Enriched in surface-labeled proteome protein 14

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enriched in surface-labeled proteome protein 18

Species:

Leishmania mexicana

UniProt:

E9ASI6_LEIMU

TriTrypDb:

LmxM.36.0660

Length:

201

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 3
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	1
GO:0009986	cell surface	2	1
GO:0031410	cytoplasmic vesicle	6	1
GO:0031982	vesicle	4	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0097708	intracellular vesicle	5	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

E9ASI6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASI6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.522
CLV_NRD_NRD_1	196	198	PF00675	0.425
CLV_PCSK_KEX2_1	112	114	PF00082	0.559
DEG_APCC_DBOX_1	152	160	PF00400	0.401
DEG_SPOP_SBC_1	59	63	PF00917	0.638
DOC_CDC14_PxL_1	156	164	PF14671	0.573
DOC_MAPK_MEF2A_6	157	164	PF00069	0.477
DOC_PP2B_LxvP_1	162	165	PF13499	0.551
DOC_WW_Pin1_4	60	65	PF00397	0.660
DOC_WW_Pin1_4	88	93	PF00397	0.488
LIG_14-3-3_CanoR_1	112	122	PF00244	0.603
LIG_14-3-3_CanoR_1	60	64	PF00244	0.685
LIG_BRCT_BRCA1_1	15	19	PF00533	0.504
LIG_eIF4E_1	174	180	PF01652	0.436
LIG_FHA_1	113	119	PF00498	0.547
LIG_FHA_1	54	60	PF00498	0.744
LIG_GBD_Chelix_1	24	32	PF00786	0.566
LIG_LIR_Gen_1	116	127	PF02991	0.588
LIG_LIR_Gen_1	171	180	PF02991	0.484
LIG_LIR_Gen_1	7	15	PF02991	0.537
LIG_LIR_Nem_3	116	122	PF02991	0.617
LIG_LIR_Nem_3	171	177	PF02991	0.404
LIG_LIR_Nem_3	7	12	PF02991	0.536
LIG_MLH1_MIPbox_1	15	19	PF16413	0.504
LIG_NBox_RRM_1	19	29	PF00076	0.479
LIG_SH2_CRK	9	13	PF00017	0.441
LIG_SH2_STAT5	18	21	PF00017	0.500
LIG_SH2_STAT5	84	87	PF00017	0.528
LIG_SH3_2	89	94	PF14604	0.491
LIG_SH3_3	86	92	PF00018	0.498
LIG_SUMO_SIM_par_1	28	33	PF11976	0.518
LIG_TRAF2_1	72	75	PF00917	0.503
MOD_CDC14_SPxK_1	91	94	PF00782	0.470
MOD_CDK_SPxK_1	88	94	PF00069	0.489
MOD_CK1_1	33	39	PF00069	0.560
MOD_CK1_1	53	59	PF00069	0.662
MOD_CK2_1	145	151	PF00069	0.384
MOD_CK2_1	69	75	PF00069	0.571
MOD_GlcNHglycan	115	118	PF01048	0.419
MOD_GlcNHglycan	170	173	PF01048	0.483
MOD_GlcNHglycan	32	35	PF01048	0.633
MOD_GlcNHglycan	47	50	PF01048	0.755
MOD_GSK3_1	113	120	PF00069	0.594
MOD_GSK3_1	33	40	PF00069	0.603
MOD_GSK3_1	55	62	PF00069	0.703
MOD_NEK2_1	13	18	PF00069	0.644
MOD_NEK2_1	30	35	PF00069	0.681
MOD_NEK2_1	37	42	PF00069	0.623
MOD_NEK2_1	4	9	PF00069	0.553
MOD_NEK2_2	173	178	PF00069	0.437
MOD_PKA_1	112	118	PF00069	0.539
MOD_PKA_2	112	118	PF00069	0.588
MOD_PKA_2	59	65	PF00069	0.559
MOD_PKB_1	41	49	PF00069	0.556
MOD_Plk_1	53	59	PF00069	0.812
MOD_Plk_4	122	128	PF00069	0.426
MOD_Plk_4	4	10	PF00069	0.481
MOD_ProDKin_1	60	66	PF00069	0.659
MOD_ProDKin_1	88	94	PF00069	0.489
MOD_SUMO_rev_2	75	83	PF00179	0.525
TRG_DiLeu_BaEn_1	175	180	PF01217	0.502
TRG_DiLeu_BaLyEn_6	191	196	PF01217	0.521
TRG_ENDOCYTIC_2	119	122	PF00928	0.493
TRG_ENDOCYTIC_2	174	177	PF00928	0.382
TRG_ENDOCYTIC_2	9	12	PF00928	0.580
TRG_ER_diArg_1	111	114	PF00400	0.606
TRG_ER_diArg_1	192	195	PF00400	0.532
TRG_ER_diArg_1	41	44	PF00400	0.499
TRG_ER_diLys_1	198	201	PF00400	0.409
TRG_NLS_MonoExtC_3	196	201	PF00514	0.503
TRG_NLS_MonoExtN_4	194	201	PF00514	0.393
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.494

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L4	Leptomonas seymouri	49%	96%
A0A1X0P888	Trypanosomatidae	27%	100%
A0A3S7XAF9	Leishmania donovani	84%	100%
A4HNS6	Leishmania braziliensis	69%	100%
A4ICR8	Leishmania infantum	84%	100%
D0A2N6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
Q4Q210	Leishmania major	85%	100%