Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania mexicana

UniProt:

E9ASH7_LEIMU

TriTrypDb:

LmxM.36.0580

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	15
GO:0032991	protein-containing complex	1	15
GO:0043226	organelle	2	15
GO:0043228	non-membrane-bounded organelle	3	15
GO:0043229	intracellular organelle	3	15
GO:0043232	intracellular non-membrane-bounded organelle	4	15
GO:0110165	cellular anatomical entity	1	15
GO:1990904	ribonucleoprotein complex	2	15

Expansion

Sequence features

E9ASH7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASH7

Function

Biological processes
Term	Name	Level	Count
GO:0007165	signal transduction	2	1
GO:0009987	cellular process	1	3
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0065007	biological regulation	1	1
GO:0006793	phosphorus metabolic process	3	2
GO:0006796	phosphate-containing compound metabolic process	4	2
GO:0008152	metabolic process	1	2
GO:0016310	phosphorylation	5	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0016301	kinase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	467	471	PF00656	0.329
CLV_NRD_NRD_1	137	139	PF00675	0.582
CLV_NRD_NRD_1	2	4	PF00675	0.661
CLV_NRD_NRD_1	230	232	PF00675	0.396
CLV_NRD_NRD_1	432	434	PF00675	0.526
CLV_PCSK_KEX2_1	137	139	PF00082	0.480
CLV_PCSK_KEX2_1	2	4	PF00082	0.651
CLV_PCSK_KEX2_1	230	232	PF00082	0.501
CLV_PCSK_KEX2_1	388	390	PF00082	0.502
CLV_PCSK_KEX2_1	432	434	PF00082	0.475
CLV_PCSK_PC1ET2_1	388	390	PF00082	0.489
CLV_PCSK_SKI1_1	119	123	PF00082	0.455
CLV_PCSK_SKI1_1	156	160	PF00082	0.394
CLV_PCSK_SKI1_1	175	179	PF00082	0.232
CLV_PCSK_SKI1_1	231	235	PF00082	0.359
CLV_PCSK_SKI1_1	295	299	PF00082	0.446
CLV_PCSK_SKI1_1	388	392	PF00082	0.529
CLV_PCSK_SKI1_1	476	480	PF00082	0.461
CLV_PCSK_SKI1_1	486	490	PF00082	0.404
DEG_APCC_DBOX_1	118	126	PF00400	0.450
DEG_APCC_DBOX_1	406	414	PF00400	0.330
DEG_Nend_UBRbox_1	1	4	PF02207	0.540
DEG_SCF_FBW7_1	68	75	PF00400	0.541
DEG_SCF_TRCP1_1	470	475	PF00400	0.289
DEG_SPOP_SBC_1	210	214	PF00917	0.412
DOC_CKS1_1	129	134	PF01111	0.430
DOC_CKS1_1	94	99	PF01111	0.437
DOC_CYCLIN_yCln2_LP_2	94	100	PF00134	0.516
DOC_PP1_RVXF_1	154	161	PF00149	0.304
DOC_PP1_RVXF_1	386	393	PF00149	0.577
DOC_PP1_RVXF_1	474	480	PF00149	0.475
DOC_PP4_FxxP_1	314	317	PF00568	0.384
DOC_USP7_MATH_1	117	121	PF00917	0.585
DOC_USP7_MATH_1	211	215	PF00917	0.369
DOC_USP7_MATH_1	284	288	PF00917	0.426
DOC_USP7_MATH_1	299	303	PF00917	0.459
DOC_USP7_MATH_1	414	418	PF00917	0.440
DOC_USP7_MATH_1	54	58	PF00917	0.488
DOC_USP7_MATH_1	72	76	PF00917	0.624
DOC_WW_Pin1_4	123	128	PF00397	0.740
