Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania mexicana

UniProt:

E9ASH5_LEIMU

TriTrypDb:

LmxM.36.0560

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

E9ASH5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASH5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	91	95	PF00656	0.616
CLV_NRD_NRD_1	108	110	PF00675	0.573
CLV_NRD_NRD_1	132	134	PF00675	0.650
CLV_NRD_NRD_1	149	151	PF00675	0.444
CLV_NRD_NRD_1	21	23	PF00675	0.520
CLV_NRD_NRD_1	36	38	PF00675	0.571
CLV_NRD_NRD_1	96	98	PF00675	0.555
CLV_PCSK_FUR_1	150	154	PF00082	0.616
CLV_PCSK_KEX2_1	108	110	PF00082	0.474
CLV_PCSK_KEX2_1	119	121	PF00082	0.537
CLV_PCSK_KEX2_1	132	134	PF00082	0.469
CLV_PCSK_KEX2_1	152	154	PF00082	0.287
CLV_PCSK_KEX2_1	23	25	PF00082	0.506
CLV_PCSK_KEX2_1	36	38	PF00082	0.524
CLV_PCSK_KEX2_1	96	98	PF00082	0.456
CLV_PCSK_PC1ET2_1	119	121	PF00082	0.615
CLV_PCSK_PC1ET2_1	152	154	PF00082	0.576
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.578
CLV_PCSK_PC7_1	92	98	PF00082	0.517
CLV_PCSK_SKI1_1	108	112	PF00082	0.525
CLV_PCSK_SKI1_1	116	120	PF00082	0.485
CLV_PCSK_SKI1_1	212	216	PF00082	0.596
DEG_APCC_DBOX_1	21	29	PF00400	0.540
DOC_CKS1_1	177	182	PF01111	0.419
DOC_MAPK_RevD_3	81	97	PF00069	0.573
DOC_PP1_RVXF_1	25	31	PF00149	0.326
DOC_USP7_MATH_1	112	116	PF00917	0.623
DOC_USP7_MATH_1	121	125	PF00917	0.497
DOC_USP7_MATH_1	2	6	PF00917	0.606
DOC_USP7_UBL2_3	215	219	PF12436	0.644
DOC_WW_Pin1_4	176	181	PF00397	0.411
LIG_14-3-3_CanoR_1	120	126	PF00244	0.645
LIG_14-3-3_CanoR_1	168	178	PF00244	0.580
LIG_14-3-3_CanoR_1	58	68	PF00244	0.573
LIG_Actin_WH2_2	202	217	PF00022	0.488
LIG_BIR_II_1	1	5	PF00653	0.656
LIG_BIR_III_3	1	5	PF00653	0.440
LIG_FHA_1	120	126	PF00498	0.570
LIG_FHA_1	158	164	PF00498	0.571
LIG_FHA_2	177	183	PF00498	0.507
LIG_FHA_2	206	212	PF00498	0.610
LIG_FHA_2	89	95	PF00498	0.587
LIG_LIR_Gen_1	234	243	PF02991	0.570
LIG_LIR_Gen_1	89	98	PF02991	0.562
LIG_LIR_Nem_3	234	239	PF02991	0.567
LIG_LIR_Nem_3	89	93	PF02991	0.568
LIG_SH2_PTP2	236	239	PF00017	0.568
LIG_SH2_STAP1	41	45	PF00017	0.692
LIG_SH2_STAP1	6	10	PF00017	0.673
LIG_SH2_STAT5	236	239	PF00017	0.568
LIG_SH2_STAT5	90	93	PF00017	0.595
LIG_SH2_STAT5	99	102	PF00017	0.355
LIG_UBA3_1	142	151	PF00899	0.326
MOD_CK1_1	124	130	PF00069	0.572
MOD_CK1_1	59	65	PF00069	0.515
MOD_CK2_1	124	130	PF00069	0.556
MOD_CK2_1	138	144	PF00069	0.404
MOD_CK2_1	152	158	PF00069	0.556
MOD_CK2_1	169	175	PF00069	0.566
MOD_CK2_1	176	182	PF00069	0.640
MOD_CK2_1	205	211	PF00069	0.590
MOD_CK2_1	40	46	PF00069	0.624
MOD_GlcNHglycan	224	227	PF01048	0.613
MOD_GlcNHglycan	50	54	PF01048	0.571
MOD_GlcNHglycan	61	64	PF01048	0.517
MOD_GSK3_1	169	176	PF00069	0.567
MOD_N-GLC_1	112	117	PF02516	0.562
MOD_N-GLC_1	17	22	PF02516	0.517
MOD_N-GLC_1	81	86	PF02516	0.569
MOD_NEK2_1	205	210	PF00069	0.590
MOD_NEK2_1	243	248	PF00069	0.544
MOD_PIKK_1	124	130	PF00454	0.649
MOD_PIKK_1	157	163	PF00454	0.570
MOD_PIKK_1	70	76	PF00454	0.550
MOD_PKA_1	119	125	PF00069	0.586
MOD_PKA_1	152	158	PF00069	0.614
MOD_PKA_2	119	125	PF00069	0.603
MOD_PKA_2	152	158	PF00069	0.588
MOD_PKA_2	59	65	PF00069	0.552
MOD_Plk_1	17	23	PF00069	0.530
MOD_Plk_1	198	204	PF00069	0.510
MOD_Plk_1	205	211	PF00069	0.511
MOD_Plk_1	88	94	PF00069	0.589
MOD_Plk_4	138	144	PF00069	0.329
MOD_ProDKin_1	176	182	PF00069	0.415
MOD_SUMO_rev_2	115	121	PF00179	0.636
TRG_DiLeu_BaEn_1	159	164	PF01217	0.581
TRG_DiLeu_BaEn_4	16	22	PF01217	0.489
TRG_DiLeu_BaEn_4	234	240	PF01217	0.566
TRG_ENDOCYTIC_2	236	239	PF00928	0.568
TRG_ENDOCYTIC_2	90	93	PF00928	0.525
TRG_ER_diArg_1	107	109	PF00400	0.570
TRG_ER_diArg_1	131	133	PF00400	0.658
TRG_ER_diArg_1	21	24	PF00400	0.514
TRG_ER_diArg_1	57	60	PF00400	0.564
TRG_Pf-PMV_PEXEL_1	109	114	PF00026	0.618
TRG_Pf-PMV_PEXEL_1	168	173	PF00026	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6Y9	Leptomonas seymouri	62%	98%
A0A1X0P948	Trypanosomatidae	29%	100%
A0A3R7P2R3	Trypanosoma rangeli	27%	100%
A0A3S7XAJ5	Leishmania donovani	95%	81%
A4HNR6	Leishmania braziliensis	81%	100%
A4ICS9	Leishmania infantum	94%	81%
Q4Q220	Leishmania major	92%	100%
V5DRQ0	Trypanosoma cruzi	30%	99%