Putative ubiquitin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-like protein, putative

Species:

Leishmania mexicana

UniProt:

E9ASH3_LEIMU

TriTrypDb:

LmxM.36.0540

Length:

317

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

E9ASH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: E9ASH3

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006259	DNA metabolic process	4	3
GO:0006281	DNA repair	5	3
GO:0006289	nucleotide-excision repair	6	3
GO:0006508	proteolysis	4	4
GO:0006511	ubiquitin-dependent protein catabolic process	7	4
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	4
GO:0006950	response to stress	2	3
GO:0006974	DNA damage response	4	3
GO:0008152	metabolic process	1	4
GO:0009056	catabolic process	2	4
GO:0009057	macromolecule catabolic process	4	4
GO:0009987	cellular process	1	4
GO:0010498	proteasomal protein catabolic process	5	3
GO:0019538	protein metabolic process	3	4
GO:0019941	modification-dependent protein catabolic process	6	4
GO:0030163	protein catabolic process	4	3
GO:0033554	cellular response to stress	3	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	3
GO:0043170	macromolecule metabolic process	3	4
GO:0043632	modification-dependent macromolecule catabolic process	5	4
GO:0044237	cellular metabolic process	2	4
GO:0044238	primary metabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0044260	obsolete cellular macromolecule metabolic process	3	4
GO:0044265	obsolete cellular macromolecule catabolic process	4	4
GO:0046483	heterocycle metabolic process	3	3
GO:0050896	response to stimulus	1	3
GO:0051603	proteolysis involved in protein catabolic process	5	4
GO:0051716	cellular response to stimulus	2	3
GO:0071704	organic substance metabolic process	2	4
GO:0090304	nucleic acid metabolic process	4	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:1901564	organonitrogen compound metabolic process	3	4
GO:1901565	organonitrogen compound catabolic process	4	3
GO:1901575	organic substance catabolic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003677	DNA binding	4	3
GO:0003684	damaged DNA binding	5	3
GO:0005488	binding	1	4
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3
GO:0005515	protein binding	2	1
GO:0031593	polyubiquitin modification-dependent protein binding	4	1
GO:0140030	modification-dependent protein binding	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	49	53	PF00082	0.277
CLV_Separin_Metazoa	219	223	PF03568	0.570
DEG_APCC_DBOX_1	278	286	PF00400	0.418
DEG_SPOP_SBC_1	102	106	PF00917	0.684
DEG_SPOP_SBC_1	79	83	PF00917	0.623
DOC_PP2B_LxvP_1	35	38	PF13499	0.532
DOC_PP4_FxxP_1	127	130	PF00568	0.714
DOC_PP4_FxxP_1	265	268	PF00568	0.561
DOC_USP7_MATH_1	122	126	PF00917	0.583
DOC_USP7_MATH_1	148	152	PF00917	0.444
DOC_USP7_MATH_1	245	249	PF00917	0.671
DOC_USP7_MATH_1	78	82	PF00917	0.616
DOC_WW_Pin1_4	103	108	PF00397	0.693
DOC_WW_Pin1_4	166	171	PF00397	0.574
DOC_WW_Pin1_4	200	205	PF00397	0.577
DOC_WW_Pin1_4	250	255	PF00397	0.692
DOC_WW_Pin1_4	94	99	PF00397	0.699
LIG_14-3-3_CanoR_1	72	80	PF00244	0.657
LIG_BIR_II_1	1	5	PF00653	0.334
LIG_EH_1	146	150	PF12763	0.638
LIG_FHA_1	12	18	PF00498	0.435
LIG_FHA_1	2	8	PF00498	0.297
LIG_FHA_1	251	257	PF00498	0.693
LIG_FHA_1	32	38	PF00498	0.473
LIG_FHA_2	21	27	PF00498	0.515
LIG_IBAR_NPY_1	118	120	PF08397	0.532
LIG_IBAR_NPY_1	223	225	PF08397	0.606
LIG_LIR_Apic_2	125	130	PF02991	0.708
LIG_NRBOX	310	316	PF00104	0.418
LIG_PCNA_yPIPBox_3	214	222	PF02747	0.495
LIG_PDZ_Class_2	312	317	PF00595	0.480
LIG_PTB_Apo_2	189	196	PF02174	0.523
LIG_SH2_CRK	120	124	PF00017	0.518
LIG_SH2_STAP1	120	124	PF00017	0.538
LIG_SH2_STAT3	198	201	PF00017	0.578
LIG_SH2_STAT3	225	228	PF00017	0.584
LIG_SH2_STAT3	278	281	PF00017	0.298
LIG_SH2_STAT5	198	201	PF00017	0.552
LIG_SH3_3	104	110	PF00018	0.737
LIG_SH3_3	12	18	PF00018	0.471
LIG_SH3_3	264	270	PF00018	0.629
LIG_SUMO_SIM_par_1	13	19	PF11976	0.470
LIG_TRAF2_1	291	294	PF00917	0.355
MOD_CK1_1	103	109	PF00069	0.615
MOD_CK1_1	151	157	PF00069	0.544
MOD_CK1_1	73	79	PF00069	0.678
MOD_CK1_1	92	98	PF00069	0.573
MOD_CK2_1	20	26	PF00069	0.532
MOD_GlcNHglycan	159	162	PF01048	0.557
MOD_GlcNHglycan	57	60	PF01048	0.264
MOD_GlcNHglycan	75	78	PF01048	0.592
MOD_GSK3_1	245	252	PF00069	0.720
MOD_GSK3_1	79	86	PF00069	0.600
MOD_GSK3_1	89	96	PF00069	0.588
MOD_N-GLC_1	83	88	PF02516	0.745
MOD_NEK2_1	1	6	PF00069	0.314
MOD_NEK2_1	20	25	PF00069	0.446
MOD_NEK2_1	233	238	PF00069	0.577
MOD_PIKK_1	129	135	PF00454	0.693
MOD_PIKK_1	245	251	PF00454	0.623
MOD_Plk_1	18	24	PF00069	0.489
MOD_ProDKin_1	103	109	PF00069	0.692
MOD_ProDKin_1	166	172	PF00069	0.569
MOD_ProDKin_1	200	206	PF00069	0.573
MOD_ProDKin_1	250	256	PF00069	0.693
MOD_ProDKin_1	94	100	PF00069	0.703
TRG_DiLeu_BaEn_1	280	285	PF01217	0.445
TRG_DiLeu_BaLyEn_6	310	315	PF01217	0.298
TRG_ENDOCYTIC_2	120	123	PF00928	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I781	Leptomonas seymouri	61%	100%
A0A0S4JQ29	Bodo saltans	44%	100%
A0A1X0P8J6	Trypanosomatidae	37%	100%
A0A3S7XAB2	Leishmania donovani	91%	100%
A0A422P276	Trypanosoma rangeli	39%	100%
A4HNR4	Leishmania braziliensis	80%	100%
A4ICT1	Leishmania infantum	91%	100%
D0A2M4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
P48510	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	85%
Q4Q222	Leishmania major	92%	100%
V5BZY0	Trypanosoma cruzi	40%	88%