DOC_WW_Pin1_4	369	374	PF00397	0.627
DOC_WW_Pin1_4	470	475	PF00397	0.332
DOC_WW_Pin1_4	68	73	PF00397	0.705
DOC_WW_Pin1_4	93	98	PF00397	0.637
LIG_14-3-3_CanoR_1	107	111	PF00244	0.696
LIG_14-3-3_CanoR_1	116	122	PF00244	0.621
LIG_14-3-3_CanoR_1	137	143	PF00244	0.586
LIG_14-3-3_CanoR_1	175	184	PF00244	0.572
LIG_14-3-3_CanoR_1	230	236	PF00244	0.420
LIG_14-3-3_CanoR_1	243	251	PF00244	0.543
LIG_14-3-3_CanoR_1	261	266	PF00244	0.459
LIG_14-3-3_CanoR_1	389	393	PF00244	0.602
LIG_14-3-3_CanoR_1	432	438	PF00244	0.529
LIG_14-3-3_CanoR_1	463	467	PF00244	0.516
LIG_14-3-3_CanoR_1	51	57	PF00244	0.703
LIG_Actin_WH2_2	450	465	PF00022	0.322
LIG_BRCT_BRCA1_1	117	121	PF00533	0.679
LIG_FHA_1	216	222	PF00498	0.353
LIG_FHA_1	346	352	PF00498	0.410
LIG_FHA_1	354	360	PF00498	0.399
LIG_FHA_1	38	44	PF00498	0.527
LIG_FHA_1	441	447	PF00498	0.465
LIG_FHA_2	211	217	PF00498	0.300
LIG_FHA_2	334	340	PF00498	0.480
LIG_FHA_2	341	347	PF00498	0.486
LIG_FHA_2	379	385	PF00498	0.503
LIG_LIR_Apic_2	312	317	PF02991	0.387
LIG_LIR_Gen_1	60	68	PF02991	0.446
LIG_LIR_Gen_1	89	98	PF02991	0.499
LIG_LIR_Nem_3	405	411	PF02991	0.492
LIG_LIR_Nem_3	60	64	PF02991	0.508
LIG_LIR_Nem_3	89	94	PF02991	0.526
LIG_PTB_Apo_2	55	62	PF02174	0.434
LIG_SH2_STAP1	151	155	PF00017	0.283
LIG_SH2_STAT5	307	310	PF00017	0.465
LIG_SH2_STAT5	34	37	PF00017	0.545
LIG_SH2_STAT5	422	425	PF00017	0.430
LIG_SH2_STAT5	487	490	PF00017	0.347
LIG_SH2_STAT5	91	94	PF00017	0.443
LIG_SH3_3	126	132	PF00018	0.480
LIG_SH3_3	82	88	PF00018	0.645
LIG_SH3_5	30	34	PF00018	0.563
LIG_Sin3_3	408	415	PF02671	0.314
LIG_SUMO_SIM_par_1	326	332	PF11976	0.415
LIG_SUMO_SIM_par_1	455	461	PF11976	0.373
LIG_SUMO_SIM_par_1	487	492	PF11976	0.312
LIG_TRAF2_1	343	346	PF00917	0.325
LIG_TRFH_1	142	146	PF08558	0.383
LIG_UBA3_1	220	228	PF00899	0.383
MOD_CDC14_SPxK_1	473	476	PF00782	0.302
MOD_CDK_SPxK_1	470	476	PF00069	0.290
MOD_CDK_SPxxK_3	128	135	PF00069	0.429
MOD_CDK_SPxxK_3	369	376	PF00069	0.431
MOD_CK1_1	101	107	PF00069	0.730
MOD_CK1_1	169	175	PF00069	0.362
MOD_CK1_1	246	252	PF00069	0.454
MOD_CK1_1	383	389	PF00069	0.501
MOD_CK1_1	461	467	PF00069	0.428
MOD_CK1_1	468	474	PF00069	0.351
MOD_CK1_1	57	63	PF00069	0.664
MOD_CK1_1	75	81	PF00069	0.583
MOD_CK2_1	244	250	PF00069	0.525
MOD_CK2_1	340	346	PF00069	0.405
MOD_CK2_1	378	384	PF00069	0.735
MOD_GlcNHglycan	246	249	PF01048	0.309
MOD_GlcNHglycan	267	270	PF01048	0.552
MOD_GlcNHglycan	301	304	PF01048	0.437
MOD_GlcNHglycan	314	317	PF01048	0.488
MOD_GlcNHglycan	325	328	PF01048	0.471
MOD_GlcNHglycan	433	436	PF01048	0.685
MOD_GlcNHglycan	470	473	PF01048	0.382
MOD_GlcNHglycan	68	71	PF01048	0.592
