4	378	384	PF00069	0.122
MOD_ProDKin_1	119	125	PF00069	0.593
MOD_SUMO_for_1	440	443	PF00179	0.639
MOD_SUMO_rev_2	327	334	PF00179	0.298
TRG_DiLeu_BaEn_1	75	80	PF01217	0.380
TRG_DiLeu_BaEn_2	329	335	PF01217	0.369
TRG_DiLeu_BaLyEn_6	236	241	PF01217	0.552
TRG_DiLeu_BaLyEn_6	53	58	PF01217	0.373
TRG_ENDOCYTIC_2	148	151	PF00928	0.310
TRG_ENDOCYTIC_2	152	155	PF00928	0.316
TRG_ENDOCYTIC_2	168	171	PF00928	0.267
TRG_ENDOCYTIC_2	232	235	PF00928	0.327
TRG_ENDOCYTIC_2	315	318	PF00928	0.375

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAC3	Leptomonas seymouri	57%	99%
A0A0S4JLV3	Bodo saltans	32%	100%
A0A0S4JVX5	Bodo saltans	33%	100%
A0A1X0P938	Trypanosomatidae	47%	100%
A0A3Q8INC1	Leishmania donovani	90%	100%
A0A3R7N2L5	Trypanosoma rangeli	47%	100%
A4HNS7	Leishmania braziliensis	71%	100%
A4ICR7	Leishmania infantum	90%	100%
Q4Q209	Leishmania major	88%	100%
Q5RFT1	Pongo abelii	31%	100%
Q5RKH7	Rattus norvegicus	29%	100%
Q8N357	Homo sapiens	31%	100%
Q8VE96	Mus musculus	27%	100%