MOD_GlcNHglycan	80	83	PF01048	0.617
MOD_GlcNHglycan	88	91	PF01048	0.619
MOD_GSK3_1	13	20	PF00069	0.621
MOD_GSK3_1	205	212	PF00069	0.388
MOD_GSK3_1	238	245	PF00069	0.570
MOD_GSK3_1	246	253	PF00069	0.412
MOD_GSK3_1	261	268	PF00069	0.425
MOD_GSK3_1	284	291	PF00069	0.340
MOD_GSK3_1	323	330	PF00069	0.439
MOD_GSK3_1	33	40	PF00069	0.545
MOD_GSK3_1	376	383	PF00069	0.743
MOD_GSK3_1	452	459	PF00069	0.501
MOD_GSK3_1	461	468	PF00069	0.380
MOD_GSK3_1	62	69	PF00069	0.647
MOD_GSK3_1	72	79	PF00069	0.604
MOD_N-GLC_1	11	16	PF02516	0.485
MOD_N-GLC_1	57	62	PF02516	0.434
MOD_NEK2_1	168	173	PF00069	0.447
MOD_NEK2_1	205	210	PF00069	0.336
MOD_NEK2_1	238	243	PF00069	0.468
MOD_NEK2_1	244	249	PF00069	0.495
MOD_NEK2_1	288	293	PF00069	0.393
MOD_NEK2_1	396	401	PF00069	0.411
MOD_NEK2_1	403	408	PF00069	0.409
MOD_NEK2_1	426	431	PF00069	0.433
MOD_NEK2_1	458	463	PF00069	0.445
MOD_NEK2_1	479	484	PF00069	0.445
MOD_NEK2_1	64	69	PF00069	0.627
MOD_NEK2_1	76	81	PF00069	0.510
MOD_PIKK_1	17	23	PF00454	0.515
MOD_PIKK_1	437	443	PF00454	0.537
MOD_PKA_1	388	394	PF00069	0.471
MOD_PKA_2	106	112	PF00069	0.701
MOD_PKA_2	115	121	PF00069	0.617
MOD_PKA_2	229	235	PF00069	0.393
MOD_PKA_2	242	248	PF00069	0.525
MOD_PKA_2	388	394	PF00069	0.471
MOD_PKA_2	431	437	PF00069	0.527
MOD_PKA_2	462	468	PF00069	0.353
MOD_Plk_1	205	211	PF00069	0.407
MOD_Plk_1	215	221	PF00069	0.321
MOD_Plk_1	345	351	PF00069	0.444
MOD_Plk_1	363	369	PF00069	0.515
MOD_Plk_1	383	389	PF00069	0.501
MOD_Plk_1	57	63	PF00069	0.658
MOD_Plk_4	106	112	PF00069	0.534
MOD_Plk_4	205	211	PF00069	0.462
MOD_Plk_4	345	351	PF00069	0.452
MOD_ProDKin_1	123	129	PF00069	0.739
MOD_ProDKin_1	369	375	PF00069	0.631
MOD_ProDKin_1	470	476	PF00069	0.333
MOD_ProDKin_1	68	74	PF00069	0.706
MOD_ProDKin_1	93	99	PF00069	0.636
TRG_DiLeu_BaEn_1	187	192	PF01217	0.466
TRG_DiLeu_BaEn_1	345	350	PF01217	0.319
TRG_ENDOCYTIC_2	91	94	PF00928	0.594
TRG_ER_diArg_1	1	3	PF00400	0.655
TRG_ER_diArg_1	137	139	PF00400	0.574
TRG_Pf-PMV_PEXEL_1	486	490	PF00026	0.306

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I384	Leptomonas seymouri	24%	69%
A0A0N1ILR3	Leptomonas seymouri	48%	88%
A0A0S4J2H1	Bodo saltans	30%	100%
A0A1X0NT03	Trypanosomatidae	24%	88%
A0A3Q8IDW5	Leishmania donovani	25%	70%
A0A3Q8IGX5	Leishmania donovani	85%	100%
A0A3R7NBP1	Trypanosoma rangeli	24%	91%
A4H8W6	Leishmania braziliensis	23%	70%
A4HX90	Leishmania infantum	25%	80%
A4ICS7	Leishmania infantum	85%	100%
C9ZTV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	90%
E9AQZ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	70%
Q4QEH1	Leishmania major	24%	74%